Abstract This paper presents the concept and the framework of Intelligent Comprehensive Decision Support Systems (ICDSS). In the framework, Knowledge Management System and Knowledge Base become the kernel and base of the whole system. This kind of framework represents the Intelligent characteristics of the system and makes it easy to implement the intelligent and comprehensive management of the system. The paper points out that the development of ICDSS will make it possible to integrate several Computer-Based Information Systems, have higher intelligence and stronger comprehensive abilities, and play the role of decision-making support more effectively.