Interaction Of Components Research Articles

Exploring You-gui Pill for the Treatment of Diabetic Erectile Dysfunction: Data Mining Analysis, Network Pharmacology and Experiments In Vitro.

The You-gui pill (YGP) is a classical compound used for treating antidiabetic erectile dysfunction (DMED). However, the specific active ingredients responsible for its effects on DMED and their mechanisms remain unclear. In this paper, we used data mining techniques to analyze high-frequency herbs and herb combinations used in Chinese medicine for the treatment of DMED based on existing literature. Using network pharmacology to study the active components and mechanism of action of YGP against DMED, molecular docking was used to analyze the interactions of the active components with major structural proteins, nonstructural proteins, and mutants. Also, the therapeutic effect of YGP on hyperglycemic modelling and its underlying mechanisms were experimentally validated in CCEC cells by analyzing the expression of its relevant target mRNAs. Network pharmacological analysis identified the three core components of YGP as quercetin, kaempferol, and β-sitosterol, and constructed a PPI network map of common targets of YGP and DMED, which included HIF-1α, ALB, Bcl-2, INS, IL-1β, IL-6, TNF-α, CASP3, and TP53. Combined with molecular docking results, these targets had a strong binding affinity between them and the active ingredient compounds, with the highest affinity for HIF-1α and TNF-α. During the in vitro cellular assay validation, the HIF-1α, ALB, Bcl-2, TNF-α, and IL-6 mRNA in CCECs cells showed positive regulation after YGP intervention. The combination of "data mining - network pharmacology - molecular docking - experimental validation" provides a powerful methodological basis for the study of the main active components and mechanism of action of YGP against DMED, as well as the development and application of the drug.

Directional Characteristic Enhancement of an Omnidirectional Detection Sensor Enabled by Strain Partitioning Effects in a Periodic Composite Hole Substrate.

An omnidirectional stretchable strain sensor with high resolution is a critical component for motion detection and human-machine interaction. It is the current dominant solution to integrate several consistent units into the omnidirectional sensor based on a certain geometric structure. However, the excessive similarity in orientation characteristics among sensing units restricts orientation recognition due to their closely matched strain sensitivity. In this study, based on strain partition modulation (SPM), a sensitivity anisotropic amplification strategy is proposed for resistive strain sensors. The stress distribution of a sensitive conductive network is modulated by structural parameters of the customized periodic hole array introduced underneath the elastomer substrate. Meanwhile, the strain isolation structures are designed on both sides of the sensing unit for stress interference immune. The optimized sensors exhibit excellent sensitivity (19 for 0-80%; 109 for 80%-140%; 368 for 140%-200%), with nearly a 7-fold improvement in the 140%-200% interval compared to bare elastomer sensors. More importantly, a sensing array composed of multiple units with different hole configurations can highlight orientation characteristics with amplitude difference between channels reaching up to 29 times. For the 48-class strain-orientation decoupling task, the recognition rate of the sensitivity-differentiated layout sensor with the lightweight deep learning network is as high as 96.01%, superior to that of 85.7% for the sensitivity-consistent layout. Furthermore, the application of the sensor to the fitness field demonstrates an accurate recognition of the wrist flexion direction (98.4%) and spinal bending angle (83.4%). Looking forward, this methodology provides unique prospects for broader applications such as tactile sensors, soft robotics, and health monitoring technologies.

Effects of classical psychedelics on implicit and explicit emotional empathy and cognitive empathy: a meta-analysis of MET task.

This meta-analysis investigates the effect of classic psychedelic drugs on empathy and focuses on cognitive and emotional empathy measured using the Multifaceted Empathy Test (MET). Empathy entails the ability to understand and share the feelings of another and is a significant component of social interaction. Several studies have examined the effects of psychedelic drugs such as LSD, psilocybin and ayahuasca on empathy, yet their overall effect has not been studied so far. In this meta-analysis, we reviewed data from studies up to November 2023 with the aim of examining the effects of various psychedelic drugs on empathic abilities broadly. Our findings suggest that classical psychedelics significantly enhance explicit and implicit emotional empathy without affecting measures of cognitive empathy. The results emphasize the need to continue testing the therapeutic potential of classic psychedelic drugs.

