Computer Compatible Tapes Research Articles

Effect of surface-modified intraocular lenses on long-term postoperative inhibition of posterior capsule opacification

We compared the posterior capsule opacification incidences at 5 years postoperatively and the neodymium–yttrium–aluminum–garnet capsulotomy rates at 10 years postoperatively for two types of intraocular lenses with different optical properties and shapes. This randomized, controlled, prospective, single-blinded study with intra-individual comparisons was conducted between July 21, 2009, and August 31, 2011, at the Dokkyo Medical University Hospital, Tochigi, Japan. Thirty patients (60 eyes) underwent bilateral cataract surgery and received a XY1 intraocular lens in one eye and a FY-60AD intraocular lens in the other. Both intraocular lenses are acrylic and manufactured by HOYA. The XY1 lens is a single-piece, tinted intraocular lens featuring an ultraviolet/ozone treatment on the posterior surface of the lens optic, aimed at enhancing posterior capsule adhesion to prevent posterior capsule opacification. Conversely, the FY-60AD is a tinted intraocular lens with modified polymethylmethacrylate C-loops and no ultraviolet/ozone treatment of the optic. Scheimpflug images were taken using EAS-1000 (NIDEK Co., Ltd., Aichi, Japan), and the scattered light intensity (computer compatible tape) on the posterior surface of the intraocular lens was calculated and evaluated as the posterior capsule opacification. The scattered light values of the XY1 and FY-60AD groups were 6.50 ± 5.69 and 11.64 ± 5.30 computer compatible tape, respectively, at 5 years postoperatively. The cumulative survival incidence after neodymium–yttrium–aluminum–garnet laser capsulotomy was 74.8 % in the XY1 group and 13.8 % in the FY-60AD group at 10 years postoperatively. The surface-modified intraocular lens XY1 reduced the incidence of posterior capsule opacification even 10 years after surgery. Surface modification to increase the adhesion between the intraocular lens and the capsule effectively prevents posterior capsule opacification.

Surface light scattering from 1-piece hydrophobic acrylic intraocular lenses with hydroxyethyl methacrylate: contralateral observation for 7 years.

To quantitatively and intraindividually compare surface light scattering for 7 years after implantation of Clareon and AcrySof intraocular lenses (IOLs). Miyata Eye Hospital, Miyazaki, Japan. Retrospective comparative case series. Clinical records of eyes that had contralateral implantation of SN60WF and SY60WF IOLs were reviewed. Light scattering on the anterior surface of IOLs, corrected distance visual acuity (CDVA), and mesopic and photopic contrast sensitivities were examined at 1 year, 3 years, and 7 years postoperatively, and they were intraindividually compared. 34, 19, and 16 patients visited at 1 year, 3 years, and 7 years postoperatively, respectively. Surface light scattering in eyes with SY60WF IOL was significantly reduced, and the rate of increase was 2.74 computer compatible tapes per year. Although there were prominent increases in eyes with SN60WF IOL, no statistically significant difference was found in their CDVA and contrast sensitivities. In eyes with Clareon IOLs, the development of surface light scattering was suppressed up to 7 years. The increase rate demonstrated that the visual acuity would be least deteriorated up to 12 years postoperatively, whereas the influence of straylight induced should be investigated.

Evaluation of clarity characteristics in a new hydrophobic acrylic IOL in comparison to commercially available IOLs

