Computer-aided Diagnosis Research Articles

Plant Disease Detection and Classification

The Plant Disease Detection and classification project, aims to develop an automated system using machine learning and deep learning techniques to detect and classify plant diseases early on by analyzing leaf images. Early disease detection is crucial for increasing crop yields, reducing pesticide use, and promoting sustainable farming practices. The system will provide detailed descriptions of detected diseases along with recommended prevention and treatment methods. By using advanced machine learning and deep learning algorithms and data augmentation techniques, the system aims to improve the accuracy and efficiency of disease detection. While existing research shows promise, challenges like dataset robustness and environmental variability remain. This project addresses these challenges by integrating diverse datasets and leveraging sophisticated machine learning algorithms. The ultimate goal is to provide farmers with a reliable tool for managing plant health, ensuring food security, and contributing to sustainable agricultural practices. This will help farmers enhance resilience in the face of increasing agricultural challenges. Key Words: Plant Disease Detection, Automated Disease Detection System, Machine Learning, Deep Learning, Data Augmentation, Data Normalization, Support Vector Machine, KNN Classifier, Convolutional Neural Network, Decision Trees, Random Forest.

Revolutionizing Radiology With Artificial Intelligence.

Artificial intelligence (AI) is rapidly transforming the field of radiology, offering significant advancements in diagnostic accuracy, workflow efficiency, and patient care. This article explores AI's impact on various subfields of radiology, emphasizing its potential to improve clinical practices and enhance patient outcomes. AI-driven technologies such as machine learning, deep learning, and natural language processing (NLP) are playing a pivotal role in automating routine tasks, aiding in early disease detection, and supporting clinical decision-making, allowing radiologists to focus on more complex diagnostic challenges. Key applications of AI in radiology include improving image analysis through computer-aided diagnosis (CAD) systems, which enhance the detection of abnormalities in imaging, such as tumors. AI tools have demonstrated high accuracy in analyzing medical images, integrating data from multiple imaging modalities such as CT, MRI, and PET to provide comprehensive diagnostic insights. These advancements facilitate personalized treatment planning and complement radiologists' workflows. However, for AI to be fully integrated into radiology workflows, several challenges must be addressed, including ensuring transparency in how AI algorithms work, protecting patient data, and avoiding biases that could affect diverse populations. Developing explainable AI systems that can clearly show how decisions are made is crucial, as is ensuring AI tools can seamlessly fit into existing radiology systems. Collaboration between radiologists, AI developers, and policymakers, alongside strong ethical guidelines and regulatory oversight, will be key to ensuring AI is implemented safely and effectively in clinical practice. Overall, AI holds tremendous promise in revolutionizing radiology. Through its ability to automate complex tasks, enhance diagnostic capabilities, and streamline workflows, AI has the potential to significantly improve the quality and efficiency of radiology practices. Continued research, development, and collaboration will be crucial in unlocking AI's full potential and addressing the challenges that accompany its adoption.

CytoNet: an efficient dual attention based automatic prediction of cancer sub types in cytology studies

Computer-assisted diagnosis (CAD) plays a key role in cancer diagnosis or screening. Whereas, current CAD performs poorly on whole slide image (WSI) analysis, and thus fails to generalize well. This research aims to develop an automatic classification system to distinguish between different types of carcinomas. Obtaining rich deep features in multi-class classification while achieving high accuracy is still a challenging problem. The detection and classification of cancerous cells in WSI are quite challenging due to the misclassification of normal lumps and cancerous cells. This is due to cluttering, occlusion, and irregular cell distribution. Researchers in the past mostly obtained the hand-crafted features while neglecting the above-mentioned challenges which led to a reduction of the classification accuracy. To mitigate this problem we proposed an efficient dual attention-based network (CytoNet). The proposed network is composed of two main modules (i) Efficient-Net and (ii) Dual Attention Module (DAM). Efficient-Net is capable of obtaining higher accuracy and enhancing efficiency as compared to existing Convolutional Neural Networks (CNNs). It is also useful to obtain the most generic features as it has been trained on ImageNet. Whereas DAM is very robust in obtaining attention and targeted features while negating the background. In this way, the combination of an efficient and attention module is useful to obtain the robust, and intrinsic features to obtain comparable performance. Further, we evaluated the proposed network on two well-known datasets (i) Our generated thyroid dataset (ii) Mendeley Cervical dataset (Hussain in Data Brief, 2019) with enhanced performance compared to their counterparts. CytoNet demonstrated a 99% accuracy rate on the thyroid dataset in comparison to its counterpart. The precision, recall, and F1-score values achieved on the Mendeley Cervical dataset are 0.992, 0.985, and 0.977, respectively. The code implementation is available on GitHub. https://github.com/naveedilyas/CytoNet-An-Efficient-Dual-Attention-based-Automatic-Prediction-of-Cancer-Sub-types-in-Cytol.

