Components Of Syndrome Research Articles

Is C-reactive Protein Related to Cardiovascular Risk Factors in Brazilian Patients undergoing Coronary Angiography?

Is C-reactive Protein Related to Cardiovascular Risk Factors in Brazilian Patients undergoing Coronary Angiography? Objective: To determine plasma levels of high sensibility C - reactive protein (hs-CRP) in patients undergoing coronary angiography and compare them with the components of the Metabolic Syndrome. Methods: Socio-economic, anthropometric and biochemical data from 95 patients undergoing coronary arteriography were collected. Results: The profiles of three groups of hs-CRP (low, moderate and high) were statistically equal in gender (p=0.625), age (p=0.879), smoking (p=0.800), alcohol consumption (p=0.560), practice physical activity (p=0.636), presence of diabetes (p=0.530), hypertension (p=0.207), SM (p=0.121), use of statins (p=0.472), total cholesterol (p=0.329) HDL-c levels (p=0.288), LDL-c (p=0.940), triglycerides (p=0.386), glucose (p=0.232), waist circumference (p=0.377), the presence of plaques (p=0.181) and catheterization of the report (p=0.207). Besides, there are more obese patients at high hs-CRP class (p=0.012). Conclusion: Although the CRP is associated with cardiovascular morbidity and it is strongly linked to the components of Metabolic Syndrome, in the patients undergoing coronary angiography evaluated in this study, a significant difference was observed only for the presence of obesity.

The Association of Blood Heavy Metal Concentration and Components of Metabolic Syndrome in Korean Male Adults

The purpose of this study was to analyse the association between blood heavy metal concentration (lead, mercury, cadmium) and components of metabolic syndrome (Mets) in Korean male adults. Data were extracted from the 5th Korea National Health and Nutrition Examination Survey (KNHANES) 2010. Participants were 965 Korean male adults aged 20 years and over. The data were analysed by using SPSS/Win 20.0. The means of blood lead, mercury and cadmium concentration in participants were 2.94μg/dl, 5.98μg/L, and 1.10μg/L, respectively. The means of Fasting Blood Glucose (FBG), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), serum Triglyceride (TG), serum High-density Lipoprotein Cholesterol (HDL-C) and Waist Circumference (WC) were 100.23mg/dl, 123.43mmHg, 81.23mmHg, 161.84mg/dl, 49.64mg/dl and 84.35cm, respectively. After adjusting for demographical characteristics (age, education, income, residential area, occupation, drinking, and smoking), increase of FBS and DBP were associated with the serum cadmium (OR = 1.465) and lead (OR = 1.147), respectively. Mercury was associated with increase of WC (OR = 1.051) and Mets (OR = 1.048). Based on the outcomes of this study, it is necessary to develop intervention strategies for reducing the lead, mercury and cadmium exposure and monitor continuous blood heavy metal concentration.

Metabolic Syndrome, Wall Motion Score and Infarct Size after AMI

The infarct size is an important marker for early and late mortality after acute myocardial infarction [1,2]. The metabolic syndrome (MetS) is interrelated atherosclerotic risk factors including insulin resistance, hypertension, a low level of high-density lipoprotein (HDL) cholesterol, a high triglyceride level, a high plasma glucose concentration, central obesity, and the increased number of components of the metabolic syndrome is associated with a higher mean carotid intima media thickness, lower ankle brachial pressure index in patients with coronary heart disease, peripheral arterial disease, or abdominal aortic aneurysm [3-5].

Evaluation of relationship between periodontitis and various components of metabolic syndrome

Evaluation of relationship between periodontitis and various components of metabolic syndrome

THE INFLUENCE OF INSULIN RESISTANCE ON THE FORMATION AND PROGRESSION OF METABOLIC SYNDROME COMPONENTS (THE RESULTS OF A FIVE-YEAR STUDY)

The combination of risk factors that make up a metabolic syndrome increases the risk of cardiovascular disease and type 2 diabetes. In the presence of insulin resistance the effects of risk factors combine, thereby increasing the probability of the development of cardiovascular disease and its complications. Aim. To study the effect of insulin resistance on the formation and progression of metabolic syndrome components on the basis of a 5-year follow-up. Material and methods. An outpatient examination of clinically healthy patients aged 20-65 years (n=711; 327 men and 384 women) was conducted. The average body mass index did not exceed 34.5 kg/m2. Biochemical blood analysis was performed to assess the state of lipid and carbohydrate metabolism. Insulin resistance was diagnosed using HOMAIR>2.6. Results. It has been detected that patients with insulin resistance have significantly higher incidence of the combination of three or more components of the metabolic syndrome (p<0.01). The incidence of multicomponent syndrome among the examined patients with insulin resistance was 69.7%, which is 1.8 times higher than in patients with initially preserved tissue sensitivity to insulin. Conclusion. The follow-up study of patients with insulin resistance shows that in the absence of correction of metabolic disorders, the development of multicomponent disorders that make up a metabolic syndrome occurs.

