Competitive Mechanism Research Articles

Injecting competition into online programming and Chinese- English translation classrooms.

The introduction of competition has the potential to enhance the efficacy of students' learning performance. Nevertheless, there have been contradictory findings about the impact of intergroup competition on students' learning performance and engagement. Therefore, further comprehensive investigations for this problem are necessary. In order to bridge this gap, the present study seeks to ascertain the efficacy of intergroup competition in relation to students' academic performance and motivation. Consequently, we present the concept of intergroup competition and implement it within the context of an online programming course and an online Chinese-English translation course. The participants of this study consist of sophomore students majoring in Computer Science and English. Initially, a total of 108 sophomore students majoring in Computer Science participated. Then, a total of 100 sophomore students majoring in English participated. A quasi-experimental study was subsequently undertaken to compare students from two courses, which are online programming and Chinese-English translation, assigning them to an experimental group and a comparison group, respectively. Then, we conducted independent samples t-tests to measure the difference between the academic performance of the two group of students from two courses. The results indicate that both groups of students who were exposed to the intergroup competition mechanism demonstrated considerably higher levels of academic performance and engagement compared to the other group of students. The findings indicate that the competition mechanism, has the potential to be a beneficial instrument for enhancing both students' learning performance and motivation.

The Z isomer of pyridoxilidenerhodanine 5'-phosphate is an efficient inhibitor of human pyridoxine 5'-phosphate oxidase, a crucial enzyme in vitamin B6 salvage pathway and a potential chemotherapeutic target.

Pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B6, acts as a cofactor in many metabolic processes. In humans, PLP is produced in the reactions catalysed by pyridox(am)ine 5'-phosphate oxidase (PNPO) and pyridoxal kinase (PDXK). Both PNPO and PDXK are involved in cancer progression of many tumours. The silencing of PNPO and PDXK encoding genes determines a strong reduction in tumour size and neoplastic cell invasiveness in models of acute myeloid leukaemia (in the case of PDXK) and ovarian and breast cancer (in the case of PNPO). In the present work, we demonstrate that pyridoxilidenerhodanine 5'-phosphate (PLP-R), a PLP analogue that has been tested by other authors on malignant cell lines reporting a reduction in proliferation, inhibits PNPO in vitro following a mixed competitive and allosteric mechanism. We also show that the unphosphorylated precursor of this inhibitor (PL-R), which has more favourable pharmacokinetic properties according to our predictions, is phosphorylated by PDXK and therefore transformed into PLP-R. On this ground, we propose the prototype of a novel prodrug-drug system as a useful starting point for the development of new, potential, antineoplastic agents.

Theoretical Investigation on the Reversible Photoswitch Mechanism of Benzylidene-Oxazolone System.

The design and application of molecular photoswitches have attracted much attention. Herein, we performed a detailed computational study on the photoswitch benzylidene-oxazolone system based on static electronic structure calculations and on-the-fly excited-state dynamic simulations. For the Z and E isomer, we located six and four minimum energy conical intersections (MECIs) between the first excited state (S1) and the ground state (S0), respectively. Among them, the relaxation pathway driven by ring-puckering motion is the most competitive channel with the photoisomeization process, leading to the low photoisomerization quantum yield. In the dynamic simulations, about 88 % and 66 % trajectories decay from S1 to S0 for Z and E isomer, respectively, within the total simulation time of ~2 ps. The photoisomeization quantum yields obtained in our study (0.20 for Z→E and 0.12 for E→Z) agree well with the experimental measured values (0.25 and 0.11), even though the number of trajectories is limited to 50. Our study sheds light on the complexity of the benzylidene-oxazolone system 's deactivation process and the competitive mechanisms among different reaction channels, which provides theoretical guidance for further design and development of benzylidene-oxazolone based molecular photoswitches.

