Complementary Actions Research Articles

Is data science a science? The essence of phenomenon and the role of theory in the emerging field

PurposeData science lacks a distinctive identity and a theory-informed approach, both for its own sake and to properly be applied conjointly to the social sciences. This paper’s purposes are twofold: to provide (1) data science an illustration of theory adoption, able to address explanation and support prediction/prescription capacities and (2) a rationale for identification of the key phenomena and properties of data science so that the data speak through a contextual understanding of reality, broader than has been usual.Design/methodology/approachA literature review and a derived conceptual research model for a push–pull approach (adapted for a data science study in the management field) are presented. A real location–allocation problem is solved through a specific algorithm and explained in the light of the adapted push–pull theory, serving as an instance for a data science theory-informed application in the management field.FindingsThis study advances knowledge on the definition of data science key phenomena as not just pure “data”, but interrelated data and datasets properties, as well as on the specific adaptation of the push-pull theory through its definition, dimensionality and interaction model, also illustrating how to apply the theory in a data science theory-informed research. The proposed model contributes to the theoretical strengthening of data science, still an incipient area, and the solution of the location-allocation problem suggests the applicability of the proposed approach to broad data science problems, alleviating the criticism on the lack of explanation and the focus on pattern recognition in data science practice and research.Research limitations/implicationsThe proposed algorithm requires the previous definition of a perimeter of interest. This aspect should be characterised as an antecedent to the model, which is a strong assumption. As for prescription, in this specific case, one has to take complementary actions, since theory, model and algorithm are not detached from in loco visits, market research or interviews with potential stakeholders.Practical implicationsThis study offers a conceptual model for practical location–allocation problem analyses, based on the push–pull theoretical components. So, it suggests a proper definition for each component (the object, the perspective, the forces, its degrees and the nature of the movement). The proposed model has also an algorithm for computational implementation, which visually describes and explains components interaction, allowing further simulation (estimated forces degrees) for prediction.Originality/valueFirst, this study identifies an overlap of push–pull theoretical approaches, which suggests theory adoption eventually as mere common sense, weakening further theoretical development. Second, this study elaborates a definition for the push–pull theory, a dimensionality and a relationship between its components. Third, a typical location–allocation problem is analysed in the light of the refactored theory, showing its adequacy for that class of problems. And fourth, this study suggests that the essence of a data science should be the study of contextual relationships among data, and that the context should be provided by the spatial, temporal, political, economic and social analytical interests.

Cooperation and opportunism in Galapagos sea lion hunting for shoaling fish.

For predators, cooperation can decrease the cost of hunting and potentially augment the benefits. It can also make prey accessible that a single predator could not catch. The degree of cooperation varies substantially and may range from common attraction to a productive food source to true cooperation involving communication and complementary action by the individuals involved. We here describe cooperative hunting of Galapagos sea lions (Zalophus wollebaeki) for Amberstripe scad (Decapterus muroadsi), a schooling, fast swimming semipelagic fish. A group of 6–10 sea lions, usually females only, drove scad over at least 600–800 m from open water into a cove where, in successful hunts, they drove them ashore. Frequently, these “core hunters” were joined toward the final stages of the hunt by another set of opportunistic sea lions from a local colony at that beach. The “core hunters” did not belong to that colony and apparently were together coming toward the area specifically for the scad hunt. Based on the observation of 40 such hunts from 2016 to 2020, it became evident that the females performed complementary actions in driving the scad toward the cove. No specialization of roles in the hunt was observed. All “core hunters” and also opportunistically joining sea lions from the cove shared the scad by randomly picking up a few of the 25–300 (mean 100) stranded fish as did scrounging brown pelicans. In one of these hunts, four individual sea lions were observed to consume 7–8 fish each in 25 s. We conclude that the core hunters must communicate about a goal that is not present to achieve joint hunting but presently cannot say how they do so. This is a surprising achievement for a species that usually hunts singly and in which joint hunting plays no known role in the evolution of its sociality.

NPT520-34 improves neuropathology and motor deficits in a transgenic mouse model of Parkinson's disease.