Successful treatment of a patient with obesity, type 2 diabetes and hypertension with the paleolithic ketogenic diet

Introduction: Metabolic syndrome is a major public health problem affecting at least 20% of the world’s adult population. Components of the metabolic syndrome include obesity, impaired glucose metabolism, hypertension and altered lipid profile. Currently, medical treatment relies on drugs. A major problem is that patients with long-standing disease are excessively medicated because of an increase in the number of symptoms over time. A few clinical studies indicate that low-carbohydrate diets, including the paleolithic as well as the ketogenic diet, may be beneficial in the treatment of conditions associated with the metabolic syndrome. Case Report: Herein, we present a case of patient with metabolic syndrome successfully treated with the paleolithic ketogenic diet. While on the diet the patient was able to discontinue eight medicines, lost weight, showed a continuous improvement in glucose parameters and her blood pressure normalized. Currently, the patient is on the paleolithic ketogenic diet for 22 months, free of symptoms and side effects. Conclusion: We conclude that the paleolithic ketogenic diet was

Anomalies of Biceps Brachii Muscle as a Potantial Component of Poland's Syndrome

Anomalies of Biceps Brachii Muscle as a Potantial Component of Poland's Syndrome

Prevalence of Metabolic Syndrome According to Three Defining Criteria in Hypertensive Population in a Rural Hospital Setting

Aim: To determine the prevalence of metabolic syndrome using National Cholesterol Education Program-Adult treatment Panel III, American Heart Association-National Heart, Lung and Blood Institute and the Joint Interim Statement criteria and determine the prevalence of each of the cardiovascular risk factors in hypertensives attending a rural cardiology clinic in North central Nigeria Methods: This cross-sectional study used the National Cholesterol Education Program-Adult treatment Panel III (NCEP-ATP III), American Heart Association-National Heart Lung and Blood institute (AHA-NHLBI) and the Joint Interim Statement (JIS) criteria to assess metabolic syndrome in 204 patients with arterial hypertension attending cardiology clinic of Federal medical centre, Bida, North central Nigeria from February 2010 to April 2013. The demographic and clinical history of the patients was taken. Results: There were 97 men (47.5%) and 107 (52.5%) women. The mean age was 53.44 ± 11.71 years and range from 21-84years. Using the NCEP-ATP III, eighty three (40.7%) hypertensives had metabolic syndrome (33 males: 16.2%, 50 females: 24.5%) while the application of AHA-NHLBI criteria, resulted in metabolic syndrome in 96 (47.1%) of hypertensives (42 males: 20.6%, 54 females: 26.5% females) and with the JIS, 108 (52.9%) hypertensives (46 males: 22.5%, 62 females: 33.9% females). The prevalence of metabolic syndrome increases with age. In both male and female hypertensives with metabolic syndrome, low high density lipoprotein cholesterol (HDL-C) and abdominal obesity were the most common cardiovascular risk factor. Conclusion: The prevalence of metabolic syndrome in hypertensives in rural Nigeria is high and varies considerably depending on the definition used. The need for public health promotion, screening and management of hypertension and other components of metabolic syndrome is hereby recommended

Mean arterial pressure as a component of metabolic syndrome

Mean arterial pressure as a component of metabolic syndrome

The role of glucose-lowering drugs in blood pressure control in patients with type 2 diabetes mellitus

Various factors contribute the development of cardiovascular complications in type 2 diabetes mellitus (DM2): hyperglycemia and components of insulin resistance syndrome, including obesity, dyslipidemia and arterial hypertension. All of them should be considered in therapeutic strategies. In the beginning of 21st century new pharmacological agents were developed leading to the major changes in DM2 treatment. So, an ideal treatment should have not only a glucose-lowering effect, but other (“non-glycemic”) actions affecting multiple coexistent factors. Since the novel classes of antidiabetic drugs with additional favorable pleiotropic effects independent from direct glucose-lowering effect have been introduced, the choice of an appropriate agent has become more complicated and requiresindividual approach and wide knowledge in this area. The present articles reviews various groups of glucose-lowering agents and their effects on blood pressure level in DM2 patients. We believe it will help to make the right individual choice of an antidiabetic agent taking into account its pleiotropic effects.

