Formulation Composition Research Articles

Biobased Acrylate Composites with Enhanced Strength for Additive Manufacturing

Abstract With the expanding use of polymers in additive manufacturing, sustainable resins for use in vat photopolymerization are required to reduce their environmental impact. One promising approach to achieve this is to incorporate biobased fillers that replace the acrylates in photopolymer resins as ‘green’ alternatives. In this study, photopolymer composites consisting of a methacrylate resin with varying calcium carbonate powder content between 0 and 50 wt.% were investigated. A digital light processing technique was used to fabricate tensile test specimens for mechanical testing. Good printability, dimensional accuracy, and good interlayer adhesion were observed for composite resin formulations that incorporated calcium carbonate up to 50 wt.%. Green parts were subsequently washed and exposed to ultraviolet radiation at various post-cure temperatures between 20 and 80 °C. Specimens were tested on an Instron universal testing machine to evaluate stress–strain characteristics, which included Young’s modulus, ultimate tensile strength, yield strength at 0.2% offset, resilience, toughness, and percent elongation at break. Elevated calcium carbonate content and higher post-cure temperatures demonstrated higher Young’s modulus values, reaching 4297 MPa for 50 wt.% calcium carbonate at a post-cured temperature of 80 °C, indicating increased stiffness and resistance to elastic deformation under load for the compositions with increased biobased filler content. The ultimate tensile strength of the composite resin formulations was higher when exposed to elevated curing temperatures and remained between 22 and 32 MPa for all concentrations of calcium carbonate. The biobased composites evaluated in this study demonstrated that the modification of acrylate resins with biobased filler powders such as calcium carbonate is a feasible approach to sustainably enhance the mechanical properties of polymeric materials for additive manufacturing.

Dynamic versus static testing and in vivo mechanical performance of poly(glycolide-trimethylene carbonate-ε-caprolactone) delayed release implants.

The manufacturing of millimeter-sized implants for delayed drug release presents several challenges. However, it allows for the encapsulation of a therapeutic agent within a single device, enabling precise control over factors such as geometry, polymer composition, and drug formulation. The relatively large size, however, means that when inserted into subcutaneous tissue the implants experience mechanical stresses that are not predicted by current in vitro methods consisting of incubation under static conditions. The absence of a suitable in vitro assay complicates the device development process, often resulting in unsuccessful preclinical testing. This study presents the fabrication of flexible implants of poly(glycolide-co-trimethylene carbonate-co-ε-caprolactone), in vitro degradation, and performance when implanted subcutenously in rats. Predicting the in vivo behaviour is addressed by the development of a scalable, high-throughput, cyclic flexural testing system. Flexural loading of the implant demonstrates a clear impact on loss in mechanical properties compared to static conditions in lipoprotein lipase. Under static conditions, a lag time of 60 days is observed before sustained release of the model dye. Conversely, the flexural loading assay results in early fracture by 20 days consistent with what is observed in the animal model. Decisively, this study emphasizes the importance of tailoring in vitro assays according to the dosage form and intended mode of administration. Implementation of a dynamic in vitro assay is invaluable to efficiently evaluate device viability and release kinetics and will, in turn, allow a more streamlined workflow for translation into preclinical models.

Topical drug formulation for enhanced permeation: A comparison of Bayesian optimisation and response surface methodology with an ibuprofen-loaded poloxamer 407-based formulations case study.

Topical skin products aim to address aesthetic, protective, and/or therapeutic needs through interaction with the human epidermal system. Traditionally, formulation development relies on empirical knowledge and trial-and-error experiments. In this paper, we introduced the Bayesian optimisation method and compared it with the traditional response surface methodology (RSM) for topical drug formulation. The objective was to optimise the formulation composition of ibuprofen gel-like to achieve a maximum flux through in vitro permeation tests (IVPTs). As a model system, poloxamer 407, ethanol, and propylene glycol (PG) were selected as the key excipients, whose concentrations were optimised. Strat-M membrane, serving as a surrogate for human skin, and Franz cell diffusion were employed in IVPTs. Two sets of experiments were conducted under identical conditions for 30 h. Under the RSM approach, the optimised ibuprofen gel-like formulation was identified with a poloxamer 407: ethanol: PG ratio of 20:20:10, achieving a measured permeation flux of 11.28 ± 0.35 μg cm-2h-1. In comparison, Bayesian optimisation, after four iterations, yielded an optimised formulation with a ratio of 20.95:19.44:12.14, resulting in a permeation flux of 14.15 ± 0.77 μg cm-2h-1. These findings highlight the potential of Bayesian optimisation as an effective tool for improving topical drug formulations.

