Complications Of Bronchial Asthma Research Articles

Singlet oxygen -derived nerve growth factor exacerbates airway hyperresponsiveness in a mouse model of asthma with mixed inflammation

BackgroundRefractory asthma, which is caused by several factors including neutrophil infiltration is a serious complication of bronchial asthma. We previously reported that nerve growth factor (NGF) is involved in AHR. NGF-derived induction of hyperalgesia is dependent on neutrophils; however, this relationship remains unclear in respiratory disease. In this study, we examined the roles of neutrophils and NGF in refractory asthma. MethodsUsing intranasal house dust mite sensitization, we established a mouse model of asthma with mixed inflammation (Mix-in). AHR, NGF production and hyperinnervation of the lungs were examined with or without different inhibitory treatments. The levels of the singlet oxygen markers, 10- and 12-(Z,E)-hydroxyoctadecadienoic acids (HODE) in the lungs, were measured by liquid chromatography-tandem mass spectrometry. An in vitro experiment was also performed to evaluate the direct effect of singlet oxygen on NGF production. ResultsNGF production and hyperinnervation were higher in Mix-in mice than in conventional eosinophilic-asthmatic mice and were positively correlated with AHR. Asthmatic parameters were inhibited by NGF neutralizing Abs and myeloperoxidase (MPO) inhibition. The 10- and 12-(Z,E)-HODEs levels were increased in the lungs and were positively correlated with MPO activity and NGF production. NGF was produced by bronchial epithelial cells in vitro upon stimulation with singlet oxygen. ConclusionsOur findings suggest that neutrophil MPO-derived singlet oxygen induces increased NGF production, leading to AHR and 10- and 12-(Z,E)-HODEs production. These findings may help to develop new therapies targeting this mechanism and to establish a new biomarker for non-type 2 and refractory asthma.

Compound Unani formulations used in Zeeq-un-Nafas (Bronchial Asthma) with their therapeutic importance: An overview

Asthma is one of the most common chronic diseases in modern society and there is increasing evidence to suggest that its incidence and severity are increasing. There is a high prevalence of usage of complementary medicine for asthma. Current estimates suggest that 300 million people worldwide suffer from Bronchial asthma. This disease is very well recognized since ancient times in Unani system of medicine. Various ancient Unani Scholars and Physicians have use different Arabic terms like Rabu (short inspiration and prolonged expiration), Buhar, Dama, Intesab-un-Nafas and Zeequn Nafas under the caption of bronchial asthma. They also described the etiopathological factors, clinical features, types, and various complications of bronchial asthma that are presented in detail in their concerning treatises. Unani physicians have been treating this disease for thousands of years and they have mentioned various single as well as compound drugs viz; Kakra Seenghi (Pistacia integerrima) Arusa (Adhatoda vasica), Ajmod (Apium graveolens), Aslussoos (Glycyrrhiza glabra), Bazrul banj (Hyoscyamus niger), Biskhapra (Trianthema portulaca), Doodhi (Euphorbia hirta), Nil(Indigofera: tinctoria), Qinnab (Cannabis sativam) etc. and the compound formulations in the forms of - Kushta, Majoon , Hubb, Sharbat, Arqiyat, Joshanda, Khenshanda, Laooq ,Tiryaq, Sikanjabeen, Rub, Roghaniyat for its treatment. The relevance formulations have been described in this review paper with their ingredients and usage also to provide the benefit to the students and researchers for their further researches

Pneumorrhachis as a complication of bronchial asthma: computed tomography findings.

Pneumorrhachis as a complication of bronchial asthma: computed tomography findings.

Emphysème épidural compliquant un asthme bronchique

Epidural emphysema is an exceptional complication of bronchial asthma, revealed by an incidental finding in chest tomography. We report a case of a 21-year-old man admitted with asthma attack complicated by subcutaneous and mediastinal emphysema. Chest tomography confirmed the mediastinal emphysema and also revealed the epidural emphysema within the vertebral canal. Neurological examination was negative. The patient showed complete recovery 10days after the onset of symptoms. The epidural emphysema is a rare complication during asthma attacks. The benignity of this complication should not require a systematic chest tomography.

