Comprehensive Review Research Articles

Exploring the Efficacy of Traditional Herbs in Combating COVID-19: A Comprehensive Review

Background: The entire world witnessed the COVID-19 pandemic outbreak. It has become deadly everywhere across the globe. COVID-19 mortality varies across age groups and has been linked to an individual's innate immunity. In contrast, it was more lethal in immunocompromised people. The spread of viruses is slowed by both passive immunity and vaccine-aided acquired immunity. However, vaccine-induced immunity is transient, and there is no assurance that vaccinemediated antibodies will be effective against all future virus mutants. As a result, natural immunity boosters have become essential supplements that must be used nowadays to stay immunized against such infections. In Ayurvedic medicine, traditional Indian spices have been used for a long time to boost the immune system and fight off different diseases. Objective: This review aims to disseminate information about traditional natural medicine in repurposing as an immunity booster and for antiviral effects in COVID-19. Methods: Using published articles from recent years, the in silico docking study, survey-based study, and in vitro and preclinical research work on selected traditional herbs for their anti-inflammatory, immunomodulating, and antiviral properties are summarized. Withania somnifera, Piper nigrum, Emblica officinalis, Andrographis paniculate, Glycyrrhiza glabra, Ocimum sanctum, Piper longum, and Curcuma longa are some of the most commonly used natural spices studied extensively and hence selected in this review. Results: This context summarizes selected plants showing immunomodulatory and antiviral effects in experimental animals, simulation, and clinical studies. Conclusion: By virtue of antiviral potential, the chosen herbs could be used for repurposing in COVID-19 management after thorough clinical investigations.

Flavonoid-metal ion Complexes as Potent Anticancer metallodrugs: A comprehensive Review.

Flavonoids and their analogous are mainly found in pink lady apples, green and black tea (catechins), celery and red peppers, onions, broccoli and spinach, berries, cherries, soybean, citrus fruits, and fungi. The different derivatives of flavonoids belonging to polyphenolic compounds such as 3,4',5,7-Tetrahydroxyflavylium (pelargonidin), 2-(3,4-Dihydroxyphenyl)chromenylium-3,5,7-triol (cyanidin), 3,3',4',5,5',7-Hexahydroxyflavylium (delphinidin), 3,3',4',5,7-Pentahydroxy-5'-methoxyflavylium (petunidin), and 3,4',5,7-Tetrahydroxy-3',5'-dimethoxyflavylium (malvidin) can act as good chelating agents for metal-chelate complex formation. These flavonoid-metal complexes have been reported to have various biomedical and pharmacological activities. Flavonoid-metal ion complexes display a broad spectrum of biological properties such as antioxidant, anti-inflammatory, anti-allergic, antiviral, anticarcinogenic, and cytotoxic activity. The literature survey showed that flavonoid metal complexes have potential therapeutic properties against various cancerous cells. The objective is to gain insight into the current perspective and development of novel anticancer metallodrug drugs. The flavonoid-metal ion complexes can be prepared by reacting flavonoid ligand with appropriate metal salt in aqueous or alcoholic reaction medium under stirring or refluxing conditions. In this review article, the various reported methods for the synthesis of flavonoid-metal complexes have been included. The utility of synthetic methods for flavonoid-metal complexes will support the discovery of novel therapeutic drugs. In this review study, short libraries of flavonoid-metal ion complexes were studied as potential anticancer agents against various human cancer cell lines. The review report reveals that metal ions such as Fe, Co, Ni, Cu, Zn, Rh, Ru, Ga, Ba, Sn etc., when binding to flavonoid ligands, enhance the anticancer activity compared to free ligands. This review study covered some important literature surveys for the last two decades. It has been concluded that flavonoid metal complexes have been associated with a wide range of biological properties that could be noteworthy in the medicinal field. Therefore, to develop a new anticancer drug, it is essential to determine the primordial interaction drug with DNA under physiological or anatomical conditions. The study of numerous flavonoid metal complexes mentioned in this paper could be the future treatment against various cancerous diseases.

A Comprehensive Review on the State of the Art of Breast Cancers in Italy.

