Masonry infill walls serve as building partitions and are generally considered non-structural components. Their weights are considered in progressive collapse analysis, but the resistance of the infill walls is normally ignored in design standards. Based on the reasonable selection of constitutive models, a refined finite element (FE) model for the collapse resistance of concrete-filled steel tubular (CFST) composite frame with infill walls was established by ABAQUS/Explicit. Cohesive elements were inserted between different masonry blocks to simulate the mortar joints. The collapse resistance contribution and reinforcement methods analysis of the CFST frame with infill walls were carried out based on the validated FE models. Results show that the infill walls significantly contribute to resisting vertical load in the initial loading stage, with a maximum contribution of 55.3%. The infill walls, which are treated as the equivalent compressive struts, change the load-resisting path and effectively improve the load redistribution ability of the frame. The V-type oblique arrangement of tie rebars has better tie effect and collapse resistance of the frame than other arrangements. After pasting the CFRP sheet and spraying the ECC material to reinforce infill walls, the peak load can be increased by 25.1% and 22.9% respectively, and the ultimate load can be increased by 96.2% and 74.5% respectively. X-type pasting the CFRP sheet reinforcement has a better collapse resistance than others. Furthermore, based on the simplification of the infill walls as the diagonal struts, the simplified calculation formulas of anti-collapse capacity of CFST frame with infill walls were studied.