Companion Resource Research Articles

Ecological-Based Mining: A Coal–Water–Thermal Collaborative Paradigm in Ecologically Fragile Areas in Western China

A substantial reduction in groundwater level, exacerbated by coal mining activities, is intensifying water scarcity in western China’s ecologically fragile coal mining areas. China’s national strategic goal of achieving a carbon peak and carbon neutrality has made eco-friendly mining that prioritizes the protection and efficient use of water resources essential. Based on the resource characteristics of mine water and heat hazards, an intensive coal–water–thermal collaborative co-mining paradigm for the duration of the mining process is proposed. An integrated system for the production, supply, and storage of mining companion resources is achieved through technologies such as roof water inrush prevention and control, hydrothermal quality improvement, and deep-injection geological storage. An active preventive and control system achieved by adjusting the mining technology and a passive system centered on multi-objective drainage and grouting treatment are suggested, in accordance with the original geological characteristics and dynamic process of water inrush. By implementing advanced multi-objective drainage, specifically designed to address the “skylight-type” water inrush mode in the Yulin mining area of Shaanxi Province, a substantial reduction of 50% in water drillings and inflow was achieved, leading to stabilized water conditions that effectively ensure subsequent safe coal mining. An integrated-energy complementary model that incorporates the clean production concept of heat utilization is also proposed. The findings indicate a potential saving of 8419 t of standard coal by using water and air heat as an alternative heating source for the Xiaojihan coalmine, resulting in an impressive energy conservation of 50.2% and a notable 24.2% reduction in carbon emissions. The ultra-deep sustained water injection of 100 m3·h−1 in a single well would not rupture the formation or cause water leakage, and 7.87 × 105 t of mine water could be effectively stored in the Liujiagou Formation, presenting a viable method for mine–water management in the Ordos Basin and providing insights for green and low-carbon mining.

Reducing the Adverse Effects of Birth Trauma Among Birth Companions

Birth trauma affects the entire family, yet limited attention has been directed to how nurses influence the experiences of birth companions. Therefore, the purpose of this article is to increase awareness of birth trauma among birth companions and provide nursing strategies to reduce the adverse effects of traumatic childbirth among birth companions. I review background information describing birth companions’ perceptions of childbirth as traumatic and the implications of birth trauma. I then present protective nursing strategies before, during, and after birth, followed by a discussion on implications. Lastly, I offer a summary of protective nursing strategies, an example of postnatal debriefing using the adapted ASSIST communication tool, and available online birth companion resources.

990-P: Estimating the National Costs of T2DM in the UK within the Context of Contemporary Guidelines

Background: The updated National Institute for Health and Care Excellence (NICE) type 2 diabetes (T2D) guidelines extend the recommendation of SGLT2 inhibitors (SGLT2i) for hyperglycaemia management to include their use in those with atherosclerotic cardiovascular disease (ASCVD), chronic heart failure (HF), chronic kidney disease (CKD) or high CVD risk. Our study estimates the potential cost consequence in the UK of the broad positioning of SGLT2i within updated guidelines (NG28-2022) versus previous guidelines (NG28-2015). Methods: The Cardiff T2D model was used to project lifetime outcomes and costs for T2D patients across established UK treatment pathways including metformin, sulfonylurea, DPP-4 inhibitors and NPH insulin with or without SGLT2i combination to reflect former vs. updated guidelines. Analyses were conducted in four subgroups (ASCVD, HF with reduced ejection fraction (HFrEF), CKD, high CVD risk). Projected outcomes were extrapolated to national level using population estimates from NICE’s guideline companion resource impact report. Results: Predicted lifetime costs for 1.7 Mn SGLT2i eligible T2D patients in the UK were estimated at £87.1 Bn with NG28-2022 compared to £101.7 Bn with NG28-2015. Net savings associated with NG28-2022 management of £14.56 Bn were attributable to comorbid CKD (£5.09 Bn), high CVD risk (£4.77 Bn), ASCVD (£3.96 Bn) and comorbid HFrEF (£0.74 Bn). Overall net savings were predicted despite an increase in pharmacy costs of £5.57 Bn. Changes in metabolic parameters and reduction in cardiovascular and kidney progression rates were predicted to prevent 20183 myocardial infarction events, 66651 HF events and 140303 events of end stage kidney failure. The magnitude of savings was a combination of event reductions and the number of eligible patients in subgroups. Conclusion: Our study indicates that uptake of SGLT2 inhibitors in line with NICE guidelines has the potential to improve health and be cost saving despite an increase in pharmacy costs. Disclosure P.Mcewan: Other Relationship; AstraZeneca. V.Foos: Other Relationship; AstraZeneca. R.Martin: Employee; AstraZeneca. J.Chen: Employee; AstraZeneca, Eli Lilly and Company.