NPT520-34 is a clinical stage, small molecule being developed for the treatment of Parkinson's disease and other neurodegenerative disorders. The therapeutic potential of NPT520-34 was first suggested by findings from cell-based assays of alpha-synuclein clearance. As reported here, NPT520-34 was subsequently evaluated for therapeutically relevant actions in a transgenic animal model of Parkinson's disease that overexpresses human alpha-synuclein and in an acute lipopolysaccharide-challenge model using wild-type mice. Daily administration of NPT520-34 to mThy1-alpha-synuclein (Line 61) transgenic mice for 1 or 3 months resulted in reduced alpha-synuclein pathology, reduced expression of markers of neuroinflammation, and improvements in multiple indices of motor function. In a lipopolysaccharide-challenge model using wild-type mice, a single dose of NPT520-34 reduced lipopolysaccharide-evoked increases in the expression of several pro-inflammatory cytokines in plasma. These findings demonstrate the beneficial effects of NPT520-34 on both inflammation and protein-pathology end points, with consequent improvements in motor function in an animal model of Parkinson's disease. These findings further indicate that NPT520-34 may have two complementary actions: (i) to increase the clearance of neurotoxic protein aggregates; and (ii) to directly attenuate inflammation. NPT520-34 treatment may thereby address two of the predominate underlying pathophysiological aspects of neurodegenerative disorders such as Parkinson's disease.

Forest regeneration and seed rain in the conversion of a stand of Pinus sp. into native forest

In Southern Brazil, the National Forests (NF) are protected areas of sustainable use; however, most of them present a significant cover with old plantations of Pinus spp. established to foster commercial forestry. Nowadays, the NF management plans propose the conversion of Pinus stands into native forests. Pinus spp. are worrisome invasive plants whose spontaneous recruitment is a challenge to forest restoration. This paper aims to analyze seed rain and woody community composition in a stand where Pinus trees were eliminated to drive spontaneous regeneration (REG) in an NF in the Southern Atlantic Forest. The seed rain was measured in the restoring area and inside an adjacent Pinus stand (PIN). The tree community structure was analyzed comparatively in REG, PIN, and in a Native Araucaria Forest (NAT). One year after Pinus cutting, the seed rain of woody species was 1,802 and 1,502 seeds m-2.year-1 in REG and PIN, respectively. REG’s seed rain had higher diversity than PIN and absence of Pinus seeds. REG and NAT presented higher diversity of tree species than PIN, although REG had the lowest basal area and tree density. Nevertheless, 188 Pinus seedlings.ha-1 were observed in REG, which indicates that complementary restoration actions are needed.

Municipal Culture Incentive Law: what are their inclusive and democratic effects on local cultural production?

Abstract This paper aims to analyze the inclusive and democratic effects of municipal cultural incentives law in Cataguases, Minas Gerais, fundamentally considering the promotion of citizenship and identity preservation based on cultural production. Data were collected through non-structured interviews with Cataguases cultural producers and analyzed according to a Marxist notion of discourse. Our findings revealed that approved purposes lead to a form of centralization on cultural production at the local level, characterized by the concentration of resources on established groups and the detachment from historically marginalized groups. Moreover, this scenario is aggravated when complementary cultural actions are transferred to the city’s cultural foundations, reinforcing the distinctive character of culture.

Municipal Culture Incentive Law: what are their inclusive and democratic effects on local cultural production?

Abstract This paper aims to analyze the inclusive and democratic effects of municipal cultural incentives law in Cataguases, Minas Gerais, fundamentally considering the promotion of citizenship and identity preservation based on cultural production. Data were collected through non-structured interviews with Cataguases cultural producers and analyzed according to a Marxist notion of discourse. Our findings revealed that approved purposes lead to a form of centralization on cultural production at the local level, characterized by the concentration of resources on established groups and the detachment from historically marginalized groups. Moreover, this scenario is aggravated when complementary cultural actions are transferred to the city’s cultural foundations, reinforcing the distinctive character of culture.

Endocannabinoid System and Its Regulation by Polyunsaturated Fatty Acids and Full Spectrum Hemp Oils.

