You have accessJournal of UrologyHealth Services Research: Quality Improvement & Patient Safety II (MP34)1 Sep 2021MP34-17 INFECTIOUS COMPLICATIONS AFTER PROSTATE BIOPSY DESPITE APPROPRIATE ANTIBIOTIC REGIMEN Valentina Grajales, Jonathan Lin, Michelle Yu, Kelly Pekala, Adam Sharbaugh, Toby Zhu, Hermoon Worku, Kody Armann, Chandler Hudson, Jordan Hay, Benjamin Davies, and Bruce Jacobs Valentina GrajalesValentina Grajales More articles by this author , Jonathan LinJonathan Lin More articles by this author , Michelle YuMichelle Yu More articles by this author , Kelly PekalaKelly Pekala More articles by this author , Adam SharbaughAdam Sharbaugh More articles by this author , Toby ZhuToby Zhu More articles by this author , Hermoon WorkuHermoon Worku More articles by this author , Kody ArmannKody Armann More articles by this author , Chandler HudsonChandler Hudson More articles by this author , Jordan HayJordan Hay More articles by this author , Benjamin DaviesBenjamin Davies More articles by this author , and Bruce JacobsBruce Jacobs More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002043.17AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Rising antibiotic resistance has driven antibiotic stewardship to minimize antibiotic use while maintaining low peri-procedural infectious complications. Our objective was to assess if appropriately augmented antibiotic regimen during transrectal prostate biopsies would reduce infectious complications in high-risk patients based on our departmental antibiotic stewardship protocol METHODS: A retrospective review of 413 patients undergoing transrectal prostate biopsies were done from January 1st to December 31st, 2020 during the implementation of our antibiotic stewardship protocol. We implemented a survey in clinic designed to identify high risk patients pre-prostate biopsy. High- risk patients received augmented antibiotics with either ceftriaxone or gentamicin in addition to one standard dose of a fluoroquinolone. We fit multivariable logistic regression models to assess the relationship between antibiotic regimen and infectious complications. RESULTS: Of the 413 patients who underwent transrectal prostate biopsies, 22 (5%) had 30-day infectious complications. The majority of patients, 338 (82%) received appropriate antibiotics as dictated by our protocol. Of the 22 patients with infectious complications, 9 (41%) received augmented antibiotics as indicated, 2 (10%) did not receive augmented antibiotics as indicated, 1 (4%) received augmented antibiotics when not indicated, 9 (41%) did not receive augmented antibiotics as indicated and 1(4%) was unknown. Inappropriate antibiotic regimen received was not an independent predictor of increased infectious complications (odds ratio [OR] 1.37, 95% CI 0.28-6.78) CONCLUSIONS: The majority of our patients received appropriate antibiotics during our intervention. Despite augmented antibiotics, over 40% of infections occurred in this group. Further intervention beyond antimicrobial augmentation should be considered for these high-risk patients such as rectal swab cultures, longer duration of antibiotics or change to perineal prostate biopsy. Source of Funding: Bruce L. Jacobs, MD MPH is supported in part by the Shadyside Hospital Foundation © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e623-e623 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Valentina Grajales More articles by this author Jonathan Lin More articles by this author Michelle Yu More articles by this author Kelly Pekala More articles by this author Adam Sharbaugh More articles by this author Toby Zhu More articles by this author Hermoon Worku More articles by this author Kody Armann More articles by this author Chandler Hudson More articles by this author Jordan Hay More articles by this author Benjamin Davies More articles by this author Bruce Jacobs More articles by this author Expand All Advertisement Loading ...