This paper presents the experimental findings from a research program investigating the blast performance of cross-laminated timber (CLT) panels with idealized and realistic boundary conditions. A total of twenty-seven static and simulated blast tests were undertaken on 5-ply CLT panels with the aim to quantify the high strain-rate effects in the connections. Two types of CLT end connections were tested, namely a relatively thin off-the-shelf angle and a thicker in-house manufactured angle, both of which used screw fasteners. Component-level testing was conducted on the connections in order to quantify their behaviour in isolation prior to incorporating them into full-scale CLT assemblies. A statistically significant dynamic increase factor (DIF) was obtained for the connections in which the failure mode consisted mainly of wood crushing and angle bending, whereas no DIF was observed for the connections where yielding and rupturing of the steel screw fasteners were the predominant failure modes. The highly-deformable thin angle connection was found to be greatly affected by axial restraint. A two-degree-of-freedom blast analysis software that was developed and validated using the experimental results, showed reasonable ability to predict the response of the CLT assemblies. The software was able to predict the displacement as well as the correct failure mode when proper modelling inputs were utilized.