Central Auditory Processing Abilities in Children with Non-Syndromic Cleft Lip and Palate: An Electrophysiological Study.

The present study compared the central auditory processing abilities using electrophysiological tests in children with non-syndromic cleft lip and palate (NSCLP) and their age-matched control group. Thirty children aged 7 to 15 years were recruited for the study. Participants were divided into 2 groups. The clinical group (children with NSCLP) comprised 15 children, while the control group (craniofacially typical peers) comprised 15 children with normal hearing sensitivity and auditory processing skills. Electrophysiological tests, including auditory brainstem responses (ABR), binaural interaction component (BIC) of ABR, auditory late latency responses (ALLR), and P300 were assessed. The results showed deviant responses in ABR, BIC, and ALLR in children with NSCLP compared to craniofacially typical counterparts. However, no significant difference was observed in P300 between the two groups. Children with NSCLP may be at a higher risk of central auditory processing disorder due to their abnormal neural transmission in the auditory nervous system. Also, assessing auditory processing abilities in children with NSCLP should include electrophysiological tests in the test battery for additional information regarding neural transmission.

SPLENDID incorporates continuous genetic ancestry in biobank-scale data to improve polygenic risk prediction across diverse populations.

Polygenic risk scores are widely used in disease risk stratification, but their accuracy varies across diverse populations. Recent methods large-scale leverage multi-ancestry data to improve accuracy in under-represented populations but require labelling individuals by ancestry for prediction. This poses challenges for practical use, as clinical practices are typically not based on ancestry. We propose SPLENDID, a novel penalized regression framework for diverse biobank-scale data. Our method utilizes ancestry principal component interactions to model genetic ancestry as a continuum within a single prediction model for all ancestries, eliminating the need for discrete labels. In extensive simulations and analyses of 9 traits from the All of Us Research Program (N=224,364) and UK Biobank (N=340,140), SPLENDID significantly outperformed existing methods in prediction accuracy and model sparsity. By directly incorporating continuous genetic ancestry in model training, SPLENDID stands as a valuable tool for robust risk prediction across diverse populations and fairer clinical implementation.

THE INFLUENCE OF LOW-MOLECULAR SUBSTANCES ON THE PHASE SEPARATION CAPACITY OF A TWO-PHASE PEG – SODIUM CITRATE – WATER SYSTEM

As is known, two-phase polymer-polymer-water and polymer-electrolyte-water systems (SPIS) are widely used in the separation and purification of biological objects in biotechnology and pharmacology, as well as in the quality control of medicinal products. Depending on the nature of these processes, it is important to purposefully change the separation capacity of SPIS. The aim of the presented research is to ensure that it is adapted to each application object by using different additives to separate and purify biological objects. The presented study investigated the phase diagrams of the water-polymer two-phase system PEG - sodium citrate - water in the presence of certain additives. The influence of additives on the separating ability of the two-phase system PEG - sodium citrate - water was determined. Analysis of the provided data shows that the variation in the parameters of the phase diagram and the different values of the separating ability n* of the two-phase system depending on the nature of the additives is associated with changes in the structure of water under the influence of these factors. This leads to changes in the interaction of the phase-forming components of the two-phase system with water, resulting in differences in the physicochemical properties, particularly the relative hydrophobicities of the two-phase system.

