We report an experimental demonstration of resonance fluorescence in a two-level superconducting artificial atom under two driving fields coupled to a detuned cavity. One of the fields is classical and the other is varied from quantum (vacuum fluctuations) to classical by controlling the photon number inside the cavity. The device consists of a transmon qubit strongly coupled to a one-dimensional transmission line and a coplanar waveguide resonator. We observe a sideband anticrossing and asymmetry in the emission spectra of the system through a one-dimensional transmission line, which is fundamentally different from the weak-coupling case. By changing the photon number inside the cavity, the emission spectrum of our doubly driven system approaches the case when the atom is driven by two classical bichromatic fields. We also measure the dynamical evolution of the system through the transmission line and study the properties of the first-order correlation function, Rabi oscillations, and energy relaxation in the system. The study of resonance fluorescence from an atom driven by two fields promotes understanding decoherence in superconducting quantum circuits and may find applications in superconducting quantum computing and quantum networks. Published by the American Physical Society 2024