Asthma knowledge and behaviours among mothers of asthmatic children in Aseer, south-west Saudi Arabia

Mothers of children with bronchial asthma consecutively admitted to Aseer central hospital, Saudi Arabia (n = 171), were interviewed using a questionnaire based on the Chicago Community Asthma Survey to study their knowledge and behaviours concerning bronchial asthma. The least known information among mothers was the complications of bronchial asthma. Breathing exercises during asthma attacks were the least practised behaviour. In a multivariate analysis, significant risk factors for poor knowledge and behaviours among mothers were female sex of the child, illiterate mother and young age of mother (< 30 years). More education is needed to help the mothers of asthmatic children to acquire the necessary knowledge and practices to care for their children.

Pneumorrhachis, pneumomediastinum, pneumopericardium and subcutaneous emphysema as complications of bronchial asthma

Pneumorrhachis (PR), or epidural emphysema, denotes the presence of air in the spinal epidural space. It can be associated with a variety of etiologies, including trauma; recent iatrogenic manipulations during surgical, anesthesiological and diagnostic interventions; malignancy and its associated therapy. It usually represents an asymptomatic epiphenomenon but also can be symptomatic by itself as well as by its underlying pathology. The pathogenesis and etiology of PR are varied and can sometimes be a diagnostic challenge. As such, there are no standard guidelines for the management of symptomatic PR, and its treatment is often individualized. Frequently, multidisciplinary approach and regimes are required for its management. PR associated with bronchial asthma is extremely rare, and only very few cases are reported in the literature. Here, we report a case of a 17-year-old Saudi male patient who is a known case of bronchial asthma; he presented with extensive subcutaneous emphysema, pneumomediastinum, pneumopericardium and pneumorrhachis as complications of an acute exacerbation of his primary ailment.

Protocols constructed around the nursing process. 1: Asthma.

The author provides a nursing process style protocol for dealing with acute attacks of bronchial asthma in adult patients. Diagnoses, laboratory work, tests, treatment plans, including interventions for nurses, nurse practitioners, and physicians, are outlined. In addition, possible complications of bronchial asthma are listed and suggestions for patient education are offered.

A Case of Mediastinal and Subcutaneous Emphysema as a Complication of Bronchial Asthma

A Case of Mediastinal and Subcutaneous Emphysema as a Complication of Bronchial Asthma

Rare complications of bronchial asthma.

A case history of bronchogenic polyps, which was a complication of bronchial asthma and pulmonary emphysema, was presented. This case is interesting due to the fact that it is unique, and I have never seen a similar case in the literature or in practice and can find no allergist or pathologist who has seen the like.

Childhood Status Asthmaticus

The complications of bronchial asthma are increasing. This paper presents clini cal and laboratory data obtained from a group of children admitted in status asthmaticus to Children's Hospital of Philadelphia and describes in detail the program of management which emerged from study of these data. Speculations are also made regarding the pathophysi ology of this illness.

Complications of bronchial asthma.

Complications of bronchial asthma.

Complications of bronchial asthma.

Complications of bronchial asthma.

Mediastinal Emphysema Occurring During an Acute Paroxysm of Bronchial Asthma

MEDIASTINAL emphysema is being recognized with greater frequency, and its clinical and roentgen features are now well established. There are many exciting factors, bronchial asthma being one of the less frequent. Schwartz (1), in 1945, was able to collect from the literature 25 cases of mediastinal and subcutaneous emphysema occurring as a complication of bronchial asthma, and added one case of his own. Since that time (through 1946) two more cases have been reported (2, 3). A case is now being presented to record this phenomenon in the roentgen literature. Macklin and Macklin's theory for the production of mediastinal emphysema is generally accepted. The mechanism of production is the same regardless of the exciting factor. In bronchial asthma the sequence of events is probably as follows: A pressure gradient is created in the pulmonary alveoli due to the increased alveolar pressure and the decrease in caliber of the pulmonary vessels resulting from the prolonged expiratory phase of the lungs. As a result of this gradient, a so-called “marginal type” of alveolus ruptures and air escapes into the interstitial pulmonary tissue. (A “marginal type” of pulmonary alveolus is one in which the base of the alveolus borders on another structure such as a bronchus, bronchiole, blood vessel, connective tissue, or pleura, in contrast to the “partitional type,” whose bases lie between alveoli.) Upon reaching the interstitial pulmonary tissue, the air spreads along the vascular sheaths to the mediastinum, where it results in mediastinal emphysema. After reaching the mediastinum the air may enter the soft tissues of the neck and chest wall, or may pass downward along the aorta and esophagus to reach the retroperitoneal space. Pneumothorax or pneumoperitoneum may complicate mediastinal emphysema. Case Report R. L., a white female, age 19, had been having acute paroxysms of bronchial asthma for several years. Early one morning, during an attack, she suddenly felt something “snap” in her upper chest, following which her neck began to swell. When seen at the Clinic about six hours later, she presented a moderate degree of subcutaneous emphysema of the neck and anterior chest wall. Auscultation of the chest revealed a peculiar sound in the region of the cardiac apex described by the clinician as “crunching” in character (Hamman's sign). In addition to dyspnea, the patient also complained of difficulty in swallowing solid foods. A chest film (Fig. 1) clearly showed the mediastinal collection of air, and the subcutaneous emphysema of the neck and superior chest wall. No film studies of the esophagus or abdomen were made. The patient was treated for her asthma and when she was seen two weeks later all signs and symptoms of the mediastinal emphysema had disappeared. Certain features concerning this complication of bronchial asthma are worth enumerating.