Breast cancer (BC) currently represents one of the most prevalent cancers among women worldwide and the leading cause of cancer death among women, also negatively affecting the quality of life (QoL) in patients. Over the past two decades, BC research has led to extraordinary advances in our understanding of the disease, resulting in more effective treatments. However, its occurrence is still increasing. Several new treatments are now under development worldwide, but they are not devoid of well-- known side effects, and a great number of patients develop endocrine resistance. Nevertheless, the design and synthesis of more suitable strategies and new drugs to treat breast cancers, overcome resistance and side effects, and obtain better therapeutic outcomes are needed. In this review, we summarize the therapies and the clinical studies currently ongoing in Italy for the treatment of BCs, mainly HER2+ MBC, HER2-low MBC, and TNBC, focusing on the most recent ones, also in consideration of diverse facets, including some aspects related to QoL. Finally, some studies related to the usefulness of physical activity in BC will be cited.

A Comprehensive Review on Niosomes as a Tool for Advanced Drug Delivery.

Over the past few decades, advancements in nanocarrier-based therapeutic delivery have been significant, and niosomes research has recently received much interest. The self-assembled nonionic surfactant vesicles lead to the production of niosomes. The most recent nanocarriers, niosomes, are self-assembled vesicles made of nonionic surfactants with or without the proper quantities of cholesterol or other amphiphilic molecules. Because of their durability, low cost of components, large-scale production, simple maintenance, and high entrapment efficiency, niosomes are being used more frequently. Additionally, they enhance pharmacokinetics, reduce toxicity, enhance the solubility of poorly water-soluble compounds, & increase bioavailability. One of the most crucial features of niosomes is their controlled release and targeted diffusion, which is utilized for treating cancer, infectious diseases, and other problems. In this review article, we have covered all the fundamental information about niosomes, including preparation techniques, niosomes types, factors influencing their formation, niosomes evaluation, applications, and administration routes, along with recent developments.

Unleashing the Potential of Sixth Generation (6 G) Wireless Networks in Smart Energy Grid Management: A Comprehensive Review

As the world continues to seek sustainable and efficient energy solutions, the integration of advanced technologies into smart energy grid management (SEGM) becomes a paramount focus. The advent of Sixth Generation (6G) wireless networks promises to revolutionize the way energy grids are monitored, controlled, and optimized. This review paper explores the potential of 6G wireless networks in the context of SEGM. It discusses the vision and potential techniques that can be harnessed to unlock the full capabilities of 6G networks. The paper delves into the challenges and opportunities presented by 6G technology, addressing issues such as scalability, security, real-time monitoring, and dynamic spectrum access. Moreover, it explores how 6G wireless networks can enable seamless integration with other advanced technologies, such as blockchain and cybertwin, to enhance the resilience and reliability of smart energy grids. The comprehensive review aims to shed light on the transformative role of 6G wireless networks, paving the way for a sustainable and intelligent future in energy grid management.

Unearthing the Potential Secondary Metabolites Isolated from the Fungus Aspergillus flocculosus : A Comprehensive Review.

Unearthing the Potential Secondary Metabolites Isolated from the Fungus Aspergillus flocculosus : A Comprehensive Review.

Food waste warriors: Indonesian communities engage through workshops and social media education

Food waste is food appropriate for human consumption but discarded in the retail or consumption process. In 2022, food waste accounts for 40.9% of Indonesia’s waste composition. Therefore, food waste community education is critical for reducing food waste. Community education can reach the young generation through workshops and social media. This research aims to evaluate various workshops and social media content in educating teenagers about food waste through community. The PRISMA guidelines become the foundation as a contribution to Sustainable Development Goals. We utilized databases such as EBSCO Host, SAGE, Taylor & Francis, and Wiley Online Library to search for relevant studies. This study’s approach is normative research including secondary data, comprehensive literature review such as workshops, social media, and food waste education journals in Indonesia. This systematic review examines food waste education content of workshops and social media in Indonesia also further content recommendations. This systematic review collected 52 papers, including journals and proceedings. The community education content in Indonesia focuses on recycling with 28.57%. Seminars/online campaigns dominate the education form with sustainable development goals (SDGs) achieved: climate action and zero hunger. This systematic review showed that it is essential to add actions toward food waste in the form of actual activities.

