Cervical Compressive Myelopathy Research Articles

Foot Tapping Test as Part of Routine Neurologic Examination in Degenerative Compression Myelopathies: A Significant Correlation between 10-sec Foot-tapping Speed and 30-m Walking Speed.

Introduction Leg spasticity in degenerative compression myelopathy causes impairment of fast and rapid repetitive movements, which tends to appear despite the disproportionate paucity of clinical weakness. As clinically useful measures used to quantify the slowness of voluntary leg movements in this pathological condition, we compared the foot tapping test (FTT) with the simple walking test, which is now considered the gold standard in this field. Methods We compared the FTT with the simple walking test, the grip-and-release test, and the functional scales of Nurick and the Japanese Orthopedic Association (JOA) in 77 patients with cervical compression myelopathy and 56 age-matched healthy subjects. The FTT was conducted on both sides separately, and the subject, while being seated on a chair, moved his/her toes up and down repeatedly to tap the floor as fast and as vigorously as possible for 10 sec with his/her heels planted on the floor. Results The number of 10-sec foot tapping in the patient group significantly correlated with the Nurick grades (r = −0.566; P < 0.0001), the JOA scores (r = 0.520; P < 0.0001), and the grip-and-release rates (r = 0.609; P < 0.0001). It also significantly correlated with the 30-m walking time (r = −0.507; P < 0.0001) and the number of steps taken (r = −0.494; P < 0.0001). Assessments of wheelchair-dependent patients and side-to-side comparison, in which the simple walking test plays no role, revealed significantly fewer FTT taps in wheelchair-bound patients than in the ambulatory patients and a significant trend for cervical compression myelopathy to dominantly affect the upper and lower limbs on the same side. Conclusions This study contributes to the reassessment of the currently underutilized FTT as part of a routine neurologic examination of degenerative compression myelopathy.

Role of Decompressive Laminectomy without Instrumentation in the Management of Nurick Grade 4 and 5 Cervical Compressive Myelopathy.

Introduction:Cervical laminectomy is a very well-known posterior decompressive procedure for cervical compressive myelopathy (CCM). Our objective is to evaluate the functional effect of posterior decompressive laminectomy for poor grade CCM.Methods:This study was an observational retrospective study carried out on patients with poor-grade CCM who underwent decompressive laminectomy from January 2010 to December 2015. Patients with Nurick Grades 4 and 5 (walking with support or bedbound) were included in the study. Clinical data and radiological information were collected from medical records, and objective scales were applied to compare the surgical outcome between preoperative score and postoperative score.Results:A total of 69 patients who underwent decompressive laminectomy for poor grade CCM were included. The mean age was 54.9 years, and the male-to-female ratio was 5.3:1. Ossified posterior longitudinal ligament comprised 52.6% cases. The follow-up data of at least 6 months’ duration after surgery was available for 57 (82.6%) cases. On comparing with preoperative Nurick grade at follow-up, 40 of the 57 patients (70.2%) were found to have improvement following surgery by at least one grade. The remaining 17 (29.8%) had either remained the same or had deteriorated further. The mean preoperative modified Japanese Orthopedic Association score was 8.4 ± 2.8, and the mean follow-up score was 11.8±0.3 (P = 0.0001). On multivariate analysis, the number of levels of laminectomy, postoperative deterioration, and anesthesia grade were predictors of outcome.Conclusion:Decompressive laminectomy for poor grade myelopathy is effective in improving functional outcome.

Multiple solitary plasmacytoma of the spine with compressive cervical myelopathy: A rare case report and review of literature

We present a case of multifocal plasmacytoma, one of the rarest hematological malignancies, with an unusual presentation of cervical myelopathy. A 60-year-old male presented with features of cervicalgia and radiculomyelopathy. There was a history of significant weight loss over 2 months with no sphincter involvement. Neurological examination showed spastic quadriparesis with extensor plantars. Radiological workup showed multiple lytic lesions from C3 to C6 with cord compression and myelomalacic changes. The patient underwent three-level corpectomy (C5–C7) with cord decompression. Reconstruction was done with an expandable titanium cage, and anterior cervical plating from C4 to T1 was done. The histopathology and immunohistochemistry markers enabled in clinching this rare diagnosis of multifocal plasmacytoma. It is essential to distinguish early between various entities among plasmacytoma as each one has a different clinical course and prognosis. Multiple solitary plasmacytoma presenting de novo with cord compression and myelopathy is an extremely rare presentation.

