Comprehensive Review Research Articles

Testicular niche repair after gonadotoxic treatments: Current knowledge and future directions.

The testicular niche, which includes the germ cells, somatic cells, and extracellular matrix, plays a crucial role in maintaining the proper functions of the testis. Gonadotoxic treatments, such as chemotherapy and radiation therapy, have significantly improved the survival rates of cancer patients but have also been shown to have adverse effects on the testicular microenvironment. Therefore, repairing the testicular niche after gonadotoxic treatments is essential to restore its function. In recent years, several approaches, such as stem cell transplantation, gene therapy, growth factor therapy, and pharmacological interventions have been proposed as potential therapeutic strategies to repair the testicular niche. This comprehensive review aims to provide an overview of the current understanding of testis damage and repair mechanisms. We will cover a range of topics, including the mechanism of gonadotoxic action, repair mechanisms, and treatment approaches. Overall, this review highlights the importance of repairing the testicular niche after gonadotoxic treatments and identifies potential avenues for future research to improve the outcomes for cancer survivors.

Fabrication of Silk Fibroin‐Derived Fibrous Scaffold for Biomedical Frontiers

AbstractSilk fibroin (SF), a natural protein derived from silkworms, has emerged as a promising biomaterial due to its biocompatibility, biodegradability, degradation rate, and tunable mechanical properties. This review delves into the intrinsic attributes of SF that make it an attractive candidate for scaffold development in tissue engineering and regenerative medicine. The distinctiveness of this comprehensive review resides in its detailed exploration of recent advancements in the fabrication techniques of SF‐based fibrous scaffolds, namely electrospinning, freeze‐drying, and 3D printing. An in‐depth analysis of these fabrication techniques is conducted to illustrate their versatility in customizing essential scaffold characteristics, such as porosity, fiber diameter, and mechanical strength. The article meticulously discusses process parameters, advantages, and challenges of each fabrication technique, highlighting the innovative advancements made in the respective field. Furthermore, the review goes beyond fabrication techniques to provide an overview of the latest biomedical applications and research endeavors utilizing SF‐derived scaffolds. From nerve regeneration and wound healing to drug delivery, bone regeneration, and vascular tissue engineering, the diverse applications underscore the versatility of SF in adopting various biomedical challenges. Finally, the article emphasizes the need for standardized characterization techniques, scalable manufacturing processes, and long‐term in vivo studies.

Molecular Insights into Plant-Microbe Interactions: A Comprehensive Review of Key Mechanisms.

In most ecosystems, plants establish complex symbiotic relationships with organisms, such as bacteria and fungi, which significantly influence their health by promoting or inhibiting growth. These relationships involve biochemical exchanges at the cellular level that affect plant physiology and have evolutionary implications, such as species diversification, horizontal gene transfer, symbiosis and mutualism, environmental adaptation, and positive impacts on community structure and biodiversity. For these reasons, contemporary research, moving beyond observational studies, seeks to elucidate the molecular basis of these interactions; however, gaps in knowledge remain. This is particularly noticeable in understanding how plants distinguish between beneficial and antagonistic microorganisms. In light of the above, this literature review aims to address some of these gaps by exploring the key mechanisms in common interspecies relationships. Thus, our study presents novel insights into these evolutionary archetypes, focusing on the antibiosis process and microbial signaling, including chemotaxis and quorum sensing. Additionally, it examined the biochemical basis of endophytism, pre-mRNA splicing, and transcriptional plasticity, highlighting the roles of transcription factors and epigenetic regulation in the functions of the interacting organisms. These findings emphasize the importance of understanding these confluences in natural environments, which are crucial for future theoretical and practical applications, such as improving plant nutrition, protecting against pathogens, developing transgenic crops, sustainable agriculture, and researching disease mechanisms. It was concluded that because of the characteristics of the various biomolecules involved in these biological interactions, there are interconnected molecular networks in nature that give rise to different ecological scaffolds. These networks integrate a myriad of functionally organic units that belong to various kingdoms. This interweaving underscores the complexity and multidisciplinary integration required to understand plant-microbe interactions at the molecular level. Regarding the limitations inherent in this study, it is recognized that researchers face significant obstacles. These include technical difficulties in experimentation and fieldwork, as well as the arduous task of consolidating and summarizing findings for academic articles. Challenges range from understanding complex ecological and molecular dynamics to unbiased and objective interpretation of diverse and ever-changing literature.

