Complex Susceptibility Research Articles

Maxingshigan decoction for treating COVID-19: A protocol for systematic review and meta analysis.

Background:Coronavirus disease 2019 (COVID-19) is a rapidly spreading disease that has been in a public health emergency of international concern since its outbreak in 2020. Due to the complex pathogenesis and susceptibility of COVID-19, many commonly used drugs for the treatment of COVID-19 have not shown excellent clinical effects. Traditional Chinese medicine has a long clinical history of preventing and treating this respiratory infectious disease. Maxingshigan Decoction (MXSG) is widely used in China to treat COVID-19. However, there is no comprehensive and systematic evidence on the effectiveness and safety of Maxingshigan Decoction.Methods:PubMed, EMBASE, Clinical Trials, the Cochrane Library, Sino Med, and China National Knowledge Infrastructure up to September 2020. This study only screens clinical randomized controlled trials on MXSG for COVID-19 to evaluate its efficacy and safety. Data were extracted by 1 investigator and checked by an independent investigator. Review Manager 5.3 software was used for the data analysis. The dichotomous data is represented by relative risk, and the continuous is expressed by mean difference or standard mean difference, eventually the data is synthesized using a fixed effect model or a random effect model depending on whether or not heterogeneity exists.Results:The time from a positive diagnosis to a negative result of 2 consecutive nucleic acid tests (not on the same day), cure rate. The results of our research will be published in a peer-reviewed journal.Conclusion:The purpose of this systematic review is to provide new evidence for the effectiveness and safety of Maxingshigan decoction in the treatment of COVID-19.PROSPERO registration number:CRD42020211962.

Anisotropic time-dependent London approach: Application to the ac response in the Meissner state

The anisotropic London equations taking into account the normal currents are derived and applied to the problem of the surface impedance in the Meisner state of anisotropic materials. It is shown that the complex susceptibility of anisotropic slab depends on the orientation of the applied microwave field relative to the crystal axes. In particular, the anisotropic sample in the microwave field is subject to a torque, unless the field is directed along with one of the crystal principle axes.

Second-Harmonic Young's Interference in Atom-Thin Heterocrystals.

Second-harmonic generation (SHG) is a nonlinear optical process that converts two identical photons into a new one with doubled frequency. Two-dimensional semiconductors represented by transition-metal dichalcogenides are highly efficient SHG media because of their excitonic resonances. Using spectral phase interferometry, here we directly show that SHG in heterobilayers of MoS2 and WS2 is governed by optical interference between two coherent SH fields that are phase-delayed differently in each material. We also quantified the frequency-dependent phase difference between the two, which agreed with polarization-resolved data and first-principles calculations on complex susceptibility. The second-harmonic analogue of Young's double-slit interference shown in this work demonstrates the potential of custom-designed parametric generation by atom-thick nonlinear optical materials.

A series of mononuclear Ln-radical complexes based on 1-methylpyrazole nitronyl nitroxide: Synthesis, structure and magnetic properties

The reaction of LnIII salts (GdIII, TbIII and DyIII) and the 1-methyl-3-pyrazole nitronyl nitroxide radical gives three isostructural complexes, namely [Ln(hfac)3(1-Me-3-NIT-Pyz)] (Ln = Gd (1), Tb (2) and Dy (3); 1-Me-3-NIT-Pyz = 2-[3-(1-methyl-pyrazolyl)]-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide; hfac = hexafluoroacetylacetone). Single crystal X-ray diffraction studies showed that all three complexes are composed of two independent mononuclear bi-spin systems, in which the central LnIII ions are eight-coordinated with three bidentate hfac− ions and one bidentate chelating 1-Me-3-NIT-Pyz radical. The coordination polyhedron of the central LnIII ions can be described as a triangular dodecahedron (D2d). In addition, there exist weak ferromagnetic couplings in the GdIII-NIT radical system in complex 1 based on magnetic fitting. Dynamic magnetic studies show that the out-of-phase component of the ac-magnetic susceptibilities of complexes 2 and 3 exhibit a certain degree of frequency dependence and the two complexes do not show any obvious magnetic relaxation behavior.

