Complaints Of Memory Loss Research Articles

Cognitive and Social-Emotional Changes Associated with Mesial Orbitofrontal Damage: Assessment and Implications for Treatment

Abstract Clinical and experimental analysis of a 47-year-old female with an isolated right orbital frontal lesion is described. Although she voiced complaints of memory loss, neurological evaluation was negative with the exception of recall of only one of three words following delay on the Mini-Mental Status Examination. Results of comprehensive neuropsychological analyses revealed subtle right anterior brain dysfunction evident in memory for non-verbal information, cognitive efficiency, complex attention, visual-spatial planning and organization, strategy application, vulnerability to proactive interference and visual-spatial working memory. A plethora of social-emotional changes were reported and verified through empirical measures. Results were consistent with her reported functional limitations and suggest that the orbital frontal cortex provides critical neural mechanisms for adaptation, though without evident effects on general intellect, language or perception. Intervention approaches are described, but many impairments have remained intractable.

Memory Complaints Herald Memory Loss

Complaints of memory loss are increasingly common as people age. This study used data from the community-based Amsterdam Study of the Elderly to

Clinical course of a cohort in the Cuban epidemic optic and peripheral neuropathy.

Nearly 51,000 Cubans were afflicted during an outbreak of an optic neuropathy (ON) and peripheral neuropathy (PN) between 1991 and 1993. We re-examined 14 of 20 affected individuals 16 months after an initial evaluation. The optic features were painless symmetric vision loss with poor visual acuity, color vision loss, central or cecocentral scotoma, optic disc pallor, and nerve fiber layer drop-out. The neurologic symptoms included stocking-glove sensory changes, hearing loss, leg cramps, sensory ataxia, hyperactive or absent reflexes, and complaints of memory loss. Two of 11 ON probands tested harbored Leber's hereditary optic neuropathy (LHON)-associated mitochondrial DNA mutations. All patients had received multivitamin therapy. We performed comparisons using the paired two-tailed t test. On re-examination, 12 of 14 patients demonstrated improvement. One patient remained unchanged. One woman with the nt-3460 mtDNA mutation showed a decline in vision. In patients not harboring mtDNA mutations, overall visual acuity, color vision, and peripheral neuropathy manifestations improved significantly (p < 0.001 for each manifestation). Most of the patients with Cuban ON and PN improved on multivitamin therapy. The significance of the mtDNA mutations is unclear. In the 2 LHON patients, manifestation of the disease may have been precipitated by nutritional deficiency. Patients with poor recovery or further deterioration should be evaluated for other factors, including poor vitamin therapy compliance and alternative diagnoses.

Age-associated memory loss: initial neuropsychological and cerebral metabolic findings of a longitudinal study.

To determine the relationships between clinical and brain function in persons with a familial risk for Alzheimer's disease, the authors assessed subjective and objective cognitive abilities, mood state, and cerebral glucose metabolism (using positron emission tomography) in 43 persons with age-associated memory impairment, with and without first-degree relatives with a clinical diagnosis of Alzheimer's disease. Subjective complaints of memory loss, mood state ratings, and objective memory measures were similar in persons with a family history of Alzheimer's disease (n = 29) compared to those without such a history (n = 14). Metabolic ratios in the frontal regions correlated with a decrease in a specific type of subjective memory complaint (mnemonics usage; p < .001) and some mood state ratings. These results indicate that parietal and temporal hypometabolism is not evident in persons with mild age-related memory complaints, even when such subjects have a familial risk for Alzheimer's disease. Moreover, self-reports of mnemonics usage may be sensitive indicators of decreased frontal lobe function. Longitudinal study will determine whether such clinical and metabolic measures will predict eventual disease progression.

Quantitative and qualitative aspects of memory performance after minor head injury

Neuropsychological investigation of minor head injury (MHI) has consistently corroborated patient subjective complaints of memory loss. An experimental group of 11 minor head-injured patients and a control group of age-matched normal volunteers were compared on the California Verbal Learning Test (CVLT) and on the Rey-Osterreith complex figure. Minor head-injured subjects were found to be impaired on measures of short-term and delayed free recall as well as on measures of organizational-semantic strategy in the retrieval phase. These findings are consistent with subjective reports from the patients and may in part explain reduced psychosocial and vocational adaptation following minor head injury.