Social Networks as a Tool for Promoting Intangible Cultural Heritage of Ukrainian Regions (based on the materials of the information and communication content of Vinnytsia Regional Centre of Folk Art)

The purpose of the article is to comprehensively investigate the materials of the informational and communicative content of the Internet site and Facebook page of the Vinnytsia Regional Centre of Folk Art and to reveal the essential aspects of the use of social networks in the conditions of a full-scale invasion as an effective tool for the presentation and popularisation of the intangible cultural heritage of Vinnytsia as a region of Central Ukraine. The research methodology consists of general scientific and specific cultural approaches, principles and methods of scientific knowledge. The systemic-structural approach was applied to the study of the organisational and methodological activities of the Vinnytsia Regional Centre of Folk Art, aimed at popularising the intangible cultural heritage of the region. The internal connections and interaction of various components of the cultural and educational activity of the Centre for Cultural and Educational Activities, aimed at the presentation and popularisation of intangible cultural heritage in the conditions of a full-scale invasion, are revealed by the results of monitoring the materials of the Internet pages of the Centre (the Internet site and Facebook pages). Formal and comparative methods were used to analyse the institutional features of work in the Vinnytsia region as a region of Central Ukraine. The method of content analysis was used to generalise the publications of the Internet site and the information of the Facebook page of the Vinnytsia Regional Centre of Folk Art, dedicated to the intangible cultural heritage of Vinnytsia, contributed to the objective determination of the main thematic trends related to the investigated problem. The scientific novelty consists in substantiating, revealing and proving the effectiveness of the use of social networks as a really effective tool for expanding the role of regional centres of folk creativity in the presentation and popularisation of the intangible cultural heritage of Vinnytsia in the information field, in particular in the conditions of a full-scale invasion. On the basis of a practical study of the materials of the informational and communicative content of the Internet site and Facebook page of the Vinnytsia Regional Centre of Folk Art, the traditional culture of Vinnytsia, which contains a preserved living folk artistic culture with a classical / traditional folklore paradigm. The interaction of the Vinnytsia regional centre of folk creativity with institutions, cultural institutions and the external environment in the matter of preservation and popularisation of the intangible cultural heritage of Vinnytsia region was revealed. Conclusions. Summarising the positive experience on the materials of the information and communication content of the Vinnytsia Regional Centre of Folk Art (website and Facebook page) demonstrated concrete achievements in the presentation, popularisation and preservation of the intangible cultural heritage of Vinnytsia in the conditions of a full-scale invasion. It is argued that the digital representation of the content of the intangible cultural heritage of the regions of Ukraine, in particular Central Ukraine, in social networks is a really effective tool for popularising the intangible cultural heritage in the information field. It is concluded that the traditional culture of Vinnytsia contains a preserved living folk artistic culture with a classical / traditional folklore paradigm. It was noted that the employees of centres of folk creativity need to have the skills to work in the spheres of SEO and SMM, which requires constant improvement of professional qualifications and stimulation of scientific and creative approaches in this direction and is a continuously relevant requirement of the time.

Carbon Dots Infused 3D Printed Cephalopod Mimetic Bactericidal and Antioxidant Hydrogel for Uniaxial Mechano-Fluorescent Tactile Sensor.

Cephalopods use stretchy skin and dynamic color-tuning organs for visual communication and camouflage. Inspired by these natural mechanisms, a fluorescent biomaterial for deformation-induced illumination and optical communication is proposed. This is the first report of 3D printed soft biomaterials infused with carbon dots hydrothermally derived from chitosan and benzalkonium chloride. These biomaterials exhibit a comprehensive array of properties, including significant uniaxial stretching, near-instantaneous response to tactile stimuli and pH, UV resistance, antibacterial, antioxidant, noncytotoxicity, and highlighting their potential as mechano-optical materials for biomedical applications. The hydrogel's durability is evaluated by cyclic stretching, folding, rolling, and twisting tests to ensure its integrity and good signal-to-noise ratio. The diffusion mechanism is determined by water imbibition kinetics, network parameters, and time-dependent breathing. Overcoming the common limitations of short lifespans and complex manufacturing processes in existing soft hybrids, this work demonstrates a straightforward method to produce durable, energy-independent, mechano-optical hydrogel. Combined with investigations, molecular dynamic modeling is used to understand the interactions of hydrogel components.