Termite Species Distribution in Florida and UF Termite Identification Services

There are 20 termite species established in Florida, but not all of them have a pest status, and some invasive termite species affect only parts of the state. This publication highlights where each termite species is known to be established, so that Florida residents, pest control companies and UF/IFAS Extension agents can easily learn the termite risk at any given location within the state. It is a companion resource to the online termite distribution map available at https://flrec.ifas.ufl.edu/termites-in-florida/termite-distribution/. The UF/IFAS termite research team provides identification services to ensure proper treatment of infestations. In addition, as some invasive species continue to spread, there is a need to continue reporting termite samples so that various communities across Florida have access to up-to-date knowledge of what termite species have been reported in their respective areas.

“Mommy, I Want to Talk to My Dad”: Exploring Parental Incarceration, Bibliotherapy, and Storybooks

Parental incarceration often involves caregivers explaining the absence of a significant attachment to a child. Developmental scholars suggest that bibliotherapy and storybooks can provide both illustrative and explanatory frameworks for caregivers to discuss difficult topics with children. Storybooks paired with caregiver wisdom might help children to understand and adjust to the loss of a parent. However, scientific-based derivatives of caregiver experiences and communication practices integrated into storybooks are largely absent from the literature. To address this gap a qualitative community-based action research study was carried out in three contiguous phases, with 22 caregivers during 8 focus groups in the Washington, D.C. Metropolitan area. Phase one entailed exploring caregiver-child communication practices related to parental incarceration. The second phase involved creating topic-specific stories integrated with bibliotherapeutic principles drawn from caregivers’ perceptions and narratives. The third phase included developing a web portal to host digital storybooks and companion resources. Catalytic validity was established through collaboration with the project team. Data analysis resulted in a robust theoretical framework and grounded theory entitled, Caregivers’ Family Relations Assessment and Communication Strategies (C-FRACS). Findings assert caregivers’ prerogatives on child well-being as a priority as it intersects with communication practices and epistemological concepts of explaining jail, prison, and parental incarceration to children.

Abstract 210: Advancing knowledgebase representation of pediatric cancer variants through ClinGen/CIViC collaboration

Abstract Childhood cancers are driven by unique profiles of somatic genetic alterations, with a significant contribution from predisposing germline variants. Understanding the genomic landscape of pediatric cancers is complicated by their rarity, the heterogeneity of variation within a given disease, and the complex forms of structural variation they contain. Variants in childhood disease may differ from those in adult versions of the same cancer type, or may have different clinical significance. Currently, pediatric variants are underrepresented in cancer variant databases, and an urgent need exists for their publicly available expert curation. To address this, the Pediatric Cancer Taskforce (PCT) was formed within the Clinical Genome Resource (ClinGen) Somatic Cancer Clinical Domain Working Group (CDWG) (https://www.clinicalgenome.org/working-groups/somatic/). The PCT is a multi-institutional group of 39 members with broad experience in childhood cancer and variant curation, whose work consists of standardization and classification of genetic variants in pediatric cancers. The CIViC knowledgebase (www.civicdb.org) is a freely available resource for Clinical Interpretation of Variants in Cancer, which leverages public curation and expert moderation to address the problem of annotating the large volume of clinically actionable cancer variants. PCT curators work together with PCT expert members and the CIViC team on variant curation, and have submitted over 230 Evidence Items and over 10 Assertions to CIViC. To further address issues specific to pediatric curation, the PCT is working with CIViC to develop new pediatric-specific CIViC features and modifications of the data model that will aid in pediatric curation. A pediatric user interface, as well as representation of large scale structural and copy number variation are being developed for version two of CIViC, expected to be released in 1-2 years, which will enable curation of a new class of structural variants often encountered in pediatric cancer. A novel standard operating procedure for childhood cancer curation in CIViC is being developed by PCT experts, curators and the CIViC team. This SOP will cover topics including curation of structural variants, as well as pediatric-specific variant tiering guidelines which take into account the sparse nature of evidence in pediatric cases. A companion resource, CIViCmine (http://bionlp.bcgsc.ca/civicmine/), will be further developed to incorporate pediatric data. These and other joint efforts of the PCT and CIViC will significantly enhance pediatric variant representation for public use, to support the care of children with cancer. Citation Format: Arpad Danos, Wan-Hsin Lin, Jason Saliba, Angshumoy Roy, Alanna J. Church, Shruti Rao, Deborah Ritter, Kilannin Krysiak, Alex Wagner, Erica Barnell, Lana Sheta, Adam Coffman, Susanna Kiwala, Joshua F. McMichael, Laura Corson, Kevin Fisher, Heather E. Williams, Matthew Hiemenz, Katherine A. Janeway, Jianling Ji, Kesserwan A. Chimene, Laura Fuqua, Lisa Dyer, Huiling Xu, Jeffrey Jean, Laveniya Satgunaseelan, Liying Zhang, Ted W. Laetsch, Donald W. Parsons, Ryan Schmidt, Lynn M. Schriml, Kristen L. Sund, Shashikant Kulkarni, Subha Madhavan, Xinjie Xu, Rashmi Kanagal-Shamana, Marian Harris, Yasmine Akkari, Nurit Paz Yacov, Panieh Terraf, Malachi Griffith, Obi L. Griffith, Gordana Raca. Advancing knowledgebase representation of pediatric cancer variants through ClinGen/CIViC collaboration [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 210.

