Objective: In this study, we evaluated social support sources for rural residents with chronic conditions and examined associations between support sources and self-reported health status. Methods: Adults in rural zip codes across the United States (N = 183; 48.6% female) participated in an online survey. Chronic disease status was determined through participant self-report of prior medical diagnoses. Support sources were elicited using scenarios that require illness assistance or emotional support. Self-rated physical and mental health were measured using 5-point Likert scales. Chi-square tests examined gender differences in preferred sources of social support. Ordinal logistic regressions assessed predictors of self-rated health status, including support source preferences. Results: Family and friends were found to be primary sources of social support for rural residents managing illness. Women tended to rely more heavily on close family members whereas men were open to more diverse sources. Gender differences were statistically significant (χ2(4) = 20.66, p < .001). Those relying on close friends rather than family when sick also reported better physical health (B = 1.79, Wald = 4.91, p = .02). Conclusion: Findings indicate informal social ties are central for the health of rural populations. Gender differences in help-seeking patterns may necessitate tailored chronic disease interventions. Fostering community linkages and leveraging natural supports will be vital for addressing rural health disparities.