The prevalence of positive cultures in primarily operated shoulders represents a growing concern. Previous studies have documented high rates of culture positivity in primary prosthetic shoulder surgery, yet the Latarjet procedure has not been specifically explored in this context. The aim of this study was to identify the rate of culture positivity in patients treated with a primary Latarjet procedure, and to identify risk factors for culture positivity. This prospective, multicentric study conducted between September 2021 and October 2022 targeted patients undergoing primary open Latarjet procedures. Patients with a history of shoulder surgery were excluded. Six deep preoperative bacteriological samples were collected: three from soft tissues (capsulolabral) and three from bony (glenoid) areas. The primary outcome was the rate of culture positivity. Secondary outcomes included the type of germs and the rate of complications. Risk factor analysis for positive cultures was undertaken using both univariate and multivariate analyses. This study encompassed 122 patients with a mean age of 26.63 ± 7.45. The rates of having at least 1, 2, and 3 cultures positive were 44.8%, 40.16%, and 34.43%, respectively. Predominantly, cultures yielded Cutibacterium acnes in 96.2% of cases. Multivariate analysis identified one main risk factor for culture positivity: preoperative shoulder CT arthrogram (CTA) use (OR = 4.44, 95% CI [1.65 - 11.9], p = 0.003) for at least one positive culture. For at least 2 positive cultures, ORs were 4.17 (p = 0.005) for CTA and 3.88 (p = 0.009) (p < 0.001) for at least 3 positive cultures. Elimination the identified modifiable risk factors reduced the rate of positive cultures to 29.27%, 24.39%, and 19.51% for at least 1, 2, and 3 positive cultures. One patient who had positive culture experienced early sepsis caused by Cutibacterium acnes. This study showed a high rate of positive cultures in Latarjet patients post surgeries. Analysis highlighted preoperative CTA use as a significant risk factor, increasing positive culture risk fourfold.
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