While there are many challenges facing transportation in the future, this article touches on just four: demographics and travel, safety, environment, and finance. These challenges, along with others, must be met in order to achieve advances in the five strategic goals of the U.S. Department of Transportation and the Federal Highway Administration: to advance safety, mobility, economic productivity, environment, and national security. Examples are presented to illustrate some of the known technology that could prove useful in these areas in the next century and include computer voice commands, automobile driver/vehicle communication systems, traffic management and incident systems, holographic hierarchical displays, intelligent vehicles, and new or hybrid energy sources.