For a Better Dictionary: Revisiting Ecolexicography as a New Paradigm

Driven by practical conundrums that users often face in maximizing (e-)dictionaries as a companion resource, this article revisits and redefines ecolexicography as a new paradigm that situates compilers and users in a relational dynamic. Drawing insights from ecolinguistics and cognitive studies, it appeals for rethinking the compiler–user relationship and placing dictionaries in a distributed cognitive system. A multidimensional framework of ecolexicography is proposed, consisting of a micro-level and a macro-level. To the micro-level, both symbolic and cognitive dimensions are added: (1) the dictionary can be symbolically viewed as a semantic and semiotic ecology; (2) dialogicality should be highlighted as an essential aspect of e-dictionary compilation/design, and distributed cognition can be emancipatory for rethinking dictionary use. The macro-level concerns the obligations of lexicographers as committed to three interrelated ecologies or ecosystems: language, socio-culture and nature. Transdisciplinary in nature, ecolexicography involves a holistic, systematic and integrative methodology to nourish lexicographical practice and research. Corpus-based Frame Analysis is introduced to identify ecologically destructive frames and ideologies so that the dictionary discourse could be reframed. The study upgrades our understanding of the ontological, epistemological and methodological aspects related to ecolexicography, serving as a call for philosophical reflections on metalexicography. It is also expected to create an opportunity for lexicographers to examine problems with (e-)dictionaries in a new light and dialogue about how to find solutions.