To perform invitro assessments of surface haze and roughness, subsurface nanoglistenings (SSNGs), and glistenings of a new hydrophobic acrylic intraocular lens (IOL) in comparison to commercially available IOLs. Universities of Utah and Alcalá, and Alcon Vision, LLC. Experimental study. The IOLs used were Clareon CNA0T0, Tecnis ZCB00 and Tecnis OptiBlue ZCB00V, Eternity W-60, enVista MX60, and Vivinex XY1. Surface haze was assessed by the pixel intensity units (PIU) from cross-sectional slitlamp images, and it was correlated to atomic force microscopy roughness. For SSNGs, the IOLs were artificially aged up to 10years, followed by Scheimpflug densitometry (computer-compatible tape unit [CCTU]) measurements. For glistenings, the IOLs were immersed in a water bath and subjected to temperature changes before analysis. The surface haze (n=10, PIU) was 4.25±0.87 (SD) (CNA0T0), 9.50±1.66 (ZCB00), 39.48±1.97 (ZCB00V), 46.68±3.16 (W-60), 44.70±4.00 (MX60), and 4.42±0.71 (XY1) (P<.001), which showed a strong correlation with surface roughness measurements (R=0.94, P=.006). The densitometry (n=10, CCTU at 10years) was 7.30±1.36 (CNA0T0), 11.88±3.10 (ZCB00), 38.12±2.24 (ZCB00V), 48.13±9.44 (W-60), 20.20±3.84 (MX60), and 6.75±6.66 (XY1) (P<.001), with no significant differences between CNA0T0 vs. ZCB00 and XY1. The glistenings density (n=30) was the lowest for the CNA0T0, W-60, and MX60 IOLs. The new Clareon CNA0T0, which is manufactured from a hydrophobic acrylic material, exhibited among the lowest levels of surface haze and roughness, SSNGs, and glistenings compared with other commercially available hydrophobic acrylic IOLs.

Evaluation of paraxial forward scattering from intraocular lens with increased surface light scattering using goniophotometry and Hartmann-Shack wavefront aberrometry.

To evaluate the influence of increases in light scattering on intraocular lens (IOL) surfaces on paraxial forward scattering using goniophotometry and Hartmann-Shack wavefront aberrometry. Surface light scattering was reproduced experimentally by acceleratedly aging 4 intraocular lenses by 0, 3, 5, and 10years each. Light scattering from both IOL surfaces was measured using Scheimpflug photography. The paraxial forward scattering from the aged IOLs was measured using a goniophotometer with a halogen light source (wavelength: 350-850nm) and telecentric optics, and changes in the maximum intensity and full width at 10% of maximum intensity (FW10%) were evaluated. The influences on the retina image were examined using a Hartmann-Shack aberrometer (wavelength: 840nm). The contrast and difference from the point spread function of the central centroids were evaluated. The mean surface light scattering from both IOL surfaces ranged from 30.0 to 118.3 computer compatible tape (CCT) and increased with each aging year. Evaluations using the goniophotometer and the Hartmann-Shack aberrometer showed no significant change in the paraxial forward scattering with the aging year (P>.45, Kruskal-Wallis test), and no association with the surface light scattering intensity was found (P>.75, Spearman rank correlation). This experimental study using aged IOLs demonstrated that surface light scattering does not influence paraxial forward scattering.

Long-term observation of surface light scattering in a foldable acrylic intraocular lens

To observe time-course changes in surface light scattering after Acrysof intraocular lens (IOL) implantation over 6 years postoperatively and its influence on visual function. Miyata Eye Hospital, Miyakonojo, Miyazaki, Japan. Retrospective comparative case series. Clinical records of eyes that had implantation of an Acrysof IOL (Group 1) or another IOL model (AR40 or Clariflex) (Group 2) were evaluated. Postoperative examinations including light scattering on the anterior surface of the IOL, corrected distance visual acuity (CDVA), and contrast sensitivity were performed 1 month and 3 years postoperatively. The same examinations were performed over the extended postoperative period, allowing analysis of time-course changes in surface light scattering and visual function. The study evaluated 24 eyes, 14 in Group 1 and 10 in Group 2. The mean time to the last postoperative examination was 8.4 years ± 1.0 (SD) (range 6.5 to 10 years). Surface light scattering in Group 1 increased, even after 3 years, at a rate of 12.02 computer-compatible tapes per year. Scattering did not increase in Group 2. The CDVA remained unchanged 3 to 6 or more years postoperatively in both groups. There was no difference in contrast sensitivity between the 2 groups 6 or more years postoperatively. Surface light scattering increased in Group 1, even after 3 years postoperatively; however, it did not affect visual function. No author has a financial or proprietary interest in any material or method mentioned.

