Related Complications Research Articles

Russia’s Foreign Policy Priorities in the Arctic Region Development at Current Stage

The article reviews the features of the processes in the Arctic region in the context of its growing importance in world politics and economics. The Arctic has the richest resources in the world. In the depths of the Arctic there is about a third of all the world’s reserves of natural gas and up to 13% of oil, huge reserves of coal, gold, copper, nickel, tin, platinum, and manganese. The growing dependence of the world economy on energy resources is pushing foreign countries to develop their interests in this region. Russia occupies a unique geopolitical position in the Arctic. The Arctic zone of Russia is singled out as a special object of state policy on the basis of its special national interests in the areas of geopolitics, economics, ecology, science, defense and national security. The development of mutually beneficial international cooperation in the Arctic meets the interests of Russia and its socioeconomic development. International cooperation in the Arctic is greatly influenced by the contradictory trends in modern international relations. As a result of the confrontation unleashed by Western countries against Russia, there was a significant complication of relations within the Arctic community. The Western Arctic states have blocked the development of common approaches to solving the most important issues for the region in the modern Arctic. In these conditions, Russia is building a multi-vector policy in the Arctic, which has brought positive results in attracting friendly states to partner cooperation on the implementation of projects in the Russian Arctic zone.

Is Bedtime Media Use Good or Bad? A Competitive Analysis Between the Sleep Displacement Hypothesis and the Media Recovery Hypothesis

ABSTRACT Bedtime media use is often maligned in research and pop culture. However, the evidence for the relationship between bedtime media use and sleep for adults has been mixed – sometimes sleep quality is negatively affected by media use, sometimes it is positively affected. Competing explanations include the sleep displacement hypothesis (i.e. media use leads to later sleep onset, less total sleep, and lower sleep quality) and the media recovery hypothesis (i.e. media use helps reduce stress, and this relaxation helps people fall and stay asleep). Two retrospective diary studies test these competing hypotheses in an undergraduate sample (n = 200) and a general population U.S. adult sample (n = 202). Overall, results provide more support for the sleep displacement hypothesis than for the media recovery hypothesis. However, some evidence suggests potential for positive relationships between media use and sleep. More work is needed to explicate the complicated relationship between bedtime media use and sleep.

Transforming healthcare performance monitoring - A cutting-edge approach with generalized additive profiles: GAMs for healthcare quality monitoring.

Recent findings indicate a growing trend in data analysis within healthcare using statistical process control. However, the diversity of variables involved necessitates the expansion of new process control methodologies. This study examined control chart applications in cardiology by using generalized additive models (GAMs) to construct profiles while involving multiple healthcare variables (08). Two distinct statistics: deviation (D), and Hotelling (T2) were employed for constructing control charts: a commonly used single-variable statistic for nonparametric profiles and an innovative multivariate statistic that assesses the contribution of each element to process changes. These statistics were tested for monitoring ischemic and hemorrhagic strokes in 1-year acute stroke (369) patients at the Faisalabad Institute of Cardiology. Demographic parameters (age, gender), vascular risk factors (diabetes, family history, sleep), socioeconomic variables (smoking, location), and blood pressure are included in the model. The research includes the computation of zero-state average run length (ARL) for assessing the performance of control charts. The characteristics of the proposed profile were analyzed, such as the T2 control chart, performing better than the D chart for medium-to-large shifts (δ ≥ 0.50). On the other hand, for small δ = 0.25, the D control chart produces smaller ARL values but more significant standard deviations. While both statistics contribute to profile monitoring, T2 is more effective at identifying and tracing medium and large shifts. In conclusion, such handy tools may aid healthcare performance monitoring, especially for complicated predictor-response relationships. Monitored profiles demonstrated that GAMs are useful for healthcare analysis and process monitoring.

Investigating the links between civil war, peace and foreign direct investment: a case study of Sri Lanka’s tourism sector

ABSTRACT It is often assumed that civil wars impede foreign direct investment (FDI). Peace is therefore typically considered important for countries to attract FDI. However, scholarly evidence is inconsistent and has uncovered a complicated relationship between conflict and FDI. While studies have tended to focus on the extractive industries, this article investigates how conflict and peace can impact FDI in the tourism industry. Using Sri Lanka as a case study, the evidence suggests that the country’s civil war (1983–2009) inhibited inward flows of tourism FDI. Since the conflict ended, the tourism sector and tourism FDI rapidly expanded. However, the areas most affected by the conflict have seen limited growth in tourism and tourism FDI. High levels of militarisation – including military involvement in tourism – have stymied tourism in these areas. This suggests a more complicated relationship between FDI, civil war and peace than is typically recognised in the current scholarship.

