The study examined the effect of knowledge management on corporate performance of pharmaceutical companies in Nigeria. The research utilized quantitative and descriptive method to analyze the study. The study’s target population comprised all the staffs of the seven (7) pharmaceutical companies listed on the floor of the Nigerian Stock Exchange. The sample size for the study was 289 employees from 7 pharmaceutical companies in Nigeria. Primary data with the aid of questionnaire consisting of 46 items, rated in a 5-point Likert scale was used. The gathered data was analyzed using both descriptive and inferential statistics. Descriptive statistics, including frequency component with aid of SPSS and in order to test the research hypotheses multiple regression was used to provide meaningful result to the hypotheses. The findings of this study have drawn conclusions that pharmaceutical companies in Nigeria have implemented a high level of knowledge management techniques. Knowledge creation primarily occurs through participation in seminars, conferences, industry products and benchmarking. The study recommended that functional heads within the pharmaceutical industry should encourage knowledge management.