Diffusion tensor imaging as an additional postoperative prognostic predictor factor in cervical myelopathy patients: An observational study.

Introduction:Multiple investigation modalities have been invented for diagnosis and for planning management of degenerative cervical myelopathy, which include magnetic resonance imaging (MRI), computed tomography scan, and plain X-rays. Diffusion tensor imaging (DTI) of the spinal cord is a special variety of MRI where diffusion of water molecules across and along the tracts is mapped. The changes in anisotropy at the stenotic level can be a postoperative prognostic factor. The aim of this study was to establish postoperative prognostic predictive value of DTI in cases of degenerative cervical myelopathy.Materials and Methods:The study included 30 indoor patients in a tertiary care hospital diagnosed with degenerative compressive cervical myelopathy based on both clinical and radiological parameters with complete clinical data including follow-up. All patients with medical neurological diseases, cases who underwent repeat surgery, cases who developed surgical site infection, and those patients who were lost to follow-up were excluded from the study. The patients underwent operative decompression through either anterior or posterior approach with or without fixation with titanium implants as per indication. All patients underwent pre- and postoperative DTI. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were noted in both pre- and postoperative imaging. Epidemiological data such as age and sex were noted. Pre- and postoperative modified Japanese Orthopedic Association (mJOA) scores were calculated.Results:There was a significant improvement in FA values postoperatively. Preoperatively, both FA and ADC values showed a significant correlation with preoperative Neurological status of the patient while postoperatively only FA values were found to be significantly correlated. The regression equations for determining postoperative mJOA score based on preoperative FA and ADC values revealed mJOA = 9.77 + 12.1 (FA), mJOA = 14.2 + 2408.4 (ADC), and mJOA = 9.54 + 11.2 (FA) +1575.5 (ADC). This means that postoperative mJOA score, i.e., postoperative clinical status improvement can be determined using DTI variables which are an objective preoperative data. However, relative strength of prediction for FA value is 66.7% and for ADC value is 28.7%.Conclusion:DTI tractography of the spinal cord will be a helpful objective prognostic factor for patients in whom surgery is planned. However, a study with larger subject size is required to increase the accuracy of determination of regression coefficient.

Analysis of correlative factors of spinal cord posterior displacement after single door laminoplasty

To observe the open angle (OA), cervical curvature angle (CA), preoperative spinal cord compression rate(PSCR), postoperative spinal cord shift (PSCS) in patients with chronic compressive cervical myelopathy undergoing C3-7 single open laminoplasty, and to explore the possible mechanism and influencing factors of postoperative average spinal cord drift, so as to provide objective basis for predicting PSCS. From May 2012 to July 2016, 32 patients with multi-segmental chronic compressive cervical myelopathy who underwent single-door laminoplasty in our department were analyzed retrospectively, including 14 cases of cervical spondylotic myelopathy, 8 cases of developmental cervical spinal stenosis with cervical myelopathy, and 10 cases of ossification of posterior longitudinal ligament. The OA of cervical spine was measured on CT, the CA was measured on X-ray, the PSCR and PSCS were measured on MRI. The patients were divided into two groups according to PSCS(group A>=2.5 mm, group B<2.5 mm). In the group A, there were 11 males and 6 females, with an average age of (56.58±9.80) years old, a mean course of the disease of (23.52±7.86) months; while in group B, there were 6 males and 9 females, with an average age of (58.46±12.53) years old, a mean course of disease of (21.13±7.75) months. The correlation analysis between PSCS and OA, CA and PSCR was performed, and multiple linear analysis of correlated parameters was carried out. The OA in group A was (40.47±9.45) °, in group B was (27.84±5.67) °. The OA in group A was higher than that in group B (P<0.01), and OA was moderately correlated with PSCS (r=0.794, P=0.000). The CA was(11.56± 4.99) ° in group A and(6.64±3.28) ° in group B . The CA in group A was higher than that in group B (P<0.01), and CA was moderately correlated with PSCS (r=0.632, P=0.000). The PSCR was (27.70±2.92) % in group A , was (24.59±2.80) % in group B . The PSCR in group A was higher than that in group B(P<0.01), PSCR was moderately correlated with PSCS(r=0.667, P=0.000). The CA dependent variable was kicked out(P>0.1), and the partial regression coefficients of OA and PSCR were 0.113 and 0.059 respectively. PSCS is the result of OA, CA and PSCR, among which PSCR has the most important influence, OA is the second, CA is the least. PSCS can be predicted by 0.059×OA+0.113×PSCR-2.266 equation, which provides a theoretical basis for preoperative evaluation of spinal cord decompression after surgery.

