Programming skills should be taught and developed; Scratch and App Inventor are two tools that can contribute significantly to developing this competence in university students. This study aims to investigate the use and effect of the programming language Scratch and App Inventor on the development of skills and competencies for learning (autonomy, attention, motivation, critical thinking, creative thinking, computational thinking, communication, problem solving and social interaction) in higher education. To achieve this goal, a systematic review of articles in English and Spanish was carried out using the PRISMA statement (research publication guidelines designed to improve the integrity of systematic review and meta-analysis reports). A search for studies was conducted in the Web of Science (WOS), Dialnet, and SCOPUS. A total of 405 papers were analyzed, of which 11 were finally selected. The results showed that both Scratch and App Inventor favor the development of skills and competencies for learning in the context of higher education, despite being underutilized strategies that all knowledge disciplines should promote.