An Exploration of Organoid Technology: Present Advancements, Applications, and Obstacles.

Organoids are in vitro models that exhibit a three-dimensional structure and effectively replicate the structural and physiological features of human organs. This work examines the potential applications of organoid technology, as well as the challenges and future directions associated with its implementation. The manuscript was put together by conducting a comprehensive literature review, which involved an in-depth evaluation of globally renowned scientific research databases. The field of organoids has generated significant attention due to its potential applications in tissue development and disease modelling, as well as its implications for personalised medicine, drug screening, and cell-based therapies. The utilisation of organoids has proven to be effective in the examination of various conditions, encompassing genetic disorders, cancer, neurodevelopmental disorders and infectious diseases. The exploration of the wider uses of organoids is still in its early phases. Research shall be conducted to integrate 3D organoid systems as alternatives for current models, potentially improving both fundamental and clinical studies in the future.

A Comprehensive Review of Preclinical Models for Polycystic Ovary Syndrome

Background: Polycystic ovary syndrome (PCOS) is a reproductive, metabolic, and endocrine disorder with unclear aetiology. PCOS, the most common cause of female reproductive and metabolic disorders, is known to affect more than one in ten women globally. PCOS and associated clinical manifestations are probably underdiagnosed despite their high occurrence. Objective: Alternative animal models have been employed to investigate the causes of PCOS or assess potential treatments. In light of this piece of information, it is challenging to create an animal model that accurately captures all components of this condition; nonetheless, the resemblance of an animal model's biology and/or biochemical characteristics to the phenotypes of PCOS in humans may boost its applicability. Result: The key characteristics of these models are closer to human situations when compared to women with PCOS, as shown by this comparison. The creation and testing of drugs for the treatment of PCOS are necessary. Conclusion:: The overview of PCOS, current preclinical models, and appropriate models chosen in different studies to mimic various phenotypes in PCOS studies are all covered in this review paper. Additionally, we have outlined the benefits and drawbacks of PCOS animal models.

A Comprehensive Review of the Status and Challenges in the Genesis of COVID 19 Vaccination Strategies

Abstract: COVID-19 continues to wreak havoc on the global population. Infection with SARSCoV- 2 can be mild, severe, and even life-threatening. It is associated with cytokine storm, lung and even heart damage. With no specific treatment available for this contagious disease, induction of herd immunity through vaccination is being perceived as the only way out through this pandemic. Throughout the world, research groups and pharmaceutical companies are working independently or in collaboration to accelerate the process of COVID-19 vaccine development. Different countries have already started vaccination drives on a large scale to combat the disease. Today, we have a few approved vaccines, some are conventional, while others are subunit protein or nucleotide vaccines. This review describes the various vaccination strategies adopted the clinical and preclinical trials in developing some of the approved COVID-19 vaccines that are being administered around the world. The review also focuses on the challenges and adverse effects reported post-vaccination. Some of the proposed therapies for COVID-19 have also been elucidated. The effectiveness and safety of vaccines towards SARS-CoV-2 new variants suggest that more research in the field needs to be continued in the future.

A Comprehensive Review of the Benzimidazole Scaffold as a Potential Nucleus for Anti-Ulcer Activity