Pinning mediated field penetration and complex susceptibility in inhomogeneous superconductors

The penetration of the magnetic field in a network consisting of the superconducting grains and intergranular region depends not only on the applied external magnetic field but also on the underlying pinning force density and fraction of the superconducting grains in the sample. Considering the underlying pinning force density in the form of the repetitive Gaussian (RG) nature we have solved the critical state model to get the spatial internal field profile at a particular time instant. The internal magnetic field as a function of the position inside the superconductor exhibits nonlinear, step-like nature. The complicated nature of the penetration of the field gets strongly affected by the size of the granular region and the total pinning force density in the superconductors. We have numerically calculated the real and imaginary parts of the complex susceptibility. The variation of the imaginary part with the temperature has a peak at a temperature which shifts towards the higher temperature with the reduction of the superconducting fraction.

Heterometallic Complexes Based on Triphenylantimony(V) Quinone-Catecholate

Heterometallic chromium(III) CrIII[(SQ-Cat)SbPh3]3 (I), copper(II) CuII[(SQ-Cat)SbPh3]2 (II), and zinc I2Zn(Q-Cat)SbPh3 (III) and IZn(SQ-Cat)SbPh3 (IV) complexes, where SQ is the corresponding o-semiquinone radical anion, and Cat is the catecholate dianion (mono- and direduced forms of the quinone fragment), are synthesized on the basis of the mononuclear triphenylantimony(V) quinone-catecholate complex (Q-Cat)SbPh3, which was derived from 4,4'-di-(6-tert-butyl-3-methylbenzo-1,2-quinone) (Q-Q). The one-electron oxidation and one-electron reduction of chromium complex I afford the paramagnetic derivatives [CrIII[(Q-Cat)SbPh3][(SQ-Cat)SbPh3]2]+ (I+) and [CrIII[(Cat-Cat)SbPh3][(SQ-Cat)SbPh3]2]– (I–), respectively, which are easily detected by EPR spectroscopy. The EPR spectroscopy data and measurements of the temperature dependence of the magnetic susceptibility of copper complex II indicate in favor of the localization of the lone electron on the organic ligand, which can be explained by the antiferromagnetic metal–ligand exchange in this complex (J(SQ-Cu) = –157 cm–1, J(SQ-SQ) = –10.0 cm–1). The coordination of (Q-Cat)SbPh3 as neutral o-quinone to zinc iodide with the formation of complex III increases significantly the oxidation ability of the quinone fragment in this complex (ERed1 = 0.43 V for III and –0.45 V for (Q-Cat)SbPh3 vs. Ag/AgCl/KCl(sat.)), and the complex can oxidize the iodide anion to iodine with the formation of paramagnetic derivative IV, whose EPR spectrum is characteristic of complexes of the M(SQ-Cat) type. The redox properties of complexes I and III are studied by cyclic voltammetry.

Estimation of Conductivity at Reduced Time for Sensing Moisture Content of Oil-Paper Insulation

Conductivity is an important parameter which has definite correlation with the amount of moisture present within the transformer insulation. However, in existing methods conductivity is usually estimated from time domain (PDC) measurement, which is inadvertently noise prone and time consuming. Considering this issue, in this article presents a novel technique for conductivity estimation for moisture sensing of oil-paper insulation using frequency domain spectroscopy measurement (FDS). To this end, FDS measurement of oil-paper insulation was performed from 50mHz to 1kHz to obtain the imaginary complex permittivity $\varepsilon ''$ ( $\omega$ ), which is a function of conductivity ( $\sigma$ ) as well as imaginary complex susceptibility $\chi ''$ ( $\omega$ ). From the knowledge of frequency variation of both $\sigma $ and $\chi ''$ ( $\omega$ ), we developed an electrical equivalent model of the insulation. The equivalent model parameters were optimized until $\varepsilon ''$ ( $\omega$ ) computed from the proposed model and that obtained from original FDS measurement were almost identical. The conductivity values obtained from the equivalent model showed good agreement when compared with PDC measurement. To validate the practicability of the proposed method, experiments were conducted on various test samples and also on a few real life transformers. Most importantly, the measurement time was found to be reduced by 78.5%, enabling diagnosis of transformer insulation at a significantly reduced time.