Approaches to Teaching the Works of Miguel de Unamuno ed. by Luis Álvarez-Castro

Reviewed by: Approaches to Teaching the Works of Miguel de Unamuno ed. by Luis Álvarez-Castro Linda Bartlett Álvarez-Castro, Luis, editor. Approaches to Teaching the Works of Miguel de Unamuno. The Modern Language Association of America, 2020, pp. 247. ISBN 978-1-60329-442-3. The articles contained in this book are diverse in scope, yet share a unifying purpose: that of providing practical pedagogical strategies for teaching the work of Miguel de Unamuno to undergraduates across various disciplines and course levels. Approaches to Teaching the Works of Miguel de Unamuno’s content and organization reflect both the breadth of its project and the range of its target audience. Professional Hispanists and other teachers and scholars deeply familiar with Unamuno’s work will find a great deal here that is useful, including the incisive analysis of specific texts and the succinct synthesis of relevant scholarly literature. Those less well-acquainted with the author and his vast body of work will appreciate the care that is given to contextualize Unamuno’s life and writings, as well as the general accessibility of the volume’s content (which includes English translations of all quotes and titles). The book’s first section, “Materials,” includes a variety of resources, such as a concise, yet thorough, summary of available editions of Unamuno’s work (including those in translation) and an extremely valuable review of the most prominent extant scholarship on his life and work. Wisely, the editor limits this survey to book-length treatments of Unamuno and his texts; the “Works Cited” in the back of the book is an excellent companion resource. The “Materials” section also includes a helpful segment on digital and audiovisual resources, including two recent films on Unamuno. “Approaches,” the second and most substantial part of the book, is organized according to four distinct instructional contexts: those emphasizing historical texts, those examining literary objects, those focusing on philosophical/religious inquiry, and the foreign language classroom. The brief introduction to this section effectively orients the reader to the material to follow. The first section in “Approaches,” “Teaching Unamuno,” consists of three articles, which are appropriately broad in scope: “Unamuno for the Twenty-First Century,” by Gonzalo Navajas; “Teaching Unamuno in Seven Contexts,” by Nelson R. Orringer, and “Teaching the Multifaceted Unamuno in a Semester-Long Undergraduate Course,” by Leslie J. Harkema. The seven chapters in the next unit, “Literary and Historical Milieu,” meaningfully situate Unamuno in his historical and literary context. These address an array of diverse topics, as the titles indicate: “Toward a Twentieth-Century Modernity: Unamuno’s Paz en la guerra” (Salvador Oropesa); “Dressing Up Unamuno’s Naked Theater: Contextualizing Unamuno’s Drama in the Classroom” (Tracie Amend); “Teaching Unamuno’s Poetry: Romanticism and Modernity” (Stephen J. Summerhill); “Unamuno, an Iberian Thinker: Portuguese Culture and Travel Literature in Por tierras de Portugal y España” (Juan Francisco Maura); “Unamuno’s Niebla: A Lesson in Paradox, Adaptation, and Innovation” (Edward H. Friedman); “The Perversion of Genius: Unamuno’s Exile and the Censors” (Ana Urrutia-Jordana); and “Unamuno’s Press Articles: The Badge of Identity of the Unamunian Intellectual” (Stephen G. H. Roberts). The nine entries in the “Critical and Theoretical Approaches” section focus almost exclusively on Unamuno’s novels: “The Pathos of the Hero in Unamuno” (Francisco LaRubia-Prado); “Of Love and Power: Teaching Unamuno’s Amor y pedagogía to Undergraduates outside the Literary Major” (Mark J. Mascia); “Trains, Time, and Technology: Teaching “Mecanópolis through Mobility and Science Fiction Studies” (Benjamin Fraser); “Unamuno’s Metafiction: Niebla as a Deviation from Convention” (Craig N. Bergeson); “Teaching Unamuno’s Novels: Confrontation and Existence” (Juan Herrero-Senés); “Abel Sánchez; or, The Reader’s Personality as Textual Assemblage” (Thomas R. Franz); “Teaching Cómo se hace una novela and Its Legacy in Contemporary Spanish Autofictions” (Cristina Carrasco); “San Manuel Bueno, mártir, as Literary Artifact” (Brian Cope); and “Teaching Miguel Picazo’s La tía Tula to College Students in the United States” (Diana Roxana Jorza). The six chapters in the subsequent part, “Comparative Literature, Philosophy, and Religion Classrooms,” present interdisciplinary approaches to teaching Unamuno beyond the Spanish [End Page 505] classroom. Contributions to this section include: C. A. Longhurst, “Belief...

Improving Physician-Patient Decision Making for Treatment of Chronic Lymphocytic Leukemia with BTK Inhibition