Towards an Inclusion Framework for Strategic Hiring

Diversity, equity, and inclusion (DEI) have become a critical issue in today’s globalized and diverse workforce. The purpose of this study is to explore and analyze the best practices and implementation strategies of a strategic hiring approach that advances DEI in hiring, offering insights that can be applied across a range of industries and sectors, ultimately contributing to a more equitable and inclusive workforce. This study aims to provide a comprehensive review of the literature on DEI and strategic hiring practices, identify the key factors that facilitate the successful implementation of DEI practices in strategic hiring, as well as the common barriers that hinder success. The research instrument included semi-structured interviews, surveys with Likert scale ratings, and document analysis to gather qualitative and quantitative data. The sample consisted of HR managers, recruiters, and hiring managers from the Business Process Outsourcing (BPO) industry, with a sample size of 25 participants selected through purposive sampling. The study incorporated an exploratory, descriptive, and interpretive research design to explore the best practices and implement strategies of strategic hiring for DEI. The results indicate that organizations can adopt strategies that promote DEI through strategic hiring. By identifying and highlighting these best practices, this study can help organizations create more diverse, equitable, and inclusive workplaces, which can lead to numerous benefits for employees, customers, and society as a whole. Keywords: Diversity, Equity and Inclusion (DEI), Diverse Workforce, Inclusive Workplaces, Strategic Hiring, Implementation Strategies

Recent Advances in Molecular Pathways and Therapeutic Implications for Peptic Ulcer Management: A Comprehensive Review.

Peptic ulcers, recognized for their erosive impact on the gastrointestinal mucosa, present a considerable challenge in gastroenterology. Epidemiological insights underscore the global prevalence of peptic ulcers, affecting 5-10+% of individuals, with a yearly incidence of 0.3 to 1.9 cases per thousand. Recent decades have witnessed a decline in complications, attributed to improved diagnostics and therapeutic advancements. The review deepens into H. pylori-associated and NSAID-induced ulcers, emphasizing their distinct prevalence in developing and industrialized nations, respectively. Despite advancements, managing peptic ulcers remains challenging, notably in H. pylori-infected individuals facing recurrence and the rise of antibiotic resistance. The pathophysiology unravels the delicate balance between protective and destructive factors, including the intricate molecular mechanisms involving inflammatory mediators such as TNF-α, ILs, and prostaglandins. Genetic and ethnic factors, rare contributors, and recent molecular insights further enhance our understanding of peptic ulcer development. Diagnostic approaches are pivotal, with upper gastrointestinal endoscopy standing as the gold standard. Current treatment strategies focus on H. pylori eradication, NSAID discontinuation, and proton pump inhibitors. Surgical options become imperative for refractory cases, emphasizing a comprehensive approach. Advances include tailored H. pylori regimens, the emergence of vonoprazan, and ongoing vaccine development. Challenges persist, primarily in antibiotic resistance, side effects of acid suppressants, and translating natural compounds into standardized therapies. Promising avenues include the potential H. pylori vaccine and the exploration of natural compounds, with monoterpenes showing therapeutic promise. This review serves as a compass, guiding healthcare professionals, researchers, and policymakers through the intricate landscape of peptic ulcer management.