Effect of a Dc Oblique Magnetic Field on the Magnetic Susceptibility of the Super-Paramagnetics Nanoparticles in Very Low Damping

The Magnetic Susceptibility of an individual Super-Paramagnetic nanoparticle in a presence of DC Oblique magnetic fields of arbitrary amplitude is investigated using Brown’s continuous diffusion model. The susceptibility is calculated and compared when for extensive ranges of the anisotropy, the dc magnetic fields in the very low damping with Matrix continued Fraction. It is shown that the shape of the Spectrum of Super-Paramagnetic nanoparticles is substantially altered by applying a dc oblique field. There is also an inherent geometric dependence of the complex susceptibility on the damping parameter arising from coupling of longitudinal and transverse relaxation modes

The Performance of the Abbott Real Time MTB RIF/INH Compared to the MTBDRplus V2 for the Identification of MDR-TB Among Isolates.

BackgroundThe GenoType MTBDRplus V2 line-probe assay (LPA) is routinely used in clinical patient management to characterise the susceptibility of Mycobacterium tuberculosis complex to rifampicin (Rif) and isoniazid (INH) directly from sputum and cultured isolates. The laboratory workflow requires skill and three separate areas to minimize contamination and banding pattern interpretation requires experienced laboratory personnel. We explored the use of the RT MTB RIF/INH assay performed on the Abbott m2000 platform as an alternative laboratory platform.MethodsIsolates (n=93) consisting of fully susceptible, Rif- or INH-mono-resistant and multi-drug resistant (MDR) strains were tested on both MTBDRplus v2 and RT MTB RIF/INH assays. Both assays target the rpoB, katG and inhA genes for resistance-detection mutations. Concordance was assessed using percent agreement and the kappa statistic. Those specimens with discordant results were further assessed using Sanger sequencing.ResultsA total of 89% (83/93) of cultured isolates generated successful results on the RT MTB/RIF-INH assay and MTBDRplus assays. Of the 10 discordant results, where sequencing was used as the reference method, the RT MTB RIF/INH assays misclassified six resistance isolates, while the LPA misclassified seven.DiscussionOverall, the RT MTB RIF/INH demonstrated good agreement with the LPA, and a better correlation with sequencing on discrepant isolates specifically with mutations occurring in codon 511 of the rpoB gene. The RT MTB RIF/INH therefore can be used to complement existing laboratory algorithms determining Rif and INH resistance profiles, with less emphasis on manual laboratory processing.

Generalization to anomalous diffusion of Budó's treatment of polar molecules containing interacting rotating groups.

A fractional Smoluchowski equation for the orientational distribution of dipoles incorporating interactions with continuous time random walk Ansatz for the collision term is obtained. This equation is written via the non-inertial Langevin equations for the evolution of the Eulerian angles and their associated Smoluchowski equation. These equations govern the normal rotational diffusion of an assembly of non-interacting dipolar molecules with similar internal interacting polar groups hindering their rotation owing to their mutual potential energy. The resulting fractional Smoluchowski equation is then solved in the frequency domain using scalar continued fractions yielding the linear dielectric response as a function of the fractional parameter for extensive ranges of the interaction parameter and friction ratios. The complex susceptibility comprises a multimode Cole-Cole-like low frequency band with width dependent on the fractional parameter and is analogous to the discrete set of Debye mechanisms of the normal diffusion. The results, in general, comprise an extension of Budó's treatment [A. Budó, J. Chem. Phys. 17, 686 (1949)] of the dynamics of complex molecules with internal hindered rotation to anomalous diffusion.

Increasing Prevalence of Multidrug-Resistant Candida haemulonii Species Complex among All Yeast Cultures Collected by a Reference Laboratory over the Past 11 Years.

There is worldwide concern with the increasing rates of infections due to multiresistant Candida isolates reported in tertiary medical centers. We checked for historical trends in terms of prevalence rates and antifungal susceptibility of the Candida haemulonii species complex in our yeast stock culture collected during the last 11 years. The isolates were identified by sequencing the rDNA internal transcribed spacer (ITS) region, and antifungal susceptibility tests for amphotericin B, voriconazole, fluconazole, anidulafungin, and 5-fluorocytosine were performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. A total of 49 isolates were identified as Candida haemulonii sensu stricto (n = 21), followed by C. haemulonii var. vulnera (n = 15) and C. duobushaemulonii (n = 13), including 38 isolates cultured from patients with deep-seated Candida infections. The prevalence of the C. haemulonii species complex increased from 0.9% (18 isolates among 1931) in the first period (December 2008 to June 2013) to 1.7% (31 isolates among 1868) in the second period (July 2014 to December 2019) of analysis (p = 0.047). All isolates tested exhibited high minimum inhibition concentrations for amphotericin B and fluconazole, but they remained susceptible to 5-fluorocytosine and anidulafungin. We were able to demonstrate the increased isolation of the multiresistant Candida haemulonii species complex in our culture collection, where most isolates were cultured from patients with deep-seated infections.