Investigation of the Anti-Inflammatory and Anti-Oxidant Activities of a Novel Kaempferol-Liposome-Loaded Hydrogel for the Treatment of Acute Eczema

Kaempferol liposome hydrogel is a novel drug carrier designed to solve the problems of the poor water solubility and low bioavailability of kaempferol. By combining kaempferol with liposomes and further forming a hydrogel, this composite formulation not only improves the stability of the drug but also enhances its penetration and therapeutic effect on the skin. It was demonstrated that the liposomal hydrogel of kaempferol had ex vivo and in vivo antioxidant activities, which could effectively inhibit the inflammatory response and oxidative stress and, thus, showed significant efficacy in the treatment of acute eczema. In the acute eczema model, kaempferol liposome hydrogel significantly improved the skin condition of mice by reducing the symptoms of skin redness, swelling, and itching. The experimental results showed that the hydrogel was rapidly absorbed into the skin after application and continued to release the drug to maintain its efficacy for a longer period of time. In addition, the kaempferol liposome hydrogel also showed good physicochemical stability and was not easily discolored or separated, making it suitable for long-term use. As an innovative drug carrier for the treatment of acute eczema, the kaempferol liposome hydrogel shows good application prospects and provides a new treatment option for eczema patients.

Enhancing postharvest quality of bananas: comparative study on the use ZnO and Ag2O nanoparticles and ZnO/Ag2O composites

The ‘Cavendish’ banana is cultivated for its flavor and nutritional value, but its climacteric nature leads to rapid ripening and reduced shelf life. Preserving postharvest quality is crucial for minimizing losses and ensuring consumer satisfaction. Nanoparticles such as ZnO and Ag2O have shown promise in extending the shelf life and maintaining the quality of perishable fruits. Therefore, this study aimed to evaluate the efficacy of ZnO- and Ag₂O-enriched edible coatings on the postharvest physicochemical quality of ‘Cavendish’ bananas stored at ambient temperature. Bananas were treated with five different formulations: (1) moringa extract alone (MG), (2) moringa extract combined with carboxymethyl cellulose and glycerol (MG + CMC + GLY), (3) carboxymethyl cellulose and glycerol with Ag2O nanoparticles (Ag2O), (4) carboxymethyl cellulose and glycerol with ZnO nanoparticles (ZnO), and (5) carboxymethyl cellulose and glycerol with a combination of Ag2O and ZnO nanoparticles (Ag2O + ZnO). The effects on key quality parameters, including weight loss, color retention, total soluble solids, total acidity, pH, and peel structure, were assessed. At the end of the storage period, the fruits treated with ZnO + Ag₂O nanoparticles demonstrated a significantly lower decay incidence of 44.44% than the control (100%). Similarly, nanoparticle-enriched treatments maintained higher L* (1.46-fold), b*(1.38-fold), and ho (1.11-fold) values than the control treatment. Remarkably, the Ag2O + ZnO composite formulation showed the most significant positive effects on total acidity, pH, and stomatal cell integrity toward improving banana quality. This study highlights the potential of ZnO/Ag2O composites as effective postharvest treatments to enhance banana quality and extend shelf life, providing a promising approach to reduce postharvest losses and ensure fruit quality during storage and transportation.

Comparative Effects of Drying Methods on Physicochemical Properties of Puree Blends of Some Indigenous Varieties of Watermelon (<i>Citrullus lanatus</i>), Orange (<i>Citrus sinensis</i>) and Mango (<i>Mangifera indica</i>) Fruits

This study evaluates the comparative effects of freeze-drying and spray-drying methods on the physicochemical properties of composite fruit puree powders produced from local varieties of watermelon (Citrullus lanatus), orange (Citrus sinensis), and mango (Mangifera indica) in Benue State, Nigeria. Composite formulations were developed by blending fruit purees in ratios of 50% watermelon, 30% orange, and 20% mango. Freeze-drying and spray-drying methods were employed to produce powders, which were subsequently analyzed for proximate composition, sensory attributes, and physicochemical properties. Freeze-dried powders retained higher vitamin C content (21.4 mg/100 g) compared to spray-dried powders (16.3 mg/100 g). Moisture content was significantly lower in freeze-dried powders (2.5%) than spray-dried powders (4.3%), while sensory evaluation showed no significant differences in overall acceptability (p>0.05). These findings suggest that freeze-drying is superior for nutrient preservation, whereas spray-drying is more energy-efficient. The results provide valuable insights for optimizing fruit powder production in agrarian settings.