Localized opacification of hydrophilic acrylic intraocular lenses after procedures using intracameral injection of air or gas

To describe clinical and laboratory findings in a series of cases of intraocular lens (IOL) opacification after procedures involving intracameral injections of air or gas. John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Experimental study. Seven hydrophilic acrylic IOLs explanted after Descemet-stripping endothelial keratoplasty (DSEK) or Descemet-stripping automated endothelial keratoplasty (DSAEK) because of a localized central optic opacification associated with decrease in visual acuity and complaints of foggy vision were analyzed. The explanted IOLs were sent to our laboratory in the dry state or in fixative by the explanting surgeons. They underwent pathological and histochemical evaluation (alizarin red and von Kossa method). Light scattering measurements were also performed on the surface of 1 explant using Scheimpflug photography. A questionnaire was sent to the surgeons to obtain information pertinent to each case. The 7 explanted IOLs were represented by 6 hydrophilic acrylic designs from 5 manufacturers. Gross and light microscopy showed that granular deposits were densely distributed in an overall round pattern within the margins of the capsulorhexis or the pupil on the anterior surface/subsurface of the IOLs. The granules stained positive for calcium (alizarin red and von Kossa method). Light scattering on the anterior optic surface was very high (228 versus 13 computer-compatible tapes on a control IOL). A localized pattern of calcification was seen on the anterior surface/subsurface ofvarious hydrophilic acrylic IOLs. Surgeons should be aware of this phenomenon following DSEK/DSAEK procedures in pseudophakic patients with hydrophilic acrylic IOLs. No author has a financial or proprietary interest in any material or method mentioned.

Optical performance of hydrophobic acrylic intraocular lenses with surface light scattering

To evaluate the potential effect of surface light scattering on the optical performance of hydrophobic acrylic intraocular lenses (IOLs) made of Acrysof material. Alcon Laboratories, Inc., Fort Worth, Texas, USA. Experimental study. Explanted IOLs from cadaver eyes with more than 50 computer-compatible tape (CCT) units of scatter were selected, yielding 7 IOLs. Clinically explanted IOLs (n = 4) were obtained after IOLs had been implanted 8.5 to 10.5 years. Explanted IOLs were matched to unused control IOLs. After proteins were removed, scatter was measured for IOLs dry, wetted (2 minutes in a balanced salt solution), and hydrated (24 hours). Badal imaging, ultraviolet-visible transmission, and modulation transfer function (MTF) measurements were performed with hydrated IOLs. Hydrated scatter values ranged from 80 to 221 CCT for explanted IOLs and 2 to 7 CCT for controls. No differences in Badal image resolution were observed between explanted IOLs and controls. The mean MTF values at 100 line pairs per mm (representing 20/20 visual acuity) were similar between explanted IOLs and controls. Over the range of 400 to 700 nm, a small reduction (mean 2.1% ± 1.4% [SD]) in transmission was observed. Surface light scattering of explanted IOLs did not affect image resolution or MTF values. Although light transmission was slightly decreased, the magnitude appeared to be inconsequential for optical performance.

Light scattering and light transmittance in a series of calcified single-piece hydrophilic acrylic intraocular lenses of the same design

To evaluate light scattering and light transmittance of Ioflex hydrophilic acrylic intraocular lenses (IOLs) explanted because of clinically significant opacification secondary to calcification. John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Experimental study. Seven explanted and 8 control Ioflex IOLs were studied. Gross and light microscopy of all the IOLs were performed. Light scattering was measured with a Scheimpflug camera, and light transmittance was assessed with a spectrophotometer. Analyses were performed at room temperature in the hydrated state, and findings of the explanted and control IOLs were compared. Light scattering was 219.71 computer compatible tape (CCT) ± 2.62 (SD) for explanted IOLs and 4.75 ± 2.50 CCT for controls. The mean light transmittance in the visible light spectrum was 75.94% to 87.25% for explanted IOLs and 97.54% to 98.97% for controls. The most striking finding was variable degrees of light transmittance between 290 nm and 350 nm (ultraviolet-A and B radiation) in the explanted and control IOLs with expiration dates in 2009/2010 but 0% transmittance in this region in all controls with expiration dates in 2011/2012. Light scattering was extremely high and transmittance was significantly reduced in calcified IOLs. Differences in transmittance observed in the 290 to 350 nm region between IOLs with different expiration dates were related to use of different hydrophilic acrylic raw material suppliers in the manufacture of the IOLs, highlighting the complexity of IOL calcification investigations.