Abstract: The benzimidazole scaffold is a promising nucleus for developing novel therapeutic agents for ulcer treatment. Its unique chemical structure provides desirable pharmacological properties, such as excellent bioavailability, metabolic stability, and low toxicity, making it an attractive candidate for ulcer treatment. Several benzimidazole derivatives have shown significant anti-ulcer activity in preclinical and clinical studies, acting through multiple pathways, including inhibition of gastric acid secretion, suppression of gastric inflammation, and promotion of mucosal protection. Some benzimidazole derivatives have also demonstrated anti-Helicobacter pylori activity, suggesting their potential for eradicating bacteria associated with ulcer formation. However, challenges such as poor solubility and limited selectivity remain. Various approaches, such as prodrug design and formulation optimization, have been explored to overcome these issues and improve the therapeutic profile of benzimidazole derivatives. Overall, the benzimidazole scaffold holds great promise as a nucleus for developing novel anti-ulcer agents. Further research and optimization efforts are needed to harness its full potential and translate it into effective treatments for ulcers. With continued advancements in medicinal chemistry and drug design, benzimidazole-based compounds may offer new therapeutic options for patients suffering from ulcers and related gastrointestinal disorders. Hence, this review highlights the knowledge about benzimidazole scaffold, the mechanism of ulcer formation, and various benzimidazole derivatives with anti-ulcer activity, which can be further studied in pre-clinical and clinical trials.

Phytochemical and Pharmacological Attributes of Nerium oleander: A Review

Background: Nerium Oleander is an Indian folk medicine popularly known as oleander, contains numerous phytoconstituents and nutritional agents for the treatment of multiple ailments. Objective: The prime objective for the current comprehensive review is to focus on the elaboration of phytochemistry along with the Pharmacological significance of N. oleander. Methods: As per literature investigations it was noticed that plant contains various phytochemical constituents, including Oleandric acid, Kaneroside, Cardenolide, Nerizoside, Neritaloside, Odoroside- H,3-Ocaffeoylquinic acid along with structural isomer, 5-Ocaffeoylquinic acid, α-tocopherol, Oleandrin, Digitoxgenin along with nutritional ingredients viz essential fatty acids like omega- 3 fatty acids, and other polyphenols reported in N. oleander. Results: In recent investigations, it was observed that oleander possesses a wide range of medicinal attributes viz. anti-inflammatory, larvicidal, anti-cancer, Antidiabetic, Cellular/humoral immune response, Hepatoprotective, Wound healing, Anti-microbial, Antioxidant, Antinociceptive, Locomotor, Diuretic, and Anti leukemic activities. Conclusion: N. oleander could be an excellent candidate for discovering new medications because of its wide range of pharmacological action and the large diversity of active phytochemicals. However, to disclose the favorable therapeutic, safety, and pharmacological virtues of N. oleander and its phytoconstituents, more clinical and experimental investigations are needed.

Nutraceuticals: New Perspective and Approach to Prevent Dysmenorrhea

Background: The words "nutrition" and "pharmaceutical" are combined to form the phrase "nutraceutical." Nutraceuticals are foods or dietary components that have an important role in regulating and sustaining normal physiological function in humans. For the treatment of dysmenorrhoea, a variety of pharmacological medications are available, however, they all have significant side effects. Dietary supplements and lifestyle management, on the other hand, were found to have a major influence on the occurrence and control of dysmenorrhea. Objective: The objective of this paper is to study a comprehensive review of the dietary and nutritional supplements with special emphasis on dysmenorrhea. This paper focuses on understanding and interpreting the details of menstrual pain and its effective nutritional diet that can be used as a treatment for avoiding menstrual discomfort. Methods: The selection of data has been done by studying a combination of various research and review papers from different databases like PubMed, NCBI, Science Direct, WHO, Cochrane Library, and Web of Science from the year 2000-2022. Results: Based on various papers and literature reviews, we have concluded about various dietary supplements and herbs that can be used to avoid pain during mensuration followed by its all-daily requirement of nutrition on different age groups and efficacy of treatments. Conclusion: According to current evidence, young women should be instructed in the proper use of dietary supplements, nutrition, and vitamins, as well as the inclusion of effective diet and lifestyle changes such as exercise and a well-balanced diet with adequate nutrition, as these are likely to reduce the negative effects of dysmenorrhea.

The development of non-natural type nucleoside to stabilize triplex DNA formation against CG and TA inversion site.