Breast tumor segmentation in ultrasound using distance-adapted fuzzy connectedness, convolutional neural network, and active contour

This study addresses computer-aided breast cancer diagnosis through a hybrid framework for breast tumor segmentation in ultrasound images. The core of the three-stage method is based on the autoencoder convolutional neural network. In the first stage, we prepare a hybrid pseudo-color image through multiple instances of fuzzy connectedness analysis with a novel distance-adapted fuzzy affinity. We produce different weight combinations to determine connectivity maps driven by particular image specifics. After the hybrid image is processed by the deep network, we adjust the segmentation outcome with the Chan-Vese active contour model. We find the idea of incorporating fuzzy connectedness into the input data preparation for deep-learning image analysis our main contribution to the study. The method is trained and validated using a combined dataset of 993 breast ultrasound images from three public collections frequently used in recent studies on breast tumor segmentation. The experiments address essential settings and hyperparameters of the method, e.g., the network architecture, input image size, and active contour setup. The tumor segmentation reaches a median Dice index of 0.86 (mean at 0.79) over the combined database. We refer our results to the most recent state-of-the-art from 2022–2023 using the same datasets, finding our model comparable in segmentation performance.

Computer-Aided Diagnosis of Endometrial Cancer Histopathologic Images Based on an Improved InceptionNeXt Model

Computer-Aided Diagnosis of Endometrial Cancer Histopathologic Images Based on an Improved InceptionNeXt Model

Part-Prototype Models in Medical Imaging: Applications and Current Challenges

Recent developments in Artificial Intelligence have increasingly focused on explainability research. The potential of Explainable Artificial Intelligence (XAI) in producing trustworthy computer-aided diagnosis systems and its usage for knowledge discovery are gaining interest in the medical imaging (MI) community to support the diagnostic process and the discovery of image biomarkers. Most of the existing XAI applications in MI are focused on interpreting the predictions made using deep neural networks, typically including attribution techniques with saliency map approaches and other feature visualization methods. However, these are often criticized for providing incorrect and incomplete representations of the black-box models’ behaviour. This highlights the importance of proposing models intentionally designed to be self-explanatory. In particular, part-prototype (PP) models are interpretable-by-design computer vision (CV) models that base their decision process on learning and identifying representative prototypical parts from input images, and they are gaining increasing interest and results in MI applications. However, the medical field has unique characteristics that could benefit from more advanced implementations of these types of architectures. This narrative review summarizes existing PP networks, their application in MI analysis, and current challenges.

ADGRU: Adaptive DenseNet with gated recurrent unit for automatic diagnosis of periodontal bone loss and stage periodontitis with tooth segmentation mechanism.

Periodontics and gingivitis are two of the most widely prevalent illnesses that affect people nowadays. The sixth most common disease in the world is periodontitis, and detecting periodontal bone loss is essential in the earlier condition and is crucial for the development of the proper diagnosis. Early bone loss detection can be assisted by using computer-assisted radiography examination. Understanding disease progression helps to select the most effective treatment action. An effective deep model is suggested to detect periodontal bone loss at an earlier stage for preventing the progression of Periodontics bone loss. This work is intimated by collecting images from online resources. Further, the images gathered from the dataset are preceded by the tooth segmentation which is done using DenseUNet + + . Further, the segmented images are given to the Adaptive DenseNet with Gated Recurrent Unit (AD-GRU) for detecting periodontal bone loss and this diagnosis is used for the periodontitis stage, where the ADGRU performance is augmented by optimizing the attributes using the Refined Red Kite Optimization Algorithm (RRKOA). The offered approach attained an accuracy of 94.45% which is higher than the88.63%, 90.58%, 89.54%, and 92.96% attained by the LSTM, DenseNet, GRU, DenseNet-GRU. The findings of the simulation proved the designed framework outperformed the traditional model with high accuracy. The developed effectual deep model-based periodontal bone loss and stage periodontitis diagnosis structure is used in healthcare applications.