Management of Depression in the Elderly

Primary care physicians have a vital role to play in identifying depression in their elderly patients. Diagnosis may be difficult, because symptoms are atypical and frequently include psychomotor agitation, somatic symptoms, and complaints of memory loss. Patients with medical illnesses, such as cancer, postmyocardial infarction, stroke, Parkinson's disease, and early Alzheimer's disease are particularly vulnerable to depression. Drugs that may cause depressive symptoms are digitalis at toxic levels, beta-blockers, centrally acting antihypertensives, immunosuppressants, and nonsteroidal anti-inflammatory agents. Cyclic antidepressants are the drugs of first choice. Selection depends on the patient's physical health and current medications and the side effect profile of the drug. Side effects are more pronounced in old age because of drug accumulation owing to slowed clearance. Troublesome side effects are anticholinergic effects, orthostatic hypotension, sedation, cardiotoxicity, and weight gain. The most useful antidepressants for geriatric patients are the secondary amines, desipramine and nortriptyline. The second-generation drug trazodone has the advantage of causing the least anticholinergic effects, but it is very sedating. Before treatment, the patient should have an electrocardiogram, liver function tests, tonometry, sitting and standing blood pressures, evaluation of urinary symptoms for outflow obstruction, review of current medications, and estimation of suicide risk. Cyclic antidepressants are contraindicated during recovery from myocardial infarction, in heart disease when there is severe impairment of myocardial performance, in seizure disorders, and in the presence of glaucoma or a large prostate. Drug interactions that may cause trouble can occur with epinephrine, MAO inhibitors, thyroid hormone, cimetidine, and centrally acting antihypertensives. Dosage should start low, increasing usually by 25 mg every 4 to 5 days until a therapeutic level is reached. Failure of a noradrenergic antidepressant after 4 to 5 weeks can be followed by a trial of a serotonergic drug. Drug serum level monitoring is useful for imipramine, desipramine, and nortriptyline. Monoamine oxidase inhibitors are effective in many elderly patients who are resistant to TCAs. Sympathomimetic drugs must be avoided with MAOIs. Elderly patients are at high risk of toxicity and drug interactions with lithium. Electroconvulsive therapy is useful for patients who do not respond to drug treatment, but medical complications, particularly cardiovascular, often occur in patients 75 or older. Many patients relapse after ECT. Psychotherapy together with pharmacotherapy may be the optimal treatment for elderly depressives. Older patients are more likely to become chronically depressed than younger patients. The risk of suicide in depressed elderly males is high, particularly in those with psychosocial problems, and depression rises with age.

Dementia: characteristics of a referral population and factors associated with progression.

We evaluated in a standard fashion 375 patients presenting with complaints of memory loss. Etiology of memory loss included senile dementia of the Alzheimer type (SDAT)-70%, vascular dementia-5%, mixed dementia (SDAT + vascular)-9%, and other etiologies-16%. Incontinence, transient symptoms, and gait disturbances occurred more frequently in vascular dementia than in SDAT. A history of cardiovascular disease and stroke was more common in vascular dementia than SDAT. Disturbances of gait, bradykinesia, and pyramidal tract findings were commonly seen in vascular dementia. Advanced technology aided diagnosis in only 6% of patients and CT was the most useful of such tests. An earlier age of onset was noted in those with a positive family history of SDAT. Duration of symptoms at presentation for SDAT patients varied inversely with the rate of progression of dementia 15 to 55 months later, suggesting that individuals who progress more slowly require more time to elapse before the family or patient realizes the need for medical attention.

Memory complaints and memory deficits in young and old psychiatric inpatients.

Memory complaints and memory deficits were investigated in 206 consecutively admitted psychiatric inpatients at the University of Iowa Psychiatric Hospital. Forty-five percent of patients over age 60 years and 29% of patients less than 60 years old had severe memory complaints. Patients with complaints of memory loss were no more likely than patients without such complaints to have a memory deficit. In patients over age 60 years, memory complaint was more common in depression than in dementing and amnestic disorders (73% v 43%), while in younger patients memory complaint was slightly more common in dementing and amnestic disorders than in depression (57% v 41%). Increasing age was significantly correlated with increasing likelihood of memory complaint for depressed patients but not for nondepressed patients. As a result of these findings, memory complaint was found to be a statistically significant marker for depression in the elderly (sensitivity = 73%, specificity = 75%) but not in younger patients. Our results confirm the clinical observation that memory complaints are a useful marker for depressed states in the elderly.

Treatment of post-traumatic headache with imipramine.

‘ neurology. In the search for an effective way to treat the chronic pain and chronic complaints of patients with post-traumatic headache, we have employed a double blind study of imipramine (Tofr#{227}nil) 2 14 patients in the past 20 months. Patients with obvious depressive symptoms or characterologic defects were excluded, as were all patients with abnormal neurologic or electroencephalographic examinations. All patients had had discomfort for over 6 weeks and all related the pain to trauma. Almost all the patients had dizzy spells, irritability, and complaints of memory loss or inability to concentrate. The pain was usually a steady dull frontal or generalized ache, increased by exertion or bending over. The headache was often made worse by sunlight or heat. Several patients objected strenuously to wearing a helmet, usually referred to as a “steel pot,” and several patients had maximal tenderness in the local area of trauma. The patients all received either imipramine 25 mg. t.i.d. or a placebo for at least 4 weeks. Six patients of 15 received the placebo. Six patients were completely, or almost completely, pain free after treatment. Two of the most dramatically im-