Abstract In this article, a novel multi-generation plant is addressed and assessed from the energy, exergy, exergoenvironmental and exergoeconomic points of view. The multi-generation plant is composed of two main units: one unit for energy production and another unit for carbon capture and methanol synthesis. Biomass fuel, solar energy and seawater are the main nutrients in the plant. Steam, Brayton, organic Rankine and Kalina cycles have been employed to generate electricity. A linear Fresnel collector-driven solar farm is considered as an auxiliary heat source. In addition, an integrated desalination unit based on a multi-effect desalination unit, a microbial fuel cell and a reverse osmosis unit has been installed in the multi-generation plant. The proposed structure for the offered multi-generation plant is designed under a new configuration and layout that had not been reported in the publications. From the outcomes, the multi-generation plant can produce 69.6 MW of net electricity, 0.53 kg/s of methanol, 0.81 kg/s of oxygen gas, 73.8 kg/s of fresh water and ~0.015 kg/s of hydrogen gas. Under such performance, the offered multi-generation plant can be 51.72 and 27.5% efficient from the points of view of energy and exergy, respectively. Further, the total cost rate and environmental impact of the plant are ~3378 US$/h and 294.1 mPts/s, respectively. A comparative analysis is developed to exhibit the superiority of the planned multi-generation plant. A five-objective optimization is also developed to achieve the optimum design data and outcomes of the plant.