Perfluoropolyether Segmented Polybutadiene Urethanes With Improved Dispersion of Silica Particles: A Surrogate Methodology for Additive Manufacturing of Composite Binders

ABSTRACTFluorinated hydroxy‐terminated polybutadiene (F‐HTPB) urethane binders were prepared by the incorporation of a perfluoropolyether (PFPE) diol (Fluorolink E10H (FL)) as a terpolymer system. Rheology measurements at 25°C showed a steady decrease in viscosity with increased cure rates at the gelation time with increasing molar loadings of FL. The optimized F‐HTPB urethane binder was then formulated with fluorinated silica particles (F‐SP) that were successfully modified with a monolayer of perfluoropolyether bound carboxylic acids using Krytox 157 FSH. Loadings up to 20 wt% F‐SPs were prepared with no phase separation demonstrating the interfacial compatibility of the fluorine‐rich PFPE domains of the binder and the silica particle surface while lowering the viscosity at full cure. These rheology measurements suggest the fluorinated binder composite formulations would advance their application as practical drop‐in feed stocks for reactive in situ additive manufacturing techniques at room temperature. This work also includes comprehensive analysis of the particles and composite formulations to include infrared spectroscopy, surface wettability measurements, calorimetry, and thermal gravimetric decomposition analysis.

Constructing an efficient segregated thermally conductive network for a PBX substitute using graphene aerogels

High-energy explosives prompt stringent control over their experimental environment, which limits the feasibility of conducting experiments. This study explores the use of melamine (Me), a safe material with a structure and physical properties similar to 1,3,5-triamino-2,4,6-trinitrobenzene (TATB), as a substitute for TATB in composite formulations aimed at improving the thermal conductivity of polymer-bonded explosives (PBXs). In waterborne polyurethane emulsion (WPU), graphene oxide (GO) was reduced and self-assembled into graphene aerogels (GA) on the surface of Me, resulting in the formation of Me@GA/PU (MGP) particles with a core-shell structure. The GA surface coating enhanced the interfacial bonding between the thermally conductive fillers (GA) and Me, improving the dispersion of the fillers within the composite. After freeze-drying and hot pressing, cylinders of MGP with a segregated thermally conductive network were obtained. The segregated network, formed by GA at low filler loading, provided an effective pathway for heat transfer and improved the thermal stability of the composites. The thermal conductivity of the MGP composite, prepared with 0.5 wt.% GO content, increased by 80% compared to the pure sample. The temperature gradient and thermal stress distribution in the composite cylinders during complex thermal cycling were evaluated using finite element analysis.

Wood polymer composite (WPC) formulation from Ethiopian indigenous lowland bamboo particles and post-consumer plastic blends: synergetic and dual effects of both coupling agent and organic crosslinking catalyst

Wood polymer composite (WPC) formulation from Ethiopian indigenous lowland bamboo particles and post-consumer plastic blends: synergetic and dual effects of both coupling agent and organic crosslinking catalyst

Algae extract-based nanoemulsions for photoprotection against UVB radiation: an electrical impedance spectroscopy study

Skin cancer is one of the most common types of cancer worldwide, with exposure to UVB radiation being a significant risk factor for its development. To prevent skin cancer, continuous research efforts have focused on finding suitable photoprotective ingredients from natural sources that are also environmentally friendly. This study aimed to develop oil-in-water photoprotective nanoemulsions containing marine macroalgae extract. A Box–Behnken experimental design was used to identify the most promising formulation composition, resulting in optimal physical properties. These properties, including droplet size, polydispersity index (PDI), and zeta potential, were evaluated using dynamic light scattering (DLS). To assess the photoprotection capacity of the formulations, electrical impedance spectroscopy (EIS) was employed to evaluate alterations in the electrical characteristics of excised pig skin membranes placed in Franz cells equipped with a 4-electrode set-up. The final composition of the nanoemulsion was caprylic/capric triglycerides 4%, Macrogolglycerol ricinoleate 30%, and algae extract 1%. The nanoemulsions had an average droplet size of 128.5 ± 8.6 nm, a PDI of 0.25 ± 0.06, and a zeta potential of 45.14 ± 0.02 mV. Compared to the control group, the photoprotective capacity of the oil-in-water nanoemulsions was statistically significant. Specifically, only a 15% reduction in the skin membrane electrical resistance following UVB exposure was observed when the formulation containing algae extract was used, whereas a 50% reduction was observed for the vehicle. In conclusion, this work demonstrates that the developed nanoemulsions based on natural ingredients show promising protective capacity against UVB exposure of the skin.

