here, we investigated if simply tilting the saddle nose down increases efficiency during uphill cycling, which would presumably improve performance. nineteen healthy, recreational cyclists performed multiple 5min trials of seated cycling at ~ 3Wkg-1 on a large, custom-built treadmill inclined to 8° under two saddle-tilt angle conditions: parallel to the riding surface and 8° nose down. We measured subjects' rates of oxygen consumption and carbon dioxide production using an expired-gas analysis system and then calculated their average metabolic power during the last two min of each 5 min trial. we found that, compared to the parallel-saddle condition, tilting the saddle nose down by 8° improved gross efficiency from 0.205 to 0.208-an average increase of 1.4% ± 0.2%, t = 5.9, p < 0.001, CI95% [0.9 to 1.9], dz = 1.3. our findings are relevant to competitive and recreational cyclists and present an opportunity for innovating new devices and saddle designs that enhance uphill-cycling efficiency. The effect of saddle tilt on other slopes and the mechanism behind the efficiency improvement remain to be investigated.