Educational Need Advancements in evidence-based treatment strategies with approved BTK inhibitors ibrutinib and acalabrutinib are improving survival of patients with chronic lymphocytic leukemia (CLL). These advances create knowledge and practice gaps as new BTK inhibitors are introduced to the treatment landscape for clinicians and patients. Education is needed to ensure that clinicians can apply current evidence and stratify patients appropriately. As new data emerges regarding long-term adverse events and the relevance of high-risk prognostic features in treatment selection; patient and provider education is warranted for effective integration of BTK inhibitors, evidence-based management strategies, patient understanding of the factors affecting treatment, improving patient-provider communication, and active participation in care decisions. Educational Initiative To meet educational needs, an educational initiative was conducted in August 2020 for HCP and patient/caregiver audiences. Both HCP and patient/caregiver programs feature live-virtual programming with interactive faculty panels, live audience polling, pre-education question submission and live Q&A. All education will remain on-demand for 12 months. HCP Elements The live-virtual CME program targets hematologic oncologists, hematologists, oncology advanced practice providers, oncology nurses, and other clinicians who manage patients with CLL. Faculty include two hematologists/oncologists with expertise in the management of patients with CLL. As a companion resource to the live CME program, expert clinical perspective was provided in the form of a patient decision library featuring four 15-minute cases from real patients, presented with interview vignettes and a focus on alignment with treatment recommendations. Patient/Caregiver Elements The live-virtual patient and caregiver directed program features a three-person panel, including one hematologist/oncologist, one hematology/oncology nurse practitioner, and one CLL patient. The initiative was conducted in partnership with the CLL Society. The full program will be featured online and will be additionally distributed in smaller chapters on social media, including Facebook and YouTube. Patients will also be invited to engage in the patient decision library to hear the stories of the four patients and the expert commentary on treatment decision-making. Methods and Anticipated Results Educational impact evaluation data will be collected through a series of surveys administered to learners prior to and following the educational programs. For the HCP program, questions will be designed to evaluate the effects of learner participation on change in knowledge, competence, and clinical practice behavior parameters. For the patient/caregiver program, questions will be designed to evaluate the effects of participation on change in knowledge, empowerment, and health-related behaviors. Impact, engagement, and attendance data to date will be reported. Some engagement statistics include total learners, target audience learners, average time in session, total in-session polling responses, question count, and total slide downloads. Impact data will be specifically gathered through an activity pretest, posttest (immediately following activity), and a 2-month follow-up posttest. The 2-month follow-up posttest has a strong focus on behavioral impact of the education and will be composed of open- and closed-ended questions. Open-ended qualitative responses will be grouped by theme. McNemar testing will be conducted on responses to knowledge and competence questions that are repeated at 3 timepoints (pre/post/follow-up) to assess statistical significance; effect size (Cohen's D) will also be reported for these questions. Disclosures Davids: TG Therapeutics: Consultancy, Research Funding; Verastem: Consultancy, Research Funding; MEI Pharma: Consultancy, Research Funding; Surface Oncology: Research Funding; AstraZeneca: Consultancy, Research Funding; Ascentage Pharma: Consultancy, Research Funding; Adaptive Biotechnologies: Consultancy; AbbVie: Consultancy; Pharmacyclics: Consultancy, Research Funding; Gilead Sciences: Consultancy; Novartis: Consultancy, Research Funding; BeiGene: Consultancy; Celgene: Consultancy; Eli Lilly: Consultancy; Genentech: Consultancy, Research Funding; Janssen: Consultancy; Bristol Myers Squibb: Research Funding; Merck: Consultancy; Research to Practice: Honoraria; Syros Pharmaceuticals: Consultancy; Zentalis: Consultancy; Sunesis: Consultancy. Mato:AstraZeneca: Consultancy, Research Funding; TG Therapeutics: Consultancy, Research Funding; Pharmacyclics: Consultancy, Research Funding; Genentech: Consultancy, Research Funding; Loxo: Consultancy, Research Funding; Adaptive: Consultancy, Research Funding; AbbVie: Consultancy, Research Funding; Janssen: Consultancy, Research Funding. Koffman:Astra Zeneca: Speakers Bureau; Miragen Therapeutics Inc: Current equity holder in publicly-traded company; Astra Zeneca: Current equity holder in publicly-traded company; Iovance Biotherapeutics: Current equity holder in publicly-traded company; Synairgen Plc: Current equity holder in publicly-traded company; Pfizer: Current equity holder in publicly-traded company; Oncternal Therapeutics Inc: Current equity holder in publicly-traded company; BeiGene: Current equity holder in publicly-traded company; TG Therapeutics: Speakers Bureau; Humanigen: Current equity holder in publicly-traded company; Bristol-Myers Squib: Speakers Bureau; MEI Pharma: Current equity holder in publicly-traded company; Bristol-Myers Squibb: Current equity holder in publicly-traded company; Sunesis Pharmaceuticals: Current equity holder in publicly-traded company; Abbvie: Current equity holder in publicly-traded company; Johnson & Johnson: Current equity holder in publicly-traded company; Verastem Oncology: Current equity holder in publicly-traded company; Inovio Pharmaceuticals Inc: Current equity holder in publicly-traded company.