Influence of Formulation Composition on the Characteristic Properties of 5-fluorouracil-loaded Liposomes.

Variations in the types and quantities of excipients used to prepare liposomes can affect the physicochemical properties of liposome formulations. This study aimed to provide information about the design and fabrication of 5-fluorouracil (5-FU)-loaded liposome formulations using different lipid and cholesterol (CHOL) derivatives. Passive loading via a small-volume incubation method was used to prepare liposomes. The particle size, polydispersity index, zeta potential, and encapsulation efficiency (EE%) of the formulations were determined. The release studies of the formulations were conducted using a Franz diffusion cell at 37 °C. In this study, a high-pressure liquid chromatography device was used to measure the amount of 5-FU. The mean particle sizes of all formulations were between 134 and 166 nm, and they had a negative charge on their surface. Increasing the cholesteryl hemisuccinate content reduced the size of the liposomes. Additionally, all formulations exhibited a low polydispersity index (0.3). The EE% of all formulations exceeded 30%. The in vitro release of 5-FU from liposome formulations followed the Korsemeyer-Peppas model. Modifying the lipid and CHOL content in the formulations, as indicated by the experimental results, can change the characteristic properties of liposomes. The use of soybean phosphatidylcholine and cholesteryl hemisuccinate appears to be a promising combination for the preparation of hydrophilic drug-loaded liposome formulations.

Quantitative Structural and Compositional Elucidation of Real-World Pharmaceutical Tablet Using Large Field-of-View, Correlative Microscopy-Tomography Techniques and AI-Enabled Image Analysis.

The purpose of this study is to present a correlative microscopy-tomography approach in conjunction with machine learning-based image segmentation techniques, with the goal of enabling quantitative structural and compositional elucidation of real-world pharmaceutical tablets. Specifically, the approach involves three sequential steps: 1) user-oriented tablet constituent identification and characterization using correlative mosaic field-of-view SEM and energy dispersive X-ray spectroscopy techniques, 2) phase contrast synchrotron X-ray micro-computed tomography (SyncCT) characterization of a large, representative volume of the tablet, and 3) constituent segmentation and quantification of the imaging data through user-guided, iterative supervised machine learning and deep learning. This approach was implemented on a real-world tablet containing 15% API and multiple common excipients. A representative volumetric tablet image was obtained using SyncCT at a 0.36-µm resolution, from which constituent particles and pores were fully segmented and quantified. As validation, the derived tablet formulation composition and porosity agreed with the experimental values, despite the micrometer-scale particle and pore sizes. The approach also revealed the formation of ordered mixture inside the tablet. Notably, the image-derived size distributions of both the agglomerated microcrystalline cellulose and its primary particulate units matched the laser diffraction-based measurements of the as-is material. Key pore attributes including the pore size distribution, spatial anisotropy, and pore interconnectivity were also qualified. Overall, this study demonstrated that the correlative microscopy-tomography approach, by leveraging phase contrast SyncCT and AI-based image analysis, can deliver new, practically-useful structural and compositional information and facilitate more efficient formulation and process development of tablets.

Lavender Oil: A Versatile Natural Therapeutic – Extraction, Composition, Applications, and Innovative Formulation Strategies

Lavender Oil: A Versatile Natural Therapeutic – Extraction, Composition, Applications, and Innovative Formulation Strategies

Enhancing Composite Performance: Hydrothermally Treated Wood Reinforcement in Recycled Polypropylene

