This work represents the performance comparison of conventional vapour compression refrigeration system (VCRS) using various refrigerants such as R134a, R152a, R600a and R290. The theoretical model has been utilized for computing work input to the compressor, refrigerating effect and coefficient of performance (COP) for R134a, R290, R600a and R152a refrigerants. This investigation has been done for the evaporator temperature range of -30 °C to 10 °C and the condenser temperature range of 40 °C to 45 °C. In this performance analysis it is seen that R290 shows favourable properties and can serve as best refrigerant among all in the group. R290 shows almost equal COP to R600a in large operating temperature range and it has very high refrigerating capacity comparatively to R134a together with its low global warming potential and ozone depletion potential. R152a and R600a also show some satisfying properties.