Reliability Evaluation of Composite Power Systems Integrated with Wind and Solar Energy Sources: A Comprehensive Review

Reliability Evaluation of Composite Power Systems Integrated with Wind and Solar Energy Sources: A Comprehensive Review

The emerging significance of RNA 5-methylcytosine modification in human cancers

Abstract RNA methylation, the most prevalent type of RNA modification, encompasses more than 60 % of all known RNA modifications. With the advancement of methylation sequencing technologies, a diverse range of biological functions associated with RNA methylation in eukaryotes has been revealed. Specifically, 5-methylcytosine (m5C) modifications have been extensively observed in various RNA molecules, including messenger RNAs (mRNAs), ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), and non-coding RNAs. These m5C modifications have been shown to impact critical RNA processes, such as mRNA translation, rRNA assembly, and tRNA stability. Notably, emerging evidence suggests that m5C modifications play significant roles in the initiation and progression of human cancers. However, a comprehensive understanding of the intricate m5C networks involved in human cancers is yet to be fully realized. In this comprehensive review, we provide an up-to-date summary of the roles and potential mechanisms underlying m5C modification in human cancers.

Edible packaging as sustainable alternative to synthetic plastic: a comprehensive review.

The choice of an appropriate packaging materials enhances the shelf life and improves quality of food during transportation, storage, and distribution. Development and innovations in food packaging systems have become essential in the food industry. Most widely used packaging materials are non-biodegradable plastics and are harmful to environment and human health. Thus, food industry is replacing non-biodegradable plastics with biodegradable plastics to reduce environmental pollution, health hazards, and food waste. Edible packaging may reduce food waste and keep perishables fresh. This review article compares edible packaging materials to synthetic ones and discusses their pollution-reducing effects. The several types of food packaging discussed in the review include those produced from polysaccharides, proteins, lipids, and composite films. The various characteristics of edible packaging are reviewed, including its barrier qualities, carrier properties, mechanical capabilities, and edibility. The carrier properties describe the capacity to transport and manage the release of active substances, and the edibility indicates acceptance of these items by the customers. Plasticizers, antimicrobials, antioxidants, and emulsifiers were included in the edible packaging to enhance the characteristics of the film. The development and implementation of edible packaging on food products from the laboratory to large-scale industrial levels, as well as their potential industrial applications in the dairy, meat, confectionary, poultry, fish, fruit, and vegetable processing sectors are addressed.

Dealcoholized Wine: A Scoping Review of Volatile and Non-Volatile Profiles, Consumer Perception, and Health Benefits

AbstractThe dealcoholization technique has gained more attention in the wine industry as it can significantly influence wine compositions and quality beyond alcohol level reduction. However, the changes occurring in the various processes of dealcoholization are not fully understood yet. This work summarizes the literature published in the last 10 years (2013–2023) about changes in color, sulfur dioxide (SO2), phenolic composition, losses of desirable volatile aroma compounds, and sensory characteristics of wine after the removal of ethanol by different processes/techniques. Several factors can influence the final characteristics of wine during the process, including physico-chemical parameters such as the initial alcohol level, the retention properties of the wine non-volatile matrix, and the characteristics of aroma components. Additionally, the quality of dealcoholized wine can be affected by the choice of dealcoholization techniques, distillation temperature, operating pressure, and membrane properties, including filtration and pore size. Low- and zero-alcohol products have the potential to expand the market and cater to diverse consumer segments. This comprehensive review would help winemakers in choosing the best techniques to produce dealcoholized wine, limiting the adverse effects, and meeting the needs of consumers.

A Comprehensive Review on Peptic Ulcer

Abstract: Up to 10% people in the world are affected by a chronic condition known as peptic ulcer. Peptic ulcer development is influenced by the pH of gastric juice and a decline in mucosal defenses. Protonpump inhibitors, histamine (H2) receptor antagonists, prostaglandin analogues and sucralfate have all been used to treat peptic ulcer disease. There has been a continuing search for an appropriate, palliative, and curative agent for the treatment of peptic ulcer disease using natural materials of plant and animal origin due to the complexity, cost, and toxicity of these medications. The goal of this review was to examine medicinal plants, phytochemicals, pathways, and research models that have been applied to the treatment of PUD in order to assess the potential contribution of natural substances to the development of herbal treatments for PUD. A literature search was used to find information utilising electronic databases such as Web of Science, Google Scholar, PubMed, Sci Finder, Reaxys, and Cochrane.