Caregiver burden: Empowering caregivers with shared decision-making strategies and skills to improve patient quality of life and outcomes.

142 Background: Data from the National Cancer Institute’s Surveillance, Epidemiology & End Results (SEER 2016) program estimates there are 15.5 million cancer survivors in the United States who rely on cancer caregivers every day. Caregivers play an essential role throughout the care continuum greatly impacting a patient’s quality of survivorship. Methods: August 2019–March 2020 the Raymond Foundation hosted nationwide caregiver focus groups and an online survey. Primary goals were reaching caregivers and the patients they serve in rural, urban, and community oncology settings to gain perspective from diverse populations. Focus groups were held in person and online via video conferencing. Results: 1012 caregivers and the patients they care for (41% male, 59% female) participated in our focus groups and online survey: 92% reported a lack of educational resources necessary to participate in shared decision making regarding treatment protocol; 90% reported they lacked communication strategies required to effectively communicate with their healthcare team; 87% reported they would like to learn more about clinical trials but did not know where to start; 85% reported they did not feel comfortable reporting treatment adverse effects; 94% reported working toward a patient-centered, advocate based care approach would lead to enhanced quality of life and improved outcomes. Conclusions: Cancer caregivers and the patients they assist understand the importance of shared decision-making and patient centered care. Based on our focus groups and survey findings, our call to action includes developing the Cancer Caregiver Advocacy Plan. This unique educational resource will provide key information to address educational gaps and empower caregivers to become informed healthcare advocates. The Cancer Caregiver Advocacy Plan will be a companion resource to the Raymond Foundation’s 2018 Cancer Caregiver Action Plan as we continue to expand our education and outreach to minimize cancer burdens for patients and caregivers.

Argonaut: A Web Platform for Collaborative Multi-omic Data Visualization and Exploration

SummaryResearchers now generate large multi-omic datasets using increasingly mature mass spectrometry techniques at an astounding pace, facing new challenges of “Big Data” dissemination, visualization, and exploration. Conveniently, web-based data portals accommodate the complexity of multi-omic experiments and the many experts involved. However, developing these tailored companion resources requires programming expertise and knowledge of web server architecture—a substantial burden for most. Here, we describe Argonaut, a simple, code-free, and user-friendly platform for creating customizable, interactive data-hosting websites. Argonaut carries out real-time statistical analyses of the data, which it organizes into easily sharable projects. Collaborating researchers worldwide can explore the results, visualized through popular plots, and modify them to streamline data interpretation. Increasing the pace and ease of access to multi-omic data, Argonaut aims to propel discovery of new biological insights. We showcase the capabilities of this tool using a published multi-omics dataset on the large mitochondrial protease deletion collection.

The changing mouse embryo transcriptome at whole tissue and single-cell resolution

During mammalian embryogenesis, differential gene expression gradually builds the identity and complexity of each tissue and organ system1. Here we systematically quantified mouse polyA-RNA from day 10.5 of embryonic development to birth, sampling 17 tissues and organs. The resulting developmental transcriptome is globally structured by dynamic cytodifferentiation, body-axis and cell-proliferation gene sets that were further characterized by the transcription factor motif codes of their promoters. We decomposed the tissue-level transcriptome using single-cell RNA-seq (sequencing of RNA reverse transcribed into cDNA) and found that neurogenesis and haematopoiesis dominate at both the gene and cellular levels, jointly accounting for one-third of differential gene expression and more than 40% of identified cell types. By integrating promoter sequence motifs with companion ENCODE epigenomic profiles, we identified a prominent promoter de-repression mechanism in neuronal expression clusters that was attributable to known and novel repressors. Focusing on the developing limb, single-cell RNA data identified 25 candidate cell types that included progenitor and differentiating states with computationally inferred lineage relationships. We extracted cell-type transcription factor networks and complementary sets of candidate enhancer elements by using single-cell RNA-seq to decompose integrative cis-element (IDEAS) models that were derived from whole-tissue epigenome chromatin data. These ENCODE reference data, computed network components and IDEAS chromatin segmentations are companion resources to the matching epigenomic developmental matrix, and are available for researchers to further mine and integrate.

