ABSTRACT This was a prospective randomized study comparing the safety and efficacy of ProSeal laryngeal mask array (PLMA) vs endotracheal intubation (ETI) in gynecological laparoscopic surgeries undertaken in 80 patients with American Society of Anesthesiologist I and II divided into two groups. The parameters assessed were insertion characteristics, hemodynamic response to insertion, gastric distension, and perioperative complications. The demographic data were comparable. The first-time success rate was slightly higher for PLMA than for ETI. The time required for achieving effective airway was longer in ETI than in PLMA (25.6 ± 8.1 seconds for ETI vs 18.2 ± 5 seconds for PLMA). The hemodynamic response to intubation/insertion was more in ETI group than in PLMA group, i.e., there was more rise in pulse rate and mean arterial pressure following ETI than PLMA insertion. Intraoperatively, no episodes of laryngospasm, bronchospasm, desaturation, and inadequate ventilation were observed in both the groups. Postoperatively, sore throat complaints were observed more with ETI than with PLMA. How to cite this article Avhad V, Oak S, Shetty A. Comparison of Safety and Efficacy of ProSeal Laryngeal Mask Array vs Endotracheal Intubation for Gynecological Diagnostic Laparoscopy. Res Inno in Anesth 2017;2(1):9-13.