Upper cervical lordosis compensates lower cervical kyphosis to maintain whole cervical lordosis after selective laminectomy

After lower-cervical-level spinal-cord tumor resection, compensatory upper cervical lordosis with lower cervical kyphosis was observed. However, no studies examined this compensation following posterior decompression surgery for cervical compressive myelopathy (CCM). The purpose of this study was to evaluate the compensatory mechanism after muscle-preserving selective laminectomy (SL) and to assess the clinical outcomes following such compensation. Enrolled in the study were 125 CCM patients who underwent C6 single-level SL, C5–C6 two-level SL, C4–C6 three-level SL, and C3–C6 four-level SL. Cervical spine lateral radiography was taken before surgery and during the final followup. The C2–C5, C5–C7, and C2–C7 angles were measured and presented respectively as the patients’ “upper,” “lower,” and “whole” cervical alignments. Patients were divided into two groups according to their postoperative C5–C7 alignment changes. We then divided the C5–C7 kyphotic-change group according to the patients’ postoperative C7 slope changes. Postoperative cervical sagittal balance and surgical outcomes were compared within the groups. Postoperative C5–C7 kyphotic change was compensated for by C2–C5 lordotic change, maintaining the preoperative C2–C7 angle. Although postoperative C5–C7 kyphotic change alone did not affect cervical sagittal balance or surgical outcomes, patients with C5–C7 kyphotic changes and C7 slope increases showed greater increases in the C2–C7 sagittal vertical axis and lower recovery rates in Japanese Orthopaedic Association scores. The patients’ postoperative lower cervical kyphotic changes were compensated for by upper cervical lordotic changes. Despite this compensation, increases in patients’ C7 slopes adversely affected sagittal balance and functional recovery.

Equine degenerative myeloencephalopathy: prevalence, impact, and management.

Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy is an inherited neurodegenerative disorder affecting many horse breeds. Clinical signs include a symmetric ataxia and an abnormal stance at rest, similar to cervical vertebral compressive myelopathy, equine protozoal myeloencephalitis, and equine herpesvirus 1 myeloencephalopathy. This review will provide an update on the disease prevalence, management, impact, and ongoing research.

Cervical compressive myelopathy caused by malfunction of a programmable cerebrospinal fluid shunt valve

Abstract The primary treatment for hydrocephalus is ventricular shunt placement, and a programmable valve is widely used for ventriculoperitoneal (VP) shunt surgery to reduce over/under drainage of cerebrospinal fluid (CSF). Here, we report a rare case of a patient who developed successive VP shunt malfunction causing spastic muscle weakness in extremities associated cervical epidural venous distension and compressive myelopathy due to over-drainage of CSF through a defective VP shunt valve a decade after the initial shunt was placed. One should be aware and cognizant of this complication and carefully follow the symptoms and potentially utilize brain MRI with and without contrast to look at over drainage stigmata to avoid the development of neurological complications.

Spinal Cord Changes After Laminoplasty in Cervical Compressive Myelopathy: A Diffusion Tensor Imaging Study.

Purpose: Validation of the efficacy of decompression surgery in patients with cervical myelopathy (CM) is important in terms of the recovery of the integrity of the spinal cord. However, to date, no longitudinal study has addressed the underlying pathological changes using diffusion tensor imaging (DTI) in CM patients. This study aimed to determine the diffusion metrics at the lesion as well as below the lesion level longitudinally in CM patients following laminoplasty using DTI.Methods: Twenty CM patients were analyzed and compared with 20 age-matched healthy controls. The primary outcome measure was the changes in the diffusion metrics [fractional isotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD)]. The secondary outcome measure was the changes in the modified Japanese Orthopedic Association (mJOA) score. Diffusion metrics obtained from six region-of-interests (ROIs; 2 anterior, 2 posterior, 2 lateral) at the lesion and below the lesion level (C7/T1) in preoperative and 6 months postoperative conditions were compared longitudinally.Results: The CM patients showed significant changes in their postoperative diffusion metrics for the anterior ROIs compared with the preoperative measures both at and below the lesion level. In the lateral and posterior cord, the preoperative AD value decreased after laminoplasty to the control at the lesion level. In contrast, MD and RD values at the lesion level and FA value at below the lesion level remained unchanged postoperatively. In addition, the postoperative anterior FA value was positively correlated with the postoperative mJOA score below the lesion level.Conclusion: This would be the first study showing changes in the spinal cord at the lesion as well as below the lesion level after laminoplasty in CM patients, which may be associated with functional recovery.