Semantic Segmentation of the Prostate Based on Onefold and Joint Multimodal Medical Images Using YOLOv4 and U-Net

Magnetic Resonance Imaging is increasing in importance in prostate cancer diagnosis due to the high accuracy and quality of the examination procedure. However, this process requires a time-consuming analysis of the results. Currently, machine vision is widely used in many areas. It enables automation and support in radiological studies. Successful detection of primary prostate tumors depends on the effective segmentation of the prostate itself. At times, a CT scan may be performed; alternatively, MRI may be the selected option. The data always reach a bottleneck stage. This paper presents the effective training of deep learning models to segment the prostate based on onefold and multimodal medical images. This approach supports the computer-aided diagnosis (CAD) system for radiologists as the first step in cancer exams. A comparison of two approaches designed for prostate segmentation is described. The first combines YOLOv4, the object detection neural network, and U-Net for a semantic segmentation based on onefold modality MRI images. The second presents the same method trained on multimodal images—a CT and MRI mixed dataset. The learning process was carried out in a cloud environment using GPU cards. The experiments are based on data from 120 patients who have undergone MRI and CT examinations. Several metrics evaluated the trained models. In the prostate semantic segmentation process, better results were achieved by mixed MRI with CT datasets. The best model achieved the value of 0.9685 for the Sørensen–Dice coefficient for the threshold value of 0.6.

Deep Learning With Optical Coherence Tomography for Melanoma Identification and Risk Prediction.

Malignant melanoma is the most severe skin cancer with a rising incidence rate. Several noninvasive image techniques and computer-aided diagnosis systems have been developed to help find melanoma in its early stages. However, most previous research utilized dermoscopic images to build a diagnosis model, and only a few used prospective datasets. This study develops and evaluates a convolutional neural network (CNN) for melanoma identification and risk prediction using optical coherence tomography (OCT) imaging of mice skin. Longitudinal tests are performed on four animal models: melanoma mice, dysplastic nevus mice, and their respective controls. The CNN classifies melanoma and healthy tissues with high sensitivity (0.99) and specificity (0.98) and also assigns a risk score to each image based on the probability of melanoma presence, which may facilitate early diagnosis and management of melanoma in clinical settings.

Research and implementation of intelligent diagnostic system for temporomandibular joint disorder

Temporomandibular joint disorder (TMD) is a common oral and maxillofacial disease, which is difficult to detect due to its subtle early symptoms. In this study, a TMD intelligent diagnostic system implemented on edge computing devices was proposed, which can achieve rapid detection of TMD in clinical diagnosis and facilitate its early-stage clinical intervention. The proposed system first automatically segments the important components of the temporomandibular joint, followed by quantitative measurement of the joint gap area, and finally predicts the existence of TMD according to the measurements. In terms of segmentation, this study employs semi-supervised learning to achieve the accurate segmentation of temporomandibular joint, with an average Dice coefficient (DC) of 0.846. A 3D region extraction algorithm for the temporomandibular joint gap area is also developed, based on which an automatic TMD diagnosis model is proposed, with an accuracy of 83.87%. In summary, the intelligent TMD diagnosis system developed in this paper can be deployed at edge computing devices within a local area network, which is able to achieve rapid detecting and intelligent diagnosis of TMD with privacy guarantee.

Utilizing Pseudo Color Image to Improve the Performance of Deep Transfer Learning-Based Computer-Aided Diagnosis Schemes in Breast Mass Classification.

The purpose of this study is to investigate the impact of using morphological information in classifying suspicious breast lesions. The widespread use of deep transfer learning can significantly improve the performance of themammogram based CADx schemes.However, digital mammograms are grayscale images, while deep learning models are typically optimized using the natural images containing three channels. Thus, it is needed to convert the grayscale mammograms into three channel images for the input of deep transfer models. This study aims to developa novel pseudo color image generation methodwhich utilizesthe mass contour information to enhance the classification performance.Accordingly, a total of 830 breast cancer cases were retrospectively collected, which contains 310 benign and 520 malignant cases, respectively. For each case, a total of four regions of interest (ROI) are collected from the grayscale images captured for both the CC and MLO views of the two breasts. Meanwhile, a total of seven pseudo color image sets are generated as the input of the deep learning models, which arecreated through a combination of the original grayscale image, a histogram equalized image, a bilaterally filtered image, and a segmented mass. Accordingly, the output features from four identical pre-trained deep learning models are concatenated and then processed by a support vector machine-based classifier to generate the final benign/malignant labels. The performance of each image set was evaluated and compared. The results demonstrate that the pseudo color sets containing the manually segmented mass performed significantly better than all other pseudo color sets, which achieved an AUC (area under the ROC curve) up to 0.889 ± 0.012 and an overall accuracy up to 0.816 ± 0.020, respectively. At the same time, the performance improvement is also dependent on the accuracy of the mass segmentation. The results of this study support our hypothesis that adding accurately segmented mass contours can provide complementary information, thereby enhancing the performance of the deep transfer model in classifying suspicious breast lesions.