Comparison of cost and complications of primary total hip arthroplasty versus oncologic proximal femur replacement

Aims and objectiveProximal femur replacement (PFR) is most commonly performed after a large resection of the proximal femur to remove tumor and is known to have high complication rates and worse function than a primary total hip replacement (THA). Many surgeons feel that current billing practices fail to adequately differentiate this procedure from a THA. This study aims to examine patients undergoing a primary THA or oncologic PFR and compare the relative economic impact and complication rates between cohorts. Materials & methodsPatient data was queried using a national database, identifying non-pediatric patients who underwent a primary THA or oncologic PFR. Exclusionary criteria were implemented, resulting in two cohorts, each with 380 patients matched in a 1:1 manner controlling for age, gender, and Charlson Comorbidity Index. Utilizing 2022 billing data, oncologic PFRs generated an average of 41.03 RVUs and primary THAs generated 19.60 RVUs. Total hospital cost was used to generate a cost:RVU ratio for each cohort. Key systemic and joint complication rates were additionally compared between cohorts. ResultsThe oncologic PFR cohort had significantly higher 90-day rates of anemia, deep vein thrombosis, and prosthetic dislocation compared to the primary THA cohort. The 90-day median hospital cost for oncologic PFR was $28,562.21 with a cost:RVU ratio of $696:1. The corresponding median hospital cost for primary THA was $9667.72, with a cost:RVU ratio of $493:1. ConclusionHospitals incur more cost per RVU for an oncologic PFR than a primary THA. Relative to primary THA, reimbursement for oncologic PFR is under-evaluated.

Play is a privilege in both humans and animals: how our recreation influences wildlife

AbstractNature‐based tourism nets roughly 8 billion annual travelers globally to all regions of Earth, with many visiting around 200,000 formally protected areas. Financially well‐off tourists pay for playful activities and effects on wildlife are potentially large and relatively uncertain. Our commentary makes 3 points. First, variation in resource privileges and associated benefits characterizes not only humans but other species. Among animals, well‐nurtured populations engage in more playful and leisurely activities than do those nutritionally impoverished. Privilege depends partially on birth sites, parents, and local conditions, but for humans recreation expands with monetary advantage. Second, nature‐based tourism has 2 generalizable effects on wildlife, each involving degree of habituation. Among non‐habituated populations, local site abandonment is frequent and modulated by seasonality, individuals' physiological states, and whether recreation is motorized or not. For habituated populations, tolerance emerges to increasing recreational exposure with some populations of species learning to rely on humans to shield as a buffer against possible predation. Third, desert bighorn sheep (Ovis canadensis nelsoni) offer a robust example of the issues surrounding the effects of tourism on wildlife because of the geographically complicated relationship between recreational pursuit and wildlife on public lands of the western United States. While protected for decades, females have failed to habituate to different forms of recreation at certain sites. The result has been flight or site abandonment. Biodiversity protection at numerous scales has made strong gains but is still needed where progress is stymied by income disparities, privilege, and increasing recreation ventures.

Inflammation and Cancer: The Most Recent Findings

An in-depth investigation into the complicated relationship between inflammation and cancer provided new findings. We explored new developments that shone a light on the involvement of inflammation in the emergence of many cancers in this study. What we know of this complex interaction has been shaped over time by historical observations that have transformed into molecular mechanistic findings. Understanding the importance of the invasion of immune cells in tumor micro-surroundings, gaining knowledge of the signaling mechanisms that control inflammation-induced carcinogenesis, and identifying inflammatory agents as possible biomarkers for diagnosis and the outlook may lead to novel therapeutic strategies and improved patient outcomes. The combination of immunotherapies and other treatment techniques offers a promising way to enhance therapeutic effects. The development of novel therapies like adoptive T-cell therapy and oncolytic viral therapy further emphasizes how far we have come. The need to manage immune evasion mechanisms and improve these therapeutic approaches further are still problems. We describe the intriguing possibility of using inflammation as a tool for targeted treatment for cancer in this investigation, with possibilities for better patient outcomes and alternative treatment methods.