Based on the sequence-specific recognition of target duplex DNA by triplex-forming oligonucleotides (TFOs) at the major groove side, the antigene strategy has been exploited as a gene-targeting tool with considerable attention. Triplex DNA is formed via the specific base triplets by the Hoogsteen or reverse Hoogsteen hydrogen bond interaction between TFOs and the homo-purine strand from the target duplex DNA, leading to the established sequence-specificity. However, the presence of inversion sites, which are known as non-natural nucleosides that can form satisfactory interactions with 2-deoxythymidine (dT) and 2-deoxycytidine (dC) in TA and CG base pairs in the target homo-purine DNA sequences, drastically restricts the formation of classically stable base triplets and even the triplex DNA. Therefore, the design of non-natural type nucleosides, which can effectively recognize CG or/and TA inversion sites with satisfactory selectivity, should be of great significance to expanding the triplex-forming sequence. Here, this review mainly provides a comprehensive review of the current development of novel non-natural nucleosides to recognize CG or/and TA inversion sites in triplex DNA formation against double-strand DNA (dsDNA).

Nonlinear Loads Modelling and Harmonics Analysis: A Review

Abstract: In modern life, the applications of nonlinear loads are increasing, especially electronic loads, such as computers, monitors, and battery chargers. Moreover, the usage of semiconductors has increased in modern lighting systems, such as LED lamps and dimmers which are used to control the lighting level. Nonlinear loads may also be in the form of variable speed drive or arc furnace loads. Due to the spread of nonlinear loads, large amounts of harmonics are generated. To study the harmonics of nonlinear loads, it is essential to represent nonlinear loads by their equivalent models in the simulation programs. This paper presents a comprehensive review of modeling methods of nonlinear loads, including time domain methods, frequency domain methods, and state space methods. Equivalent circuits are presented for different types of nonlinear loads, including static loads, dynamic loads and arc furnace loads. The paper also presents the harmonic analysis performed by the Fourier transform of different types of nonlinear loads, including harmonic percentage and its angle. This paper is considered as a comprehensive reference for researchers and engineers to model nonlinear loads and is useful in power system planning for connecting nonlinear loads where mixing nonlinear loads of similar harmonic profiles causes worse situations. Moreover, knowing the nonlinear load profile will help in the suitable mixing of linear loads to achieve lower harmonics levels.

A comprehensive review of the docking studies of chalcone for the development of selective MAO-B inhibitors.

Monoamine oxidase B is a crucial therapeutic target for neurodegenerative disorders like Alzheimer's and Parkinson's since they assist in disintegrating neurotransmitters such as dopamine in the brain. Pursuing efficacious monoamine oxidase B inhibitors is a hot topic, as contemporary therapeutic interventions have many shortcomings. Currently available FDA-approved monoamine oxidase inhibitors like safinamide, selegiline and rasagiline also have a variety of side effects like depression and insomnia. In the quest for a potent monoamine oxidase B inhibitor, sizeable, diverse chemical entities have been uncovered, including chalcones. Chalcone is a renowned structural framework that has been intensively explored for its monoamine oxidase B inhibitory activity.The structural resemblance of chalcone (1,3-diphenyl-2-propen-1-one) based compounds and 1,4-diphenyl-2-butene, a recognized MAO-B inhibitor, accounts for their MAO-B inhibitory activity. Therefore, multiple revisions to the chalcone scaffold have been attempted by the researchers to scrutinize the implications of substitutions onthe molecule's potency. In this work, we outline the docking investigation results of various chalcone analogues with monoamine oxidase B available in the literature until now to understand the interaction modes and influence of substituents. Here we focused on the interactions between reported chalcone derivatives and the active site of monoamine oxidase B and the influence of substitutions on those interactions. Detailed images illustrating the interactions and impact of the substituents or structural modifications on these interactions were used to support the docking results.