Multicomponent adsorption mechanism of CO2, SO2, NO, and C7H8 from flue gases on nitrogen-doped biochar: Experimental and computational insights

The comprehensive control of CO2 and gaseous pollutants in coal-fired flue gas is urgent and difficult. As a green low-cost adsorbent, nitrogen-doped biochar has potential application in the control technology of flue gas pollutants. Still, its multi-component adsorption characteristics for flue gas are unclear. In this study, the multi-component adsorption characteristics of CO2, SO2, NO, and C7H8 on nitrogen-doped biochar were explored at different temperatures (25–120 °C), and the competitive mechanism of multi-component adsorption was revealed through continuous adsorption experiments and numerical calculation. The adsorption capacities of CO2, SO2, NO, and C7H8 by nitrogen-doped biochar can reach 38.1, 78.9, 3.1, and 245.2 mg/g, among which CO2, SO2, and C7H8 show strong competitive effects. Their adsorption capacities are decreased by 42 % (CO2), 28 % (SO2), and 27 % (C7H8) respectively compared with the single-component adsorption. This is because there are not only more C7H8 adsorption sites on nitrogen-doped carbon, but also C7H8 can partially occupy the adsorption sites of SO2 and CO2 during multi-component adsorption. Combined with the calculation results of density functional theory, the competitive ability of the three gases can be ranked as follows: C7H8 > SO2 > CO2.

Methodological Aspects of Analysis of Competition in Regional Markets of Services for Children with Disabilities

The modern development of social services markets is aimed at introducing competition mechanisms into them. These trends create the need to develop and use a methodology for assessing competition, taking into account the characteristics of each market. Existing methods for calculating various indices are labor-intensive for social markets and do not take into account their specifics: a significant share of government institutions, a narrow segment of consumers, and significant differentiation in prices for services. The article proposes a methodology for analyzing competition in the market of psychological and pedagogical support for children with disabilities, based on the use of two groups of indicators: objective and subjective indicators. To analyze subjective assessments, a coefficient of satisfaction with the price-quality ratio is proposed. Statistical indicators are used as objective assessments. The proposed methodology was tested using the example of markets for psychological and pedagogical support for children with disabilities in a number of regions of Russia. The results obtained allowed us to draw a conclusion about the state of competition in the markets under consideration and identify “problem” regions. The presented methodology allows us to obtain relatively adequate results of the analysis of competition in the market of psychological and pedagogical support for children with disabilities and can be extended to other markets in the social sphere with appropriate adjustments.

Effect of isavuconazole on the pharmacokinetics of sunitinib and its mechanism

BackgroundSunitinib, a newly developed multi-targeted tyrosine kinase inhibitor (TKI), has become a common therapeutic option for managing advanced renal cell carcinoma (RCC). Examining the mechanism underlying the interaction between sunitinib and isavuconazole was the aim of this effort.MethodsThe concentrations of sunitinib and its primary metabolite, N-desethyl sunitinib, were analyzed and quantified using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Our study evaluated the potential interaction between isavuconazole and sunitinib using rat liver microsomes (RLM), human liver microsomes (HLM), and in vivo rat models. For the in vivo study, two groups (n = 5) of Sprague-Dawley (SD) rats were randomly allocated to receive sunitinib either with or without co-administration of isavuconazole. Additionally, the effects of isavuconazole on the metabolic stability of sunitinib and N-desethyl sunitinib were studied in RLM in vitro.ResultsOur findings demonstrated that in RLM, isavuconazole exhibited a mixed non-competitive and competitive inhibition mechanism, with an IC50 (half maximal inhibitory concentration) value of 1.33 µM. Meanwhile, in HLM, isavuconazole demonstrated a competitive inhibition mechanism, with an IC50 of 5.30 µM. In vivo studies showed that the presence of isavuconazole significantly increased the pharmacokinetic characteristics of sunitinib, with the AUC(0→t), AUC(0→∞), and Tmax rising to approximately 211.38%, 203.92%, and 288.89%, respectively, in contrast to the control group (5 mg/kg sunitinib alone). The pharmacokinetic characteristics of the metabolite N-desethyl sunitinib in the presence of isavuconazole remained largely unchanged compared to the control group. Furthermore, in vitro metabolic stability experiments revealed that isavuconazole inhibited the metabolic processing of both sunitinib and N-desethyl sunitinib.ConclusionsIsavuconazole had a major impact on sunitinib metabolism, providing fundamental information for the precise therapeutic administration of sunitinib.