Job Satisfaction In Banking Sector

Job satisfaction is a journey, not a destination. Job satisfaction and employee performance havea complicated relationship. Employee recognition, monetary awards, social rewards, and other variablescan all contribute to job satisfaction, which can lead to greater and better job performance. In today'shighly competitive corporate environment, client satisfaction is a critical component of success.Employees from the private sector who join banks do so with full awareness of the immense strain they willbe under. The fact that they are aware of the stress that comes with working in the private sector causesthem to psychologically prepare before coming to work here. This study is to determine the degree of jobsatisfaction and the elements that contribute to it among operational bank personnel in both public andprivate sector banks. On the one hand, the factors, and on the other, it establishes a link between thevariablesfactors studied and work satisfaction.

The Optimal Suture Bite Depth in Laparoscopic Pyeloplasty: A Comparative Study in Children.

Background: Modified Anderson-Hynes pyeloplasty is currently preferred for ureteropelvic junction obstruction (UPJO). Extravasation of urine and anastomotic stenosis are the most common complications after Anderson-Hynes pyeloplasty, which are closely linked with the technique for anastomosis. However, there are currently no clear guidelines for the suture bite depth in suturing the anastomosis during pyeloplasty. Objective: To analyze the optimal suture bite depth in laparoscopic Anderson-Hynes pyeloplasty. Study Design: A total of 90 children aged 4-14 years with UPJO-induced hydronephrosis who were surgically treated in the First People's Hospital of Lianyungang from July 2019 to July 2022 were prospectively recruited. All received laparoscopic Anderson-Hynes pyeloplasty using 5-0 Vicryl continuous sutures. According to the suture bite depth, the patients were divided into group A (depth 1 mm, n = 46) and group B (depth 0.5 mm, n = 44). Operation time, postoperative drainage volume, time of ureteral stent removal, incidence of postoperative complications, and time to hydronephrosis resolution were compared between groups. Results: Group A showed significantly less postoperative drainage volume, and shorter time of ureteral stent removal and hydronephrosis resolution (all P < .05). Four cases in group B received replacement of a double-J stent. Except for 1 patient receiving reoperation for anastomotic stenosis caused by massive extravasation of urine, the replaced double-J stent was successfully removed from the remaining 3 patients at 3 months, and the symptoms of anastomotic stenosis disappeared. No significant difference was detected in the operation time between groups (P > .05). Conclusion: An appropriate deeper suture bite depth for anastomosis may reduce postoperative urine extravasation and related complications in children who received laparoscopic pyeloplasty for UPJO-induced hydronephrosis.

The effect of oral probiotics in the last trimester on the human milk and infant gut microbiotas at six months postpartum: A randomized controlled trial

ObjectiveThe main aim of this study was to evaluate the effect of oral probiotics on the human milk microbiota and determine whether that influenced infant microbiota development. MethodsA total of 27 pregnant women were recruited; 14 were assigned to the probiotic group, and the rest were assigned to the control group. Their infants were likewise assigned to the probiotic group or the control group. Pregnant women in the probiotic group received probiotic supplementation from 32 weeks of gestation until delivery. Human milk samples and infant fecal samples were collected at 6 months after delivery, and 16S rRNA sequencing was used to analyze the composition of the human milk and infant gut microbiota (NCT06241222). ResultsIn the control group, bacterial microbiota were detected in 8 out of 13 milk samples, whereas in the probiotic group, only 6 out of 14 milk samples contained bacterial microbiota. We examined the composition of the human milk and infant gut microbiota in both the control and probiotic groups. Spearman correlation analysis revealed that various genera in human milk were correlated with the infant gut microbiota. The Linear discriminant analysis effect size (LEfSe) showed that 6 bacteria in the human milk microbiota in the control group were significantly more abundant than those in the probiotic group. Nine bacteria were significantly more abundant in the human milk microbiota in the probiotic group than the control group. According to the LEfSe results, 11 bacteria in the infant gut microbiota in the control group were significantly more abundant than those in the probiotic group. Fourteen bacteria were significantly more abundant in the infant gut microbiota in the probiotic group than in the control group. ConclusionThe infant gut microbiota at 6 months has a complicated relationship with the maternal human milk microbiota. Oral probiotic supplementation can change the composition of the human milk microbiota and the infant gut microbiota.