Advanced Data Science Applications in Vehicles: A Comprehensive Review

Purpose: This research paper aims to explore the transformative impact of data science applications within the automotive industry, with a focus on the evolution of vehicles into intelligent, connected, and autonomous entities. Through an extensive literature review and analysis of recent developments, the paper seeks to provide a comprehensive understanding of the current state and future prospects of data science in vehicles.
 Methodology: Advancements in sensor technologies, such as LiDAR, HD maps, radars, location tracking and cameras, are discussed, highlighting their role in data collection for applications like advanced driver assistance systems (ADAS) and autonomous driving. Relevant citations are provided. This subsection covers the collection and transmission of real-time data through telematics systems, showcasing their importance for predictive maintenance, fleet management, and personalized insurance programs. Citations support the presented information. The deployment of edge computing for real-time data processing in vehicles is discussed, emphasizing its significance for safety-critical applications like collision avoidance. Citations are provided to support the information. This section explores the application of machine learning algorithms to predict vehicle failures, optimize fuel efficiency, and analyze driver behavior. The importance of leveraging historical data to create accurate models is highlighted with supporting citations.
 Findings: The pivotal role of data science in enabling autonomous vehicles to navigate complex environments is discussed, emphasizing the use of machine learning models for real-time decision-making. Citations support the presented information. This subsection explores the integration of data science in traffic management systems, covering dynamic traffic signal control, congestion prediction, and route optimization. Citations support the findings related to traffic management applications. The paper discusses challenges associated with widespread implementation, including data privacy concerns, cybersecurity risks, and the need for standardized communication protocols. Additionally, potential future directions are outlined, such as the integration of blockchain for secure data sharing and the development of advanced human-machine interfaces.
 Unique Contribution to Theory, Practice and Policy: This research paper provides a well-rounded contribution by seamlessly integrating theoretical concepts, practical applications, and policy considerations in the realm of advanced data science applications in vehicles.

Applications of samarium complexes as cytotoxic, bioimaging and DNA interacting agents: a comprehensive review

Abstract Cisplatin coined a term Metallodrug and later a tradition of Metallodrugs was established. Later, severe renal and metabolic toxicities of the platinum based drugs prompted the medicinal chemists to develop new and novel metallotherapeutics with different metal cores. Henceforth, chemists designed the metal complexes based on copper, cobalt, vanadium iron and zinc. These complexes were reported for their antibacterial, anticancer, antidiabetic and enzyme inhibitors. Later, chemists also focused on lanthanide metal ions and resulted in the design of metal complexes for the application of bio imaging cellular studies as well as chemotherapeutic agents. This review throws a light on the recent advances in the development of the samarium complexes as efficient and versatile biological agents. Samarium complexes based on various ligand systems and ancillary ligands have been mentioned in this review stating their biological efficacy and potency against variable cancer cell lines, their DNA interactive behaviour.

Synergizing Geophysical Analysis and Geotechnical for Artificial Recharge Well and Aquifer Studies: A Comprehensive Review

The harvesting of surface runoff stands as a pivotal process in artificially recharging groundwater, playing a crucial role in augmenting groundwater within aquifers. Groundwater recharge via recharge wells is one of the successful direct sub-surface methods. To pinpoint the most suitable locations for recharge wells, a combination of geophysical surveys, including Electrical Resistivity, Magnetic, and Electrologging surveys, was used. These geophysical surveys serve as essential tools for comprehending the sub-surface lithology and played a pivotal role in identifying distinct aquifers and determining their respective dimensions, thereby aiding in the precision of recharge well placement. Our objective is to review the various methods to assess the underground water storage capacity of the aquifer based on tests viz. Sieve Analysis, Soil Water Retention Capacity, and Lateral Permeability tests. These combination of theoretical and practical evaluations aim to determine the aquifer's potential for storing groundwater. Geophysical surveys are invaluable for deriving various relationships through diverse analyses. Moreover, exploring the correlation between geophysical methods, such as electrical resistivity, and shear strength parameters is essential for comprehending the strength characteristics of subsurface layers.