The endocannabinoid system (ECS) consists of endogenous cannabinoids, their receptors, and metabolic enzymes that play a critical homeostatic role in modulating polyunsaturated omega fatty acid (PUFA) signaling to maintain a balanced inflammatory and redox state. Whole food-based diets and dietary interventions linked to PUFAs of animal (fish, calamari, krill) or plant (hemp, flax, walnut, algae) origin, as well as full-spectrum hemp oils, are increasingly used to support the ECS tone, promote healthy metabolism, improve risk factors associated with cardiovascular disorders, encourage brain health and emotional well-being, and ameliorate inflammation. While hemp cannabinoids of THC and CBD groups show distinct but complementary actions through a variety of cannabinoid (CB1 and CB2), adenosine (A2A), and vanilloid (TRPV1) receptors, they also modulate PUFA metabolism within a wide variety of specialized lipid mediators that promote or resolve inflammation and oxidative stress. Clinical evidence reviewed in this study links PUFAs and cannabinoids to changes in ECS tone, immune function, metabolic and oxidative stress adaptation, and overall maintenance of a well-balanced systemic function of the body. Understanding how the body coordinates signals from the exogenous and endogenous ECS modulators is critical for discerning the underlying molecular mechanisms of the ECS tone in healthy and disease states. Nutritional and lifestyle interventions represent promising approaches to address chronic metabolic and inflammatory disorders that may overlap in the population at risk. Further investigation and validation of dietary interventions that modulate the ECS are required in order to devise clinically successful second-generation management strategies.

Protein Phosphatase 2B Dual Function Facilitates Synaptic Integrity and Motor Learning.

Protein phosphatase 2B (PP2B) is critical for synaptic plasticity and learning, but the molecular mechanisms involved remain unclear. Here we identified different types of proteins that interact with PP2B, including various structural proteins of the postsynaptic densities (PSDs) of Purkinje cells (PCs) in mice. Deleting PP2B reduced expression of PSD proteins and the relative thickness of PSD at the parallel fiber to PC synapses, whereas reexpression of inactive PP2B partly restored the impaired distribution of nanoclusters of PSD proteins, together indicating a structural role of PP2B. In contrast, lateral mobility of surface glutamate receptors solely depended on PP2B phosphatase activity. Finally, the level of motor learning covaried with both the enzymatic and nonenzymatic functions of PP2B. Thus, PP2B controls synaptic function and learning both through its action as a phosphatase and as a structural protein that facilitates synapse integrity.SIGNIFICANCE STATEMENT Phosphatases are generally considered to serve their critical role in learning and memory through their enzymatic operations. Here, we show that protein phosphatase 2B (PP2B) interacts with structural proteins at the synapses of cerebellar Purkinje cells. Differentially manipulating the enzymatic and structural domains of PP2B leads to different phenotypes in cerebellar learning. We propose that PP2B is crucial for cerebellar learning via two complementary actions, an enzymatic and a structural operation.

Heat/pH-boosted release of 5-fluorouracil and albumin-bound paclitaxel from Cu-doped layered double hydroxide nanomedicine for synergistical chemo-photo-therapy of breast cancer

Considerable attention has been devoted to nanomedicine development for breast cancer therapy, while the therapeutic efficiency is far from satisfactory owing to non-specific biodistribution-caused side effects and limitation of single modal treatment. In this study, we have developed a novel nanomedicine for efficient combination breast cancer therapy. This nanomedicine was based on copper-doped layered double hydroxide (Cu-LDH) nanoparticles loaded with two FDA-approved anticancer drugs, i.e. 5-fluorouracil (5-FU) and albumin-bound paclitaxel (nAb-PTX) with complementary chemotherapeutic actions. The 5-FU/Cu-LDH@nAb-PTX nanomedicine showed pH-sensitive heat-facilitated therapeutic on-demand release and demonstrated the moderate-to-strong synergy of photothermal therapy and chemotherapy in inducing apoptosis of breast cancer cells (4 T1). This nanomedicine had a high colloidal stability in saline and serum, and efficiently accumulated in the tumor tissue. Remarkably, this nanomedicine nearly eliminated 4 T1 tumors in vivo after a two-course treatment under mild 808 nm laser irradiation (0.75 W/cm2, 3 min) at very low doses of 5-FU and nAb-PTX (0.25 and 0.50 mg/kg, 8–50 times less than that used in other nanoformulations), without observable side effects. Therefore, this research provides a novel approach to designing multifunctional nanomedicines for on-demand release of chemotherapeutics to cost-effectively treat breast cancer with minimal side effects in future clinic applications.