Digitizing success: Leveraging digital human resource practices for transformative productivity in Chinese SMEs

Background& Purpose: In the rapidly evolving digital landscape, digital human resource (HR) practices in small and medium-sized enterprises (SMEs) have become a vital success factor. This study adopts the resource-based view of the firm to explore the complicated relationships among digital HR practices, digital transformation, innovative work behavior, disruptive innovation, and work productivity in the context of Chinese SMEs. MethodsThis study provides fundamental insights by drawing data from Jiangsu province, China. Data from 339 managerial staff members were collected and analyzed using SmartPLS (4.0) with a partial least squares structural equation model (PLS-SEM). Several measures, model fit, and hypothesis tests were conducted. FindingsDigital HR practices significantly affect digital transformation, innovative work behavior, and productivity. Furthermore, digital transformation is a powerful driver that positively influences innovative work behavior and productivity in SMEs. Interestingly, innovative work behavior positively influenced work productivity, exemplifying the vital role of inspired thinking and problem-solving abilities. This study also investigates the moderating role of disruptive innovation, highlighting its influence on the association between digital HR practices and digital transformation. However, disruptive innovation does not significantly moderate the association between digital transformation and innovative work behavior, suggesting fascinating nuances for SMEs. Conclusion/valueThis research extends our understanding of the interaction between digitalization, HR, and innovation, and proposes practical implications for SMEs aiming to harness the transformative potential of digitization. Several theoretical and practical implications are developed for future studies on related SMEs.

Sleep disturbance as a poor prognostic predictor in patients with advanced non-small-cell lung cancer treated with immune checkpoint inhibitors: A prospective study

BackgroundSleep disturbances are highly prevalent in oncology and often exacerbate symptoms, leading to reduced quality of life, which in turn may further affect the tolerability and efficacy of oncological treatments. Sleep disturbance and cancer have an intimate and complicated relationship, and may be a negative predictor of cancer treatment. The present study aimed to characterize the relationship between sleep disturbance and immune checkpoint inhibitor (ICI) therapy in patients with advanced non-small cell lung cancer (NSCLC). MethodsData from 171 patients with advanced NSCLC, who underwent ICI treatment between December 2020 and October 2022, were analysed in our prospective study. Sleep disturbances were evaluated according to the Pittsburgh Sleep Quality Index (PSQI), with a cut-off value of 5, to investigate the impact of sleep disturbance on the survival of patients with NSCLC and the efficacy of ICI treatment. ResultsThe median progression-free survival (PFS) was10.4 months (9 5% confidence interval [CI]:9.84–10.97). Univariate and multivariate analyses revealed that sleep disturbance and depressive symptom predicted worse prognosis with shortened PFS. Patients who experienced sleep disturbance exhibited a significant reduction in PFS (9.2 vs. 11.8 months; HR: 1.83 [9 5% CI 1.27–2.6 5]; p = 0.001), as did those with depressive states (HR 1.5 5 [9 5% CI 1.06–2.28]; p = 0.02 5). Additionally, patients with sleep disturbance and depressive symptoms exhibited significantly lower objective response rates and disease control rates. ConclusionSleep disturbance could be a factor for prognosis in patients with advanced NSCLC undergoing first- or second-line treatment with ICIs, including shorter PFS and reduced efficacy.

Quantum geometrodynamics revived: II. Hilbert space of positive definite metrics

Abstract This paper represents the second in a series of works aimed at reinvigorating the quantum geometrodynamics program. Our approach introduces a lattice regularization of the hypersurface deformation algebra, such that each lattice site carries a set of canonical variables given by the components of the spatial metric and the corresponding conjugate momenta. In order to quantize this theory, we describe a representation of the canonical commutation relations that enforces the positivity of the operators q_{ab} s^a s^b for all choices of s. Moreover, symmetry of q_{ab} and p^{ab} is ensured. This reflects the physical requirement that the spatial metric should be a positive definite, symmetric tensor. To achieve this end, we resort to the Cholesky decomposition of the spatial metric into upper triangular matrices with positive diagonal entries. Moreover, our Hilbert space also carries a representation of the vielbein fields and naturally separates the physical and gauge degrees of freedom. Finally, we introduce a generalization of the Weyl quantization for our representation. We want to emphasize that our proposed methodology is amenable to applications in other fields of physics, particularly&amp;#xD;in scenarios where the configuration space is restricted by complicated relationships among the degrees of freedom.

