Objective To report our clinical experience of using computer-aided orthopedic surgery (CAOS) in the treatment of patients with pelvic fracture who had been injured in the earthquake at Yaan,Lushan,Sichuan,China.Methods From 20 April to 3 May,2013 we treated 6 patients with pelvic fracture using CAOS in the Lushan earthquake rescue.They were 3 men and 3 women,aged from 20 to 54years (average,39.7 years).By the Tile classification,there were 2 cases of type B and 4 cases of type C.One case was complicated with open fractures of bilateral tibias,2 with costal fracture,3 with femoral fracture,2 with lumbar fracture,one with patellar fracture,one with humeral fracture,and 5 with skin contusion.The 6 patients received surgery under computer-aided navigation system 3 to 10 days after injury (average,6days).X-ray follow-ups of the pelvis were conducted post-surgery and the therapeutic effects were assessed by the Matta criteria.Results Altogether 11 cannulated screws were implanted,including 6 sacroiliac screws (5 S1 ones and one S2) and 5 pubic ramus screws (2 antegrade ones and 3 retrograde ones).All the surgeries went on uneventfully with no neurovascular injury.The average amount of bleeding for each cannulated screw was 20 mL.The total intraoperative bleeding ranged from 60 to 200 mL,averaging 110 mL.The time of radiation exposure for each screw averaged 10 seconds and the operative time 110 minutes.Postoperative review of the pelvic X-ray films showed satisfactory fracture reduction.Four cases were rated as excellent and 2 as good.All the surgical wounds healed primarily with no wound infection,deep vein thrombosis,multiple organ dysfunction syndrome or other complications.Conclusion CAOS is a feasible,safe and effective method for treatment of pelvic fractures in an earthquake rescue not only because it has common advantages of minimal invasion,high accuracy,less radiation exposure,shorter operative time and early stabilization but also because it can provide damage control for the patients who have been severely injured in the earthquake. Key words: Pelvis; Fracture, bone; Multiple trauma; Surgery, computer-assisted; Earthquakes