Compounds In Aqueous Solution Research Articles

Water activity and surface tension of aqueous ammonium sulfate and D-glucose aerosol nanoparticles

Abstract. Water activity (aw) and interfacial energy or surface tension (σ) are key thermodynamic parameters to describe the hygroscopic growth of atmospheric aerosol particles and their ability to serve as cloud condensation nuclei (CCN), thus influencing the hydrological cycle and climate. Due to size effects and complex mixing states, however, these parameters are not well constrained for nanoparticles composed of organic and inorganic compounds in aqueous solution. In this study, we determined aw and σ by differential Köhler analysis (DKA) of hygroscopic growth measurement data for aerosol particles smaller than 100 nm composed of aqueous ammonium sulfate (AS), D-glucose (Gl), and their mixtures. High-precision measurements of hygroscopic growth were performed at relative humidities (denoted RH) ranging from 2.0 % to 99.6 % with a high-humidity tandem differential mobility analyzer (HHTDMA) in three complementary modes of operation: hydration, dehydration, and restructuring. The restructuring mode (hydration followed by dehydration) enabled the transformation of initially irregular particles into compact globules and the determination of mass equivalent diameters. The HHTDMA-derived growth factors complemented by DKA allows for determination of water activity and surface tension from dilute to highly supersaturated aqueous solutions that are not accessible with other methods. Thus, for mixed AS / Gl nanoparticles with mass ratios of 4:1 and 1:1, the upper limit of solute mass fraction (Xs) was 0.92 and 0.98, respectively. For pure AS and Gl, the DKA-derived aw is in good agreement with electrodynamic balance and bulk measurement data. For AS particles, our aw data also agree well with the Extended Aerosol Inorganics Model (E-AIM III) over the entire concentration range. In contrast, the UNIFAC model as a part of AIOMFAC (Zuend et al., 2011) was found to overestimate aw in aqueous Gl particles, which can be attributed to unaccounted intermolecular interactions. For mixed AS and Gl nanoparticles, we observed a non-monotonic concentration dependence of the surface tension that does not follow the predictions by modeling approaches constructed for mixed inorganic/organic systems. Thus, AS / Gl particles with a 1:1 mass ratio exhibited a strong decrease of σ with increasing solute mass fraction, a minimum value of 56.5 mN m−1 at Xs≈0.5, and a reverse trend of increasing σ at higher concentrations. We suggest that D-glucose molecules surrounded by ammonium sulfate ions tend to associate, forming non-polar aggregates, which lowers the surface tension at the air–droplet interface. We analyzed the uncertainty in the DKA-derived water activity and surface tension, related to the instrumental errors as well as to the morphology of the nanoparticles and their phase state. Our studies have shown that under optimal modes of operation of HHTDMA for moderate aqueous concentrations, the uncertainty in aw and σ does not exceed 0.2 %–0.4 % and 3 %–4 %, respectively, but it increases by an order of magnitude in the case of highly concentrated nanodroplet solutions.

Extraction of Bioactive Compounds from Cistus creticus Leaves and Their Use in the Preparation of Yogurt Desserts

The objective of this study was to determine the optimal conditions for the recovery of bioactive and antioxidant compounds in aqueous solutions of Cistus creticus leaves and then employ the optimal extract for the enrichment of yogurt samples. The optimal conditions were established by a response surface methodology and were determined to be a liquid-to-solid ratio of 48 mL/g at 76 °C for 41 min. The optimum extract yielded TPC 157.17 mg GAE/g dw and TFC 2.38 mg QE/g dw, while FRAP and DPPH values were 1258.52 and 933.67 μmol AAE/g dw, respectively. HPLC-DAD was utilized to identify and quantify specific polyphenols, like myricetin rhamnoside, in the extract. The optimal extract was then added to yogurt desserts during their preparation at three different concentrations to study how the physicochemical characteristics of the yogurt, as well as the antioxidant capacity added during enrichment, were affected. Statistical analysis of the results was carried out in order to obtain more valid data. It seems that the most suitable concentration for yogurt fortification was 0.1% w/v of the extract as, at this concentration, the yogurts exhibited higher antioxidant capacity, and their physicochemical characteristics were improved.

