Rapid change of global market dynamics makes the survival of startups difficult. This study investigates the integration of startups' marketing approach with proactive market orientation in order to adapt these changing dynamics of the market. Customer orientation, new-product development, innovation orientation and competitiveness are explained as encouraging components of proactive market orientation to be robust and long-run in the in competitive environment. Case studies of the paper are involving the most innovative and valuable brands of the world as well customer-centric. The most fundamental purpose of the paper is to emphasize the importance of marketing approach through those companies’ proactive behaviors. With the continues startup culture, they can give inspirations for the early-stage entrepreneurs while designing their marketing strategies. The article presents a strategic point of view for marketing decisions based on theoretical background of the phenomenon and recommends a holistic roadmap for practitioners in the journey of entrepreneurship. It is also aimed to contribute to the literature and pioneer for the further studies.