The unequal distribution of economic education: A report on the race, ethnicity, and gender of economics majors at U.S. colleges and universities

Economic education is distributed unequally. Among U.S. undergraduates, women and underrepresented minority students collectively major in economics at 0.36 the rate that white, non-Hispanic men do. The authors establish a definition of full inclusion in economic education and use that definition to evaluate the status quo and to compare institutions. A companion resource, hosted by the Federal Reserve Bank of New York, provides interactive access to the data to attract and inform the attention of economists, university administrators, and others. The authors explain why the need to improve the distribution of economic education is urgent, including the imperative to support economic policymaking. Lastly, they point the way forward, identifying currently available resources and reasonable next steps for all involved parties to take.

Genome properties in 2019: a new companion database to InterPro for the inference of complete functional attributes.

Automatic annotation of protein function is routinely applied to newly sequenced genomes. While this provides a fine-grained view of an organism's functional protein repertoire, proteins, more commonly function in a coordinated manner, such as in pathways or multimeric complexes. Genome Properties (GPs) define such functional entities as a series of steps, originally described by either TIGRFAMs or Pfam entries. To increase the scope of coverage, we have migrated GPs to function as a companion resource utilizing InterPro entries. Having introduced GPs-specific versioned releases, we provide software and data via a GitHub repository, and have developed a new web interface to GPs (available at https://www.ebi.ac.uk/interpro/genomeproperties). In addition to exploring each of the 1286 GPs, the website contains GPs pre-calculated for a representative set of proteomes; these results can be used to profile GPs phylogenetically via an interactive viewer. Users can upload novel data to the viewer for comparison with the pre-calculated results. Over the last year, we have added ∼700 new GPs, increasing the coverage of eukaryotic systems, as well as increasing general coverage through automatic generation of GPs from related resources. All data are freely available via the website and the GitHub repository.

Resource Letter GECC-2: The Greenhouse Effect and Climate Change: The Intensified Greenhouse Effect

Human activities over the past 200 years have increased Earth's greenhouse effect by about 1% relative to the radiative fluxes that drive the climate system. This Resource Letter introduces the physics of this intensified greenhouse effect and of the processes that govern resultant change in climate and provides resources for further study. Context for this examination is provided in a companion Resource Letter (GECC-1) that examined the radiative fluxes that comprise Earth's climate system and the present-day greenhouse effect. The increase in global temperature and other changes in climate resulting from the intensified greenhouse effect are of great societal concern. Developing prognostic capability to determine these responses to the small perturbations that constitute the intensified greenhouse effect to an accuracy that would be useful to inform policymaking is the major challenge facing climate scientists today.

Resource Letter GECC-1: The Greenhouse Effect and Climate Change: Earth's Natural Greenhouse Effect

Earth's greenhouse effect is manifested as the difference between thermal infrared radiation emitted at the Earth surface and that emitted to space at the top of the atmosphere. This difference, which is due mainly to absorption and downward emission of radiant energy by atmospheric trace gases, results in global mean surface temperature about 32 K greater than what it would otherwise be for the same planetary absorption of solar radiation, and is thus of enormous importance to Earth's climate. This Resource Letter introduces the physics of the greenhouse effect and more broadly of Earth's climate system and provides resources for further study. A companion Resource Letter (GECC-2), planned for the following issue, examines the increase in the greenhouse effect due to human activities over the past 200 years and its consequences for Earth's climate system.

Review of The mindfulness and acceptance workbook for social anxiety and shyness: Using acceptance and commitment therapy to free yourself from fear and reclaim your life.