Aqueous Electrocatalytic Reduction as a Low‐Carbon and Green Route for Chemical Synthesis and Environmental Remediation

AbstractThe green electricity‐driven electrocatalytic reduction of organic compounds in aqueous solution has merged as a sustainable and green platform for organic electrosynthesis, upcycling of chemical waste, and environmental remediation. Compared with the thermocatalytic hydrogenation process, the electrocatalytic reduction of organic compounds uses water as a proton source, which enables its operation at ambient conditions with simplified reaction schemes and significantly reduces operation cost and energy consumption. Most studies have demonstrated the development of electrocatalysts to boost the current efficiency, conversion, and product selectivity of the electrocatalytic reduction processes. Still, little attention has been paid to the mechanism (e. g., electron/proton transfer route) and related energetics behind the electrocatalytic reduction process. This Concept overviews the recent development of the electrocatalytic reduction systems for environmental remediation, pollutant upcycling, and valorization of biomass‐derived chemicals. This Concept highlights the underlying mechanisms and aims to provide instructive guidance on designing efficient and selective electrocatalytic systems.

Discovery of water-soluble semicarbazide-containing sulfonamide derivatives possessing favorable anti-glaucoma effect in vivo and drug-like properties

In order to obtain topical and non-irritating anti-glaucoma drugs, novel semicarbazide-containing sulfonamide derivatives were designed and synthetized by sugar tail method in this study. The hydrophilic monosaccharides were expected to form interaction with the hydrophilic site of hCA II meanwhile the linker semicarbazides are used to further enhance water solubility, and more importantly, regulate the pH values of the target compounds in aqueous solution. First, all target compounds were synthesized and evaluated for their CA inhibitory activities. The results showed our target compounds demonstrated comparable activity to the positive control drug acetazolamide. The best derivative 11d exhibits an IC50 value of 14 nM for hCA II and 2086-fold selectivity over CA I. Subsequently, physicochemical properties study showed that the target compounds displayed very good water solubility (up to 3 %) and neutral pH value in solutions. Meanwhile, the artificial membrane permeability assay was performed to verify that the target compound could also pass through the membrane structure despite their strong water solubility. In the glaucomatous rabbit eye model, the applied topically representative compounds showed strongly lowered intraocular pressure (IOP), as 1 % or 2 % water solutions. Subsequent drug-like evaluation showed our target compounds possessed low hemolysis effect and low cytotoxicity toward human corneal epithelial cell line. Also, it was not found that these target compounds had significant inhibition of hERG and CYP. In addition, these novel analogs also displayed good liver microsomal metabolic stability and plasma stability. Finally, docking studies provided the rational binding modes of representative compounds in complex with hCA II. Taken together, these results suggested that compound 11d may be a promising hCA II inhibitor deserving further development.

Adsorptive Removal of Synthetic Organic Compounds in Aqueous Solutions by Fresh Nipa Palm Fronds

Adsorptive Removal of Synthetic Organic Compounds in Aqueous Solutions by Fresh Nipa Palm Fronds

Does acute exposure to thimerosal, an organic mercury compound, affect the mitochondrial function of an infant model?

BackgroundThimerosal (TM) is a toxic, organometallic mercury compound (which releases ethyl-mercury-containing compounds in aqueous solutions) used as a preservative in vaccines. Mitochondria are organelle which are highly vulnerable to many chemical compounds, including mercury (Hg) and its derivatives. MethodWistar rats (at 21 days of age) were used to model a child’s TM exposure following childhood vaccination, divided in two groups: TM exposed (20 μg/kg/day) and unexposed controls (saline solution), both for 24 h. Atomic Fluorescence Spectrometry was used to quantify the amounts of mercury in tissues. The electron transport chain (ETC) from isolated mitochondria was evaluated using an oxygen electrode. The mitochondrial membrane potential and H2O2 production were analyzed using selective fluorescence probes. The activity of some enzymes (SOD, CAT, GPx, and AChE) and secondary markers of oxidative stress (GSH, GSSG, total free thiol) were also examined in tissues. ResultsHg accumulation in the brain and liver was higher in exposed animals when compared to the control. Liver-isolated mitochondria showed that TM improved respiratory control by 23%; however, states 3 and 4 of the ETC presented a decrease of 16% and 37%, respectively. Furthermore, brain-isolated mitochondria presented an improvement of 61% in respiratory control. Brain enzyme activities were significantly impacted in TM-exposed rats compared to unexposed rats as follows: decreases in SOD (32%) and AChE (42%) and increases in GPx (79%) and CAT (100%). GPx enzyme activity in the liver was significantly increased (37%). Among secondary oxidative stress markers, the brain’s total reduced thiol (SH) concentration was significantly increased (41%). ConclusionAcute TM treatment exposure in a Wistar rat model mimicking TM exposure in an infant following childhood vaccination significantly damaged brain bioenergetic pathways. This study supports the ability of TM exposure to preferentially damage the nervous system.

