As ultra-thick laminates are widely used in the field of aerospace and marine as the main load-bearing structure, extreme service conditions lead to increasing thickness of composite structures. However, the effect of the increase in thickness on the compressive properties of ultra-thick laminates is still unclear. Herein parameters including fiber volume fraction, fiber waviness, void content and free edge effect that affect the compressive strength with increasing thickness are studied. The results show that the fiber volume fraction of ultra-thick laminates does not change significantly with the increase of thickness due to the adoption of the zero-bleeding process, while the fiber waviness and void contribute to the thickness effect on compressive strength. On the other hand, the high interlaminar stress of the free edge contributes to the premature delamination of the specimen, which dominates the compressive strength of the ultra-thick laminate. Finally, compared with the thin laminate (2 mm), the compressive strength of ultra-thick laminate drops sharply (nearly 28%), but when the thickness increases from 30 to 70 mm, the drop of compressive strength is not obvious (only 10%). When the material and curing process are consistent, the weak interlaminar properties of ultra-thick laminates does not change significantly with the increase of thickness, which leads to the insignificant decrease in compression strength of ultra-thick laminates with the increase of thickness. The proposed empirical relationship between the compressive strength and thickness of quasi-isotropic laminates can provide important theoretical basis and experimental reference for the design of ultra-thick composite structures.