Complication Of Dengue Fever Research Articles

Characteristics and Ophthalmic Manifestations of the Classic Dengue Fever Epidemic in Singapore (2005-2006).

The aim of this study was to report the characteristics and ophthalmic manifestations associated with dengue fever (DF) in the 2005-2006 DF epidemic in Singapore. A retrospective case series. Eleven patients (7 males, 4 females) who were 14 to 40 years old (mean age, 27.3 years) with visual complaints occurring 1 to 2 weeks after the onset of DF underwent a complete ophthalmologic examination. The presenting visual acuity (VA) ranged from 6/6 to counting fingers. Five patients had bilateral eye involvement. Ophthalmic findings included retinal hemorrhages (15 eyes), cotton wool spots (15 eyes), retinal pigment epithelium alterations (5 eyes), optic disc swelling (3 eyes), foveolitis (3 eyes), and hyperemia (2 eyes). Impaired color vision was noted in 12 eyes. Visual field defects were noted in 13 eyes; 4 of these eyes were asymptomatic. Fundus fluorescein angiography was done in 9 patients; the findings include choroidal hyperfluorescence (9 eyes), blocked fluorescence (8 eyes), and capillary nonperfusion (1 eye). In 2 eyes, it was normal. Electrophysiology confirmed optic neuropathy in 3 eyes and maculopathy in 1 eye. The follow-up ranged from 12 days to 12 months. The VA at the last follow-up ranged from no light perception to 6/6. Visual field abnormalities were noted in 5 eyes despite a normal VA. Dengue fever is associated with a wide spectrum of ophthalmic manifestations. Rarely, ophthalmic complications in DF can result in permanent visual impairment. Further work can be done to elucidate the relationship between systemic and ocular manifestations of DF.

Isolated Bell's palsy – An unusual presentation of dengue infection

Dengue fever is a very common arthropod – borne infection in tropical countries. Neurological complications in dengue fever are relatively uncommon and among these, isolated cranial neuropathies have been reported only very rarely. We present an unusual neurological complication of Bell's palsy (lower motor neuron 7 th nerve palsy) associated with dengue infection. To the best of our knowledge, there have been very few documented cases of Flavivirus causing isolated Bell's palsy.

Spontaneous splenic rupture in dengue fever with non-fatal outcome in an adult

A 26-year-old male presented with fever for five days and abdominal pain for 24 hours. System examination identified a soft abdomen with diffuse tenderness. CT-abdomen findings were consistent with splenic rupture with intra and peri-splenic hematoma. Laboratory investigations showed a platelet count of 40,000 per mm(3). In due course he developed hypotension and underwent splenectomy. Non-structural protein 1 (NS1) dengue antigen was positive in the admission sample and IgM dengue antibodies were detected in the follow-up sample. Histopathology of the spleen showed normal architecture with no evidence of hyperplasia, cellular infiltrates or haematological malignancy. Splenic rupture is a rare, but potentially fatal complication of dengue fever and severe dengue which should be suspected when a patient presents with abdominal pain and hypotension. Our case highlights the occurrence of splenic rupture in the viremic phase of dengue illness before the development of IgM antibodies.

Myocarditis Complicating Pregnancy in Dengue Hemorrhagic Fever

Dengue hemorrhagic fever (DHF) is a spectrum of disease ranging from uncomplicated febrile illness to various devastating hemorrhagic manifestation and refractory shock. Cardiac complication in dengue fever (DF) is not common. Myocarditis has been a known complication of dengue fever. We report the case of myocarditis complicating DHF in a 34 years old female at 36 weeks of gestation with probable fetal myopericarditis.

Management of Severe Refractory Thrombocytopenia in Dengue Hemorrhagic Fever With Intravenous Anti-D Immune Globulin

Dengue hemorrhagic fever (DHF) is a potentially lethal complication of dengue fever due to shock and/or bleeding. Bleeding in DHF is due to thrombocytopenia and/or coagulopathy. The authors present their experience of usage of intravenous anti-D in 5 children with DHF and severe refractory thrombocytopenia (<10,000/mm3). It was administered in a dose of 50 to 75 μg/kg. Mean platelet count was 6800/mm3 before and 33,600, 44,600, and 79,000/mm3 after intravenous anti-D administration at 24, 48, and 72 hours, respectively. Average drop in hemoglobin after administration of anti-D was 2.28 g/dL. Intravenous anti-D can possibly be a treatment option for refractory thrombocytopenia in DHF.