Advances and Challenges of Bioassembly Strategies in Neurovascular In Vitro Modeling: An Overview of Current Technologies with a Focus on Three-Dimensional Bioprinting.

Bioassembly encompasses various techniques such as bioprinting, microfluidics, organoids, and self-assembly, enabling advances in tissue engineering and regenerative medicine. Advancements in bioassembly technologies have enabled the precise arrangement and integration of various cell types to more closely mimic the complexity functionality of the neurovascular unit (NVU) and that of other biodiverse multicellular tissue structures. In this context, bioprinting offers the ability to deposit cells in a spatially controlled manner, facilitating the construction of interconnected networks. Scaffold-based assembly strategies provide structural support and guidance cues for cell growth, enabling the formation of complex bio-constructs. Self-assembly approaches utilize the inherent properties of cells to drive the spontaneous organization and interaction of neuronal and vascular components. However, recreating the intricate microarchitecture and functional characteristics of a tissue/organ poses additional challenges. Advancements in bioassembly techniques and materials hold great promise for addressing these challenges. The further refinement of bioprinting technologies, such as improved resolution and the incorporation of multiple cell types, can enhance the accuracy and complexity of the biological constructs; however, developing bioinks that support the growth of cells, viability, and functionality while maintaining compatibility with the bioassembly process remains an unmet need in the field, and further advancements in the design of bioactive and biodegradable scaffolds will aid in controlling cell adhesion, differentiation, and vascularization within the engineered tissue. Additionally, integrating advanced imaging and analytical techniques can provide real-time monitoring and characterization of bioassembly, aiding in quality control and optimization. While challenges remain, ongoing research and technological advancements propel the field forward, paving the way for transformative developments in neurovascular research and tissue engineering. This work provides an overview of the advancements, challenges, and future perspectives in bioassembly for fabricating neurovascular constructs with an add-on focus on bioprinting technologies.

Combined Efficacy of Q-Switched 785 nm Laser and Tranexamic Acid Cream in the Treatment of Melasma: A Prospective Clinical Study

Background and Objectives: Melasma, a hypermelanotic dermatologic condition that mainly affects women, poses challenges due to its complex etiology involving environmental and genetic factors. Its pathophysiology, marked by intricate histological changes, is not fully understood. This study explored the efficacy and safety of a new 785 nm picosecond laser in treating facial melasma. Materials and Methods: An 11-participant cohort, comprising women with Fitzpatrick phototypes II-III, underwent a treatment protocol with a new 785 nm picosecond laser. The clinical evaluation used the Global Aesthetic International Score (GAIS) and the Five-Point Likert Scale Questionnaire. The aim of the study was to understand the capacity of the 785 nm wavelength laser to interact with both the pigmentary and vascular components of melasma. Results: The GAIS outcomes revealed excellent (18.2%), good (54.5%), poor (18.2%), and no results (9.1%). The Likert Scale responses varied from very satisfied (18.2%) to slightly satisfied (9.1%). Clinical images at three months demonstrated resolution of melasma with no adverse events. Conclusions: This non-invasive procedure showed positive outcomes and high patient tolerance, emphasizing its potential in melasma management. However, in order to fully understand the interactions of pigmentary and vascular components with the 785 nm wavelength laser, further research is required. The small cohort represents a limitation for this study, therefore studies that include a larger number of patients are needed to assess the effectiveness of this laser treatment for facial melasma.