Ionic structure of cationic surfactant at the air/water interface

The adsorption of ionic surfactants and counter-ions at the air/water interface is important for many industrial processes. In the literature, the surface tension and surface potential data showed a complicated relationship that cannot be explained by the conventional models, either fully associated or fully dissociated models. Alternatively, ionic surfactants can have a partial association at the air/water interface. The degree of association varies with surface concentration and generates a distribution of counter-ions near the surface. This study reconciles the partial association and ionic distribution by a new quantification model. The model successfully described the surface tension and surface potential data for CTAB (cetyltrimethylammonium bromide). The model shows that the counter-ion association degree plays a deterministic role in limiting the adsorption capacity of ionic surfactants. The proposed structure is also consistent with X-ray surface reflectivity, in which CTAB demonstrated a condensed layer of counter-ion. The molecular insights can be extended to other ionic surfactants and oil/water interfaces.

GraphixMatch: Improving semi-supervised learning for graph classification with FixMatch

Graph classification is a critical problem that predicts the properties of an entire graph representing complicated relationships. This problem has been extensively studied in a supervised manner in various industries via graph convolutional networks that required large numbers of labeled graphs. However, labeled graphs are typically expensive and time-consuming to obtain in the real-world. Training graph classification models is difficult because of the sparseness of labeled data. Therefore, semi-supervised learning (SSL) algorithms that make full use of unlabeled data and overcome the lack of labels have led to the expansion of graph classification studies. In this study, we propose GraphixMatch to learn the graph properties of both labeled and unlabeled graphs based on the use of FixMatch for graph classification. To effectively capture the characteristics of a graph, we newly define and apply weak and strong augmentation of the graph. We evaluate the proposed method on seven benchmarks from a public dataset. We show that compared with various SSL methods, the simplified proposed method with weak and strong augmentation is superior. Furthermore, we conduct extensive additional experiments to derive the important parameters of GraphixMatch.

Evaluating the impact of DEM interpolation algorithms on relief index for soil resource management

Abstract Soil resource management is fundamentally integral to environmental sustainability and agricultural productivity. The digital elevation model (DEM) is the fundamental data for analyzing landform surfaces, which introduces an opportunity to obtain a broad spectrum of terrain factors to simplify interpreting the patterns and processes in the geoscience field. The accuracy and resolution of DEM are crucial for their effective use, and many algorithms have been developed to interpolate digital elevation data from a set of known points. Although primary topographic variables derived from grid datasets are important, secondary variables, such as the relief index (RFI), play a more critical role in understanding the complicated relationship between soil properties and landform attributes. The RFI is attained from a DEM by calculating the elevation range within a given neighborhood surrounding a central cell. It is an essential predictor of soil natural resource management that measures the degree of differentiation surface relief. In addition, it is beneficial for perceiving the landscape and its management. This study presents a comprehensive zonal analysis comparing the RFI values derived from multiple interpolation-based DEMs. It investigates deterministic and geostatistical interpolators, such as inverse distance weighted and natural neighbor across distinct zones with diverse topographical characteristics. The findings indicated a high correlation between the RFI and the reliability of the DEM, and the natural neighbor technique provided superior performance against others. The results revealed that the choice of spatial interpolation technique significantly affects the accuracy and reliability of RFI models.

The epic of the Baikal-Amur Mainline is the fate of millions. On the 50th anniversary of the start of construction