Pharmacokinetic Characteristics of a Nifedipine and Lidocaine Fixed Combination in the Form of Rectal Cream: Two Decades Data Analysis

The creation of medicines' fixed combinations from compounds with complementary effects is one of the most popular directions in modern pharmacology and pharmaceutics. In case of nifedipine and lidocaine fixed combination such approach is quite obvious. The present review article is devoted to the analysis of clinical and non-clinical studies results on the assessment of the pharmacokinetic characteristics of these medicines. Although the oral route is the most convenient for drug administration, there are a number of circumstances where this is not possible from either a clinical or pharmaceutical perspective. In these cases, the rectal route may represent a practical alternative and can be used to administer drugs for both local and systemic actions. Research data of last decades suggested that nifedipine, a calcium channel blocker, could be effective in reducing anal resting pressure and in healing chronic anal fissure and acute thrombosed hemorrhoids. Another component of fixed combination lidocaine is a local anesthetic usually used to relieve pain of anal fissures and symptomatic hemorrhoids. In combinations lidocaine and nifedipine have complementary actions. Analysis of all available studies (during last 2 decades) which were aimed to investigate pharmacokinetic characteristics of a nifedipine and lidocaine fixed combination in the form of rectal cream showed that following topical application, the active ingredients nifedipine and lidocaine are absorbed into the bloodstream in only small quantities that have no major implications for the safety of the product, and systemic absorption, if any, was incomparably lower than absorption following per os administration of the two active ingredients.

Implementación de una política de acceso abierto en tres instituciones argentinas

En Argentina, el movimiento de Acceso Abierto (AA) comenzó a difundirse entre bibliotecarios e investigadores desde 2003. El gobierno nacional impulsó la vía verde al AA mediante la creación del Sistema Nacional de Repositorios Digitales y el mandato de colocar en disponibilidad pública los resultados y datos de investigación financiados con fondos estatales (Ley 26.899). A lo largo del artículo se examinó el proceso de implementación de esta política en tres instituciones del Sistema Nacional de Ciencia, Tecnología e Innovación: el Consejo Nacional de Investigaciones Científicas y Técnicas, la Universidad Nacional de Córdoba y la Universidad Nacional de Villa María. El estudio de caso se basa en una matriz comparativa con datos obtenidos de sitios web institucionales y de repositorios, entrevistas a informantes clave y análisis de textos legales. Ésta consta de cinco dimensiones: tecnología; procedimientos; contenidos; visibilidad y usabilidad; acciones complementarias. Los resultados demuestran que el crecimiento del AA expresa trayectorias particulares en cada institución, las cuales se manifiestan en formas organizativas y procesos de trabajo, volumen y tipo de contenidos depositados, pautas administrativas y tecnologías adoptadas, entre otros aspectos. Se observa aquí una interacción entre la política general, los contextos locales y los responsables de la implementación.

A comprehensive management model to maximize the benefits of agriculture drainage water reuse.

Water scarcity in Egypt is an escalating challenge due to the ever-increasing water demands and limited resources. Economically, agricultural drainage water reuse (ADWR) in irrigation is an essential option to cope with freshwater shortage. However, it requires environmentally sound management to minimize possible risks on irrigated soils and human health. Consequently, this research aims at assessing and managing the reuse process by developing a statistically based quality control model capable to investigate the observed and expected capability of the process. Additionally, complementary corrective actions and the decision models were proposed when the reuse processes operate in violation of the standards. These models were tested and validated using data collected from the year 2015 to 2019 at the Delengat pump station in the Western Nile Delta region, which mixes the Delengat drain water with the El-Hager irrigation canal. After raising the awareness amongst the farmers and providing them adequate sanitation services, it was inferred that the ADWR process could provide safe drainage water to be mixed with fresh water. Based on the performed simulations, both models proved to be systematic, quantitative, suitable for computers, and helpful in making informed decisions concerning the sustainability of the reuse process under future water uncertainty. PRACTITIONER POINTS: ▪In Egypt, drainage water reuse is an essential option to cope freshwater shortage. ▪A statistically based quality control model was developed to investigate the capability of the agriculture drainage water reuse process. ▪Additionally, complementary corrective actions and decision models were proposed when the reuse processes operate in violation of the standards. ▪Both the models proved helpful in making informed decisions concerning the sustainability of the reuse process under the future water uncertainty.