Friday, September 28, 2018 1:00 PM–2:30 PM abstracts: a new look at imaging: 202. The Functional relevance of diffusion tensor imaging in comparison to conventional MRI in patients with cervical compressive myelopathy

BACKGROUND CONTEXT Most of cervical myelopathy are easily diagnosed by conventional T2-weighted magnetic resonance imaging together with a history of specific symptoms and neurological examinations. Although MRI has played an important role in the diagnosis and follow-up of spinal cord lesions at present, it still lacks relevance to the functional outcome and prognosis. A recently introduced technique, diffusion tensor imaging (DTI), has been investigated for estimating the neural tissue integrity in the brain and spinal cord. It would be important to validate the advantage of DTI in terms of functional relevance compared to conventional MRI. PURPOSE To determine the functional relevance of diffusion tensor imaging (DTI) metrics and conventional MRI (signal intensity change in T2, compression ratio) by measuring the correlation of these parameters with clinical outcome measured by the modified Japanese Orthopedic Association (mJOA) score. STUDY DESIGN/SETTING This is a prospective cohort study. PATIENT SAMPLE A total of 20 cervical myelopathy (CM) patients participated. OUTCOME MEASURES The mJOA score, Conventional MRIs (T2-weighted images) and DTI metrics [fractional anisotropy (FA), apparent diffusion coefficient (ADC)] at each lesion and below each lesion (C7/T1) level were acquired using a 3-T Achieva MRI. METHODS Conventional MRIs abd DTI metrics parameters were correlated with the mJOA scores to determine the functional relevance. RESULTS Ninety percent of CM patients showed signal changes and 30% of patients noted a more than 40% canal compression ratio in conventional MRIs at the lesion level; however, these findings were not correlated with the mJOA score (p<.05). In contrast, FA values on DTI showed high sensitivity to CM (100%), which was well correlated with the mJOA score (p=.034, r=0.475) below the lesion level (C7/T1). CONCLUSIONS This study showed a meaningful symptomatic correlation between mJOA scores and FA values below the lesion levels in CMpatients. It could give us more understanding of the pathological changes in spinal cords matched with various clinical findings in CM patients than the results from conventional MRI. Most of cervical myelopathy are easily diagnosed by conventional T2-weighted magnetic resonance imaging together with a history of specific symptoms and neurological examinations. Although MRI has played an important role in the diagnosis and follow-up of spinal cord lesions at present, it still lacks relevance to the functional outcome and prognosis. A recently introduced technique, diffusion tensor imaging (DTI), has been investigated for estimating the neural tissue integrity in the brain and spinal cord. It would be important to validate the advantage of DTI in terms of functional relevance compared to conventional MRI. To determine the functional relevance of diffusion tensor imaging (DTI) metrics and conventional MRI (signal intensity change in T2, compression ratio) by measuring the correlation of these parameters with clinical outcome measured by the modified Japanese Orthopedic Association (mJOA) score. This is a prospective cohort study. A total of 20 cervical myelopathy (CM) patients participated. The mJOA score, Conventional MRIs (T2-weighted images) and DTI metrics [fractional anisotropy (FA), apparent diffusion coefficient (ADC)] at each lesion and below each lesion (C7/T1) level were acquired using a 3-T Achieva MRI. Conventional MRIs abd DTI metrics parameters were correlated with the mJOA scores to determine the functional relevance. Ninety percent of CM patients showed signal changes and 30% of patients noted a more than 40% canal compression ratio in conventional MRIs at the lesion level; however, these findings were not correlated with the mJOA score (p<.05). In contrast, FA values on DTI showed high sensitivity to CM (100%), which was well correlated with the mJOA score (p=.034, r=0.475) below the lesion level (C7/T1). This study showed a meaningful symptomatic correlation between mJOA scores and FA values below the lesion levels in CMpatients. It could give us more understanding of the pathological changes in spinal cords matched with various clinical findings in CM patients than the results from conventional MRI.