Study of clinical parameters and laboratory evaluation of metabolic syndrome in adolescents

Introduction: Worldwide incidence of obesity is rising. Genetic predisposition, urbanization, sedentary lifestyle, television watching, food habits, and lack of exercise are contributing factors. They result in obesity-related morbidity like metabolic syndrome, stroke in young, coronary artery disease, and diabetes. Materials and Methods: A cross-sectional study was undertaken among 1000 adolescents of both genders, aged 12-19 years in three schools of Pimpri, Pune, after obtaining approval from Institutional Ethical Committee. The criterion used to diagnose metabolic syndrome was International Diabetes Federation definition. The Chi-square test was used to explore the association between metabolic syndrome and various predictors. A P value of 0.05 was accepted as the level of statistical significance. Results: In the study sample, the prevalence of metabolic syndrome was 16/1000. Females were more likely to have metabolic syndrome (male:female = 7:9). Factors associated were body mass index (BMI), waist-hip ratio (WHR), birth weight, skin fold thickness, body fat percentage, faulty dietary habits, and sedentary lifestyles (P < 0.05). Among all, the components of metabolic syndrome, raised triglyceride (75%), and fasting blood sugar level (75%) were more prevalent than high-density lipoprotein-cholesterol (44%) and hypertension (37.5%). Conclusion: Metabolic syndrome was found to be more prevalent in females of age group 16-19 years, among the obese population, associated with birth weight, BMI, and WHR.

Anthropometric, biochemical, and variables alterations in the metabolic syndrome among obese children and adolescents with and without non-alcoholic fatty liver disease

Introduction: the non-alcoholic fatty liver disease (DHGNA) is a comorbidity associated with common obesity in the pediatric age group, whose impact on the nutritional status has been investigated. Objective: to verify that obese children and adolescents with DHGNA have more anthropometric, biochemical, and related to tests alterations that determine the diagnosis of metabolic syndrome (SM) compared to those obese without DHGNA. Methods: this was a cross-sectional study conducted in the pediatric outpatient service. The groups with and without DHGNA were compared regarding anthropometric, biochemical, and metabolic syndrome components of SM. SM or test alterations that are diagnostic criteria for SM were evaluated for association with DHGNA. Results: 59 obese subjects were evaluated; 25.4% presented DHGNA. The groups presented significant differences in alterations in weight, BMI, total cholesterol, vitamin D, folic acid, uric acid, C-reactive protein, GGT, total bilirubin, and alkaline phosphatase (p <0.05). The high Anthropometric, biochemical, and variables alterations in the metabolic syndrome among obese children and adolescents with and without non-alcoholic fatty liver disease Fabio da Veiga Ued1, Marina Coelho de Souza2, Angela Regina Leonesi Maluf3, Virginia Resende Silva Weffort 4 1 Nuticionista. Mestre. Professora do Curso de Nutricao da Universidade Federal do Triângulo Mineiro – UFTM. Uberaba, MG – Brasil. 2 Academica do Curso de Nutricao da UFTM. Uberaba, MG – Brasil. 3 Medica. Mestre. Medica Pediatra do Hospital das Clinicas da UFTM. Uberaba, MG – Brasil. 4 Medica. Doutora. Professora do Departamento Materno-Infantil do Curso de Medicina da UFTM. Uberaba, MG – Brasil. Alteracoes antropometricas, bioquimicas e de variaveis da sindrome metabolica entre criancas e adolescentes obesos com e sem doenca hepatica gordurosa nao alcoolica DOI: 10.5935/2238-3182.20150118

Effects of omega-3 on metabolic markers in postmenopausal women with metabolic syndrome

