The study investigated the effects of spousal incompatibility on marital stability in Lagos metropolis. In carrying out the research, a descriptive survey research design was employed. Cluster sampling method was used to select a sample of 200 respondents from the population of all married women in Eti-Osa Local Government Area of Lagos State. Three research questions and hypotheses were formulated to guide the study. A researcher-designed questionnaire was the major instrument used in collecting the data which were analyzed using Pearson Product Moment Correlation coefficient statistical tool. Results showed that there is a statistically significant positive relationship between the educational levels of spouses and marital stability. The findings also suggest that age differences between couples and religion also impacted on marital stability of couples. Based on these findings, it was recommended that youth who intend to marry should seek the informed counsel of a professional marriage counselor to help them in making the right choices and exposing them to the indices of spousal compatibility in marriage.