Humans are the most important valuable resource to run a company towards its objectives. Among other resources, Human resources play a vital role in taking part in the maximum contribution to organizational performance. Every organization will have a goal to achieve and the most common goal is to earn profit and added to that to capture the market area for a long time and continuous expansion. To achieve these goals and objectives, organizations have to bring various resources like Money, Power, Raw materials, Humans, etc., All these resources will take part in the organization's performance and its effectiveness completely depends upon “how we are managing those resources?”. Management is all about getting optimized output with minimal input. How we are handling the cash? how we are handling the raw materials? will reflect in the organization's performance. Similarly, human resource has to be managed properly. In the early days, there is no representative for workers to care for them and communicate their needs to the management. The evolution of Human Resource practices like recruitment, training, and development, performance management, compensation management, etc., made some valuable measures in managing employees. As technology grows every day many transformations have occurred in various sectors and domains. In Human Resources, clerical HR practices were now replaced by the internet and it is called e-HRM practices. Manufacturing Industries are slowly transforming into e-HRM Practices and this paper focuses on evaluating its effectiveness. A questionnaire was prepared and distributed to 496 manufacturing companies in Tamil Nadu. This research found that factors measuring the effectiveness of e-HRM practices were correlated and shows its effectiveness is high. e-HRM practices create various advantages like less time-consuming, more accuracy, etc.