Restenosis in Patients with Percutaneous Coronary Intervention, Etiologies and Remedy: A Comprehensive Review of Current Literature

Restenosis in Patients with Percutaneous Coronary Intervention, Etiologies and Remedy: A Comprehensive Review of Current Literature

Advancements in machine learning for predicting phases in high-entropy alloys: a comprehensive review

High entropy alloys (HEAs) are distinguished by their enhanced physicochemical properties, attributed to the formation of various phases such as solid solution (SS), intermetallic (IM), or a combination (SS + IM). These phases contribute distinctively to the microstructure of the alloys. A critical aspect of alloy design revolves around accurately predicting these phases, which has led to the integration of sophisticated data vetting methods and Machine Learning (ML) algorithms in recent research. This review paper aims to provide a comprehensive analysis of the advancements in phase prediction accuracy within HEAs, an essential component in the development of these alloys. HEAs are known for their intricate compositions, offering a wide spectrum of material properties, making them particularly relevant for applications aimed at future sustainability. Phase engineering in HEAs unlocks the potential for creating materials tailored to eco-friendly technologies and energy-efficient solutions. The challenge in predicting phase selection in HEAs is accentuated by the limited data available on these complex materials. This review delves into how advanced data vetting techniques and ML algorithms are being employed to overcome these challenges, thus contributing significantly to sustainable material design. The paper examines various algorithms used in HEA phase prediction, including KNN (K-Nearest Neighbors), SVM (Support Vector Machines), ANN (Artificial Neural Networks), GNB (Gaussian Naive Bayes), and RF (Random Forest). It discusses the testing accuracy of these algorithms in classifying HEA phases, revealing variations in their effectiveness. The review highlights the superior accuracy of ANNs, followed closely by KNN and SVM, while noting the comparatively lower accuracy of GNB. This comprehensive review synthesizes current research efforts in utilizing computational methods to design HEAs, underlining their broader implications in expediting the discovery and development of diverse metal alloys. These efforts are pivotal in meeting the evolving demands of modern engineering applications, thereby contributing to the advancement of materials science.

Phage therapy in prosthetic joint infections caused by Staphylococcus aureus - A literature review.

Prosthetic joint infections (PJIs) are dreaded arthroplasty complications often caused by Staphylococcus aureus. Due to methicillin-resistant S. aureus (MRSA) strains or biofilm formation, successful treatment remains difficult. Currently, two-stage revision surgery constitutes the gold standard therapy of PJIs, sometimes replaced or supplemented by debridement, antibiotics, and implant retention (DAIR). Given the dire consequences of therapeutic failure, bacteriophage therapy might be another treatment option. Here we provide a comprehensive literature review addressing theefficacy of phages applied against S.aureus as causative agent of PJIs. The included 17 publications had in common that the applied phages proved to be effective against various S. aureus isolates including MRSA even in biofilms. Experiments with mice, rats, rabbits, and moth larvaeconfirmed favorable features of phage preparations in PJI treatment in vivo; including its synergistic with antibiotics. Case reports of PJI patients unanimously described the bacterial eradication following, alongside other measures, intravenous and intra-articular phage administration. Generally, no major side effects occurred, but in some cases elevated liver transaminases were observed. To conclude, our review compiled promising evidence suggesting the safety and suitability of phage therapy as an adjuvant to DAIR in S. aureus PJIs, and thus, underscores the significance of further research.

Left atrial strain analysis in the realm of pediatric cardiology: Advantages and implications.

Left atrial (LA) strain analysis has emerged as a noninvasive technique for assessing LA function and early detection of myocardial deformation. Recently, its application has also shown promise in the pediatric population, spanning diverse cardiac conditions that demand accurate and sensitive diagnostic measures. This research article endeavors to explore the role of LA strain parameters and contribute to the growing body of knowledge in pediatric cardiology, paving the way for more effective and tailored approaches to patient care. A comprehensive literature review was conducted to gather evidence from studies using echocardiographic strain imaging techniques across pediatric populations. LA strain parameters exhibited greater sensitivity than conventional atrial function indicators, with early detection of diastolic dysfunction and LA remodeling in pediatric cardiomyopathy, children with multisystem inflammatory syndrome, rheumatic heart disease, as well as childhood renal insufficiency and obesity offering prognostic relevance as potential markers in these pediatric subpopulations. However, there remains a paucity of evidence concerning pediatric mitral valve pathology, justifying further exploration. LA strain analysis carries crucial clinical and prognostic implications in pediatric cardiac conditions, with reliable accuracy and sensitivity to early functional changes.