Unleashing the Power of Green Chemistry in Phytoconstituent Extraction by Hydrotropic Solubilization

The extraction of natural products is a critical area of focus in the interdisciplinary domain of applied chemistry, biology, and technology, with an emphasis on the development of eco-friendly and sustainable methodologies driven by increasing consumer demand for environmentally friendly alternatives and industry concerns about sustainable, non-toxic extraction techniques. The yield and composition of natural extracts are contingent upon the extraction method employed and the solvent selected. Emerging technologies are designed to reduce extraction time, increase extraction yield, eliminate the use of solvents, and lessen environmental impact. The pharmaceutical industry has conducted extensive research into the application of innovative extraction technologies, including green technologies. In line with the development of “green technology,” the use of green solvents for the extraction of phytochemicals, as opposed to conventional non-eco-friendly solvents, is of paramount importance. Hydrotropes are one such class of green solvents that enhance the solubility of poorly water-soluble or hydrophobic compounds in aqueous solutions by reducing toxicity, cost-effectiveness, and pH independence. These compounds have the potential to enhance the bioavailability, solubility, dissolution rate, extraction yield, and purity of extracted phytoconstituents. Their use minimizes energy consumption and costs, making them an efficient and sustainable choice in the extraction process. This review highlights the extensive use of hydrotropes in the innovative extraction of phytoactive compounds. It provides a comprehensive overview of hydrotrope chemistry, addresses toxicological concerns, and discusses state-of-the-art extraction technologies. The review also examines factors affecting the yield of phytoconstituents and explores available drug delivery systems. The potential of hydrotropes in this context is promising, paving the way for more efficient and environmentally friendly extraction methodologies.

Decoration of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) with N-oxides increases the T1 relaxivity of Gd-complexes.

High complex stability and longitudinal relaxivity of Gd-based contrast agents are important requirements for magnetic resonance imaging (MRI) because they ensure patient safety and contribute to measurement sensitivity. Charged and zwitterionic Gd3+ -complexes of the well-known chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) provide an excellent basis for the development of safe and sensitive contrast agents. In this report, we describe the synthesis of DOTA-NOx, a DOTA derivative with four N-oxide functionalities via "click" functionalization of the tetraazide DOTAZA. The resulting complexes Gd-DOTA-NOx and Eu-DOTA-NOx are stable compounds in aqueous solution. NMR-spectroscopic characterization revealed a high excess of the twisted square antiprismatic (TSAP) coordination geometry over square antiprismatic (SAP). The longitudinal relaxivity of Gd-DOTA-NOx was found to be r1 =7.7 mm-1 s-1 (1.41 T, 37 °C), an unusually high value for DOTA complexes of comparable weight. We attribute this high relaxivity to the steric influence and an ordering effect on outer sphere water molecules surrounding the complex generated by the strongly hydrated N-oxide groups. Moreover, Gd-DOTA-NOx was found to be stable against transchelation with high excess of EDTA (200 eq) over a period of 36 h, and it has a similar in vitro cell toxicity as clinically used DOTA-based GBCAs.

Thermal stability and vapor-liquid equilibrium of aqueous solutions of choline and tetramethylammonium taurate

The thermal degradation of tetramethylammonium taurate and choline taurate and aqueous solutions of these compounds were examined. The thermal degradation products for each of the solid compounds are identified and the data show that the compounds lose less than 1 % of their mass when heating is below 85 °C for 10 h. However, it is difficult to distinguish between the degradation of the compounds and the loss of strongly retained water. The degradation products of the compounds in aqueous solution are also identified and a degradation pathway is proposed. Additionally, the vapor–liquid equilibrium of the compounds in aqueous solutions was measured and the data was fit to the non-random two-liquid (NRTL) model. The data indicate significant deviations from ideality as described by the activity coefficients of the solutions. The results provide insight into the selection of absorber stripping temperatures, the modeling of absorber columns that utilize aqueous ionic absorber fluids, and how these properties are impacted by different cations.

