Genetics-related topics are complex, and students often struggle to grasp them. Therefore, the use of educational games is recommended, as they incorporate methodologies that connect theoretical knowledge with playful elements. This study aimed to assess the contribution of a game created on the Wordwall platform to high school students' understanding of genetics and its relationship with cancer development. To achieve this, a questionnaire was administered, consisting of questions at basic, intermediate, and advanced levels, to assess students' prior knowledge of the subject matter. Following this, a lecture was delivered, explaining genetic concepts and processes while relating them to various malignant neoplasms. Subsequently, students were provided with a link to access the educational game via WhatsApp, using their smartphones. Those without electronic devices completed the virtual activity using school computer lab computers. After playing the game, an increase in the percentage of correct answers was observed at all three knowledge levels: basic knowledge increased by 43.85%, intermediate by 35.9%, and advanced by 43.3%. Participation in the interactive game facilitated a better understanding of the subject matter for students and encouraged skills such as logical reasoning, creativity, problem-solving, and socialization among peers.
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