Productivity of wells in South-West Iran has decreased due to completion and production problems in recent decades. This is a large risk against sustainable production from the fields. To allow stable production, an important measure is completion and production optimization including artificial lift methods. This was investigated using simulations validated by pilot field tests. Several case studies were considered in terms of their completion and production. Five scenarios were investigated: natural production through annulus and tubing (scenario-1 and 2), artificial gas lift production through annulus (scenario-3), through tubing using non-standard gas lift (scenario-4) and using standard gas lift (scenario-5). Scenario-1 is currently the case in most wells of the field. To find the optimal scenario and completion/production parameters, simulations of 11 wells of an oilfield in the region were carried out using nodal and sensitivity analysis. The optimized parameters include wellhead pressures (WHPs), tubing dimensions, maximum tolerable water cuts and gas oil ratios and artificial gas injection rate. Simulation results were validated by pilot field tests. In addition, appropriately selected wellhead and Christmas trees for all scenarios were depicted. Simulations confirmed by field pilot tests showed that optimization of completion and production mode and parameters can contribute largely to production improvement. The results showed that the current scenario-1 is the worst of all. However, production through tubing (scenario-2) is optimal for wells which can produce with natural reservoir pressure, with an increase of 800 STB/Day rate per well compared with scenario-1. However, for wells requiring artificial gas lift, the average production rate increase (per well) from the annulus to tubing production was 1185 STB/Day. Next, using the standard gas lift (scenario-5) was found to be the optimal mode of gas lifting and is strongly recommended. WHPs in scenario-5 were the greatest of all, whereas scenario-1 gave the lowest WHPs. The optimal tubing diameter and length were determined. The greatest maximum tolerable water cut was obtained using scenario-5, whereas the lowest was with scenario-1. The maximum tolerable GOR was around 1900 scf/STB. Changing of scenarios did not have significant effect on maximum tolerable GOR. The optimal artificial gas injection rates were found. This validated simulation work proved that completion and production optimization of mode and parameters had considerable contribution to production improvement in South-West Iran. This sequential comprehensive work can be applied in any other field or region.