Low noise pavement characterization through TCN analysis

The use of low-noise pavements is a valid solution to reduce road traffic noise at source. Further studies are needed to optimize their design and ensure their durability. In this work, low-noise pavements were characterised using innovative and traditional methods on four different pavements: two of them contained crumb rubber added by dry and wet processes, one had an optimized texture and the last one was a traditional dense asphalt concrete. Using a sensor inside the tyre, the tyre cavity noise (TCN) was recorded and analysed, putting it in relation with the Close Proximity Method (CPX) data and the pavement texture measured by a laser profilometer. This paper aims to improve the knowledge of the relationship between the vibrational components of the tyre-pavement interaction using new and old descriptors, extending the types of pavements studied in past researches.

The Effects of Social Interaction Intervention on Cognitive Functions Among Older Adults Without Dementia: A Systematic Review and Meta-Analysis

Abstract Background and Objectives Previous systemic reviews, predominantly including observational studies, have shown that participation in social activities is a protective factor against cognitive decline. However, this association is subject to potential reverse causality, creating a knowledge gap in our understanding of the effect of social interaction interventions on cognitive function. Therefore, this study aims to conduct a systematic review and meta-analysis of randomized controlled trials to examine the effects of social interaction interventions on cognitive decline among older adults without dementia. Research Design and Methods This systematic review, registered in PROSPERO (CRD42022367828), systematically searched 6 databases from inception to May 6, 2022, to identify relevant articles on the effects of activities with social interaction components on cognitive function in community-dwelling older adults without dementia aged above 60. Two independent reviewers conducted study selection, data extraction, and bias assessment, with RevMan5.3 used for meta-analysis. Subgroup analysis was conducted to assess variation in intervention effects among subgroups. Results We included 11 studies for qualitative analysis and 8 studies for the meta-analysis. The results showed that social interaction intervention had a significant effect on executive function (standardized mean difference [SMD] = 1.60; 95% CI, 0.50 to 2.70; p = .004), but not attention and memory. The subgroup analysis showed a greater cognitive benefit for healthy older adults, but not those with mild cognitive impairment. Moreover, in-person social interaction positively affected global cognition, whereas online interaction did not. Discussion and Implications Social interaction interventions have a limited impact on cognitive function in older adults without dementia but showed potential effects on executive function. This finding offers insights for implementing social intervention in the community.

Marketing mental health services: a mixed-methods analysis of racially and ethnically diverse college students’ engagement with and perspectives on U.S. university mental health clinics’ websites

BackgroundThe United States (U.S.) faces a significant mental health crisis, with around 52.9 million adults experiencing mental health disorders, with young adults (18–25 years old), such as college students, having the highest prevalence and lowest service utilization rates. While efforts to expand mental health services through “push” strategies are in place (e.g., training therapists in evidence-based therapies), limited initial engagement suggests a need for “pull strategies” and targeted marketing that make services attractive to college students and increase demand. This mixed-methods study identifies U.S. university mental health clinic websites and website characteristics that are attractive and engaging to college students interested in seeking mental health services (i.e., students were considering or actively looking for mental health support).MethodsEleven U.S. university websites were chosen (10 randomly and one from the university where students were attending) from a pool of 44 Psychological Clinical Science Accreditation System training clinics websites. Fifty-seven college students (Mage = 20.95, SD = 2.97; 81% female; 68% racial/ethnic minority) were videorecorded engaging with two U.S. university mental health clinic websites, completed self-report engagement measures, and gave detailed feedback about websites through semi-structured interviews.ResultsLikert scale scores revealed moderate engagement with all websites (e.g., they were interesting and helpful). Qualitative results indicated that websites that provided important and easily understood information about key features of services (e.g., types, evidence-base, and cost), therapist backgrounds, psychoeducation, used lay language, and had an appealing website layout (e.g., color, font, images, organization, and interactive components) generated greater consumer interest and trust in their mental health services.ConclusionsThis study emphasizes the importance of using marketing strategies to enhance college students’ engagement through mental health service websites. Salient features, psychoeducation, and effective promotional strategies (e.g., how information is presented) were identified as crucial for website engagement and subsequent mental health service uptake. Using marketing strategies, such as tailoring language to consumer literacy levels, describing the evidence-base of services, and improving website design may address college students’ needs and enhance initial mental health service engagement.