The Baikal-Amur Mainline is one of the most ambitious and controversial Soviet projects on the sociopolitical and historical trail of perception. The proposal to build a new railway north of the Trans-Siberian Railway was put forward at the beginning of the 20th century. The idea was approached in the 1920s and 1930s. Surveys were conducted, and construction began on one of the sites, which was interrupted by the Great Patriotic War (World War II). Moreover, during the war years, the upper structure of the track and a number of engineering structures were dismantled on the constructed site, which were used for the construction of the extremely important rockade railway in the Stalingrad area, which played a significant role in supplying Soviet troops during the Battle of Stalingrad. The interest in the construction of the BAM of the Soviet leadership in the 1960s and 1970s arose again in the context of an aggravation of the political situation — the complication of relations between the USSR and the People’s Republic of China. However, already during this period, the question was reasonably raised not only about the political, but also the economic strategic significance of the project from the perspective of the country’s development prospects, the development of natural resources in this region, the development of transport links between the European, Siberian, and Far Eastern territories of the state. In the period after the collapse of the USSR, the BAM construction project, not without the influence of those who were under Western influence in the country’s leadership circles, was classified as erroneous, extremely costly, economically and socially unjustified. Today, in society, the state, under the influence of many factors of recent years, there is an understanding of the importance of completing and developing the BAM construction project. This project has played a big role in the lives of millions of people, many organizations and institutions. Among them is the Leningrad Institute of Railway Engineers — today the St. Petersburg State University of Railways of Emperor Alexander I, whose students, graduates, scientists and specialists have been involved in various forms in the construction of the Baikal-Amur Mainline for half a century.

The complicated relationship between asthma and swimming

Introduction: Apart from pharmacological treatment, non-pharmacological strategies including physical activity play a significant role in the management of asthma. The aim of this paper is to examine various topics related to swimming and asthma. They include the detailed effect of swimming on asthma control,the potential role of swimming in early childhood asthma development, exercise induced asthma in swimmers as well as the relationship between asthma and cold water swimming. Review methods: This article is based on the literature found in the PubMed Database from the period of 1971-2024 with the use of keywords such as “asthma”, “swimming”, “cold water swimming”, “exercise induced asthma”, “childhood asthma” Description of the state of knowledge: Swimming is a safe form of physical activity for asthma patients.Swimming training enhances aerobic capacity, reduces exercise-induced bronchoconstriction and improves lung function in both pediatric and adult patients. However, there is a concern regarding indoor swimming pools that chlorine can potentially induce airway inflammation. There is research suggesting that early life swimming pool exposure may contribute to the asthma development in atopic children. There is some premise to the thought that cold water swimming may help alleviate asthma symptoms, but it also carries many risks.Swimming is a major cause of exercise induced asthma in professional athletes. Conclusions: Alongside appropriate pharmacological treatment, swimming is a valuable strategy in asthma management in both pediatric and adult asthma patients. The risks of chlorinating pools are still not known to outweigh the benefits of swimming for asthmatics. Further research should be carried out on safety of early swimming in atopic children. Cold water swimming should also be evaluated in terms of safety and potential benefits for asthma patients.

The importance of positive employee experience and its development through using predictive analytics

Purpose The study aims to explore the organizational benefits of positive employee experience and to provide a framework for measuring it. The positive employee experience has a profound impact on employees’ attitudes; thus, it is particularly important to what extent an organization can create the conditions supporting this. Design/methodology/approach The study is based on literature review and the framework needs to be empirically tested to draw final conclusions. Findings Organizational performance and success are influenced by employees’ well-being, commitment, job satisfaction and the high level of individual performance. However, this grouping of variables is not exhaustive, but in practice, it is often not necessary to fully understand the complex and complicated relationships among the organizational variables. However, a positive employee experience has an impact on all of these variables. According to our understanding and experience, the task of management is not to strengthen the variables describing employee attitudes individually, based on the knowledge of specific relations presented in the management literature and selected for the sake of a single research, but to create an acceptable level of the positive employee experience, which is able to strengthen these variables in a way that is useful for the organization. Originality/value In this study, the authors introduce the concept of the positive employee experience and the ways and steps to measure it. The authors review the methodology of predictive analytics, the main principles of data collection and the types of data with their possible applications. Finally, the limitations of the framework and the risks of enhancing the positive employee experience are also discussed.

Oral microbiome and its relationship with oral cancer.

As the initial point for digestion, the balance of oral microorganisms plays an important role in maintaining local and systemic health. Oral dysbiosis, or an imbalance in the oral microbial community, may lead to the onset of various diseases. The presence or abnormal increase of microbes in the oral cavity has attracted significant attention due to its complicated relationship with oral cancer. Oral cancer can remodel microbial profiles by creating a more beneficial microenvironment for its progression. On the other hand, altered microbial profiles can promote tumorigenesis by evoking a complex inflammatory response and affecting host immunity. This review analyzes the oncogenic potential of oral microbiome alterations as a driver and biomarker. Additionally, a potentially therapeutic strategy via the reversal of the oral microbiome dysbiosis in oral cancers has been discussed.