Integration of genomics, metagenomics, and metabolomics to identify interplay between susceptibility alleles and microbiota in adenoma initiation

BackgroundColorectal cancer (CRC) is a multifactorial disease resulting from both genetic predisposition and environmental factors including the gut microbiota (GM), but deciphering the influence of genetic variants, environmental variables, and interactions with the GM is exceedingly difficult. We previously observed significant differences in intestinal adenoma multiplicity between C57BL/6 J-ApcMin (B6-Min/J) from The Jackson Laboratory (JAX), and original founder strain C57BL/6JD-ApcMin (B6-Min/D) from the University of Wisconsin.MethodsTo resolve genetic and environmental interactions and determine their contributions we utilized two genetically inbred, independently isolated ApcMin mouse colonies that have been separated for over 20 generations. Whole genome sequencing was used to identify genetic variants unique to the two substrains. To determine the influence of genetic variants and the impact of differences in the GM on phenotypic variability, we used complex microbiota targeted rederivation to generate two Apc mutant mouse colonies harboring complex GMs from two different sources (GMJAX originally from JAX or GMHSD originally from Envigo), creating four ApcMin groups. Untargeted metabolomics were used to characterize shifts in the fecal metabolite profile based on genetic variation and differences in the GM.ResultsWGS revealed several thousand high quality variants unique to the two substrains. No homozygous variants were present in coding regions, with the vast majority of variants residing in noncoding regions. Host genetic divergence between Min/J and Min/D and the complex GM additively determined differential adenoma susceptibility. Untargeted metabolomics revealed that both genetic lineage and the GM collectively determined the fecal metabolite profile, and that each differentially regulates bile acid (BA) metabolism. Metabolomics pathway analysis facilitated identification of a functionally relevant private noncoding variant associated with the bile acid transporter Fatty acid binding protein 6 (Fabp6). Expression studies demonstrated differential expression of Fabp6 between Min/J and Min/D, and the variant correlates with adenoma multiplicity in backcrossed mice.ConclusionsWe found that both genetic variation and differences in microbiota influences the quantitiative adenoma phenotype in ApcMin mice. These findings demonstrate how the use of metabolomics datasets can aid as a functional genomic tool, and furthermore illustrate the power of a multi-omics approach to dissect complex disease susceptibility of noncoding variants.

Corrigendum: Entrapment of a Pseudo-Tetrahedral CoII Center by Thioether Sulfur Bound {Co2 (μ-L)} Fragments: Synthesis, Field-Induced Single-Ion Magnetism and Catechol Oxidase Mimicking Activity.

It has come to the attention of the authors that Figure 6, the values of effective magnetic moments for complexes 1 and 2, giso, E/D values in Abstract section and in the Magnetic properties sections, giso and E/D values in Table 1, and D value for complex 2 in Conclusions section were changed mistakenly in the final stage of manuscript preparation. The data published in Figure 6 reveal the results obtained for older measurement on different batches of the complexes. The correct values, corresponding to the results obtained for the same batches of complexes for which the DC and AC magnetic measurements were done, are presented below. These mistakes do not affect the integrity of the research and overall conclusions of the published paper. The corrected Figure 6 and corresponding text are given below. Magnetic properties. Investigation of the magnetic features of complexes 1 and 2 proceeded using a PPMS device on which the temperature (1.9–300 K) and field (0–9 T) dependent magnetic data were obtained (Figure 6). Figure 6 Temperature dependence of the effective magnetic moment (inset: temperature dependence of the molar magnetic susceptibility) for complexes 1 and 2 (Left). The isothermal magnetizations measured in the range of B=0–9 T and at T=2, 5 and 10 K (Right). The magnetic properties of the complexes are primarily due to the presence of central tetrahedral CoII ion since octahedral LS-CoIII ions are diamagnetic. The value of effective magnetic moment (μeff) of complex 1 at 300 K is 3.5 μB, slightly lower than the spin-only value of 3.9 μB for S=3/2, g=2.0. Thereafter upon cooling the μeff value raises slightly up to ca 75 K and then, it drops sharply to a minimum at 1.9 K, where it adopts the value of 3.2 μB. In the case of complex 2, the μeff value at 300 K is 5.0 μB which is again much higher that the calculated value for isotropic S=3/2 spin. It decreases gradually upon cooling up to ca 50 K and then, it declines sharply to a minimum at 4.4 K reaching the value of 4.2 μB. The high μeff value at 300 K indicates considerable contribution of a spin-orbit coupling to the ground state in the complex 2. Isothermal magnetization experiments (Figure 6) for 1 and 2 in the applied field range of B=0–9 T at different constant temperatures T=2, 5 and 10 K reveal that the magnetization does not show saturation suggesting the presence of magnetic anisotropy. To extract the parameters affected by magnetic anisotropy arising from crystal field effects (g, D), both the susceptibility and magnetization data were fitted simultaneously. The best fit parameters were calculated using the PHI program package[26] for S=3/2 and they are as follows: giso=2.05, D=−23.6 cm−1, E/D=0, zJ/hc=0 cm−1, χTIP=−13.0×10−4 cm3 mol−1 for 1 and giso=2.61, D=−24.3 cm−1, E/D=0.01, zJ/hc=0.05 cm−1, χTIP=2.0×10−4 cm3 mol−1 for 2. The presence of temperature-independent paramagnetism (TIP) term accounts for the four surrounding CoIII ions. The observed D values for 1 and 2 are relatively close compared to those (−31.31 cm−1 and −21.88 cm−1) obtained in our previous investigations with complexes having similar molecular structures.[10] The authors wish to emphasize that with these corrections, the reported ZFS parameters relevant for the discussion of single molecule magnetism (i.e. the D values) did not change at all and the overall conclusions published in the original version of the article are not affected.

