Background: Muscle strength is an essential factor in maintaining one's health and quality of life. Resistance training programs have been known to be effective in improving muscle strength. However, their success can be affected by various factors, including exercise variety, volume, intensity, frequency, and duration. To optimize the effects of a resistance training program, a comprehensive planning approach is essential. Study Objective: This study aimed to conduct a systematic review of the literature to explore a comprehensive planning approach in optimizing resistance exercise programs to improve muscle strength. Materials and Methods: A systematic method was used to identify relevant studies from various scientific databases. Inclusion and exclusion criteria were established to select studies that fit the research objectives. Data from the selected studies were extracted and analyzed to evaluate the effectiveness and planning approaches used in resistance exercise programs. Results: The results of this systematic review indicate that a comprehensive planning approach, including individualization of the program, progressive and adaptive, integration of functional exercises, and periodic monitoring and evaluation, are critical factors in optimizing resistance exercise programs. Studies showed differences in the effectiveness of resistance training programs based on these factors. Conclusion: By integrating a comprehensive planning approach, resistance exercise programs can be optimized to achieve maximal muscle strength gains. Practical implications of these findings include relevance to specific populations and application in the context of rehabilitation. Future research should focus more on understanding the interactions between these factors and explore more specific planning approaches to improve the effectiveness of resistance training programs.