Cavitation and induced noise are common issues in the operation of mixed-flow pumps, affecting their stability. Studying these phenomena is of both academic and engineering interest. Previous research has mainly focused on modifying the impeller blade profile or optimizing the pump structure to reduce cavitation and noise. In this paper, we apply a bionic design to the mixed-flow pump impeller by mimicking the natural shape of a humpback whale's pectoral fin on the leading edge of the blade. We compare the cavitation suppression and noise reduction effects of this design with those of a conventional mixed-flow pump. Unsteady flow calculations for the original pump at different flow rates revealed that at its rated speed, increasing flow rates led to lower pressure in the low-pressure region on the suction surface of the impeller, expanding the cavitation-prone area. By applying the bionic design, we studied the unsteady cavitation flow and its induced noise. Results showed that the impeller and guide vane experienced larger pressure pulsations at the rotation frequency and its multiples. The bionic modification increased the cavitation initiation speed and reduced the cavity volume within the runner. With an NPSH (net positive suction head) of 6.76, the void volume in the bionic pump was only 79% of that in the original pump, and the head increased by 16%. Additionally, the bionic design reduced the maximum far-field sound pressure level by 12.5%, achieving significant noise reduction. This study demonstrates that the bionic design effectively controls dynamic flow separation, reduces flow-induced noise, and enhances the mixed-flow pump's performance. These findings have important theoretical and practical implications for optimizing mixed-flow pump design, improving energy efficiency, and reducing noise.