DMDLK-Net: A dynamic multi-scale feature fusion network with deformable large kernel for medical segmentation

Abstract. Skin disease image segmentation is a crucial component of computer-aided diagnosis, providing precise localization and delineation of lesions that enhance diagnostic accuracy and efficiency. Despite significant advancements in convolutional neural networks (CNNs), there remains substantial room for improvement in segmentation performance due to the diverse and complex nature of skin lesions. In this study, we propose DMDLK-Net, a dynamic multi-scale feature fusion network with deformable large kernels, specifically designed to address the challenges in skin disease segmentation. Our network incorporates a Dynamic Deformable Large Kernel (DDLK) module and a Dynamic Multi-Scale Feature Fusion (DMFF) module, enhancing the model's ability to capture intricate lesion features. We present the performance of DMDLK-Net on the ISIC-2018 dataset, highlighting its promising results. Key contributions of this work include the innovative use of deformable large kernels for adaptive feature extraction and the introduction of dynamic multi-scale fusion to balance local and global information. Our experimental results confirm the effectiveness of DMDLK-Net in delivering high-precision segmentation, thus providing a reliable tool for clinical applications.

Case Report: Facial fracture sequelae: the importance of using a specific customized implant (PSI) for orbital reconstruction

The reconstruction of orbital fracture sequelae is a major challenge due to concerns regarding surgical approach and implant stability. Few anatomical sites of such minute size have presented with as much variation in treatment as the orbital floor fractures and related sequelae. Our patient developed sequelae of an orbital fracture over the last 3 years, presenting with dystopia, ophthalmoplegia, and diplopia in the supra- and lateroversion and aesthetic impairment. The variety of implant materials for reconstruction after orbital fractures is extensive, and the decision as to which material to use continues to be debated. The continuing development of computer-aided diagnosis and management and the construction of stereolithographic models offer comparable reproduction of anatomical detail. This technology is described in relation to the planning of trauma surgery and sequelae and the planning of ablative surgery for malignant neoplasms of the head and neck. The use of specific 3D printed titanium implants for bone defects was first reported in cranial reconstruction in 2012, and several studies have reported their use in orbital fractures. The advantages of this implant were increased stiffness, preventing shape loss during placement, a precise fit, and decreased surgical time. However, in the existing literature, the one-piece implant done in this way was a precise fit; therefore, it is possible that navigation between intraoperative anatomical landmarks is lost. However, in cases where reconstruction is difficult, such as extensive orbital wall fractures and large orbital sequelae, the 3D printed implant has been helpful in decreasing surgical time and can be accessed by a limited surgical approach with a precise fit. Our clinical case involved a 37-year-old male patient who experienced severe physical aggression in 2020, amid the COVID-19 pandemic. At the time, due to the overwhelming healthcare demands and resource constraints imposed by the pandemic, immediate surgical intervention for the correction of the fracture was not feasible. As a result of this delay, the patient developed sequelae of the orbital fracture over the last 3 years.

Automating cancer diagnosis using advanced deep learning techniques for multi-cancer image classification

Cancer detection poses a significant challenge for researchers and clinical experts due to its status as the leading cause of global mortality. Early detection is crucial, but traditional cancer detection methods often rely on invasive procedures and time-consuming analyses, creating a demand for more efficient and accurate solutions. This paper addresses these challenges by utilizing automated cancer detection through AI-based techniques, specifically focusing on deep learning models. Convolutional Neural Networks (CNNs), including DenseNet121, DenseNet201, Xception, InceptionV3, MobileNetV2, NASNetLarge, NASNetMobile, InceptionResNetV2, VGG19, and ResNet152V2, are evaluated on image datasets for seven types of cancer: brain, oral, breast, kidney, Acute Lymphocytic Leukemia, lung and colon, and cervical cancer. Initially, images undergo segmentation techniques, proceeded by contour feature extraction where parameters such as perimeter, area, and epsilon are computed. The models are rigorously evaluated, with DenseNet121 achieving the highest validation accuracy as 99.94%, 0.0017 as loss, and the lowest Root Mean Square Error (RMSE) values as 0.036056 for training and 0.045826 for validation. These results revealed the capability of AI-based techniques in improving cancer detection accuracy, with DenseNet121 emerging as the most effective model in this study.

