Tunisia located in the Northern African margin was subjected to Late Permian-Early Cretaceous N-S extension subsequent to Pangea breakup and leading to the Tethyan opening and widening. During Mid- and Late Cretaceous, the NE–SW crustal extension that established the Pantelleria-Malta-Sirt grabens system underlining the eastern margin stretched also the Tunisian Atlassic domain and created and/or reactivated many NW-SE extensional structures as much as the grabens in central Tunisia and led to volcanism and halokinesis along several weak zones. The Neogene compressional tectonics inverted the earlier extensional structures and disturbed most of the halokinetic features established within the post-Triassic cover. The Mrhila-Labaied-Trozza fault relay zone located in the middle of central Tunisia shows both extensional and compressional structures with Triassic extrusive features and seems to be a key feature for understanding the geodynamic development of the area. In this survey, we combined field and geophysical data together with analog models to decipher the structure and the kinematic evolution of the study area. The survey showed that the studied structures are associated to reactive Mesozoic salt ridges established along an extensional fault relay zone engaging both NW-SE, E-W and NE-SW inherited fractures that initially created extensional corridors allowing Triassic evaporites extrusion and accumulation, then guided the deformation of the area following transpressional and local pure compressional regimes depending on the fractures and stress orientations during its tectonic inversion. The analog modeling provided possible interpretation of the successive deformational stages of the study area from the salt ridge growth to its tectonic inversion.