Poultry breeding under public sector in India – Achievements and future perspectives: A comprehensive review

Poultry sector in India is reaching new heights due to advances made in breeding, nutrition, health and management. Notably, poultry breeding has played a crucial role in the unprecedented growth and development of the sector through the selection of highly specialized sire and dam lines and subsequently, crossing them to produce varieties suited for commercial and backyard production. Government interventions and public sector institutions have been relentlessly working to make poultry farming remunerative in rural backyards. In this context, climate change, disease outbreaks, stagnant gains, welfare and ethical issues are the major challenges which call for immediate attention. Some possible interventions to address these issues include: incorporation of climate resilience and welfare traits in the selection indices for selection of birds, embarking on genome-based selection to exploit the genomic variability in the population for substantial gains, gene silencing and CRISPR/Cas9 mediated genome editing approaches for improving productivity and boosting immune responses. Collection and analysis of real-time data using artificial intelligence and data analytics will also help in improving predictions for health and welfare traits in poultry. This review provides a detailed account of the achievements of public sector with regard to poultry breeding in the country and presents future perspectives for continued viability and sustainability of the sector.

Challenges, Limitations and Pitfalls of PET and Advanced MRI in Patients with Brain Tumors - A Report of the PET/RANO Group.

Brain tumor diagnostics have significantly evolved with the use of PET and advanced MRI techniques. In addition to anatomical MRI, these modalities may provide valuable information for several clinical applications such as differential diagnosis, delineation of tumor extent, prognostication, differentiation between tumor relapse and treatment-related changes, and the evaluation of response to anticancer therapy. In particular, joint recommendations of the RANO group, the EANO, and major European and American Nuclear Medicine societies highlighted that the additional clinical value of radiolabeled amino acids compared to anatomical MRI alone is outstanding and that its widespread clinical use should be supported. For advanced MRI and its steadily increasing use in clinical practice, the Standardization Subcommittee of the Jumpstarting Brain Tumor Drug Development Coalition provided more recently an updated acquisition protocol for the widely used dynamic susceptibility contrast perfusion MRI. Besides amino acid PET and perfusion MRI, other PET tracers and advanced MRI techniques (e.g., MR spectroscopy) are of considerable clinical interest and are increasingly integrated into everyday clinical practice. Nevertheless, these modalities have shortcomings which should be considered in clinical routine. This comprehensive review provides an overview of potential challenges, limitations and pitfalls associated with PET imaging and advanced MRI techniques in patients with gliomas or brain metastases. Despite these issues, PET imaging and advanced MRI techniques continue to play an indispensable role in brain tumor management. Acknowledging and mitigating these challenges through interdisciplinary collaboration, standardized protocols, and continuous innovation will further enhance the utility of these modalities in guiding optimal patient care.

Quality Indicators of Endoscopic Retrograde Cholangiopancreatography in Korea.

Endoscopic retrograde cholangiopancreatography (ERCP) is a procedure that requires significant experiences and skills and has various procedure-related complications, some of which can be severe and even result in the death of patients. Expanding ERCP availability has the advantage of increasing accessibility for patients. However, ERCP poses a substantial risk if performed without proper quality management. ERCP quality management is essential for both ensuring safe and successful procedures and meeting the social demands for enhanced healthcare competitiveness and quality assurance. To address these concerns, the Korean Pancreatobiliary Association established a task force to develop ERCP quality indicators (QIs) tailored to the Korean medical environment. Key questions for five pre-procedure, three intra-procedure, and four post-procedure measures were formulated based on a literature search related to ERCP QIs and a comprehensive clinical review conducted by experts. The statements and recommendations regarding each QI item were selected through peer review. The developed ERCP QIs were reviewed by external experts based on the latest available evidence at the time of development. These domestically tailored ERCP QIs are expected to contribute considerably to improving ERCP quality in Korea.

