Composited International Diagnostic Interview (CIDI). All determinants of interest were assessed with questionnaires that have proven adequate psychometric properties among Dutch older persons. Differences between depressed participants with or without a comorbid ADwere analysed by independent t-tests or chisquare statistics. Multivariate logistic regression analyses were performed to assess the association between previously identified determinants of comorbid AD. Subsequently, recent life-events, early traumatisation, the big five personality characteristics, and sense of mastery were added in separate models. These models were adjusted for the determinants found to be significantly associated with comorbid AD in any of the previous models. Results: More than one third of the patients suffered from any comorbid AD. The most frequent comorbid AD was social phobia (n1⁄462, 17.7%), followed by panic disorder with and without agoraphobia (n1⁄452, 14.9%), agoraphobia (n1⁄436, 10.3%) and finally generalized anxiety disorder (n1⁄433, 9.4%). Having a comorbid AD was consistently associated with a lower age and being female. Nonetheless, other determinants differed across the individual AD. The severity of depressive symptoms was only associated with the presence of a comorbid panic disorder, as was early traumatization. Finally, personality characteristics were associated with comorbid social phobia but not any of the other anxiety disorders. Conclusions: In line with previous studies we found that a fair percentage of depressed older patients suffer from a comorbid AD. Important determinants differ across the individual AD disorders and some determinants are even masked when lumping all AD together as often done. These findings point to the importance of acknowledging the individual comorbid AD. The findings stress the need to examine determinants of individual comorbid AD and by age groups. Knowledge of determinants of comorbid AD in depression may guide development of more specific interventions.