The Mindfulness and Acceptance Workbook for Social Anxiety and Shyness: Using Acceptance and Commitment Therapy to Free Yourself From Fear and Reclaim Your Life by Jan E. Fleming and Nancy L. Kocovski, Oakland, CA: New Harbinger Publications, Inc., 2013, 168 Pages. (ISBN-10: 1608820807, US $19.95 Paperback) Reviewed by RANDI E. MCCABE DOI: http://dx.doi.org/10.1037/a0038090Individuals who are dispositionally shy may desperately wish to engage more socially but feel inhibited from doing so due to feelings of awkwardness and anxiety. This anxiety may be associated with a range of situations, including social interactions such as making conversation, and performance situations such as giving a speech. Feelings of social anxiety and fears of negative selfevaluation can directly interfere with life satisfaction and goal attainment as negative reinforcement leads individuals to alter their life path in ways that minimise the experience of social discomfort. For a subset of people, social anxiety leads to significant clinical distress and impairment warranting a diagnosis of social anxiety disorder. The evidence-based psychological treatment of choice for individuals suffering from social anxiety disorder is cognitive behaviour therapy (CBT), an approach that encompasses a variety of treatment packages, the majority of which include a central emphasis on exposure. CBT has been associated with moderate to large effect sizes; however, dropout rates are in the range of 10-20% and a portion of treatment completers achieve only a partial response (Rodebaugh, Holaway, & Heimberg, 2004). Thus, there is a need for new approaches that may meet the needs of those who do not respond to traditional CBT protocols. This book provides just that option.In The Mindfulness and Acceptance Workbook for Social Anxiety and Shyness, the authors present a comprehensive treatment approach for overcoming shyness and social anxiety using mindfulness and acceptance strategies. In developing their treatment program, Fleming and Kocovski drew from the work of Steve Hayes (Acceptance and Commitment Therapy; ACT), Jon Kabat- Zinn (Mindfulness-Based Stress Reduction; MBSR), and Zindel Segal (Mindfulness-Based Cognitive Therapy; MBCT), who contributed the foreword for the book. Integrating ACT, MBSR, and MCBT strategies, the authors have specifically tailored the program to individuals with social anxiety. The book naturally developed out of the authors' own research program investigating group mindfulness- and acceptance-based therapy for social anxiety (MAGT). A major strength of the book is that it is based on empirical evidence showing both in an open trial and in a randomized controlled trial (RCT) that MAGT is associated with a significant reduction in social anxiety that is equivalent to the efficacy associated with CBT. Thus, the workbook offers a viable treatment option for consumers with social anxiety and for therapists working with clients with social anxiety. The approach may be used as an initial treatment or as an alternate option if standard CBT was not a good fit or the gains realised were suboptimal. The authors do a thorough job of summarising the research literature on mindfulness- and acceptance-based strategies for social anxiety, including their own work in this area, in Appendix A of the workbook.Overall, the book is well-written and a quick read with short chapters and focused exercises. In the introduction, the authors orient the reader to the roots of the approach taken in the book (ACT, MBCT, and MBSR) as well as the authors' inspiration for the book. They provide an overview of the organisation of the book as well as how to use it. An attractive feature of this workbook is the companion resources provided on the publisher's website. Users of the workbook can download all the worksheets as well as listen to audio files of the seven main meditation exercises (mindful eating, observing the mountain, body scan, mindful stretching, awareness of thinking, imagining VITAL action, and loving kindness). …

The 2014 Scope and Standards of Practice for Psychiatric Mental Health Nursing: Key Updates

The 2014 Psychiatric-Mental Health Nursing: Scope and Standards of Practice is the specialty’s description of competent nursing practice. The scope portion of this document identifies the focus of the specialty by defining nursing practice extents and limits. Standards are statements that identify the duties and obligations for which specialty nurses are held accountable, including general registered nurses and advanced practice nurses. This article begins with a brief overview of the revision process. The author describes key factors that influenced the revision, such as external documents and current priorities in healthcare, and synthesizes significant changes to the document, including commentary and comparisons to the generalist Scope and Standards of Practice. Implications for nursing education and a companion resource are discussed

Poverty and Pediatric Palliative Care: What Can We Do?

It has been recognized that families of children with life-limiting health conditions struggle with significant financial demands, yet may not have awareness of resources available to them. Additionally, health care providers may not be aware of the socioeconomic needs of families they care for. This article describes a mixed-methods study examining the content validity and utility for health care providers of a poverty screening tool and companion resource guide for the pediatric palliative care population. The study found high relevance and validity of the tool. Significant barriers to implementing the screening tool in clinical practice were described by participants, including: concerns regarding time required, roles and responsibilities, and discomfort in asking about income. Implications for practice and suggestions for improving the tool are discussed. Screening and attention to the social determinants of health lie within the scope of practice of all health care providers. Social workers can play a leadership role in this work.

Food and drink in American history: a "full course" encyclopedia

This three-volume encyclopedia on the history of American food and beverages serves as an ideal companion resource for social studies and American history courses, covering topics ranging from early American Indian foods to mandatory nutrition information at fast food restaurants.