Pediatric Rectosigmoid Atypical Juvenile Polyps Presenting With Rectal Prolapse and Acute Bleeding: A Case Report and a Comprehensive Literature Review.

Rectosigmoid solitary juvenile polyps are benign lesions, relatively frequent in childhood. The clinical debut of a pediatric polyp with bleeding is relatively frequent, but there are very few reports of rectal prolapse of polyps. We present the case of a 7-year-old female patient with no previous history who presented with rectal prolapse of a polyp with acute bleeding. An urgent endoscopic examination was performed and 2 rectosigmoid polypoid lesions were found and resected. The anatomopathological study showed that these were 2 hamartomatous polyps with mild dysplasia. The patient is asymptomatic and is being followed up. The literature concerning rectal prolapse of polyps in the pediatric population is scarce. In a pediatric patient with a rectal prolapse, this entity should be considered in the differential diagnosis.

The past, present, and future of crowdsourcing and innovation: A bibliometric analysis and future research agenda

This research article addresses the current status and emerging trends in the literature at the intersection of crowdsourcing and innovation. While separate reviews exist for crowdsourcing and innovation individually, a comprehensive literature review specific to their intersection is lacking. Therefore, this study conducts a bibliometric meta-analysis of the extensive body of literature in the field of innovation and crowdsourcing, aiming to fill this research gap. The analysis encompasses all articles in Elsevier's Scopus database that incorporate relevant terms in their titles, abstracts, or keywords, resulting in a sample of 180 articles. VosViewer and Bibliometrix package in R are employed for the analysis. The analysis reveals three key research clusters, including the role of crowdsourcing in fostering organizational innovation, crowdsourcing-based social capital formation and its impact on organizational value creation, and the role of crowdsourcing platforms in facilitating engagement between the crowd and the organization. Adopting a holistic perspective, this research contributes new insights into the interconnections between crowdsourcing and innovation research fields. Additionally, the analysis provides clarity on research content, evolutionary context, and reveals emerging research trends in this domain.

Dijitalleşme sürecinde tüketicilerin bankacılık hizmet tercihini şekillendiren unsurlara yönelik bir inceleme

With a focus on banking services specifically, this study attempts to investigate the variables influencing consumers' choices for services during the digitalization process. A review of the literature was done for this purpose, and the data gathered was arranged and given as a summary of the literature. Within the scope of the research, firstly, the factors shaping consumers' digital banking service preference were discussed in a general framework, subsequently the subject was detailed around the determined headings. In this context, the subject is discussed in terms of search, experience and credence properties of service products, perceived risk, privacy, and security concern (and privacy paradox) and consumer characteristics, suggestions for future research are presented in the conclusion section. With the goal of addressing the consumer's service choice in the digitalization process with a holistic approach and current concepts, particularly for financial services, it is assessed that the study will provide a distinctive contribution. The study is the product of a comprehensive literature review; therefore care was taken to ensure that the elements identified were comprehensive, both in terms of digital services in general and in banking services in particular. However, it is possible to talk about different factors that are likely to shape consumer behavior in the digitalization process and are beyond the scope of this study. In addition, the rapid change and transformation environment caused by digitalization brings with it the need to constantly address the issue with new research.

Comprehensive literature review on children automatic speech recognition system, acoustic linguistic mismatch approaches and challenges

Comprehensive literature review on children automatic speech recognition system, acoustic linguistic mismatch approaches and challenges