Abstract: Aim: The aim of this study was to assess the effect of soft denture liners on mandibular ridge resorption in complete denture wearers after two years of use. Methodology: The study included 32 patients ranging in age from 35 to 65 years old. Those patients were completely edentulous with well formed ridges, Class I relation and no medical problem. Thirty two selected patients were divided into two groups, namely Experimental group and Control group. Control group (n = 16, 8 males and 8 females) received conventional maxillary and mandibular complete dentures. Whereas in Experimental group, (n = 16, 8 males and 8 females) silicone lined lower complete denture were made. Three panoramic radiographs (orthopantomogram [OPG]) were taken for each participant to assess the amount of bone resorption; immediately, one year, and two years after denture insertion. For comparing two groups at three different time intervals, analysis of variance (ANOVA) two way with post-hoc tests was used. A statistically significant pvalue of less than 0.05 was considered. Results: After denture delivery, there was significant change in bone height in all patients ( p < 0.001) . The comparison of bone height between the two groups in different regions at different time intervals revealed a significant difference in bone levels at baseline to one year and baseline to two years. However, Experimental group experienced 50% less bone loss than control group over a two-year period. Conclusion: Based on the findings of the current study, it can be inferred that use of soft liners helps in reducing residual ridge resorption significantly when compared with conventional denture material.