Objectives: The research aims to enhance the effectiveness of the deep learning model for detecting lung adenocarcinoma using VGG16 CNN with transfer learning on medical images. The proposed model addresses the overfitting issues of existing models, thereby improving lung cancer detection accuracy. Methods: The lung CT scan images are analyzed for detection and classification using VGG16, leveraging transfer learning techniques. The dataset includes labeled lung images from LUNA 16, Kaggle, and other datasets, which are augmented to introduce variability and reduce overfitting. The images are resized format to 224 × 224 pixels. During the validation and training phases, the model's performance is evaluated based on accuracy, and precision. Findings: The adjusted VGG16 model attains a training accuracy of 99.42%, a validation accuracy of 99.13%, and a validation precision of 95.45%, indicating strong generalization capabilities, outperforming other existing models. Novelty: This research presents a new method for detecting lung cancer by combining advanced preprocessing and data augmentation techniques with the VGG16 architecture using transfer learning. This combination greatly enhances the model's ability to detect cancer accurately, setting a new standard in the field. Keywords: Lung cancer, VGG16, Transfer learning, Data augmentation, medical imaging, CT (Computer Tomography)
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