To improve vertical seismic isolation and seismic resilience in isolation bearings, this paper introduces an innovative three-dimensional isolation bearing combining a disc-spring system (DSS), a high-damping rubber bearing (HDR), and a horizontal spring system (HSS). The DSS is designed with low vertical stiffness to enhance vertical isolation, while the HSS provides self-centering force to improve the seismic resilience of the HDR. This study first presents a comprehensive theoretical analysis of the horizontal and vertical stiffness composition. The vertical performance of this three-dimensional isolation bearing is attributed to the DSS, while the HSS and HDR jointly contribute to its horizontal performance. Seven specimens were designed and subjected to shear-compression cyclic tests to assess the horizontal and vertical cyclic performance. Experimental parameters included loading amplitude, loading frequency, vertical pre-load, and DSS combinations for vertical tests, and axial compression force, loading frequency, shear strain, and HSS function in horizontal tests. The cyclic performance parameters for the three-dimensional isolation bearing, including equivalent damping ratio, equivalent stiffness, and energy dissipation, was evaluated. In general, the proposed three-dimensional isolation bearing exhibits stable cyclic performance and advantageous seismic resilience, warranting its promotion to practical engineering applications.