New subgrid-scale models for the large-eddy simulation of compressible turbulent flows are developed and tested based on the Favre-filtered equations of motion for an ideal gas. A compressible generalization of the linear combination of the Smagorinsky model and scale-similarity model, in terms of Favre-filtered fields, is obtained for the subgrid-scale stress tensor. An analogous thermal linear combination model is also developed for the subgrid-scale heat flux vector. The two dimensionless constants associated with these subgrid-scale models are obtained by correlating with the results of direct numerical simulations of compressible isotropic turbulence performed on a963grid using Fourier collocation methods. Extensive comparisons between the direct and modelled subgrid-scale fields are provided in order to validate the models. A large-eddy simulation of the decay of compressible isotropic turbulence – conducted on a coarse323grid – is shown to yield results that are in excellent agreement with the fine-grid direct simulation. Future applications of these compressible subgrid-scale models to the large-eddy simulation of more complex supersonic flows are discussed briefly.