Capacity configuration of fuel cell hybrid vehicles using enhanced multi-objective particle swarm optimization with competitive mechanism

A well-designed hybrid powertrain is crucial for ensuring the safe, efficient, and durable operation of fuel cell hybrid vehicles. This paper introduces a modular design approach for powertrains, utilizing a Competitive mechanism-based Multi-Objective Particle Swarm Optimization (CMOPSO) algorithm integrated with nested dynamic programming. In this approach, the upper layer employs the CMOPSO algorithm to design the powertrain system, while the lower layer optimizes power coordination for each proposed design. This two-layer optimization framework considers factors such as vehicle economy and durability. Under WLTP conditions, the capacity configuration results are a fuel cell with a rated power of 22 kW, 100 batteries in series, and 7 batteries in parallel. Furthermore, the modular approach outperforms three other algorithms in terms of solution count, diversity, and overall performance metrics. The study also highlights that the vehicle’s power demand characteristics, influenced by different driving cycles, significantly affect capacity configuration results. Sensitivity analysis reveals that both the total operating cost and manufacturing cost of the vehicle are most sensitive to variations in the fuel cell rated power.

Responses of survival, antioxidant system and intestinal microbiota of native snail Bellamya purificata to the invasive snail Pomacea canaliculata

Pomacea canaliculata is one of the most successful invader in worldwide, adversely affecting native ecosystem through direct predation or indirect competition, while the mechanism of indirect effects on native species remain poorly understood. To clarify the effects of P. canaliculata on the native near-niche species, Bellamya purificata, a widespread freshwater gastropod in China, was selected as the research subject. The changes of mortality, histology, antioxidant system as well as the intestinal flora diversity of B. purificata were explored in present study. The results showed that the median lethal dose of P. canaliculata culture solution for B. purificata was 23.76 ind/L and a concentration-dependent damage of both the gonad and hepatopancreas were observed, the gonadal villi were dissolved and the hepatopancreas cells were broken at 20 ind/L. Furthermore, different concentrations of P. canaliculata culture solution leading to the antioxidant damage on the enzyme or non-enzyme systems of B. purificata at various degrees. Additionally, a decrease in the diversity of the intestinal flora was observed, accompanied by an increase in the abundance of pathogenic bacteria such as Pseudomonas and Aeromonas after the exposure of the culture solution of P. canaliculata. Last, after being recovered in freshwater for 24 h, the antioxidant damage of B. purificata and the disturbance of intestinal flora diversity were still not recovered especially in the high concentration group. The indirect competitive mechanism of P. canaliculata culture solution on B. purificata were explored from the aspects of tissue, biochemical level and intestinal flora, which enriched the research of P. canaliculata invasion on native snails in China, and provided new insights for the study of the invasion strategy of P. canaliculata.

On the Role of Group Competition Mechanism in International Chinese Classroom

International Chinese language education is a field that has attracted much attention in recent years. Under the background of China's increasing international influence, more and more people realize the importance of learning Chinese. However, with the development of international Chinese education, we should also pay attention to the research of international Chinese education classroom strategy. Based on the observation of online open courses, with group competition mechanism as the theoretical basis, take the class “Whose bag is this” in the first grade of a primary school in the Philippines as an example, observed the classroom group competition mechanism, this paper mainly introduces the competition mechanism into the Chinese language teaching classroom advantages and disadvantages, and further put forward the principles and methods of classroom competition mechanism. The aim is to provide new teaching ideas for Chinese teachers and facilitate and improve their teaching efficiency and quality.