Polarity of Aqueous Solutions

This short review describes the expansion of the solvatochromic approach utilizing water-soluble solvatochromic dyes to the analysis of solvent features of aqueous media in solutions of various compounds. These solvent features (polarity/dipolarity, hydrogen bond donor ability (HBD acidity), and hydrogen bond acceptor ability (HBA basicity)) vary depending on the nature and concentration of a solute. Furthermore, the solvent features of water (the solvent dipolarity/polarizability and hydrogen bond donor ability) in solutions of various compounds describe multiple physicochemical properties of these solutions (such as the solubility of various compounds in aqueous solutions, salting-out and salting-in constants for polar organic compounds in the presence of different inorganic salts, as well as water activity, osmotic coefficients, surface tension, viscosity, and the relative permittivity of aqueous solutions of different individual compounds) and are likely related to changes in the arrangement of hydrogen bonds of water in these solutions.

Chemical stability of Pb[(UO2)2O2(OH)2](H2O) and Pb2[(UO2)5O6(OH)2](H2O)2 compounds in aqueous solutions

The chemical stability of Pb[(UO2)2O2(OH)2](H2O) and Pb2[(UO2)5O6(OH)2](H2O)2 compounds in aqueous solutions was studied. The acid-base boundaries of the existence of these compounds in aqueous solutions were established, the hydrolysis products were identified, and the solubility was determined. Based on the data obtained, the equilibrium constants of dissolution reactions, the Gibbs functions of the formation and dissolution of Pb[(UO2)2O2(OH)2](H2O) and Pb2[(UO2)5O6(OH)2](H2O)2, were calculated, the solubility curves of the compounds under study, and the phase diagrams of U(VI) and Pb(II) in saturated aqueous solutions and in equilibrium solid phases were calculated.

Virtual Model Compound Approach for Calculating Redox Potentials of [Fe2S2]-Cys4 Centers in Proteins - Structure Quality Matters.

The midpoint potential of the [Fe2S2]-Cys4-cluster in proteins is known to vary between -200 and -450 mV. This variation is caused by the different electrostatic environment of the cluster in the respective proteins. Continuum electrostatics can quantify the impact of the protein environment on the redox potential. Thus, if the redox potential of a [Fe2S2]-Cys4-cluster model compound in aqueous solution would be known, then redox potentials in various protein complexes could be calculated. However, [Fe2S2]-Cys4-cluster models are not water-soluble, and thus, their redox potential can not be measured in aqueous solution. To overcome this problem, we introduce a method that we call Virtual Model Compound Approach (VMCA) to extrapolate the model redox potential from known redox potentials of proteins. We carefully selected high-resolution structures for our analysis and divide them into a fit set, for fitting the model redox potential, and an independent test set, to check the validity of the model redox potential. However, from our analysis, we realized that the some structures can not be used as downloaded from the PDB but had to be re-refined in order to calculate reliable redox potentials. Because of the re-refinement, we were able to significantly reduce the standard deviation of our derived model redox potential for the [Fe2S2]-Cys4-cluster from 31 mV to 10 mV. As the model redox potential, we obtained -184 mV. This model redox potential can be used to analyze the redox behavior of [Fe2S2]-Cys4-clusters in larger protein complexes.

Drug repurposing for the treatment of COVID-19: Targeting nafamostat to the lungs by a liposomal delivery system