The low thermal stability of cellulose presents unique technological challenges to the formulation of wood and plastic composites that are compatible and processable. For this, hydrothermal modification is a well-established technology for improving dimensional stability and durability of wood's components, in addition to providing better interaction with the polymer. This study produced polymer composites in which hydrothermally treated wood waste fibers (WT) reinforce a recycled polypropylene (RPP) matrix. Wood waste fibers were selected by grain size and distribution, treated hydrothermally, and characterized by SEM, ATR-FTIR, and water sorption. Composites were produced varying the reaction time of treatment hydrothermal (from 30 to 180 minutes), granulometric size (from 425 to 1400 μm) and percentage of WT (from 10 to 20%), following a 2³ full-factorial experimental design, by extrusion with internal recirculation and the mechanical test specimens were modulated by injection. Tensile, flexion, IZOD impact and water sorption tests were statistically analyzed. Reaction time was the most statistically significant factor. Composites of wood waste fibers treated for 30 min and containing 20% of WT presented better mechanical properties than expected. However, the preservation of the lamellar fibers during the reaction time allowed for better adherence to the polymer, and the insertion of a greater quantity of fibers in the material provided greater rigidity in the composite. In general, the results obtained gives properties of stability and resistance to damage of composites containing hydrothermally treated wood fibers.

Effect of formulation composition on trastuzumab stability.

For monoclonal antibody drug products as for other biologics, while the innovator drug products first becomes commercially available, they are often followed by one or more biosimilar products. These biosimilars often differ from the innovator product, as well as from each other, in their formulation composition. However, the impact of the formulation composition on the stability of the active pharmaceutical ingredient subjected to different 'stresses' is still not understood. We have evaluated the effect of different formulations on structural stability and aggregation behavior of a monoclonal antibody, trastuzumab (both the drug substance and the final drug product), against three most common stresses encountered during production, storage, and formulation into a lyophilized product - freeze-thaw, freeze-drying, and agitation. Irrespective of the stabilizer used, the formulations exhibited good conformational stability against all three stresses. However, the freeze-drying process caused a significant increase in the number of soluble aggregates, but only in sucrose containing formulations. On the other hand, agitation in sorbitol containing formulation led to a significant increase in insoluble aggregates. This effect could also be attributed to the absence of surfactant in this formulation composition. The stabilizing effect of trehalose appeared to be independent of its concentration. Therefore, the effect of formulation composition is more pronounced for aggregation of trastuzumab than for its conformational stability. Our findings suggest that formulation design warrants consideration of both conformational stability and aggregation behavior of the active ingredient.

Mechanical properties of hemp fiber‐reinforced thermoset and thermoplastic polymer composites: A comprehensive review

AbstractHemp fibers have mechanical characteristics similar to those of synthetic fibers, which makes them an attractive material for producing environmentally friendly composites. Hemp fibers have excellent mechanical properties and a unique hydrophilicity, requiring for extra attention in composite formulations. Hemp fibers are a very versatile vegetable fiber that is frequently utilized in structural composites. In addition, hemp has shown potential in a variety of other fields, including as sports goods, building, and lighter materials. The present article aims to give a comprehensive summary of the status of sophisticated studies in hemp fiber reinforced composites at present time. The most important research on thermoset and thermoplastic materials reinforced with hemp fiber is compiled and discussed in this publication. This document also provides an overview of the primary attributes of hemp fibers, talks about how to develop these attributes chemically, explains how to create and describe hemp fiber composites, and identifies areas that need more research. In summary, this study ends with several important recommendations and future approaches that draw attention to the issues that require further investigation and potential industrialization of composites.Highlights Advances in hemp fiber extraction and chemical treatments. Performance traits of hemp‐reinforced thermoset and thermoplastic composites. Tribological, and moisture absorption properties of hemp fiber composites. SEM analysis revealing composite structural characteristics. Future applications and sustainability of hemp fiber in polymers.

Release-modulating mechanism and comparative pharmacokinetics in beagle dogs of bethanechol-loaded oral dosage forms.