Postoperative Walking Ability of Non-ambulatory Cervical Myelopathy Patients.

A retrospective analysis. The aim of this study was to clarify the postoperative improvement of walking ability and prognostic factors in nonambulatory patients with cervical myelopathy. Many researchers have reported the surgical outcome in compressive cervical myelopathy. However, regarding severe gait disturbance,, it has not been clarified yet how much improvement can be expected. One hundred thirty-one nonambulatory patients with cervical myelopathy were treated surgically and followed for an average of 3 years. Walking ability was graded according to the lower-extremity function subscore (L/E subscore) in Japanese Orthopedic Association score. We divided patients based on preoperative L/E subscores: group A, L/E subscore of 1 point (71 patients); and group B, 0 or 0.5 point (60 patients). The postoperative walking ability was graded by L/E subscore: excellent, ≥2 points; good, 1.5 points; fair, 1 point; and poor, 0.5 or 0 points. We compared preoperative and postoperative scores. The cutoff value of disease duration providing excellent improvement was investigated. Overall, 50 patients were graded as excellent (38.2%), and 21 patients were graded as good (16.0%). In group B, 17 patients (28.3%) were graded as excellent. Seventeen patients who were graded as excellent had shorter durations of myelopathic symptoms and/or gait disturbance (7.9 and 3.8 months respectively) than the others (29.5 and 8.9 months, respectively) (P < 0.05). Receiver-operating characteristic curve showed that the optimal cutoff values of the duration of myelopathic symptoms and gait disturbance providing excellent improvement were 3 and 2 months, respectively. Even if the patients were nonambulatory, 28.3% of them became able to walk without support after operation. If a patient becomes nonambulatory within 3 months from the onset of myelopathy or 2 months from the onset of gait disturbance, surgical treatment should be performed immediately to raise the possibility to improve stable gait. 3.

Risk Factor Analysis of Change in Intraoperative Neurophysiologic Monitoring During Cervical Open Door Laminoplasty

The aim of this study is to determine the risk factors affecting intraoperative neurophysiologic monitoring (IONM) changes, when such changes take place, and clinical outcomes associated with IONM change during cervical open door laminoplasty (COL) for cervical compressive myelopathy. Between 2010 and 2015, 79 patients who underwent COL with IONM recording were studied. Changes in motor evoked potentials or somatosensory evoked potentials over an alarm criterion were defined as IONM change. Patients with IONM change were assigned to the alarm group, and the others were classified as the control group. Baseline data and radiographic measurements were compared between the 2 groups. Radiologic parameters including maximal compression level (MCL), area and diameter of the spinal canal and ventral compressive lesion, stenosis grade, and occupying ratio of area (ORA) and length at the MCL were measured with magnetic resonance imaging. Thirteen patients were assigned to the alarm group and 66 patients were assigned to the control group. Multivariate analysis identified ORA at the MCL (odds ratio, 1.520; 95% confidence interval, 1.192-1.37; P= 0.001) as an independent risk factor for IONM change. Immediately after decompression, the IONM change occurred. One of 4 patients who did not fully recover from the IONM change had postoperative motor deficits. IONM change during COL occurred immediately after decompression, and a risk factor of IONM change was ORA at the MCL. If the IONM change was not fully recovered, a new motor deficit occurred after COL.

Symptomatic cord compression by paraspinal musculature following cervical laminectomy: rare complication.

Cervical laminectomy is an effective treatment for multilevel cervical compressive myelopathy. Symptomatic spinal cord compression (SSCC) by paraspinal musculature (PSM) following cervical laminectomy is rarely reported. The aim of this study was to evaluate the frequency and pathogenesis of this complication after cervical laminectomy. Between 2007 and 2016, the medical records of 1309 cervical laminectomy patients were reviewed. From these 1309 records, seven patients (five men and two women; average age, 64.12years; range 48-78years) with SSCC by PSM following cervical laminectomy were identified. The incidence and possible risk factors of this rare condition were evaluated. The frequency of SSCC by PSM following cervical laminectomy was 0.53%. Presenting symptoms included paralyses and paresthesias, depending on the level and severity of cervical spinal cord compression. The initial onset of neurologic deterioration varied from 12h to 21days after operation. Most patients recovered well after surgical management with an average Barthel index of 74.3 at 6months after surgery. In comparison with 63 controls, this rare complication was associated with preoperative cervical kyphosis, prior antiplatelet therapy, and posterior decompression with prone position. SSCC by PSM is a rare but devastating complication following cervical laminectomy, especially in those patients with preoperative kyphosis, prior antiplatelet treatment, and decompression with prone position. MRI is an ideal tool to identify this complication. Rapid cervical cord decompression and avoidance of recurrent compressive events can achieve a good clinical outcome. These slides can be retrieved under Electronic Supplementary Material.