Clinical Utility of Deep Learning Assistance for Detecting Various Abnormal Findings in Color Retinal Fundus Images: A Reader Study.

To evaluate the clinical usefulness of a deep learning-based detection device for multiple abnormal findings on retinal fundus photographs for readers with varying expertise. Fourteen ophthalmologists (six residents, eight specialists) assessed 399 fundus images with respect to 12 major ophthalmologic findings, with or without the assistance of a deep learning algorithm, in two separate reading sessions. Sensitivity, specificity, and reading time per image were compared. With algorithmic assistance, readers significantly improved in sensitivity for all 12 findings (P < 0.05) but tended to be less specific (P < 0.05) for hemorrhage, drusen, membrane, and vascular abnormality, more profoundly so in residents. Sensitivity without algorithmic assistance was significantly lower in residents (23.1%∼75.8%) compared to specialists (55.1%∼97.1%) in nine findings, but it improved to similar levels with algorithmic assistance (67.8%∼99.4% in residents, 83.2%∼99.5% in specialists) with only hemorrhage remaining statistically significantly lower. Variances in sensitivity were significantly reduced for all findings. Reading time per image decreased in images with fewer than three findings per image, more profoundly in residents. When simulated based on images acquired from a health screening center, average reading time was estimated to be reduced by 25.9% (from 16.4 seconds to 12.1 seconds per image) for residents, and by 2.0% (from 9.6 seconds to 9.4 seconds) for specialists. Deep learning-based computer-assisted detection devices increase sensitivity, reduce inter-reader variance in sensitivity, and reduce reading time in less complicated images. This study evaluated the influence that algorithmic assistance in detecting abnormal findings on retinal fundus photographs has on clinicians, possibly predicting its influence on clinical application.

Feasibility validation of automatic diagnosis of mitral valve prolapse from multi-view echocardiographic sequences based on deep neural network.

To address the limitations of traditional diagnostic methods for mitral valve prolapse (MVP), specifically fibroelastic deficiency (FED) and Barlow's disease (BD), by introducing an automated diagnostic approach utilizing multi-view echocardiographic sequences and deep learning. An echocardiographic data set, collected from Zhongshan Hospital, Fudan University, containing apical 2 chambers (A2C), apical 3 chambers (A3C), and apical 4 chambers (A4C) views, was employed to train the deep learning models. We separately trained view-specific and view-agnostic deep neural network models, which were denoted as MVP-VS and MVP view-agonistic (VA), for MVP diagnosis. Diagnostic accuracy, precision, sensitivity, F1-score, and specificity were evaluated for both BD and FED phenotypes. MVP-VS demonstrated an overall diagnostic accuracy of 0.94 for MVP. In the context of BD diagnosis, precision, sensitivity, F1-score, and specificity were 0.83, 1.00, 0.90, and 0.92, respectively. For FED diagnosis, the metrics were 1.00, 0.83, 0.91, and 1.00. MVP-VA exhibited an overall accuracy of 0.95, with BD-specific metrics of 0.85, 1.00, 0.92, and 0.94 and FED-specific metrics of 1.00, 0.83, 0.91, and 1.00. In particular, the MVP-VA model using mixed views for training demonstrated efficient diagnostic performance, eliminating the need for repeated development of MVP-VS models and improving the efficiency of the clinical pipeline by using arbitrary views in the deep learning model. This study pioneers the integration of artificial intelligence into MVP diagnosis and demonstrates the effectiveness of deep neural networks in overcoming the challenges of traditional diagnostic methods. The efficiency and accuracy of the proposed automated approach suggest its potential for clinical applications in the diagnosis of valvular heart disease.

Whole slide cervical cancer classification via graph attention networks and contrastive learning