Data caching technologies in modern microprocessors

Objective. The study presented in the paper is aimed at studying the methods for improving the efficiency of software in modern computing systems with a hierarchical memory structure. Method. The study is based on data caching technologies in microprocessors. Result. The article presents the results of the analysis of various approaches to the development of efficient software taking into account the characteristics of the memory subsystem of the computing system, which made it possible to prove the importance of cache memory in improving the performance and interaction of computer components. Conclusion. Cache memory is a critical element in the architecture of microprocessors, playing a key role in determining the performance of the computing system. Optimizing the use of cache can significantly improve data access time and, as a result, overall system performance. Software developers need to pay special attention to the characteristics of the memory subsystem when designing and implementing solutions.

An investigation of the relationship between social networking site activities and muscle dysmorphia in young men

While the connection between social networking sites (SNSs) and body image has been reported more broadly in prior literature, the link between SNSs and muscle dysmorphia (MD) is less understood. The aim of this study was to investigate the strength and nature of the relationship between MD and SNSs among men in the general population. With SNSs allowing users to view and interact with online content, this study focussed on three SNS activities: (a) viewing men’s celebrity and fashion content, (b) viewing fitness-related content and (c) the importance of received likes and comments. Young men ( N = 95) completed an online questionnaire recording demographic information, SNS activities and MD symptomatology. A hierarchal regression revealed that the importance of received likes and comments significantly predicted MD symptomatology over and above demographic factors. These findings reflect a need to emphasise the interactive components of SNSs within body image literature.

Mechanism of tetracycline sorption on carbon-bentonite

Antibiotics increased industrial production is the reason of their occurrence in wastewater, soils, groundwater, and drinking water. In this regard, treating the environment for pharmaceuticals is one of the urgent environmental challenges. Synthesis of adsorbents using different types of raw materials by the methods of mechanochemical activation makes it possible to significantly increase their sorption capacity due to the accumulation of various kinds of defects in the crystal structure of the adsorbent. We obtained the bentonite-carbon composite using roller-ring vibratory mill with coal-bentonite ratio of 30 : 70 and 50 : 50. However, the nature of the interaction between carbon and bentonite correlates with changes of surface area and porosity. The porous structure parameters of the samples show the mechanochemical activation of the mixture involves their components interactions. The authors studied the structural and chemical changes during the modification of bentonite with activated carbon by analysing the vibrational spectra of carbon, initial, and modified aluminosilicate samples. According to infrared spectroscopy of adsorbents, absorption bands characteristic of Si-O-C bond vibrations occurred. The paper investigates the sorption capacity of mechanochemically modified natural clay mineral Dash-Salakhli bentonite towards tetracycline hydrochloride. Research investigates the kinetics of the process and rapid sorption of tetracycline. The paper provides possible mechanisms of chemisorption due to donor-acceptor interaction and ion-exchange processes.

Strategic housing decisions and the evolution of urban settlements: optimality modelling and empirical application in Ulaanbaatar, Mongolia.

Investments in housing influence migration and landscape construction, making them a key component of human-environment interactions. However, the strategic decision-making that builds residential landscapes is an underdeveloped area of research in evolutionary approaches to human behaviour. Our contribution to this literature is a theoretical model and an empirical test of this model using data from Ulaanbaatar, Mongolia. We develop a model of strategic housing decisions using stochastic dynamic programming (SDP) to explore the trade-offs between building, moving and saving over time, finding different trade-offs depending on optimization scenarios and housing costs. Household strategies are then estimated using data on 825 households that settled in the Ger districts of Ulaanbaatar between 1942 and 2020. The Ger districts are areas of self-built housing that feature both mobile dwellings (gers) and immobile houses (bashins). Using approximate Bayesian computation (ABC), we find the parameters of our dynamic programming model that best fit the empirical data. The model is able to capture the time horizon of housing changes and their bi-directionality, showing that moving from a fixed to mobile dwelling can also be an optimal strategy. However, the model underpredicts household persistence in dwelling types. We discuss deviations from model predictions and identify a more detailed exploration of risk and population mixes of strategies as key steps for future research.