DENGUE FEVER

One of the major health hazards that has erupted in Pakistan within the recent past years and has caused loss of life of many young people is Dengue Fever. Objective: Main objective was to find clinico-pathologic parameters which are essentially associated with complications and contribute to the adverse outcome. Material &amp; Methods: This prospective study was conducted on 106 seropositive cases of dengue fever. Patients were taken from Abbasi Shaheed Hospital, Karachi from June 2008 to March 2009. Results: The most common hematological abnormalities were thrombocytopenia and leucopenia. Platelets count below 50 × 103/ μL was seen in (78%) cases and 49 % patients had total white cell count below 4 ×103 /μL. Partial thromboplastin time was significantly prolonged in (26%) cases whereas prothrombin time was normal in all patients. Liver enzymes both Aspartate Aminotransferase (AST) and Alanine Amino-transferase were significantly elevated in (60%) patients. Blood urea nitrogen (BUN) and creatinine was deranged in (23%) patients. Conclusions: Fever was the most common clinical presentation( 86 % of the patients). Hematological parameters (low platelet count, low total leucocytes count, prolonged APTT and raised hematocrit) and biochemical parameters (raised aminotransferases, blood urea nitrogen) have strong association with the complications of dengue fever and hence are associated with the poor outcome of disease.

Splenic necrosis as a rare complication of dengue fever

Splenic necrosis as a rare complication of dengue fever

Bilateral acute angle closure glaucoma in a patient with dengue fever: case report

Ocular complications in dengue fever are uncommon but may result in visual loss. The authors report the first documented case of a patient with dengue fever who presented with simultaneous bilateral acute angle closure glaucoma. The disease was confirmed by specific serological tests. Despite the treatment, severe visual impairment occurred in this case.

Maculopathy and Dengue

To the Editor: We thank Su and Chee (1) for their interest in our article, “Retinal Hemorrhages in 4 Patients with Dengue Fever” (2). We reported the findings of this small case series to highlight the presence of retinal hemorrhage as a manifestation of ophthalmic complication in patients with dengue fever. We wanted to describe characteristic clinical features (such as association of onset of visual symptoms with resolution of fever and nadir of thrombocytopenia) and propose epidemiologic explanations for the sudden rise in the incidence of observed ocular complications of dengue fever in our population. Our article did not attempt to conclude that the retinal hemorrhages were responsible for the patients’ visual symptoms, as suggested by Su et al. In fact, we stated that in all 4 patients “fundoscopic examination showed macular hemorrhages and exudative maculopathy.” The range of dengue-related ophthalmic complication is still being investigated, and we agree with Su and Chee that other ophthalmic manifestations may occur in patients with dengue fever. In a retrospective observational case series involving 22 eyes of 13 patients with visual impairment from dengue infection, carried out in our hospital, Chan et al. (3) found evidence of retinal hemorrhage, macular edema, cotton wool spots, retinal vasculitis, exudative retinal detachment, and anterior uveitis. Therefore, physicians and ophthalmologists should be aware of the possibilities of ophthalmic complications in the management of patients with dengue fever.

A novel dengue fever (DF) and dengue haemorrhagic fever (DHF) analysis using artificial neural network (ANN)

Dengue fever (DF) is an acute febrile viral disease frequently presented with headache, bone or joint and muscular pains, and rash. A significant percentage of DF patients develop a more severe form of disease, known as dengue haemorrhagic fever (DHF). DHF is the complication of DF. The main pathophysiology of DHF is the development of plasma leakage from the capillary, resulting in haemoconcentration, ascites, and pleural effusion that may lead to shock following defervescence of fever. Therefore, accurate prediction of the day of defervescence of fever is critical for clinician to decide on patient management strategy. To date, no known literature describes of any attempt to predict the day of defervescence of fever in DF patients. This paper describes a non-invasive prediction system for predicting the day of defervescence of fever in dengue patients using artificial neural network. The developed system bases its prediction solely on the clinical symptoms and signs and uses the multilayer feed-forward neural networks (MFNN). The results show that the proposed system is able to predict the day of defervescence in dengue patients with 90% prediction accuracy.

Dengue Fever as A Cause of Acute Disseminated Encephalomyelitis (ADEM)

Dengue fever is very common in Bangladesh. Every year a large number of urban populations suffer from this viral infection. Various presentations of dengue fever have been documented. Neurological complications in dengue fever are relatively uncommon. Among these, Acute Disseminated Encephalomyelitis (ADEM) has been observed in very few cases. Here we present a case of 13 year old girl suffering from ADEM following dengue fever. Keyword: Acute Disseminated Encephalomyelitis, Dengue fever, Neurological complication.DOI: http://dx.doi.org/10.3329/jom.v12i2.8428 JOM 2011; 12(2): 185-187

The ocular complications of dengue fever during the last epidemic in Greece

The ocular complications of dengue fever during the last epidemic in Greece

The Ocular Complications of Dengue Fever

This paper calls attention to dengue as probably a cause of such paralyses as are known to be associated with diphtheria, and gives reasons for the belief in such association, and the fact that it has been hitherto overlooked.