Efficient adsorptive removal of methyl green using Fe3O4/sawdust/MWCNT: Explaining sigmoidal behavior

The 4R concept (reduce, reuse, recycle and repurpose) in water management necessitates innovative adsorption techniques that utilize sustainable and natural materials. This study investigates the use of natural sawdust embedded in magnetic iron oxide to treat wastewater. The performance of the newly synthesized Fe3O4/sawdust adsorbent was also compared to the native Fe3O4 and Fe3O4/MWCNT. Methyl Green (MG) was used as a model pollutant due to its wide use and potential toxicity. The new adsorbents demonstrated a high removal efficiency that exceeds 97 % under ambient conditions. The study investigates the effect of pH on adsorption, revealing a significant shift in removal efficiency as pH increases, with an optimal pH of around 7. The pH dependence is explained based on the point-of-zero-charge of the Fe3O4 adsorbent and the structure of the dye. The thermodynamic parameters (ΔH°, ΔS°, and ΔG°) of adsorption were determined through a temperature study. The adsorption equilibrium was found to be endothermic, therefore preferring elevated temperatures. Because the adsorption data of the study exhibited S-shaped-like curves, sigmoidal models were used to describe the adsorption isotherms. This provided new insights into the competitive adsorption mechanisms acting on the heterogeneous Fe3O4/sawdust surfaces. The kinetics study indicates rapid and efficient adsorption with pseudo-second-order reaction. The half-life of the reaction was as low as 4.8 min. The findings suggest a rapid, highly efficient and sustainable method to remove organic pollutants from wastewater.

A modified cyclic elastoplastic constitutive model considering the variational dynamic recovery term of back stress for FGH95 under asymmetrical cyclic loading

The asymmetric cyclic loading process occurs in aero-engine turbine discs. A constitutive model that accurately describes the cyclic elastoplastic behaviour of the material is important for structural design and low cycle fatigue life prediction of turbine discs. In this paper, the low cycle fatigue test of FGH95 was carried out at 620℃ under 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0% and 1.1% strain amplitude with strain ratio equal to 0. The material exhibited cyclic hardening followed by cyclic softening at high strain amplitudes and cyclic softening at low strain amplitudes. The mean stress relaxation rate was similar for each strain amplitude. In addition, the evolution of effective stress and back stress was obtained through the method of internal stress division. Then, the relationship between the change in stress amplitude and the change in internal stress was discussed. The results showed that with cyclic loading, cyclic hardening/softening of FGH95 was affected by the competition mechanism of back and effective stresses. Considering that slip deformation and crystal lattice rotation coexist in plastic deformation, the dynamic recovery term of the Abdel-Karim and Ohno model was used. In order to characterize the different magnitudes of back stress change in materials at different plastic strain intervals, a dynamic recovery term coefficient was introduced to the dynamic recovery term and the critical surface of the back stress. The modified model was used to compare with experimental results. Then, it gives a good description of the material’s mean stress relaxation and strain amplitude variation and gives good agreement on the hysteresis loop.

Evolution of monopoly regulation

The monopolistic organization of markets is as deeply rooted as the competitive one. It requi­res market actors to take this into consideration. It requires national regulators to counteract it or at least to restrict the freedom of monopolists to the extent that they cannot abuse their market power and negatively affect public welfare. Both the ways of monopolization and the ways of counteracting it are evolving, constantly upset­ting the balance between competition and mono­poly, requiring new ways of regulating mono­polies. The authors research the evolution of monopoly regulation: from spot prohibitions of anticompetitive practices in ancient times to the systemic balancing of competitive and state mechanisms of monopoly regulation today. The article is systematized all approaches to mono­po­ly regulation into three groups, such as: antitrust regulation as control and counteraction to abuse of dominant position by a monopolist; direct regulation of permitted monopolies, including licensing, price regulation and regula­tion of access to a key resource; structural reform of monopolistic industries and introduce­tion of competition in the potentially competitive segments of it – outside the bottleneck in the value chain, where a key resource of a permitted monopoly is exploited. The combination of the theoretical foundations of state monopoly regulation with the practice of such regulation within each approach illustrates the synergy of their joint application and opens up prospects for their exploitation not only for traditional forms of monopoly, but also for neo-monopolies that are emerged in the digital unregulated sector

Mechanism of activation of contact-dependent growth inhibition tRNase toxin by the amino acid biogenesis factor CysK in the bacterial competition system.

