Shear Thickening Fluids (STFs) constitute a special class of materials which exhibit phase transition from low to high viscosity state when exposed to shearing forces, particularly, when the applied shear rate exceeds a critical value. The last decade has witnessed a mutual symbiotic relationship between STF and high-performance fabrics such as Kevlar®, Dyneema®, Ultra High Molecular Weight Polyethylene (UHMWPE) etc., to produce new light weight and flexible protective materials systems with enhanced knife, stab and ballistic resistant properties than the existing ones. In this study, we explore the effect of particle shape and size on the high strain rate dynamic response of nanosilica dispersions. Shear thickening fluid (STF) was synthesized using fumed silica and spherical nanosilica particles, comprising the dispersed phase, whereas PPG400 (Polypropylene Glycol) was used as the dispersion medium. Ultrasonic homogenization technique was used for the synthesis of STF. The low strain rate rheological characterization was conducted on MCR302 rheometer at 25°C, whereas the high strain rate characterization was performed on inhouse designed and developed SHPB (Split Hopkinson Pressure Bar) apparatus. Fumed silica (FS) particles possess high specific surface area owing to their fractal structure. Therefore, their low molecular weight dispersions exhibit shear thickening behavior thus making them potential candidates for liquid body armour applications. On the other hand, spherical silica dispersions exhibit shear thickening behavior in high phase volume concentrations. Experimental studies showed that spherical silica based STF dispersions exhibited enhanced shear thickening in the low strain rate domain, as well as better mechanical response in terms of higher peak stress under high strain rate compressive loading conditions, during SHPB testing, in comparison to their fumed silica counterpart. Thus, it can be inferred that the mechanical response of nano-silica dispersions is influenced by the shape of the particles constituting the dispersed phase.