Objective The aim of this study was to evaluate the effect of diet alone or combined with omega-3 supplementation on metabolic and inflammatory markers in postmenopausal women with metabolic syndrome.Methods This randomized, controlled trial included 87 Brazilian women (age ≥ 45 years and with amenorrhea ≥ 12 months). Exclusion criteria were: cardiovascular disease, insulin-dependent diabetes, cancer, autoimmune diseases and use of either statins or hormone therapy. Participants were randomized to diet alone (n = 43, control) or diet plus omega-3 supplementation, 900 mg/day orally (n = 44). All women were provided with an individualized dietary prescription. Clinical, anthropometrical (body mass index and waist circumference) and biochemical variables were measured. The inflammatory profile included C-reactive protein, tumor necrosis factor α and interleukins (IL-1β and IL-6). The intervention time was 6 months, with assessments at initiation and completion. Data were analyzed according to intention-to-treat, using the independent t-test and ANOVA.Results There were significant reductions in body mass index and waist circumference in both groups (p < 0.05) without significant changes in body fat or muscle mass. Intervention with diet plus omega-3 was associated with significant reduction in systolic (< 12.2%) and diastolic (< 8.2%) blood pressure, serum triglyceride concentration (< 21.4%), and insulin resistance (< 13.1%) (p < 0.05), as well as a reduction in serum IL-6 concentration (< 28.5%) (p = 0.034).Conclusion In postmenopausal women with metabolic syndrome, dietary intervention plus supplementation of omega-3 resulted in a further decrease in triglycerides and blood pressure and also in an improvement in insulin resistance and inflammatory markers, important components of metabolic syndrome.

Optimal Waist Circumference Cut-Off Point for Multiple Risk Factor Aggregation: Results from the Maracaibo City Metabolic Syndrome Prevalence Study

Context and Objective. The purpose of this study was to determine optimal waist circumference (WC) cut-off values for the detection of multiple risk factor aggregation in individuals from Maracaibo, Venezuela.Participants and Methods. A total of 1,902 adult individuals of both genders belonging to MMSPS were included. Complete physical, laboratory, and anthropometric examination were done to evaluate Metabolic Syndrome (MS) components and insulin resistance. ROC curves were plotted for risk factor aggregation in order to assess WC cut-off point. Logistic regression models were constructed to assess risk factors associated with the WC.Results. There were 52.2% females and 47.8% males, with WC of90.7±13.7 cm and98.2±15.9 cm, respectively. ROC curves exhibited a WC cut-off point for women of 90.25 cm (68.4% sensitivity, 65.8% specificity) and 95.15 cm (71.1% sensitivity, 67.4% specificity) for men. HOMA2-IR and high blood pressure were associated with a WC over these cut-off points, as well as 2.5-fold risk increase for multiple risk factor aggregation (OR 2.56; CI 95%: 2.05–3.20;P&lt;0.01).Conclusions. These population-specific WC cut-offs are readily applicable tools for detection of risk factor aggregation. Insulin resistance is closely associated with this definition of abdominal obesity, which may serve as a surrogate for its assessment.

Prevalence of metabolic components in university students.

OBJECTIVE: to identify the frequency of components of Metabolic Syndrome (MetS) among university students. METHOD: descriptive study with 550 students, from various courses run by a public university. The socioeconomic data, lifestyle, and components of MetS were filled out using a questionnaire. Blood sample collection was undertaken in the university itself by a contracted clinical analysis laboratory. RESULTS: 66.2% were female, with a mean age of 22.6±4.41; 71.7% were sedentary; 1.8% stated that they smoke; and 48.5% were classified as at medium risk for alcoholism. 5.8% had raised abdominal circumference and 20.4% had excess weight; 1.3% and 18.9% had raised fasting blood glucose levels and triglycerides, respectively; 64.5% had low HDL cholesterol and 8.7% had blood pressure levels compatible with borderline high blood pressure. Thus, of the sample, 64.4% had at least one component for MetS; 11.6% had two, and 3.5% had three or more. CONCLUSION: a significant proportion of the population already has the components for metabolic syndrome, and this profile reinforces the importance of early diagnosis so as to reduce the risk of developing chronic comorbidities.

Correlation between serum levels of hepcidin and ferritin in patients with metabolic syndrome in R.Macedonia