The effect of positive changes during intraoperative monitoring on the functional improvement in patients with cervical compressive myelopathy

Cervical compressive myelopathy (CCM) is a progressive, degenerative spine disease and the most common cause of spinal cord dysfunction in older individuals. Current clinical guidelines for spinal surgery strongly recommend multimodal intraoperative monitoring (IOM) during spinal surgery as a reliable and valid diagnostic adjunct to assess spinal cord integrity. The aim of this study was to evaluate the effect of positive changes during IOM on the functional status in patients with CCM. Patients who underwent spinal surgery with IOM due to CCM were enrolled. During the surgery, patients underwent IOM using motor evoked potential (MEP) and somatosensory evoked potential (SEP). MEP and SEP were checked before and immediately after decompression. A shortened in latency greater than 10% or an increase in amplitude greater than 50% was regarded as a ‘positive changes’. Subjects were divided according to the presence of positive changes. Motor scores of American Spinal Injury Association (ASIA) impairment scale and Korean version of modified Barthel index (K-MBI) were evaluated before and after operation. Twenty-nine patients underwent spinal surgery due to CCM. Among these patients, 11 showed positive changes in MEP during IOM. When the two groups were compared, improvement rate in the AISA motor score and K-MBI were significantly higher in patients with positive changes than in patients without positive changes at 1 month after surgery. The duration of hospital stay was significantly shortened in the ‘positive change’ group. Regardless of positive change, nearly all patients suffered from neuropathic pain after operation. Positive changes in MEP during IOM may affect better functional improvement 1 month after operation and early discharge without significant complications in CCM patients. However they do not affect the neuropathic pain. Thus, tailored, proper management is needed to achieve maximal functional recovery in each patient after cervical spinal decompression surgery.

The effect of positive changes during intraoperative monitoring of the functional improvement in patients with cervical compressive myelopathy

BackgroundCervical compressive myelopathy (CCM) is a progressive, degenerative spine disease and the most common cause of spinal cord dysfunction in older individuals. Current clinical guidelines for spinal surgery recommend multimodal intraoperative monitoring (IOM) during spinal surgery as a reliable and valid diagnostic adjunct to assess spinal cord integrity. The aim of this study was to evaluate the effect of positive changes during IOM on the functional status in patients with CCM.MethodsPatients who underwent spinal surgery with IOM due to CCM were enrolled. During the surgery, patients underwent IOM using motor evoked potential (MEP) and somatosensory evoked potential (SEP). MEP and SEP were checked before and immediately after decompression. A decrease in latency >10% or an increase in amplitude >50% was regarded as a “positive changes”. Subjects were divided according to the presence of positive changes. Motor scores of American Spinal Injury Association (ASIA) impairment scale and Korean version of Modified Barthel Index (K-MBI) were evaluated before and after operation.ResultsTwenty-nine patients underwent spinal surgery due to CCM. Eleven patients showed positive changes in MEP during IOM. When the two groups were compared, improvement rate in the ASIA motor score and K-MBI were significantly higher in patients with positive changes than in patients without positive changes at 1 month after surgery. However, 6 months after surgery, there were no significance differences between the groups. Regardless of positive change, nearly all patients suffered from neuropathic pain after operation.ConclusionPositive changes in MEP during IOM may affect functional improvement 1 month after operation and early discharge without significant complications in CCM patients. However, they do not affect the neuropathic pain and long-term functional outcome. Thus, tailored proper management is needed to achieve maximal functional recovery in each patient after cervical spinal decompression surgery.

Muscle-Preserving Selective Laminectomy Maintained the Compensatory Mechanism of Cervical Lordosis After Surgery.