Microstructure, AC susceptibility and electrical properties of K2CO3 added YBa2Cu3O7−δ superconductor

The effect of potassium carbonate addition on YBa2Cu3O7-δ is reported. Samples with starting composition YBa2Cu3O7-δ(K2CO3)x were prepared using the solid reaction method with x = 0, 0.1, 0.3, 0.4, 0.5, 1.0 and 5.0 wt%. The four-point probe electrical resistance, AC susceptibility, X-ray diffraction method and field emission scanning electron microscopy (FESEM) were used to characterize the samples. Addition of K2CO3 did not affect the orthorhombic structure and the microstructure. The average grain size was between 12 and 13 µm and not affected by the addition of K2CO3. A slight decrease in the onset transition temperature was observed for x ≤ 1.0. The x = 5.0 wt% samples showed a significantly reduced transition temperature. Samples with x = 0 to 0.5 wt% showed a peak in the imaginary part of the complex susceptibility known as the peak transition temperature, Tp of around 85–86 K while the x = 5.0 wt% samples showed Tp reduced to 82 K . The critical current density at Tp was between 15 and 19 A/cm2. This work showed that K2CO3 and KClO3 have totally different effects on YBa2Cu3O7-δ superconductor.

Developmental programming of mitochondrial biology: a conceptual framework and review.

Research on mechanisms underlying the phenomenon of developmental programming of health and disease has focused primarily on processes that are specific to cell types, organs and phenotypes of interest. However, the observation that exposure to suboptimal or adverse developmental conditions concomitantly influences a broad range of phenotypes suggests that these exposures may additionally exert effects through cellular mechanisms that are common, or shared, across these different cell and tissue types. It is in this context that we focus on cellular bioenergetics and propose that mitochondria, bioenergetic and signalling organelles, may represent a key cellular target underlying developmental programming. In this review, we discuss empirical findings in animals and humans that suggest that key structural and functional features of mitochondrial biology exhibit developmental plasticity, and are influenced by the same physiological pathways that are implicated in susceptibility for complex, common age-related disorders, and that these targets of mitochondrial developmental programming exhibit long-term temporal stability. We conclude by articulating current knowledge gaps and propose future research directions to bridge these gaps.

Interaction of cavity solitons on an unstable background.

The interaction of two cavity solitons in a driven semiconductor laser above lasing threshold is investigated. We focus on the case in which the background field of the solitons is turbulent because the laser is below the injection locking point. We show that the solitons move spontaneously and either reach some equilibrium distance or merge. Different behaviors are found depending on how far from the injection locking point the laser is. The laser is modeled by a set of effective Maxwell-Bloch equations which include an equation for the macroscopic polarization that mimics the complex susceptibility of the semiconductor. In that way we avoid the emergence of an unphysical behavior of the background which instead appears when the polarization is adiabatically eliminated, which amounts to assuming infinite gain linewidth. The simulations are slow because the time scales of the different dynamical variables differ by four orders of magnitude. Yet, we show that the results of the complete set of equations can be accurately reproduced with a reduced set of equations where the polarization is adiabatically eliminated but a diffusion term is included in Maxwell equation, which accounts for the finiteness of the gain linewidth.