Contact-dependent growth inhibition (CDI) is a bacterial competition mechanism, wherein the C-terminal toxin domain of CdiA protein (CdiA-CT) is transferred from one bacterium to another, impeding the growth of the toxin recipient. In uropathogenic Escherichia coli 536, CdiA-CT (CdiA-CTEC536) is a tRNA anticodon endonuclease that requires a cysteine biogenesis factor, CysK, for its activity. However, the mechanism underlying tRNA recognition and cleavage by CdiA-CTEC536 remains unresolved. Here, we present the cryo-EM structure of the CysK:CdiA-CTEC536:tRNA ternary complex. The interaction between CdiA-CTEC536 and CysK stabilizes the CdiA-CTEC536 structure and facilitates tRNA binding and the formation of the CdiA-CTEC536 catalytic core structure. The bottom-half of the tRNA interacts exclusively with CdiA-CTEC536 and the α-helices of CdiA-CTEC536 engage with the minor and major grooves of the bottom-half of tRNA, positioning the tRNA anticodon loop at the CdiA-CTEC536 catalytic site for tRNA cleavage. Thus, CysK serves as a platform facilitating the recognition and cleavage of substrate tRNAs by CdiA-CTEC536.

Enhanced photoresponse in Au-decorated MoSe2 photoanodes for dual-wavelength photoelectrochemical applications

By utilizing photovoltage competition between two photoelectrodes, we have successfully fabricated a photoelectrochemical (PEC) device that features switchable photocurrent polarity for wavelength-selective photodetection. Composed of distinct semiconductor materials, this device exhibits a negative photocurrent density of −1.98 μA/cm2 under 365 nm illumination and a positive photocurrent density of 0.46 μA/cm2 under 650 nm illumination, without requiring an external power source. The observed bidirectional photocurrent is attributed to the photovoltage competition mechanism between the photoelectrodes. Notably, the photocurrent and responsivity under 650 nm illumination are significantly enhanced following the deposition of Au nanoparticles on the MoSe2 photoelectrode. In a three-electrode system without ZnO electrodes, the photoresponse is increased by three orders of magnitude after Au nanoparticle modification. Similarly, in a two-electrode system with ZnO electrodes, the photoresponse is enhanced by more than fifty times following Au modification. This enhancement promotes more efficient redox reactions within the device, thereby offering a novel strategy for wavelength-selective photodetection. This innovation has substantial application potential in the field of photoelectrochemistry.

Polarized benzene rings can promote the interaction between CaM and the CaMBD region of nNOS.

The neuronal nitric oxide synthase (nNOS) subtype of nitric oxide synthase (NOS) is an enzyme required for learning and memory. Overactivation of nNOS can lead to oxidative/nitrite stress, which is complicit in the pathophysiology of various neurological and psychiatric disorders. Previous studies have shown that calmodulin (CaM) forms complexes with Ca2+ and binds to the calmodulin-binding domain (CaMBD) of nNOS, thereby upregulating its catalytic activity in hippocampal neurons. To date, there has been no explanation for the non-covalent interactions in the CaMBD-CaM binding structure model of nNOS. In this study, we aimed to investigate the intrinsic factors involved in the binding of CaM to NOS-CaMBD and designed interfering peptides based on the N0 peptide structure of the original nNOS-CaMBD sequence: N1 (obtained from the L734F mutation), N2 (obtained from the F731Y and F740Y mutations), and N3 (obtained from the F731L, V738L, and F740L mutations). We employed homology modeling to construct six CaM-peptide complex models, aiming to elucidate the roles of key amino acid residues within the N0 peptide in its interaction with CaM by means of molecular dynamics simulations. The effect of the peptides on the activation and release of NO by nNOS in neurons was assessed using murine primary neuronal cells. When measuring neuronal NO content, it was found that adding N2 and N3 to cultivated neurons significantly increased nNOS activity, leading to the increased NO production. We found that interfering peptides could stably bind to CaM. Among them, N2 and CaM exhibited the strongest binding ability, indicating that the polarized benzene ring significantly enhanced the binding between nNOS-CaMBD and CaM. Conversely, the binding ability between N0 and CaM was the weakest, as they exhibited the worst polar contact, weakest hydrogen bonding, and the lowest binding free energy. The simulation results also highlighted several important amino acid residues: The K76 of CaM plays an important role in polar contact and hydrogen bonding formation, the L734 residue suppressed model flexibility to a certain extent and had an adverse effect on the overall binding free energy of the model. These results, compared with the results of cellular NO content, a preliminary verification of the antagonistic competitive mechanism between CaM allosteric activation of nNOS and SUMOylation hyperactivation was performed. In summary, this study explored the ability and mode of action of key residues in nNOS-CaMBD on the binding of interfering peptides to CaM, thereby providing new structural perspectives for the activation of nNOS by CaM and recommendations for drug design targeting the specific inhibition of nNOS.