A retrospective single-center study. The aim of this study was to evaluate the compensatory mechanism of cervical lordosis (CL), the changes in cervical sagittal alignment, and range of motion (ROM) after muscle-preserving selective laminectomy (SL). CL increases as a compensatory mechanism for the adjustment of cervical sagittal balance or horizontal gaze. However, laminoplasty invades this mechanism and causes kyphosis in higher T1 (C7) slope patients. SL is a posterior surgery selecting the decompression laminae without disturbing the extensor musculature and facet joints. The clinical features and radiological findings of 125 cervical compressive myelopathy patients who underwent C6 single-level SL, C5-C6 two consecutive levels SL, C4-C6 three consecutive levels SL, and C3-C6 four consecutive levels SL were enrolled. Cervical spine lateral radiography was performed before surgery and at the final follow-up. The patients were divided into two groups according to the preoperative C7 slope. Postoperative cervical alignment change was compared between the higher and lower C7 slope groups. Subsequently, pre- and postoperative cervical alignment and cervical ROM were analyzed according to the number of consecutive laminae surgically treated. Patients with higher C7 slope had greater lordotic cervical alignment and larger C2-C7 sagittal vertical axis (SVA) pre- and postoperatively. No kyphotic alignment change was observed, even in the higher C7 slope group. C6 SL and C5-C6 SL did not affect C2-C7 angle, and did not increase C2-C7 SVA after surgery. Although C4-C6 SL and C3-C6 SL demonstrated postoperative slight increase in C2-C7 SVA, C2-C7 angle never decreased after surgery. Cervical ROM slightly reduced in the C4-C6 SL and C3-C6 SL groups; however, no reduction of ROM was observed in the C6 SL and C5-C6 SL groups. SL preserved the inherent compensatory CL that had been observed preoperatively and maintained cervical sagittal balance after surgery. 4.

Safety and tracking of intrathecal allogeneic mesenchymal stem cell transplantation in healthy and diseased horses

BackgroundIt is currently unknown if the intrathecal administration of a high dose of allogeneic mesenchymal stem cells (MSCs) is safe, how MSCs migrate throughout the vertebral canal after intrathecal administration, and whether MSCs are able to home to a site of injury. The aims of the study were: 1) to evaluate the safety of intrathecal injection of 100 million allogeneic adipose-derived MSCs (ASCs); 2) to assess the distribution of ASCs after atlanto-occipital (AO) and lumbosacral (LS) injection in healthy horses; and 3) to determine if ASCs homed to the site of injury in neurologically diseased horses.MethodsSix healthy horses received 100 × 106 allogeneic ASCs via AO (n = 3) or LS injection (n = 3). For two of these horses, ASCs were radiolabeled with technetium and injected AO (n = 1) or LS (n = 1). Neurological examinations were performed daily, and blood and cerebrospinal fluid (CSF) were evaluated prior to and at 30 days after injection. Scintigraphic images were obtained immediately postinjection and at 30 mins, 1 h, 5 h, and 24 h after injection. Three horses with cervical vertebral compressive myelopathy (CVCM) received 100 × 106 allogeneic ASCs labeled with green fluorescent protein (GFP) via AO injection and were euthanized 1–2 weeks after injection for a full nervous system necropsy. CSF parameters were compared using a paired student’s t test.ResultsThere were no significant alterations in blood, CSF, or neurological examinations at any point after either AO or LS ASC injections into healthy horses. The radioactive signal could be identified all the way to the lumbar area after AO ASC injection. After LS injection, the signal extended caudally but only a minimal radioactive signal extended further cranially. GFP-labeled ASCs were not present at the site of disease at either 1 or 2 weeks following intrathecal administration.ConclusionsThe intrathecal injection of allogeneic ASCs was safe and easy to perform in horses. The AO administration of ASCs resulted in better distribution within the entire subarachnoid space in healthy horses. ASCs could not be found after 7 or 15 days of injection at the site of injury in horses with CVCM.