Analysis of dielectric response of epoxy-mica insulation with temperature normalization

To decrease equipment costs and facilitate the simple and convenient on-site frequency dielectric spectroscopy (FDS) testing of epoxy-mica insulation of stator coils, specimens from a stator coil, subjected to 623 hours of 48 kV AC electrical ageing, were tested at temperatures from 0 to 120°C and frequencies from 10−1 to 107 Hz. The master curves and shift factors of the real and imaginary susceptibility components were obtained by the temperature normalization method. According to the horizontal shift factor, the complex susceptibility of the insulation increased exponentially with temperature. Regarding the vertical shift factor, the characteristic peak of the imaginary component of the complex susceptibility, representing the interface polarization of the epoxy-mica insulation, increased exponentially with temperature, and its movement can be expressed by the Arrhenius equation. The master curves of the temperature from 20 to 100°C and the frequency from 1 to 103 Hz can be fitted to the six-degree Debye relaxation model and Havriliak-Negami function. Through the shift factors and master curves, FDS data from 20 to 100°C can be estimated without temperature control.

Anomalous diffusion of a dipole interacting with its surroundings.

A fractional Fokker-Planck equation based on the continuous time random walk Ansatz is written via the Langevin equations for the dynamics of a dipole interacting with its surroundings, as represented by a cage of dipolar molecules. This equation is solved in the frequency domain using matrix continued fractions, thus yielding the linear dielectric response for extensive ranges of damping, dipole moment ratio, and cage-dipole inertia ratio, and hence the complex susceptibility. The latter comprises a low frequency band with width depending on the anomalous parameter and a far infrared (THz) band with a comb-like structure of peaks. Several physical consequences of the model relevant to anomalous diffusion in the presence of interactions are discussed. The entire calculation may be regarded as an extension of the cage model interpretation of the dynamics of polar molecules to anomalous diffusion, taking into account inertial effects.

Dispersion of magnetic susceptibility in a suspension of flexible ferromagnetic rods

The properties of suspensions of magnetosomes extracted from magnetotactic bacteria are investigated. By using dynamic light scattering and measuring the dispersion of magnetic susceptibility it is shown that sonicated samples with broken magnetosome chains have qualitatively different behavior in comparison with native samples. This is explained by the presence of flexible chains of magnetosomes in non-sonicated samples which have the qualitative features of magnetic susceptibility predicted by the model of flexible magnetic rods. • The model of flexible magnetic rods of magnetic susceptibility is proposed. • Broken magnetosome chains have qualitatively different behavior as native samples. • Frequency dependence of magnetosomes' complex susceptibility is analyzed.

The influence of hydrodynamic effects on the complex susceptibility response of magnetic fluids undergoing oscillatory fields: New insights for magnetic hyperthermia

In this work, we perform Langevin dynamics simulations to examine microstructure-macroscopic related properties of magnetic fluids in an attempt to understand the influence of the long range viscous hydrodynamic and dipolar interparticle interactions on the complex susceptibility response of a magnetic suspension undergoing an oscillatory magnetic field. The simulations use periodic boundary conditions in order to properly compute particle interactions through the Ewald summation technique. The imaginary part of the complex susceptibility predicted by the simulations is presented in terms of the frequency, particle volume fraction, and Péclet number. This property is used to investigate the process of magnetic hyperthermia. A detailed comparison between our simulations and the prediction of an asymptotic theory for a small Péclet number in the absence of hydrodynamic interactions shows an excellent agreement. The influence of the hydrodynamic and dipolar interactions on the average rate of temperature rise is investigated here. The coupling between the particle relaxation time and the forcing frequency of the applied field is also discussed. The simulations exhibit inhomogeneous chainlike structures in the numerical box induced by interparticle dipolar interactions. We find that the presence of these structures enhances magnetic heating production, whereas hydrodynamic interactions weaken this effect. Our results also suggest that the way of combining and controlling physical parameters at moderate frequencies of the applied oscillatory field can improve the heating performance of magnetic hyperthermia.