The metabolic syndrome (MS) is a complex of interrelated risk factors for cardiovascular disease and diabetes. These factors include hyperglycemia, hypertension, high triacylglycerol levels, low HDL-cholesterol (HDL-c) levels, and abdominal obesity. Evidence suggests that iron influences glucose metabolism, even in the absence of significant iron overload. Iron stores, expressed as serum ferritin concentration, have been proposed to be a component of the insulin-resistance syndrome. In 1997, Moirand et al. first reported the presence of histologically proven liver iron overload in overweight subjects with abnormal glucose metabolism and dyslipidemia. The aim of this study was to evaluate the correlation between serum levels of hepcidin and ferritin in patients with metabolic syndrome in R.Macedonia. The study included 240 subjects - 60 males are with MS and 60 males as control group. 60 females are with MS and 60 females as control group. Individuals aged 18 years or older were eligible to participate in the study. In this analysis we included subjects with available complete data allowing their classification according to established criteria for MetS. In detail, the following features were considered: 1) abdominal obesity, defined as the presence of waist circumference ≥102 cm in men or ≥88 cm in women; 2) fasting plasma glucose ≥ 6.1 mmol/l or drug treatment for elevated blood glucose; 3) serum triglycerides ≥ 1.69 mmol/l or drug treatment for elevated triglycerides; 4) serum HDL cholesterol in men< 1.03 mmol/l and <1.29 mmol/l in women or drug treatment for low HDL-C; 5) blood pressure ≥130/85 mmHg or drug treatment for elevated blood pressure. Statistical analysis showed that males and females with MS had statistically higher ferritin levels than control group. Statistical analysis showed that males and females with MS had statistically higher hepcidin levels than control group. Serum ferritin levels significantly correlate with hepcidine in all participants with MS excluded females control group.Body mass, BMI, waist circumference, hip circumference, and WHR are statistically significant higher in subjects with MS compared to control groups. Concentrations of lipid parameters for all examinated groups. The concentrations of HDL- cholesterol, triglycerides and apo A are significantly increased in subjects with MS compared to control groups. It has been demonstrated that the prevalence of MS is increasing worldwide, largely the result of greater obesity and sedentary lifestyles. The concentration of serum hepcidin is associated with gender. Males hepcidine levels are higher than females levels. We found a statistically higher hepcidin levels in both groups with MS, compared to control groups, and males hepcidine levels are almost twice higher then females hepcidine levels in bout groups (control group and group with MS). The authors found a strong positive relationship between increased iron stores measured by the concentration of plasma ferritin and risk of type 2 diabetes, impaired glucose tolerance and metabolic syndrome in middle age and older people. The average concentration of ferritin in men is almost twice higher than in postmenopausal women, and three times higher than in premenopausal women with metabolic syndrome.

Metabolic syndrome related health inequalities in Korean elderly: Korean National Health and Nutrition Examination Survey (KNHAES).

While the prevalence of metabolic syndrome is increasing, little is presently known about this syndrome in Korean elderly. This study aimed to group metabolic risk factors and to examine the associations between groups of health living conditions and metabolic syndrome using data from the Korean National Health Examination and Nutritional Assessment (KNHANES). A total of 1,435 subjects aged over 65 years old with both biochemical and dietary data information were obtained from the 4th and 5th KNHANES (2007–2012). Using stratified and multistage probability sample data, five components of metabolic syndrome were adopted to identify health inequalities. Our findings show that groups of health living conditions such as dietary pattern, body image, muscle mass, and fat mass were differentially associated with metabolic syndrome risk factors. Future studies are necessary to examine the underlying mechanisms of individual health living conditions to better understand the role of metabolic risk factors in metabolic syndrome in elderly.

Comparison of Hispanic and non-Hispanic patients with HCC.

294 Background: In the U.S., Hispanics have a higher incidence of hepatocellular cancer (HCC) and higher disease-specific mortality. The country of origin for Hispanics varies throughout the U.S. However, little is known about Hispanics with HCC in the Northeast. We compared Hispanic and non-Hispanic patients with HCC at a Boston teaching hospital. Methods: Hispanic patients with HCC seen at Beth Israel Deaconess Medical Center (BIDMC) from 1998-2012 were identified in our database. Ethnicity was determined from demographic and language preference information in electronic medical records and supplemented by comparing surnames with the 1990 Census Spanish Surname List. The comparison group was identified by randomly choosing non-Hispanic patients diagnosed the same years as Hispanic patients. We compared both groups using Chi Squared test. Results: 59 Hispanic and 89 non-Hispanic patients with HCC were included in the analysis. The majority (48%) of Hispanic HCC patients were Puerto Rican. Although the median age at diagnosis was similar (59.1 vs 60.3 years for Hispanics and non-Hispanics), there were more women in the Hispanic cohort (28.8% vs 12.4% p0.012). Hispanics had greater odds of not having private insurance (OR 4.24, 95%CI: 2.101, 8.554). Evaluation of HCC risk factors revealed Hispanics were significantly more likely to have hepatitis C (OR 3.68, 95% CI: 1.830, 7.420). In addition, the incidence of Metabolic Syndrome was significantly higher for Hispanics (44.7% vs. 21.7% p0.025). Although individual components of metabolic syndrome were higher in Hispanics, they were not statistically significant: hypertension (52.5% vs 40.4%), Diabetes Mellitus (39% vs 25%), BMI ≥ 30 (39% vs 27%), hypertrigylceridemia (57% vs 52%) and low HDL levels (50% vs 41%). Hispanics were more likely to have received Transarterial Chemoembolization (TACE) and Radiofrequency ablation (RFA) treatments (OR 2.48, 95% CI: 1.261, 4.858). Conclusions: Hispanic HCC patients at BIDMC were more likely to have hepatitis C, metabolic syndrome and to be female than their non-Hispanic counterparts. Outreach to Hispanic communities to identify patients with hepatitis C and metabolic syndrome, particularly in women, may improve HCC prevention, screening and treatment outcomes.

