Objective The infusion room is the last part of an outpatient visit, with high patient density, large staff mobility, and a wide variety of conditions. In addition, most patients are accompanied by their families during infusion, and nursing staff in infusion rooms have to face more trivial and miscellaneous tasks than nursing staff in other treatment departments, which are more complex. The purpose of this research is to explore the impact of the Six Sigma method and CI strategy on the quality of nursing management in infusion rooms, so as to provide reference for clinical research. Methods A total of 2142 patients treated in our outpatient infusion rooms from June 2019 to June 2020 was included into this retrospective analysis. Of these, 1105 patients admitted before 2020 received routine care management services and were considered as the control group. Another 1037 patients were admitted after 2020 and received the Six Sigma method combined with CI strategic care management and were considered as the research group. The incidence of adverse events during treatment was counted in both groups, and patients' compliance behavior and psychology were investigated. After treatment, patients' evaluation of the quality of nursing and their satisfaction with the nursing were investigated. Results The incidence of adverse events during infusion in the research group was dramatically lower than that in the control group, while the compliance behavior scores were higher (P < 0.05). In addition, SAS and SDS in the research group were lower than those in the control group, while the quality of nursing were higher (P < 0.05). It was also clear that the research group had 93.39% satisfaction with nursing, which was also higher than the control group (P < 0.05). Conclusion Implementation of infusion room nursing management according to the Six Sigma method with CI strategic plan can avoid adverse events and improve infusion nursing satisfaction. It also helps reduce the incidence of dispute events.