Despite tremendous global efforts since the beginning of the COVID-19 pandemic, still only a limited number of prophylactic and therapeutic options are available. Although vaccination is the most effective measure in preventing morbidity and mortality, there is a need for safe and effective post-infection treatment medication.In this study, we explored a pipeline of 21 potential candidates, examined in the Calu-3 cell line for their antiviral efficacy, for drug repurposing. Ralimetinib and nafamostat, clinically used drugs, have emerged as attractive candidates. Due to the inherent limitations of the selected drugs, we formulated targeted liposomes suitable for both systemic and intranasal administration. Non-targeted and targeted nafamostat liposomes (LipNaf) decorated with an Apolipoprotein B peptide (ApoB-P) as a specific lung-targeting ligand were successfully developed. The developed liposomal formulations of nafamostat were found to possess favorable physicochemical properties including nano size (119–147 nm), long-term stability of the normally rapidly degrading compound in aqueous solution, negligible leakage from the liposomes upon storage, and a neutral surface charge with low polydispersity index (PDI). Both nafamostat and ralimetinib liposomes showed good cellular uptake and lack of cytotoxicity, and non-targeted LipNaf demonstrated enhanced accumulation in the lungs following intranasal (IN) administration in non-infected mice. LipNaf retained its anti-SARS-CoV 2 activity in Calu 3 cells with only a modest decrease, exhibiting complete inhibition at concentrations >100 nM. IN, but not intraperitoneal (IP) treatment with targeted LipNaf resulted in a trend to reduced viral load in the lungs of K18-hACE2 mice compared to targeted empty Lip. Nevertheless, upon removal of outlier data, a statistically significant 1.9-fold reduction in viral load was achieved. This observation further highlights the importance of a targeted delivery into the respiratory tract. In summary, we were able to demonstrate a proof-of-concept of drug repurposing by liposomal formulations with anti-SARS-CoV-2 activity. The biodistribution and bioactivity studies with LipNaf suggest an IN or inhalation route of administration for optimal therapeutic efficacy.

Enhancement of integrated nano-sensor performance comprised of electrospun PANI/carbonaceous material fibers for phenolic detection in aqueous solutions

The detection of trace levels of organic residue in water samples is a key health issue. This manuscript describes the fabrication of integrated nano-sensors composed of electrospun microfibers consisting of a nanocomposite of carbonaceous materials (CNMs) containing polyaniline (PANI) and polycaprolactone (PCL) for phenolic detection in aqueous solutions. The morphology of the resulting microfiber composite was characterized by scanning electron microscopy. It revealed elongated fibers with a highly interconnected web-like pattern in the presence of reduced graphene oxide (rGO). Shorter microfibers were observed in the composite filled with multi-walled carbon nanotubes (MWCNTs), whereas large agglomerates were formed upon the incorporation of single-walled CNTs (SWCNTs) and graphene 300 (G300). Comparative analysis showed that the PANI/CNM sensors exhibited the best electrochemical properties, in particular in the presence of rGO and MWCNTs, where greater electrical conductivity was achieved, i.e., 4.33 × 10−3 and 7.22 × 10−4 S/cm, respectively, as compared to the PANI-PCL sensor (3.79 × 10−4 S/cm). All the PANI/CNM sensors exhibited high sensitivity. Notably, PANI/rGO was found to have a detection limit of 8.34 × 10−3 µM for aminophenol. All the sensors exhibited good selectivity in the presence of interference to detecting phenolic compounds in aqueous solutions, thus confirming their value for industrial applications.

Eluates from façades at the beginning of their service time affect aquatic and sediment organisms

Biocides are used in building materials to prevent microbial growth during storage (in-can preservatives) as well as after application (film preservatives). These compounds can leach out from the material into the environment and harm non-target organisms. In this study, the ecotoxicological effect of leachates at the beginning of a façade lifetime, on sediment and aquatic organisms was examined. For this purpose, leaching tests were carried out in the setting of a natural weathering experiment and a laboratory immersion with façade samples consisting of render/paint systems. The leaching experiments were performed with three different formulations, namely no biocides containing control, a formulation containing only in-can preservatives (benzisothiazolinone (BIT), methylchloroisothiazolinone (CMIT), and methylisothiazolinone (MIT)), and, as is common in organic building materials, containing both in-can and film preservatives (octylisothiazolinone (OIT) and terbutryn (TB)). In order to elucidate the effects of in-can and film preservative-containing eluates the toxicity of the generated leachables was evaluated on the model of several aquatic and sediment organisms, namely luminescent bacteria (Vibrio fischeri), green algae (Scenedesmus subspicatus), Salmonella typhimurium TA1535/pSK1002 (umu-test), fish-egg (Danio rerio), Chironomus riparius, and Lumbriculus variegatus. It was demonstrated that in-can preservatives leach out rapidly at the beginning of a façade lifetime and despite the short half-life of these compounds in aqueous solutions, they could be detected at high concentrations in the eluates. Furthermore, eluates from early sampling times, predominantly containing in-can preservatives, were found to cause toxic effects on sediment and aquatic organisms. The results demonstrate that in-can preservatives can impose a significant stress factor on the environment.