Light transmittance of 1-piece hydrophobic acrylic intraocular lenses with surface light scattering removed from cadaver eyes

To assess the potential effect of surface light scattering on light transmittance of 1-piece hydrophobic acrylic intraocular lenses (IOLs) with or without a blue-light filter. John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Experimental study. Intraocular lenses were obtained from human cadavers (49 IOLs total; 36 with blue-light filter) and from finished-goods inventory (controls). The IOLs were removed from cadaver eyes and the power and model matched to unused controls. After surface proteins were removed, the IOLs were hydrated for 24 hours at room temperature. Surface light scattering was measured with a Scheimpflug camera (EAS-1000 Anterior Segment Analysis System). Light transmittance was measured with a Lambda 35 UV/Vis spectrophotometer (single-beam configuration; RSA-PE-20 integrating sphere). Hydrated scatter values ranged from 4.8 to 202.5 computer-compatible tape (CCT) units for explanted IOLs with blue-light filter and 1.5 to 11.8 CCT units for controls; values ranged from 6.0 to 137.5 CCT units for explanted IOLs without a blue-light filter and 3.5 to 9.6 CCT units for controls. In both groups, there was a tendency toward increasing scatter values with increasing postoperative time. No differences in light transmittance were observed between explanted IOLs and controls in both groups (IOLs with blue-light filter: P=.407; IOL with no blue-light filter: P=.487; both paired t test). Although surface light scattering of explanted IOLs was significantly higher than that of controls and appeared to increase with time, no effect was observed on light transmittance of 1-piece hydrophobic acrylic IOLs with or without a blue-light filter.

Surface light scattering and visual function of diffractive multifocal hydrophobic acrylic intraocular lenses 6 years after implantation

To evaluate the surface light scattering associated with diffractive multifocal intraocular lenses (IOLs) and visual function 6 years after implantation. Private practice. Retrospective comparative case series. Patients received a hydrophobic acrylic IOL and were followed for more than 6 years. Six years postoperatively, the intensity of the surface light scattering was measured using a Scheimpflug camera-based anterior segment analyzer. The corrected distance (CDVA) and near (CNVA) visual acuities and contrast sensitivity were assessed. Twenty eyes of 10 patients received a diffractive multifocal IOL (Acrysof Restor SA60D3, study group), and 16 eyes of 8 patients received a monofocal IOL (Acrysof SA60AT, control group). Six years postoperatively, the anterior surface light scattering was more than 100 computer compatible tape units in both groups, with no significant difference between groups (P=.417). The mean CDVA and CNVA in the study group were -0.06 logMAR ± 0.04 (SD) and -0.04 ± 0.05 logMAR, respectively; however, the CNVA in both groups decreased compared with that at 1 year, as did the CDVA in the control group. Contrast sensitivity was within normal range at all spatial frequencies in both groups. There were no significant correlations between surface light scattering and the changes in corrected visual acuities (distance or near) between 1 year and 6 years postoperatively in either group. Although there was significantly increased surface light scattering 6 years postoperatively, the visual function with a diffractive multifocal IOL was comparable to that with a monofocal IOL.

Light scattering and light transmittance in intraocular lenses explanted because of optic opacification

To assess light scattering and light transmittance in intraocular lenses (IOLs) explanted because of optic opacification. John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Experimental study. Poly(methyl methacrylate) (PMMA) IOLs with snowflake degeneration, hydrophilic acrylic IOLs with different calcification patterns, and 1 calcified silicone IOL explanted from an eye with asteroid hyalosis were studied with gross and light microscopy. Light scattering was measured with an EAS-1000 Scheimpflug camera. Light transmittance was measured with a Lambda 35UV/Vis spectrophotometer (single-beam configuration with RSA-PE-20 integrating sphere). Analyses were performed at room temperature in the hydrated state and compared with controls. The study evaluated 8 PMMA IOLs, 22 hydrophilic acrylic IOLs, and 1 silicone IOL. Light scattering was as follows: 208 to 223 computer-compatible tapes (CCTs) for PMMA IOLs with snowflake degeneration (control = 9 CCTs); 90 to 227 CCTs for calcified hydrophilic acrylic IOLs (controls = 12 to 23 CCTs); 223 CCTs for the calcified silicone IOL (control = 5 CCTs). The mean light transmittance in the visible light spectrum was 81.08% to 97.10% for PMMA IOLs (control = 98.80%); 78.94% to 97.32% for hydrophilic acrylic IOLs (controls = 97.32% to 98.66%); 94.68% for the silicone IOL (control = 97.74%). Intraocular lens opacification led to very high levels of light scattering and a potential for decreased light transmittance, which play a role in the development of symptoms such as glare and halos, decreased contrast sensitivity, and eventually decreased visual acuity. No author has a financial or proprietary interest in any material or method mentioned.