THE PRESENT STATUS OF BRONCHOSCOPY IN BRONCHIAL ASTHMA

Article1 February 1936THE PRESENT STATUS OF BRONCHOSCOPY IN BRONCHIAL ASTHMALOUIS H. CLERF, M.D., F.A.C.P.LOUIS H. CLERF, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-8-1050 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a discussion of bronchial asthma one should bear in mind that patients sent as cases of asthma for investigation or treatment often present signs or symptoms that do not conform to the textbook description of this condition. In other words, there are many pathologic conditions that simulate asthma and may be regarded clinically as such. It is only by a careful study that the correct diagnosis is made. The rôle of bronchoscopy in bronchial asthma therefore includes the investigation of the tracheobronchial tree to rule out certain conditions that might simulate asthma. In addition bronchoscopy permits the collection of...Bibliography BROWN GT: The diagnosis of bacterial allergy, South. Med. Jr., 1934, xxvii, 856. CrossrefGoogle Scholar CLARKE JA: Pulmonary atelectasis as a complication of bronchial asthma, Arch. Int. Med., 1930, xlv, 624. CrossrefGoogle Scholar CLERF LH: Bronchoscopy as an aid in diagnosis and treatment of bronchial asthma, Jr. Am. Med. Assoc., 1927, lxxxix, 872. CrossrefGoogle Scholar FLETCHER GW: Asthma from the standpoint of the rhinologist, Manitoba Med., 1935. Google Scholar HALLIDAY AA: On the bronchoscopic method of diagnosis and treatment of certain disorders of the lungs and bronchi, Canad. Med. Assoc. Jr., 1927, xvii, 561. Google Scholar JACKSON C: Chronic nonspecific infection of the lungs, Jr. Am. Med. Assoc., 1926, lxxxvii, 727. Google Scholar KERN RA: Problems in diagnosis and treatment of bronchial asthma and hay fever, Atlantic Med. Jr., 1926, xxix, 334. Google Scholar LUKENS RM: Bronchoscopy in the treatment of asthma, Laryngoscope, 1925, xxxv, 227. Google Scholar MOORE WF: Ciliary inhibition or destruction in tracheobronchial asthma, Am. Jr. Med. Sci., 1925, clxix, 799. CrossrefGoogle Scholar WEILLE FL: Studies in asthma, New Eng. Jr. Med., 1931, ccv, 848. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication November 25, 1935. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBACTERIAL VACCINES IN THE TREATMENT OF BRONCHIAL ASTHMAAsthma bronchialeLXXXII The Allergic Factor in Chronic Bronchopulmonary InfectionsBronchoscopic therapy in allergic asthmaUSE AND ABUSE OF BRONCHOSCOPY IN ALLERGIC ASTHMALXXIV Bronchopulmonary Infections in Allergic IndividualsSurvey of bronchial asthma in soldiers: Bronchoscopic findings and incidence of respiratory infectionXCV Recent Advances in Otolaryngologic AllergyAllergy as related to otolaryngology and ophthalmologyProgress in asthma and hay fever 1 February 1936Volume 9, Issue 8Page: 1050-1056KeywordsAsthmaBronchoscopySigns and symptoms ePublished: 1 December 2008 Issue Published: 1 February 1936 PDF downloadLoading ...