Risk Factors for Significant Intraoperative Blood Loss During Unilateral Expansive Open-Door Cervical Laminoplasty for Cervical Compressive Myelopathy

Unilateral expansive open-door cervical laminoplasty is an effective and safe procedure for cervical compressive myelopathy but occasionally is accompanied with significant intraoperative blood loss (SIBL). The aim of the present study was to elucidate the risk factors for SIBL in patients undergoing cervical laminoplasty for multilevel cervical compressive myelopathy and to identify the effect of SIBL on neurologic complications. A total of 215 patients who received cervical laminoplasty between January 2010 and August 2016 were enrolled in the study. SIBL was defined as 500 mL or more of blood volume during surgery. Patients were subdivided into 2 groups according to whether they suffered from SIBL (n= 26) or not (n= 189). Patient characteristics and clinical data were collected. Univariate and multivariable analysis were performed to identify independent risk factors for SIBL. The incidence of SIBL during unilateral expansive open-door cervical laminoplasty was 12.1%. The multivariable logistic regression analysis showed Pavlov ratio (odds ratio [OR] 0.002, P= 0.009), ossification of the posterior longitudinal ligament (OR 2.677, P= 0.038), and number of complete hinge fractures (OR 1.842, P= 0.015) were independent risk factors for SIBL during cervical laminoplasty. Patients with SIBL during cervical laminoplasty had a greater rate of neurologic complications during hospitalization (P= 0.012), worse neurologic recovery rate at discharge (P= 0.01), and longer postoperative length of stay (P= 0.003). This study suggested that Pavlov ratio, ossification of the posterior longitudinal ligament, and number of complete hinge fractures were independent risk factors for SBIL during cervical laminoplasty. SIBL in cervical laminoplasty was associated with greater neurologic complications and worse neurologic functional recovery.

Narrow width of muscle-preserving selective laminectomy demonstrated sufficient surgical outcomes and reduced surgical invasiveness

Sufficient width of laminectomy or laminoplasty is considered a criterion for successful surgical outcomes following posterior cervical decompression. No previous study has focused on surgical outcomes achieved by wide versus narrow decompression. This study examined whether narrow laminectomy width (LW) affected surgical outcomes in cervical compressive myelopathy (CCM). Between 2005 and 2010, we performed muscle-preserving selective laminectomy (SL) with decompression between the bilateral medial margin of the facet joints (wide SL). After 2010, we began to perform narrow SL, in which the LW was no more than 2–3 mm wider than the spinal cord width (SW). Clinical features and radiological findings from 97 CCM patients in whom SL was performed at two consecutive levels, including the C4/5 level, were examined in this study. The relationship between LW and patients’ functional outcomes was analyzed. Mean blood loss was lower in the narrow SL group than in the wide SL group. The length of hospital stay was also shorter in the narrow SL group. The wide SL group showed greater posterior spinal cord shift. The incidence of C5 palsy correlated with LW and LW minus SW (LW-SW). The recovery rate (RR) of Japanese Orthopaedic Association score was comparable between the two groups. The RR was not correlated with LW and LW-SW. Sufficient functional recovery can be achieved by narrow SL, and it offers advantages over wide posterior decompression, including reduced surgical invasiveness and complications. Wide decompression width is not always necessary for CCM patients.

Axonal damage is remarkable in patients with acutely worsening symptoms of compression myelopathy: biomarkers in cerebrospinal fluid samples.

To determine levels of biomarkers reflecting damage to axon, myelin, astrocytes, and neuron in cerebrospinal fluid (CSF) of patients with cervical compression myelopathy. We collected 69 CSF samples from patients before spinal surgery for acutely worsening compression myelopathy (AM, 20), chronic compression myelopathy (CM, 20), and lumbar canal stenosis (LCS 29; control). We measured levels of phosphorylated neurofilament subunit H (pNF-H), tau (reflecting axonal damage), myelin basic protein (MBP) (reflecting demyelination), S100b (reflecting astrocyte damage), and neuron-specific enolase (NSE) (reflecting neuronal damage). Change of neurological function by surgery was determined using a Japanese Orthopaedic Association (JOA) score for cervical myelopathy. Significantly higher levels of pNF-H were detected in AM compared with those in either CM or LCS (P < 0.01). Significantly higher levels of tau were detected in AM compared with those in CM (P < 0.05). Levels of MBP were undetectable in almost all the patients. Levels of S100b were equivalent in the three groups. Levels of NSE in AM and CM were significantly lower than those in LCS (P < 0.01). The recovery rate of JOA score was significantly greater for patients with AM than CM. We found a positive correlation between pNF-H and recovery of JOA score (r = 0.381, P = 0.018). The present results suggest that axonal damage is remarkable compared with demyelination, astrocytic, and neuronal damage in AM. Better clinical outcome in AM with high CSF levels of pNF-H indicates that axonal compensatory plasticity in spinal cord is preserved, and pNF-H can be predictive of good surgical outcome for AM. These slides can be retrieved under Electronic Supplementary Material.