Effect on visual acuity of increased surface light scattering in intraocular lenses

To assess the long-term increase in surface light scattering of foldable hydrophobic acrylic intraocular lenses (IOLs) and to evaluate its effect on visual acuity. Miyata Eye Hospital, Miyazaki, Japan. Cross-sectional study. The clinical records of patients who received an Acrysof IOL (study group) or a Sensar AR40 or AR40e IOL (control group) were reviewed retrospectively. Surface light scattering of IOLs was measured 1 year postoperatively or later. The corrected distance visual acuity (CDVA) at the surface-light-scattering examination was compared with the CDVA 1 month after IOL implantation. The changes in CDVA over time were compared with the increase in surface light scattering. The study evaluated 466 eyes of 337 patients. Surface light scattering in the study group continued to increase up to 15 years postoperatively. The light scattering was higher on the anterior IOL surface after 4.5 years. Increased surface light scattering had no significant impact on CDVA; however, there were more cases with decreased CDVA when the surface light scattering exceeded 50 computer-compatible tape steps. Surface light scattering with the implanted foldable hydrophobic acrylic IOL continuously increased during the postoperative years and was a risk for decreased visual acuity.

The Relationship Between the Density of Lens and Liquefaction Time Using Liquefaction Device

PurposeTo investigate the effect of lens density on liquefaction time by using liquefaction device (AquaLase®, Alcon Laboratories, TX, U.S.A.).MethodsCataract surgery using AquaLase® was performed on 47 eyes. With a Scheimpflug camera, the density and thickness of lens were measured in eye of each patient preoperatively. During surgery, liquefaction time and total number of pulses were recorded. The correlation of both density and thickness of lens with liquefaction time and total number of pulses was analyzed.ResultsThe mean density of anterior cortex, nucleus, and posterior cortex was 112.45±42.1 computer compatible tapes (CCT), 76.5±22.7 CCT, and 70.9±52.2 CCT, respectively. The mean thickness was 0.97±0.30 mm, 2.76±0.54 mm, and 0.81±0.24 mm, respectively. The mean liquefaction time was 174.8±108.2 seconds. The mean total number of pulses was 4799±3007. There was no significant difference between the density of each area of lens (anterior cortex, nucleus, posterior cortex, and total lens) and liquefaction time (p>0.05), and between the thickness of each area of lens and liquefaction time (p>0.05). There was no significant difference between the density of each area of lens and total number of pulses (p>0.05), and between the thickness of each area of lens and total number of pulses (p>0.05).ConclusionsWhen extraction of soft to moderate density cataract was performed with AquaLase®, liquefaction time and total number of pulse did not correlate to the density and thickness of lens.

Surfactant Induced Glistenings: Surface Active Ingredients in Ophthalmic Solutions May Enhance Water Entry into the Voids of Implanted Acrylic Intraocular Lenses

To investigate the light scattering properties of acrylic intraocular lenses (IOLs) placed in eyes treated with diclofenac sodium (Diclod, Wakamoto, Japan) and betamethasone phosphate (Rinderon, Shionogi, Japan) ophthalmic solutions. The light scattering properties of IOLs (MA30BA, Alcon laboratories) placed in 32 eyes treated with Diclod and 31 treated with Rinderon were evaluated 3 years after implantation using Scheimpflug photography. The averaged intensity of glistenings was 9.0 CCT (computer compatible tapes) in the Diclod test group and 4.2 CCT in the Rinderon test group (p = 0.002). The intensity of surface light scattering for the Diclod and Rinderon test groups was 24.0 CCT and 26.9 CCT, respectively (p = 0.081). The Diclod test group had a greater number of glistenings than the Rinderon test group. Both drugs have similar anti-inflammatory properties and Diclod, unlike Rinderon, also contains the surfactant polysorbate. We proposed that the presence of surfactant, or other ingredient, in commercially available eyedrops may enhance the development of glistenings.

