Abstract Background: Colorectal cancer (CRC) is a significant health issue in the United States, ranking as the third most diagnosed cancer and the second leading cause of cancer-related deaths. The incidence of CRC varies across the east coast of the United States due to multiple factors, including disparities in lifestyle, healthcare accessibility, and environmental exposures. Community-based participatory research plays a vital role in identifying effective interventions to enhance awareness of cancer risk and prevention in specific communities. Methods: This study focused on Asian Americans, Blacks, and Hispanics residing in the Greater Philadelphia (PA), New Jersey (NJ), and New York City (NYC) areas. The Synergistic Partnership for Enhancing Equity in Cancer Health (SPEECH) collaborated with community-based organizations' leaders and staff to streamline recruitment, workshop delivery, and survey data collection. The workshop curriculum covered essential CRC information, including facts, dietary habits, and screening guidelines. Pre- and post-workshop surveys were used to assess changes in CRC knowledge and screening intention. The distribution of participants was analyzed using Arc GIS. Results: [GXM1] The study population consisted of 212 Asian, 172 Hispanic/Latino, and 126 African American/Black participants. Geographical data was obtainable for 486 participants, primarily from New York (n=286, 58.8%), Pennsylvania (n=150, 30.9%), and New Jersey (n=49, 10.1%). These states form the Pennsylvania, New Jersey, and New York City (PNN) region, which is known for its high concentrations of neighborhoods experiencing persistent poverty, especially in areas densely populated by minorities. Distinct examples include neighborhoods within the Bronx borough of New York City and Philadelphia County in Pennsylvania. Alarmingly, in some counties within the PNN region, as many as 26% of the census tracts are categorized as persistently impoverished. This pattern of concentrated poverty is supported by several existing studies and research reports. Conclusions: The distribution of participants aligned with the study area of SPEECH and areas characterized by persistent poverty. These findings provide valuable insights to guide efforts in improving cancer health equity in the identified regions. Citation Format: Thoin F. Begum, Ellen Kim, Lin Zhu, Yin Tan, Evelyn T. González, Marilyn A. Fraser, Yingzhang Lin, Nathaly Rubio-Torio, Tenya Blackwell, Carolyn Martin, Safa Ibrahim, Ming-Chin Yeh, Grace X. Ma. Examining the geographical distribution of a colorectal cancer awareness community outreach program [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr A040.