Optical properties of Makrofol under various alpha fluences

The optical properties of Makrofol samples are investigated under various fluences of alpha exposure (2 MeV at 5×102, 103, 5×103, 104 , 5×104, 105, 5×105 and 106 alphas.cm2 alongside the unirradiated ones (pristine). Several analyses, including UV–visible, diffused reflectance spectroscopy (DRS), photoluminescence (PL), Fourier transform infrared/attenuated total reflectance (FTIR-ATR), X-ray photoelectron spectroscopy (XPS) and sessile drop technique, are carried out to reveal the subsequent variations in the optical features of the irradiated polymer foils. The optical transmittance of the irradiated samples notably increases against the pristine ones, while it undergoes a+ plateau over various fluences. Additionally, the scattering events are more prominent in pristine samples over UV (240–400 nm) and IR (900–1040 nm) compared to the irradiated ones. While there are negligible physical alterations on the polymer surface, the photoluminescence emission gradually decreases with increasing alpha fluences in the irradiated samples mainly due to the reduction in the population of the aromatic rings. The latter is also verified by means of the surface chemical analyses such as XPS, FTIR-ATR and sessile drop/contact angle measurements. XPS reveals that the alpha particles give rise to the successive scissions of C–C and CO bonds and the consequent recombination events in the form of C–O bonds, evidenced by the changes in their abundance percentages. Concurrently, the surface hydrophilicity initially elevates up to a certain fluence and then reduces at higher fluences, indicating a couple of competitive mechanisms are involved in the context of the interactions of the alpha particles with the Makrofol polycarbonate (PC).

The sulfurization precipitation and competition mechanisms of Cu(II) and As(V) in electrolyte towards efficient recovery of copper

The sulfide precipitation has been widely used to recover Cu(II) and remove As(V) in copper smelting electrolyte based on the Cu(II)-As(V) separation. However, the recovery efficiency was undesirable due to the inaccurate control of process parameters. It was necessary to investigate the process and mechanisms of sulfurization precipitation for accurate adjustment. Herein, under the single and mixed solutions of Cu(II) and As(V), the process parameters were investigated and the precipitation mechanisms were explored. And when using actual electrolytes, the corresponding sulfurization process and mechanisms were also revealed. The sulfurization results of single component solutions suggested that Cu(II) was rapidly precipitated in one step, but As(V) firstly generated intermediate, then it was gradually reduced to As(III) for a longer time and quickly precipitated in the form of amorphous. This phenomenon caused the significantly faster removal speed of Cu(II) than that of As(V). For their mixed solutions, only a small amount of As(V) were removed by adsorbing the precipitate at the low S/Cu molar ratios (RS/Cu), and Cu(II) and As(V) could achieve a good separation. Simultaneously, it revealed that the sulfidation competitive mechanisms were related to the solubility product constant (Ksp) and initial As(V) concentrations. In addition, the similar rules were also observed in actual electrolytes. Moreover, under RS/Cu = 1.2 and reaction time of 10 min, the arsenic content of sulfide precipitates in the actual electrolyte was less than 2.5%, which showed a great separation also could be obtained for the actual electrolyte. This result met the requirement of Cu(II) recovery. It can provide a good reference for adjusting sulfidation parameters in the actual process to achieve efficient copper recovery, reduce the production of hazardous waste containing arsenic at the source and realize the cleaner production of copper smelting system.