Two-Dimensional Conductive Metal-Organic Framework for Small-Molecule Sensing in Aqueous Solution.

Two-dimensional (2D) conductive metal-organic frameworks (cMOFs) have emerged as powerful transducers for electrochemical sensing. However, electrochemical sensing in aqueous solutions remains at a very early stage for 2D cMOFs. Herein, the interfacial capacitances of a 2D cMOF are utilized for electrochemical sensing for the first time. Various redox-innocent compounds along with redox-active compounds in aqueous solutions are successfully detected based on the responses of two capacitance peaks at low voltages. The quantitative sensitivity to ascorbic acid is even an order of magnitude higher than the previous voltammetric method. Further investigation demonstrates that the responses are rooted in the pseudocapacitances of the 2D cMOF, i.e., the transitions among the multiple redox states of the ligands. The analytes are suggested to alert the d-p conjugation and exchange electrons with the 2D cMOF. These deep insights in response mechanisms represent an important step for promoting the application of 2D cMOFs in chemical sensing.

Solubility Enhancement of Hydrophobic Compounds in Aqueous Solutions Using Biobased Solvents as Hydrotropes

Solubility Enhancement of Hydrophobic Compounds in Aqueous Solutions Using Biobased Solvents as Hydrotropes

Investigation of Chemical Constituents and Antioxidant Activity of Biologically Active Plant-Derived Natural Products.

The aim of this publication is to present rapid screening methods (visual/colorimetric) that will enable quick identification of the presence of biologically active compounds in aqueous solutions. For this reason, 26 plant extracts obtained by ultrasound-assisted extraction were analysed for the content of these compounds. Higher plants, used as a raw material for extraction, are common in Europe and are easily available. The article proposes a comparison of various protocols for the identification of various compounds, e.g., phenolic compounds (phenols, tannins, anthocyanins, coumarins, flavones, flavonoids), vitamin C, quinones, quinines, resins, glycosides, sugars. Initial characterisation of the composition of plant extracts using fast and inexpensive methods allows you to avoid the use of time-consuming analyses with the use of advanced research equipment. In addition, the antioxidant activity of plant extracts using spectrophotometric methods (DPPH, ABTS, FRAP assay) and quantitative analysis of plant hormones such as abscisic acid, benzoic acid, gibberellic acid, indole acetic acid, jasmonic acid, salicylic acid, zeatin, zeatin riboside, and isipentenyl adenine was performed. The obtained results prove that the applied visual methods show different sensitivity in detecting the sought chemical compounds. Therefore, it is necessary to confirm the presence or absence of bioactive substances and their concentration using modern analytical methods.

Radiation-Initiated Dehalogenation of Organofluorine Compounds in Aqueous Solutions

Radiation-Initiated Dehalogenation of Organofluorine Compounds in Aqueous Solutions

Chemical-free fabrication of carbon fiber aerogels from egg boxes for the removal of pharmaceutically active compounds in aqueous solution

The presence of pharmaceuticals and personal care products (PPCPs) in aquatic environments extremely concerns to human health and the ecosystem; thus, their removal is essential. This work produced carbon fiber aerogels from egg box waste using a chemical-free fabrication process. The pyrolyzed egg box aerogel (PEBA) exhibited three-dimensional interconnected carbon nanofibers with high surface area and pore volume. The adsorption capacity and removal efficiency of four PPCPs, namely, diclofenac (DIC), caffeine (CF), tetracycline (TC), and ciprofloxacin (CIP), from water were high and comparable to other carbon-based adsorbents, and the adsorption time was much faster (within 20 min). The Redlich-Peterson and the pseudo-second-order models were the best-fitted isotherm and kinetic models, respectively, which imply multilayer adsorption at high concentrations and the chemisorption process. Furthermore, mechanisms responsible for the adsorption of all PPCPs were elucidated. PEBA was applied in the fixed-bed column experiment to mimic the continuous adsorption process. In addition, PEBA was recyclable after low-temperature heat treatment. The adsorption capacity (8.1 mg/g) and removal efficiency (94.03 %) for TC was still high after three cycles. Metabolomics analysis revealed that no secondary pollution is released into water after thermal treatment. Therefore, PEBA has the potential as an efficient adsorbent for removing PPCPs from water.