Association between prevalence of hypertension and components of metabolic syndrome: the data from Kailuan community

This study aimed to investigate the potential association between prevalence of hypertension and components of metabolic syndrome (MetS) in general population of North China. A cross-section survey was conducted from September to December 2013 in Kailuan community of a Northern China city, Tangshan. Anthropometric measurements, blood tests and questionnaire surveys were administered to a total of 4675 subjects enrolled in this study. In this study, hypertension was defined as blood pressure>140/90 mmHg or medication for previously diagnosed hypertension. The definition of MetS adapted the IDF/AHA/NHLBI criteria. The prevalence of hypertension among population with or without individual or clustered components of MetS was compared and the respective contribution of every component of MetS to prevalence of hypertension was analyzed using multivariate logistic analysis. The overall prevalence of hypertension was 31.6% in enrolled subjects. People with components of MetS such as central obesity, elevated TG, high blood pressure, and abnormal glucose metabolism had a higher prevalence of hypertension compared with those without. The prevalence of hypertension in people with 0, 1, 2, 3, 4, and 5 components of MetS was 18.4%, 27.8%, 32.6%, 35.6%, 43.9%, and 54.7% (p < 0.05), respectively. After adjusting for age, gender, BMI, smoking and alcohol drinking, the prevalence of hypertension was significantly correlated with the following component of MetS including central obesity (OR 1.23 (1.04–1.46), p < 0.05), elevated TG (OR 1.21 (1.03–1.43), p < 0.05), high blood pressure (OR 3.34 (2.86–3.90), p < 0.05), and abnormal glucose metabolism (OR 1.23 (1.04–1.45), p < 0.05). Components of MetS could significantly contribute to the development of hypertension. Overall lifestyle improvement and control of metabolic associated risk factors should be the cornerstone of hypertension control in China.

Abstract 2168: Components of metabolic syndrome and total cancer mortality

Abstract Metabolic syndrome becomes more and more common primarily due to the epidemic of overweight and obesity in both developed and developing countries. Epidemiologic studies have shown that obesity increases the risk of several cancers. However, it largely remains unclear whether the components of metabolic syndrome are associated with total cancer mortality. Therefore, we sought to evaluate this important question in the Third National Health and Nutrition Examination Survey (NHANES). Data on demographics, socioeconomics, lifestyle factors, and the components of metabolic syndrome were collected among 19,296 men and women aged 18 years or older (pregnant women excluded). Cancer mortality outcomes of these subjects were determined by linkage to the National Death Index (NDI), and the most recent year of the linkage was in 2010. A total of 1,111 cases of all sites of cancer have been documented during this period of time. Weighted Cox proportional hazards regression was used to compute relative risks (RR) with 95% confidence intervals (CIs) for total cancer mortality in relation to the components of metabolic syndrome. After adjustment for age, sex, race, education, marital status, and cigarette smoking, subjects in the highest quartile (Q) of serum glucose experienced a 25% increased risk of total cancer when compared with those in the lowest quartile [RR (95% CI): 1.250 (1.247-1.253)]. The significant positive association was also observed for systolic blood pressure [Q4 vs. Q1: RR (95% CI): 1.278 (1.274-1.282)]. Conversely, a reduced risk of total cancer was found for high-density lipoprotein (HDL) cholesterol [Q4 vs. Q1: RR (95% CI): 0.798 (0.796-0.800)]. No apparent effect was detected for waist circumference and serum triglyceride. To our knowledge, the present study is among the first to demonstrate that some components of metabolic syndrome modulate the risk of total cancer among a representative population in the US. Our findings offer novel evidence for the potential role of metabolic syndrome in cancer carcinogenesis and mechanistic data for the associations between obesity and the risk of some cancers. Citation Format: Wambui G. Gathirua-Mwangi, Jianjun Zhang. Components of metabolic syndrome and total cancer mortality. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2168. doi:10.1158/1538-7445.AM2014-2168