Lessons from a Surgical Center Satellite Warehouse in a Large Brazilian Public Hospital.

Brazilian public hospitals face several operational problems not only related to poor public management practices and their complex nature, but also the economic, and social contexts. Considering this scenario and the fact that efforts in supply management might affect a hospital organization’s excellence, this research aims to identify improvements in the logistic operations at the surgical center satellite warehouse of a Public Hospital located in Brazil. A case study based on an exploratory and qualitative approach was conducted by employing document analysis, semi-structured interviews, and on-site observations. Seven major problems concerning lack of surgical material, the non-definition of crucial logistic parameters, low information flow, surgical supply control, and management problems were pointed and addressed by seven independent but complementary actions that considered the Brazilian healthcare system’s particularities. Given the nature of exploratory research, the results are not exhaustive and cannot be generalized to different contexts. However, they help understand that reducing the waste of the logistics processes makes it possible to improve the attention to the local population that uses public health services.

Improving Students’ Vocabulary Mastery Through Bingo Games

This research was aimed to improve the vocabulary mastery of students through Bingo Game. This research was an action research study. The place of the research was at SDK Petra Madiun, East Java, Indonesia. The subject of the research was fourth grade students of SDK Petra Madiun, consisting 30 students. It was done in two cycles. The researcher did some steps for each cycle. They were planning, action, observation, and reflection. The data were collected by using test, observation, and interview. Furthermore, the data were analyzed by using descriptive statistics. It was compared between the scores of pre test (before implementing Bingo game) and post test (after implementing Bingo game). The research findings showed that vocabulary mastery of most students improved after Bingo Game was used in the teaching and learning process. It was indicated by the increase of the mean of students’ vocabulary score in the pre-test and post-test (67.22 to 80.57). The students’ involvement and classroom interaction during the implementation of the game improved. It was showed by students’ enthusiasm during the game. They tried to be the first winner and raised their competitiveness among them. In addition, the implementation of Bingo Game and the complementary actions were successful to help the students memorize and understand new words easily. In conclusion, the students’ vocabulary mastery improved through the implementation of Bingo Game.

Between flowers and fears: the new coronavirus pandemic (COVID-19) and the flower retail trade

Abstract In order to support a better understanding of the current scenario of the crisis installed by the New Coronavirus (SARS-CoV-2: COVID-19) in the flower retail trade, it is presented a descriptive exploratory research carried out between April and May 2020 with 30 flower shop managers located in the Southern region of Brazil. The results showed that the most significant impacts were the drop in the number of customers, which reduced the company’s income when compared to the values sold before the pandemic, and that the pandemic scenario generated a 45.3% reduction in financial transactions on average. Among the flower shops in this survey, 70% of flower shops were closed for an average of 21.4 days, when they were reopened with restrictions on attendance related to hours or the number of people inside the stores. The e-commerce and social media were the main tools to confront this situation, and the most used Apps were WhatsApp and Instagram. But other actions such as discounting on purchases by quantity, free delivery and marketing in the surrounding were also registered. Among the possible complementary actions in order to face this crisis and which can have positive effects, it is highlighted the online courses directed to the trade of gardening kits, the adoption of the Just In Time (JIT) methodology that can result in partnerships with local producers in order to reduce inventory costs and purchase prices, and the organization of collective purchasing groups to bargain prices with wholesalers, as well as the reduction of transportation and operational costs at Veiling in Holambra.

Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses

BackgroundTissue plasminogen activator (tPA) is a serine protease involved in fibrinolysis. It is released by endothelial cells, but also expressed by neurons and glial cells in the central nervous system (CNS). Interestingly, this enzyme also contributes to pathological processes in the CNS such as neuroinflammation by activating microglia and increasing blood–brain barrier permeability. Nevertheless, its role in the control of adaptive and innate immune response remains poorly understood.MethodstPA effects on myeloid and lymphoid cell response were studied in vivo in the mouse model of multiple sclerosis experimental autoimmune encephalomyelitis and in vitro in splenocytes.ResultstPA-/- animals exhibited less severe experimental autoimmune encephalomyelitis than their wild-type counterparts. This was accompanied by a reduction in both lymphoid and myeloid cell populations in the spinal cord parenchyma. In parallel, tPA increased T cell activation and proliferation, as well as cytokine production by a protease-dependent mechanism and via plasmin generation. In addition, tPA directly raised the expression of MHC-II and the co-stimulatory molecules CD80 and CD86 at the surface of dendritic cells and macrophages by a direct action dependent of the activation of epidermal growth factor receptor.ConclusionsOur study provides new insights into the mechanisms responsible for the harmful functions of tPA in multiple sclerosis and its animal models: tPA promotes the proliferation and activation of both lymphoid and myeloid populations by distinct, though complementary, mechanisms.

