The rapidly changing healthcare market requires healthcare institutions to adjust their operations to address regulatory, strategic, and other risks. Healthcare organizations use a wide range of IT systems producing large amounts of sensitive and confidential data. However, few tools are available to measure the data governance activities of healthcare institutions and align healthcare data management with legislation. The Governance, Risk, and Compliance (GRC) Model focused on integrating that ability to achieve organizational goals. The demand for corporate governance is crucial for protecting the healthcare system from risks. An adaptation of a modified version that includes strategy, processes, technology, people, as well as legal and business requirements was developed to analyze the factors affecting IT GRC implementation in healthcare organizations. Although about 48% of participants reported that their organizations implemented IT GRC programs, 16% stated that they are considering implementing IT GRC programs soon. In almost 71% of healthcare organizations, IT governance, risk management, and compliance are integrated. Among the factors influencing the implementation of IT GRC programs in Saudi healthcare organizations, legal context ranked as the most critical, followed by process, strategy, then technology, business, and finally, people contexts. This study shows that healthcare organizations must assess various factors for the effective implementation of IT GRC activities.