Bethanechol chloride (BTC), a quaternary ammonium compound used in bladder dysfunction treatment, requires challenges in developing optimal oral dosage forms due to its high water-solubility, short half-life, rapid elimination and four times a day administration. The aim of this study was to develop optimal BTC-loaded oral dosage forms that could provide both rapid onset and sustained therapeutic effects while reducing the frequency of conventional four-times-daily dosing (Mytonin® tablets). Four different BTC-loaded oral dosage forms were designed including gastro-retentive tablet (GRT), controlled-release tablet (CRT), bilayer tablet (BLT), and tablet-in-tablet (TIT). Then, release-modulating mechanism and in vivo pharmacokinetics in beagle dogs were compared. The release profiles of the four BTC-loaded dosage forms varied according to system design and formulation composition. The optimized GRT F-5 showed rapid buoyancy within 15 s and floated for 12 h, while continuously releasing the drug. CRT showed Fickian diffusion release, whereas BLT and TIT exhibited biphasic immediate and sustained release profiles. Polymer swelling behavior was analyzed using the Vergnaud model, where GRT F-5 and CRT showed n values < 0.5, confirming diffusion-controlled polymer hydration mechanism. In the instrumental analysis, the hydrogen bonding formation of BTC with release-modulating polymers, such as hydroxypropyl methylcellulose and polyethylene oxide and loosening of the polymer structure was crucial as the water influx increased. In pharmacokinetic studies in beagle dogs, the area under the plasma concentration-time curve (AUC) by normalizing dose for 48 h for GRT, CRT, BLT, and TIT were 90.2 %, 108.6 %, 83.8 %, and 76.4 %, respectively, compared with that of the reference drug (Mytonin® tablets, immediate release, four times a day). Interestingly, the plasma maximum concentration (Cmax) and AUC)0-12h of GRT F-5 and and Mytonin® tablets for the first 12-h period were much higher compared with that of other BTC-loaded CRT, BLT, and TIT. BTC was absorbed throughout the gastrointestinal tract, but is preferably absorbed in the stomach and upper intestinal sites. However, the GRT F-5 could provide more therapeutic potential for improving patient compliance in bladder dysfunction treatment by achieving both rapid onset and sustained drug release with reduced dosing frequency.

A comprehensive update on over the counter artificial tears.

Artificial tears play a critical role in the management of dry eye disease (DED), providing patient symptomatic relief and improving ocular surface health. Its clinical importance has driven pharmaceutical innovation in terms of its formula and ingredients. The following article is an overview of the artificial tear products on the market. The artificial tears on the market vary in terms of their active ingredients, inactive ingredients, preservatives, and formulation. The particular chemical composition of ingredients and formulation plays a clinical role in treating ocular pathology. Conversely, certain ingredients can cause more ocular damage than other ingredients. Upon review of the artificial tears on the market, the authors conclude that clinicians should consider the products' composition when designating a treatment for DED. Different artificial tear composition may benefit specific causes of DED such as evaporative, aqueous-deficient, glaucoma, ocular surface tumors, corneal ulcers, and viral conjunctivitis.

Revolutionizing Dental Polymers: The Versatility and Future Potential of Polyetheretherketone in Restorative Dentistry.

Polyetheretherketone (PEEK) has emerged as a revolutionary material in modern dentistry because of its unique combination of mechanical strength, biocompatibility, and versatility. This literature review examines the current applications and future potential of PEEK in various dental disciplines. PEEK's favorable properties, including its low specific weight, high strength-to-weight ratio, and ability to be easily machined, have led to its adoption in prosthetics, implantology, and dental esthetic restorations. This material has shown promise for fabricating crowns, bridges, removable partial denture frameworks, and implant components. PEEK's radiolucency and bone-like elastic modulus make it particularly suitable for dental implants and abutments. Additionally, its resistance to degradation and compatibility with various surface treatments enhances its long-term performance in the oral environment. While challenges such as bonding to other dental materials and aesthetic limitations exist, ongoing research is addressing these issues through surface modifications and composite formulations. As the dental field continues to evolve, PEEK's adaptability and biocompatibility position it a key player in the development of next-generation dental materials and techniques, potentially transforming patient care and treatment outcomes in dentistry.

Обоснование параметров пресс-гранулятора для линии приготовления высокобелковой кормовой добавки для с/х птицы

On the basis of the analysis of the composition of on the basis of the analysis of the composition of traditional formulations for broilers the conclusion is made about the necessity of obtaining the meat and fish component at a lower cost. It is concluded that it is necessary to obtain meat and fish components of lower production cost. By analysing the existing by analysing the existing designs of press-granulators the direction in their improvement is established. The innovative scheme of the press-granulator is offered, for which the parameters are theoretically justified parameters are substantiated by theoretical way. The use of this device as a part of technological line for production of high-protein granulated additive has shown its high efficiency in comparison with extruding. Key words: FORMULATION, FEED, PRESS-GRANULATOR, SCHEME, PARAMETERS, PRODUCTIVITY, MEAT AND FISH BONE RAW MATERIALS, SOYA FLOUR, POWER, ENERGY