Cervical cancer is one of the most common cancers among women, which seriously threatens women’s health. Early screening can reduce the incidence rate and mortality. Thinprep cytologic test (TCT) is one of the important means of cytological screening, which has high sensitivity and specificity, and has been widely used in the early screening of cervical cancer. The automatic diagnosis of whole slide images (WSIs) by computers can effectively improve the efficiency and accuracy of doctors’ diagnoses. However, current methods ignore the intrinsic relationships between cervical cells in WSIs and neglect contextual information from the surrounding suspicious areas, and therefore limit their robustness and generalizability. In this paper, we propose a novel two-stage method to implement the automatic diagnosis of WSIs, which constructs Graph Attention Networks (GAT) based on local and global fields respectively to capture their contextual information in a hierarchical manner. In the first stage, we extract representative patches from each WSI through suspicious cell detection, and then employ a Local GAT to classify cervical cells by capturing correlations between suspicious cells in image tiles. This classification process provides the confidence and feature vectors for each suspicious cell. In the second stage, we perform WSI classification using a Global GAT model. We construct graphs corresponding to top-Kg and bottom-Kg cells for each WSI based on results from Local GAT, and introduce a supervised contrastive learning strategy to enhance the discriminative power of the extracted features. Experimental results demonstrate that our proposed method outperforms conventional approaches and effectively showcases the benefits of supervised contrastive learning. Our source code and example data are available at https://github.com/feimanman/Whole-Slide-Cervical-Cancer-Classification.

Reconstruction error based implicit regularization method and its engineering application to lung cancer diagnosis

The automatic diagnosis of lung cancer via artificial intelligence faces two hotspot issues: (1) insufficient data and (2) excessive redundant information, which make it difficult for convolutional neural networks (CNNs) to learn discriminative information of lung cancer. In this paper, we present the reconstruction error based implicit regularization method (REbIRM) that regularizes CNNs at the loss layer. During each training iteration, the reconstruction errors introduced by the two-stage discriminative auto-encoder are used to sharpen the generalization ability of deep CNNs by improving the decision boundary. In the application process, the trained deep CNN is used for completing computed tomography (CT) diagnostics. The main clinical benefit of our approach is that it is domain independent, requiring no specialized knowledge, and can therefore be applied to different types of datasets. To the best of our knowledge, this is the first attempt to implicitly regularize CNNs based on the reconstruction errors. Finally, experimental results on three CT image classification datasets show that REbIRM can achieve impressive results and that, in conjunction with Dropout, it obtains the state-of-the-art performance. REbIRM is also robust to the selection of hyper-parameters and only has the sublinear influence on the convergence of deep CNNs. Besides, empirical and theoretical evidence are provided to indicate that REbIRM prefers to converges in a constrained parameter space with flatter minima, which explains why it can generalize to new data. Finally, the nature of REbIRM is further explored through visualization techniques to analyze how it works in training deep CNNs.

LesionNet: an automated approach for skin lesion classification using SIFT features with customized convolutional neural network

Accurate detection of skin lesions through computer-aided diagnosis has emerged as a critical advancement in dermatology, addressing the inefficiencies and errors inherent in manual visual analysis. Despite the promise of automated diagnostic approaches, challenges such as image size variability, hair artifacts, color inconsistencies, ruler markers, low contrast, lesion dimension differences, and gel bubbles must be overcome. Researchers have made significant strides in binary classification problems, particularly in distinguishing melanocytic lesions from normal skin conditions. Leveraging the “MNIST HAM10000” dataset from the International Skin Image Collaboration, this study integrates Scale-Invariant Feature Transform (SIFT) features with a custom convolutional neural network model called LesionNet. The experimental results reveal the model's robustness, achieving an impressive accuracy of 99.28%. This high accuracy underscores the effectiveness of combining feature extraction techniques with advanced neural network models in enhancing the precision of skin lesion detection.

Comparative Analysis of Neural Network Architectures for Automated Fracture Detection in Hand X-ray Images

The application of several neural network architectures—including Fully Connected Networks (FCN), Convolutional Neural Networks (CNN), pretrained ResNet, Vision Transformer (ViT-B-16)—for the classification of hand X-ray images into "Fractured" and "Not Fractured"—categories is investigated in this work. The main goals are to evaluate these models' fracture detection ability and determine which architectural design fits this work. Because transfer learning let the model use past information from big-scale picture datasets, the pretrained ResNet model emerged as the most effective with high accuracy, stability, and resilience. The bespoke CNN also performed well, displaying excellent feature extraction powers especially for medical imaging. But the non-pretrained ResNet model overfitted, meaning deeper networks find it difficult to generalize without pretraining. Though innovative, the Vision Transformer performed poorly since it depends on a lot of training data and finds difficult learning of intricate spatial properties from little datasets. Although acting as a baseline, the FCN's simple architecture and incapacity to detect spatial hierarchies in images meant it could not match the efficacy of CNN models. Emphasizing the important function of transfer learning in clinical applications, the results show that pretrained CNN architectures, especially ResNet, offer the most consistent and accurate method for automatic fracture diagnosis in medical pictures.