How competition play a role in dental pricing? A study on French medico-administrative and tax reports dataset

ObjectivesFrench dentists charge additional fees for dental prostheses. This paper aims to provide new information on the determinants of dental price setting and inform public decision-making in the context of the widespread rejection of prosthetic dental care for financial reasons. We focus on the competitive mechanism in the dental prosthetics market and measure the impact of the density of professionals and competitors' prices on the fees charged by dentists. MethodsWe use data merging from an administrative health insurance database and information from tax declarations of French dentists. We test the effect of competitor prices and competition on individual price-setting using instrumental variables. The database obtained included 29,220 dentists. ResultsPractitioners’ prices grow with competitors’ prices (+1€ in competitor prices entails an increase of + 0.37€ in the practitioner's price). Women set lower prices, and having a young child in the household predicts an increase in price of 6.8€ (p-value=0.014). Rural areas present lower fees than urban areas (+11.4€ (p value=0.000)). ConclusionProsthetic prices are strategic complements that are compatible with the application of monopolistic competition in the dental care market. We encourage the regulator to develop competitive mechanisms, for example, through a public offer at moderate prices.

Electrochemical membrane systems for remediating ammonium-containing wastewater via coupling capacitance adsorption and oxygen reduction

As the main nitrogen-containing pollutant of industrial and agricultural wastewater, ammonium (NH4+) is obtainable from the natural nitrogen cycle and industrial emission. Electrochemical recovering nitrogen (N) from nitrate-polluted wastewater to produce ammonia (NH3) is a promising route to mitigate pollution risks and create economic values. Since side reactions at the electrodes are inevitable, and the competition mechanism between electric double layer capacitance (EDLC) behavior and side reactions is still unclear. Herein, electrochemical selective NH4+ recovery from wastewater was achieved by coupling NH4+ adsorption and side oxygen reduction reaction (ORR) in a novel electrochemical membrane extraction system using Ti3C2TX-based gas-diffusion cathodes. Batch experiments showcase simultaneous NH4+ removal and recovery, with TiOX/TiC-C exhibiting the highest removal capability of 408 mgN g−1. In situ Raman spectroscopy revealed the critical role of the four-electron transfer ORR reaction in the conversion of NH4+ to NH3. Density functional theory (DFT) showed that excellent electron-donating ability for NH4+ of TiOX/TiC-C electrode (1.97 eV) facilitated NH4+ diffusion onto electrode interface. The study sheds light on the intricate interplay between NH4+ adsorption and ORR, highlighting the significance of tailored support and vacancy engineering in advancing wastewater treatment and resource recovery.

Glow-type luminol chemiluminescence based on a supramolecular enhancer of cyclodextrin

BackgroundChemiluminescence (CL) bioassay is one of the most advanced and used detection method in clinical diagnosis and biomedical research because of the advantages of low background, easy operation, and wide-field imaging without a light source or microscope. The luminol/hydrogen peroxide/horseradish peroxidase (luminol/H2O2/HRP) system is the most popular CL system, but its application in high-throughput imaging detection is challenged due to its low luminescence efficiency and flash-type emission which is difficult in ensuring the reproducibility and consistency of detection results. ResultsWe reported a glow-type CL system of luminol@CD/H2O2/HRP by using a supramolecular enhancer of cyclodextrin (CD). This luminol@CD/H2O2/HRP system exhibited a luminescence lifetime of 41 min for sensitive and accurate imaging analysis. The long-lasting CL emission was attributed to the formation of a 1:1 host–guest complex between luminol and CD, which could stabilize the emitter and effectively reduce nonradiative relaxation. The formation of luminol@CD complex was determined through NMR experiments and theoretical analysis. Under optimum conditions, the luminol@CD/H2O2/HRP system showed higher sensitivity and much better precision than classical luminol/H2O2/HRP system for imaging detection of HRP. Especially, this glow-type luminol@CD/H2O2/HRP system realized CL imaging of microwell arrays on microfluidic chips. In addition, the luminol@CD/H2O2/HRP system was successfully applied for point-of-care detection of 17β-estradiol based on a competitive mechanism of host–guest recognition. SignificanceAn efficient CL system is crucial for obtaining reproducible and consistent results for accurate detection. Our luminol@CD/H2O2/HRP system emitted strong and persistent luminescence, resulting in reliability and efficiency at both CL macroscopic and microscopic imaging detection. We expected the luminol@CD/H2O2/HRP CL system to be applied in various detection fields.