Limitation of Scheimpflug videophotography system in quantifying posterior capsule opacification after intraocular lens implantation

Purpose To assess the applicability of Scheimpflug videophotography system for the quantitative comparison of posterior capsule opacification after intraocular lens (IOL) implantation of different materials. Design Retrospective, nonrandomized, interventional case series. Methods Three groups (n = 15 eyes, each) underwent cataract surgery with implantation of acrylic, silicone, or hydrogel IOL. One year after surgery, the scatter light density at the anterior IOL surface level was measured using EAS-1000. Another three groups (n = 32 eyes, each) received acrylic, silicone, or hydrogel lens. One week after surgery, the scatter light density at the posterior capsule was measured. Results Scatter light density at the anterior IOL surface 1 year after implantation was 7.5 ± 3.0 computer-compatible tape (CCT) steps in the acrylic group, 6.0 ± 2.3 CCT steps in the silicone group, and 5.0 ± 3.2 CCT steps in the hydrogel group; the density in the acrylic group was significantly greater than that in the hydrogel group ( P = .026). Scatter light density at the posterior capsule level 1 week after surgery was 28.3 ± 8.9 CCT steps in the acrylic group, 22.2 ± 2.0 CCT steps in the silicone group, and 26.7 ± 6.7 CCT steps in the hydrogel group; there was a significant difference between the acrylic and silicone groups ( P = .0005) and between the silicone and hydrogel groups ( P = .008). Conclusions The IOL material significantly influences the scatter light density measurements of Scheimpflug videophotography system, and thus the intensity of posterior capsule opacification quantified by this system cannot be directly compared with different optic materials.

Three-Year Prospective Randomized Study of Incidence of Posterior Capsule Opacification in Eyes Treated with Topical Diclofenac and Betamethasone

Purpose: To investigate the incidence of posterior capsule opacification (PCO) in eyes treated with diclofenac sodium (DFNa) and betamethasone phosphate (BMS) ophthalmic solutions. Methods: A total of 200 eyes with silicone intraocular lens implantation were treated with topical agents for 3 months postoperatively. Twenty-six cases of the DFNa group and 34 of the BMS group met the criteria, and the severity of PCO was evaluated after 3 years. Results: The results of axial densitometry by Scheimpflug photography were 27.8 computer-compatible tapes (CCT) in the DFNa-treated group and 32.6 CCT in the BMS-treated group (p = 0.1539). Posterior capsulotomy was performed in 11.5% of the DFNa group and 17.6% of the BMS group (p = 0.8375). The photographic grading of PCO showed no difference. Conclusion: The incidence of PCO in eyes treated with DFNa appears to be equal to that after BMS treatment.

Clinical Evaluation of Posterior Capsule Opacification in Eyes With Different Small-Incision Intraocular Lenses

To present a new method to quantify posterior capsular opacity with an anterior eye segment image analyzer (EAS 1000, NIDEK). This study was comprised of patients who underwent phacoemulsification intraocular lens (IOL) implantation. Three types of IOLS, acrylic, silicone, and polymethylmethacrylate (PMMA) were allocated to 30 eyes and clinically evaluated. Patients were observed for 3 years postoperatively using an anterior eye segment image analyzer (EAS1000). Opacity was determined by calculating the area of opacity from a retroillumination image. In the retroillumination mode of analysis, the measurement was limited to a 4-mm-diameter region of the pupillary zone to eliminate the influence of anterior capsular opacity. For color map analysis, the threshold level was expressed as the color tone of 0-255 CCT (computer compatible tape). The glare disability was measured to evaluate the three types of IOLs. The color map analysis revealed a time-related increase in the opacity level of patients receiving the PMMA IOL implant. Three years after surgery, the levels were significantly higher in the PMMA group (P < 0.01) compared to the acryl and silicone groups: acryl (17.5 +/- 3.8), silicone (18.0 +/- 6.2%), and PMMA 36.5 +/- 32.9%. Quantitative evaluation using an anterior eye segment image analyzer is effective for observing the degree of posterior capsule opacification. The color map analysis using an anterior eye segment image correlated with the visual function revealed that the time-related increase in the opacity level was significant during the third year in patients receiving PMMA IOL implantation.