Indigenous Microbiota to Leverage Traditional Dry Sausage Production.

The main issue addressed in this review is the need for innovation in the artisanal production of dry fermented sausages—leveraging rather than discarding tradition, together with some practical strategies available to achieve it. Throughout the text, emphasis is placed on the autochthonous microbiota responsible for the identity and unique sensory characteristics of these products. The available strategies to introduce innovation in this manufacturing process rely on metabolic flexibility of microbial strains. In this sense, this review evaluates the application of several tools aimed at improving the quality and safety of artisanal dry fermented sausages focusing on the microbial community role. The most studied alternatives to enhance dry sausage production comprise the use of autochthonous starter cultures—including functional and/or probiotic strains, the production of bacteriocins, and the generation of bioactive peptides, which have been thoroughly covered herein. The purpose of this work is to review recent research about novel different strategies available for food technologists to improve safety and quality in the manufacture of dry fermented sausages. Additional support strategies—quality product registers and innovation through tradition—have been suggested as complementary actions towards a successful introduction of indigenous microbial communities into traditional dry sausage production.

Mechanisms controlling pancreatic islet cell function in insulin secretion.

Metabolic homeostasis in mammals is tightly regulated by the complementary actions of insulin and glucagon. The secretion of these hormones from pancreatic β-cells and α-cells, respectively, is controlled by metabolic, endocrine, and paracrine regulatory mechanisms and is essential for the control of blood levels of glucose. The deregulation of these mechanisms leads to various pathologies, most notably type 2 diabetes, which is driven by the combined lesions of impaired insulin action and a loss of the normal insulin secretion response to glucose. Glucose stimulates insulin secretion from β-cells in a bi-modal fashion, and new insights about the underlying mechanisms, particularly relating to the second or amplifying phase of this secretory response, have been recently gained. Other recent work highlights the importance of α-cell-produced proglucagon-derived peptides, incretin hormones from the gastrointestinal tract and other dietary components, including certain amino acids and fatty acids, in priming and potentiation of the β-cell glucose response. These advances provide a new perspective for the understanding of the β-cell failure that triggers type 2 diabetes.

Zadania administracji publicznej w zakresie ochrony zieleni oraz formy ich realizacji – uwagi wybrane

Public administration tasks in the scope of green areas protection and the forms of their implementation – selected remarks The article presents forms of administration activities which may influence the condition of green areas. It is pointed out that the analysis of public administration tasks in the scope of green areas protection cannot be limited only to the solutions presented in the Act of April 16, 2004 on the protection of the environment. It is stressed that actions taken on the basis of other legal acts, not necessarily directly related to the protection of the environment, may also have an influence on the condition of green areas. Both planning acts and decisions issued in specific cases may have this kind of character. The legal effects resulting from them may indirectly affect the green areas. Therefore, the necessity of taking complementary actions by all authorities is indicated, the application of which may ensure effective protection of green areas. Solutions that may enable it are already existing and operational, but they should be properly used.

Fournier Syndrome-Surgical and Intensive Care Treatment

Fournier’s Gangrene, also referred to as necrotising fasciitis, Mellene Syndrome or Fournier Syndrome (FS), is a soft-tissue acute infection of the perinium with secondary necrotising cellulitis caused by anaerobic germs or gram-negative bacilli or both. This infection may develop in apparently normal skin, affects the tegumentary and fascial planes but it affects the muscle - aponeurotic plane very rarely dissecting the necrotic tissues, as it rapidly moves towards sepsis, with multiple failure of the organs and death. Treatment consists of agressive surgical debridement, broad spectrum antibiotic therapy, hyperbaric oxiygen therapy (OHB) and other complementary actions.