Retinoic acid and TGF-β orchestrate organ-specific programs of tissue residency

Tissue-resident memory T (TRM) cells are integral to tissue immunity, persisting in diverse anatomical sites where they adhere to a common transcriptional framework. How these cells integrate distinct local cues to adopt the common TRM cell fate remains poorly understood. Here, we show that whereas skin TRM cells strictly require transforming growth factor β (TGF-β) for tissue residency, those in other locations utilize the metabolite retinoic acid (RA) to drive an alternative differentiation pathway, directing a TGF-β-independent tissue residency program in the liver and synergizing with TGF-β to drive TRM cells in the small intestine. We found that RA was required for the long-term maintenance of intestinal TRM populations, in part by impeding their retrograde migration. Moreover, enhanced RA signaling modulated TRM cell phenotype and function, a phenomenon mirrored in mice with increased microbial diversity. Together, our findings reveal RA as a fundamental component of the host-environment interaction that directs immunosurveillance in tissues.

Матрица когнитивных фильтров – инструмент анализа лингвокреатем в современном онлайн-дискурсе на английском языке

The article introduces the matrix of cognitive filters as a research method that makes it possible to model the process of inferring the meaning of lingua-createmes in multimodal online discourse. Multimodal linguistic systems are based on a complex interaction of multimodal components. These components combine with basic cognitive mechanisms in decoding various complex phenomena in digital Internet discourse. The research revealed a classification of key cognitive mechanisms that generate the meaning of creative multimodal elements: banner blindness, evaluative categorization, conceptualization, (de)compression of information, profiling, conceptual metaphor, conceptual metaphthonymy, and conceptual integration. The research material involved 18,000 monomodal verbal and multimodal lingua-createmes selected by continuous sampling from English-language Internet resources, as well as visual and verbal corpora. The method proved effective in modelling the general cognitive resonance of lingua-createmes and predicting cognitive resonance / dissonance (positive or negative) in communication. The practical lingua-cognitive experiment involved 335 English-speaking respondents from eleven countries. They were asked to use the matrix of cognitive filters to perform a step-by-step decoding of several creative multimodal elements. The method proved highly effective for detecting cognitive resonance or mental tension, i.e., positive or negative cognitive dissonance. The method demonstrated good prospects for obtaining additional data on reactions to lingua-creative discursive elements.

Interface-Interactive Nanoarchitectonics: Solid and/or Liquid.

The methodology of nanoarchitectonics is to construct functional materials using nanounits such as atoms, molecules, and nanoobjects, just like architecting buildings. Nanoarchitectonics pursues the ultimate concept of materials science through the integration of related fields. In this review paper, under the title of interface-interactive nanoarchitectonics, several examples of structure fabrication and function development at interfaces will be discussed, highlighting the importance of architecting materials with nanoscale considerations. Two sections provide some examples at the solid and liquid surfaces. In solid interfacial environments, molecular structures can be precisely observed and analyzed with theoretical calculations. Solid surfaces are a prime site for nanoarchitectonics at the molecular level. Nanoarchitectonics of solid surfaces has the potential to pave the way for cutting-edge functionality and science based on advanced observation and analysis. Liquid surfaces are more kinetic and dynamic than solid interfaces, and their high fluidity offers many possibilities for structure fabrications by nanoarchitectonics. The latter feature has advantages in terms of freedom of interaction and diversity of components, therefore, liquid surfaces may be more suitable environments for the development of functionalities. The final section then discusses what is needed for the future of material creation in nanoarchitectonics.