Effect of Different Concentrations of Tranilast on Posterior Capsule Opacification

To evaluate the effect of different concentrations(0.5, 1.0, 2.0%) of tranilast eyedrops in preventing fibrous posterior capsule opacification (PCO) in rabbits. Experimental phacoemulsification procedures and in-the-bag placement of intraocular lens(IOL) implant were performed. An anterior eye segment analysis system(EAS-1000, Nidek Co, Ltd) was used to evaluate the degree of PCO during 5 weeks after surgery. The development of PCO was significantly suppressed in the eyes treated with tranilast eyedrops from 1 week after surgery. The mean PCO density after treatment with 0.5% tranilast was 59.1 +/- 9.3 (mean deviation +/- standard error) and 57.1 +/- 8.2, while for 1.0% tranilast it was 40.1 +/- 6.8 and 46.6 +/- 8.4, and for 2.0% tranilast it was 38.5 +/- 6.0 and 37.5 +/- 5.6 (computer compatible tape, CCT) at 1 week and 5 weeks, respectively. In the control group, the mean PCO density was 89.3 +/- 10.4 and 137.4 +/- 32.8 at 1 week and 5 weeks, respectively(p < 0.05). However, no significant statistical difference was observed in any of the findings for the 3 different tranilast concentrations. These results suggest that the 0.5% tranilast eyedrops, which are already available on the market, are sufficiently effective for inhibiting PCO.

Effect of tranilast eyedrops in preventing posterior capsule opacification: preliminary report

Purpose To evaluate the effect of tranilast eyedrops in preventing fibrous opacificationof the posterior lens capsule after cataract extraction and intraocular lens (IOL)implantation. Setting The Second Department of Ophthalmology, Toho University School of Medicine, Tokyo, and Shohzankai Medical Foundation, Miyake Eye Hospital, Nagoya, Japan. Methods This study comprised eyes having continuous curvilinear capsulorhexis and phacoemulsification/aspiration followed by implantation of a posterior chamber IOL in the capsular bag. In this prospective, randomized, controlled, and double-masked trial, tranilast 0.5% (Rizaben®) eyedrops (15 eyes) or its placebo eyedrops (20 eyes) were given 4 times a day for 3 months after surgery. An anterior eye segment analysis system (EAS 1000, Nidek Co., Ltd.) was used to evaluate the degree of fibrous posterior capsule opacification (PCO) 1 week and 1 and 3 months after surgery. Results The mean PCO density in the tranilast group was 17.1 cct ± 4.6 (SD), 20.0 ± 3.6 cct, and 23.0 ± 7.7 cct (cct = computer compatible tape) at 1 week and 1 and 3 months, respectively. In the control group, it was 18.2 ± 5.3, 30.2 ± 7.8, and 38.4 ± 8.0 cct, respectively. There was a significant difference in the 1 and 3 month findings between the 2 groups ( P < .001). Conclusion Tranilast was effective in preventing fibrous PCO at an early postoperative stage. The possible mechanism of its effect may be prevention of collagen synthesis by minimizing transforming growth factor type β released during lens epithelial cell metaplasia.

In vivo quantitative measurement of posterior capsule opacification after extracapsular cataract surgery

Purpose: To introduce a new in vivo quantitative measurement of posterior capsule opacification (PCO) after extracapsular cataract surgery and also to analyze the correlation between opacification density and the patient’s visual acuity. Methods: Prospectively, the opacification density value in the central 3-mm portion of the posterior capsule was quantitated by means of an area densitometry with the Scheimpflug photography system (EAS-1000). The EAS-1000 examination was performed on 40 eyes with clinically significant PCO both before and after undergoing Nd:YAG laser posterior capsulotomy, and on 10 eyes without PCO. The correlation between the opacification density value and the visual acuity was analyzed with a linear regression analysis. Results: The mean opacification density values ± SD were 48.8 ± 29.5 computer-compatible tapes (CCT) steps in the PCO group before capsulotomy, 15.5 ± 7.8 CCT steps in the PCO group after capsulotomy, and 12.9 ± 4.9 CCT steps in the non-PCO group. The mean opacification density value in the PCO group before capsulotomy was significantly greater than that in the PCO group after capsulotomy or than that of the non-PCO group. A linear regression analysis determined that the opacification density value also correlated well with the visual acuity (R 2 = .808). Conclusions: We have established a new in vivo quantitative measurement of PCO. Because the opacification density value obtained by this measurement correlated well with the patient’s visual acuity, we consider this measurement to be useful in both the research and clinical management of PCO.